Geroscience February 2024 PMID 38041783

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

David E Harrison, Randy Strong, Peter Reifsnyder, Nadia Rosenthal, Ron Korstanje, Elizabeth Fernandez, Kevin Flurkey, Brett C Ginsburg, Meredith D Murrell, Martin A Javors, Marisa Lopez-Cruzan, James F Nelson, Bradley J Willcox, Richard Allsopp, David M Watumull

Mentions

181
Peak: 85 in Dec 2023
across 6 sources since Dec 2023

Extended reach

6,622,898
potential audience

Total likes

96,616

Video views

4,352,642

Mentions per month

Dec 2023 – Nov 2025

Where it's discussed

  • X / Twitter110 posts
  • News36 articles
  • YouTube27 videos
  • Blogs4 articles
  • Facebook3 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions emphasize the positive effects of astaxanthin and meclizine, with comments like 'astaxanthin extended lifespan by 12%' and 'meclizine by 8%' echoing across various posts. Others raised points about the importance of negative results, stating 'publishing negative results is equally important,' which showcases the thoughtful consideration of research outcomes. The tone is generally optimistic and inquisitive, suggesting a recognition of the article's relevance and potential impact on health and longevity.

AgreementModerate agreement

Most discussions express a favorable view of the findings, particularly regarding astaxanthin and meclizine.

InterestHigh interest

Users show high curiosity about the implications of the study, especially concerning longevity.

EngagementModerate engagement

While some posts discuss the methods, others raise questions and share insights, reflecting moderate engagement.

ImpactHigh impact

Several users highlight the publication's potential significance for future research and health advancements.

Abstract in brief

  • In a study using genetically diverse UM-HET3 mice, the Nrf2 activator astaxanthin (Asta) increased male lifespan by 12%, while the mTORC1 inhibitor meclizine (Mec) raised it by 8%.
  • Both treatments began at 12 months of age and neither significantly affected body weight, although females showed lower weights with Asta and Mec.
  • Five additional compounds tested, including fisetin and dimethyl fumarate, did not lead to significant increases in lifespan, suggesting the need for further investigation into sex-specific aging effects and optimal dosages.

Top posts

Most liked on X and Bluesky
João Pedro de Magalhães
@jpsenescence · X

New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and meclizine (mTORC1 inhibitor) extended mouse lifespan. Five compounds didn’t, including fisetin - the first senolytic tested so far. https://t.co/Lw2Vml7nL9

Dec 3, 2023 · 79 likes · 18 shares · 18,175 followers View post →
Agingdoc
@agingdoc1 · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/gid7wHwnCI https://t.co/g3bZo4jcTW

Dec 3, 2023 · 61 likes · 11 shares · 41,360 followers View post →
João Pedro de Magalhães
@jpsenescence · X

Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negative result of 2024 was the ITP study showing that a senolytic (fisetin) does not extend lifespan in genetically diverse mice. 4/4 https://t.co/Lw2Vml7VAH

Dec 30, 2024 · 44 likes · 6 shares · 18,175 followers View post →
Ben Greenfield
@bengreenfield · X

One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate to a potential human lifespan increase of 9 years—9 healthy years. Impressive: https://t.co/0HT1sEBYje

Dec 29, 2023 · 32 likes · 3 shares · 94,874 followers View post →
Andrew Steele
@statto · X

Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18IZd Fisetin: same. In fact, it didn’t even clear senescent cells which is the mechanism by which it’s said to increase lifespan! https://t.co/5tVTrLeyO3

Jan 4, 2024 · 11 likes · 1 share · 12,387 followers View post →
Agingdoc
@agingdoc1 · X

Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version

Dec 4, 2023 · 10 likes · 1 share · 41,360 followers View post →

All mentions

david gardner
@davidga42845449 · X

@Longevity_EDU The Inteventions Testing Program (ITP) also showed it extended the male mouse lifespan by 12%. https://t.co/DlkTYmo0Qf

