iScience November 2023 PMID 38026207

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2.

Qian Wang, Zhiteng Li, Yicheng Guo, Ian A Mellis, Sho Iketani, Michael Liu, Jian Yu, Riccardo Valdez, Adam S Lauring, Zizhang Sheng, Aubree Gordon, Lihong Liu, David D Ho

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Peak: 11 in Mar 2023

across 3 sources since Mar 2023

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188,043

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Mar 2023 – Feb 2024

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The discussions reveal a strong focus on the variant's evolution and implications, with phrases like 'distinct pathways' and 'immune evasion' indicating deep interest and engagement. The tone is scientifically curious and cautious, reflecting both excitement over new insights and concern over ongoing challenges in managing these variants.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, highlighting the evolving nature of SARS-CoV-2 variants and their implications for immunity.

InterestHigh interest

Participants appear highly interested, frequently referencing the specific variant (BA.2.75) and emphasizing the significance of antibody evasion and affinity changes.

EngagementModerate engagement

Comments often include references to the evolutionary pathways and potential public health consequences, indicating active engagement.

ImpactModerate impact

The discussions suggest the research could impact ongoing vaccine development and public health strategies, though some focus remains on understanding rather than immediate action.

Abstract in brief

The Omicron BA275 sublineage of SARS-CoV-2 has evolved into multiple variants with different spike mutations, notably CH11 and BN1, which are increasing in prevalence worldwide.
Two main evolutionary pathways have emerged: one producing variants like CH11 with decreased receptor affinity but high antibody resistance, and another like BN1 with increased receptor affinity and moderate antibody evasion.
Most circulating variants, except BN1, show strong antibody escape, highlighting that immune evasion is the key factor driving the current transmissibility of SARS-CoV-2.]

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Evolution of SARS-CoV-2 Omicron BA.2.75 and Its Impact on Viral Spread

The Omicron BA.2.75 sublineage of SARS-CoV-2 has evolved into multiple variants with different spike mutations, notably CH11 and BN1, which are increasing in prevalence worldwide. Variants show varying receptor affinity…

Jarod Moua · Feb 23, 2024 17 views

PromisingPreprints

@PromPreprint · X

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2 https://t.co/z6o9YWg8J0

Mar 28, 2023 · 3,310 followers View post →

SallyBee87

@Bee87Sally · X

RT @ejustin46: DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.…

Mar 23, 2023 · 5 shares · 33 followers View post →

Antoinette Roquentin

@denkentutweh · X

RT @ejustin46: DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.…

Mar 23, 2023 · 5 shares · 1,473 followers View post →

VintageKidsGoodies

@VintageKidsNL · X

RT @ejustin46: DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.…

Mar 23, 2023 · 5 shares · 546 followers View post →

Papa Mojo Jojo ☭

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RT @ejustin46: DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.…

Mar 23, 2023 · 5 shares · 918 followers View post →

Outbreak Science

@outbreaksci · X

New preprint: Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2 https://t.co/Itj3OEj14a #COVID19

Mar 23, 2023 · 1,376 followers View post →

Jean-B. de Saussure

@Jbs10twit · X

RT @ejustin46: DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.…

Mar 23, 2023 · 5 shares · 4,777 followers View post →

Emmanuel

@ejustin46 · X

DISTINCT evolutionary pathways of OMICRON subvariants "Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2" https://t.co/gKXSLYihck https://t.co/yNMdyO4KAe

Mar 22, 2023 · 27 likes · 5 shares · 17,299 followers View post →

Pooled Sequencing

@pooledseq · X

bioArXiv_ Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2 https://t.co/VlUqqppyiA

Mar 22, 2023 · 419 followers View post →

bioRxiv Microbiology

@biorxiv_micrbio · X

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2 https://t.co/RJ1bd3KNEO #biorxiv_micrbio

Mar 22, 2023 · 2 likes · 1 share · 20,828 followers View post →

bioRxiv

@biorxivpreprint · X

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2 https://t.co/eIDiE7vPie #bioRxiv

Mar 22, 2023 · 136,986 followers View post →

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2.

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Evolution of SARS-CoV-2 Omicron BA.2.75 and Its Impact on Viral Spread