Aug 30, 2025 · 56 followers View post →
TT
@TT_brain · X

If you are a male mouse, Meclizine and Astaxanthin can extend lifespan by ~10%. https://t.co/uNdBrmoZ3L

Aug 10, 2025 · 50 followers View post →
Mr T.
@Mr_T____1776 · X

@NHAunleashed Vitamin #2: Astaxanthin https://t.co/d51bTl9DW8

Jun 18, 2025 · 1,104 followers View post →
Boni
@insilications · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 31, 2024 · 6 shares · 182 followers View post →
John Greene
@Greene_Thoughts · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 31, 2024 · 6 shares · 1,674 followers View post →
Richard Harper
@harpersnotes · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 31, 2024 · 6 shares · 2,237 followers View post →
Prof Steve Horvath
@prof_horvath · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 31, 2024 · 6 shares · 7,485 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 30, 2024 · 6 shares · 624 followers View post →
Dani ✌️
@danielsil44 · X

RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…

Dec 30, 2024 · 6 shares · 1,201 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/U1vlHK2ALA

Dec 30, 2024 · 1 like · 2,241 followers View post →
João Pedro de Magalhães
@jpsenescence · X

Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negative result of 2024 was the ITP study showing that a senolytic (fisetin) does not extend lifespan in genetically diverse mice. 4/4 https://t.co/Lw2Vml7VAH

Dec 30, 2024 · 44 likes · 6 shares · 18,175 followers View post →
Hua Bai
@TheBaiLab · X

RT @jpsenescence: @KarlPfleger Hmm, do senolytics increase lifespan? I've seen some smaller studies suggest they do but in the ITP they did…

Sep 15, 2024 · 1 share · 957 followers View post →
João Pedro de Magalhães
@jpsenescence · X

@KarlPfleger Hmm, do senolytics increase lifespan? I've seen some smaller studies suggest they do but in the ITP they didn't: https://t.co/Lw2Vml7nL9

Sep 15, 2024 · 8 likes · 1 share · 18,175 followers View post →
Alpine Institute: Longevity Research & Diagnostics
@alpinelongevity · X

For more details, check out the full study: https://t.co/suKKn4czHm

Aug 25, 2024 · 1,339 followers View post →
Madam Mitochondria
@Madam_Mito · X

@Ketogenic_EU @siimland Ref; https://t.co/nckOIffkqO

Aug 8, 2024 · 10,344 followers View post →
David Fendrich
@fnedrik · X

@siimland Why not astaxanthin for antioxidant defence, given the recent longevity study on male mice? https://t.co/9ilzdpCqqL

Jul 23, 2024 · 8 likes · 268 followers View post →
BIOCOACH
@BIOCOACHAPP · X

RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…

May 29, 2024 · 4 shares · 140 followers View post →
REJUVENS
@rejuvens · X

RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…

May 29, 2024 · 4 shares · 69 followers View post →
evolut
@evolutli · X

RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…

May 29, 2024 · 4 shares · 31 followers View post →
michaelreuter
@michaelreuter · X

RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…

May 29, 2024 · 4 shares · 4,288 followers View post →
NOMIX
@NOMIX_AI · X

Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan #longevity #healthspan #rejuvenation https://t.co/55cNyS9AUl

May 29, 2024 · 3 likes · 4 shares · 595 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @LammingLab: Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.

Apr 18, 2024 · 2 shares · 403 followers View post →
Nguyen An Hoang
@NguyenAnHoang4 · X

RT @LammingLab: Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.

Apr 18, 2024 · 2 shares · 59 followers View post →
Lamming Lab
@LammingLab · X

Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.

Apr 17, 2024 · 6 likes · 2 shares · 5,835 followers View post →
Rene Sugar
@renesugar · X

https://t.co/ErAyUZHu4N "while meclizine (Mec), an mTORC1 inhibitor, extended the male lifespan by 8% (p = 0.03)."

Apr 14, 2024 · 3,957 followers View post →
Rene Sugar
@renesugar · X

https://t.co/ErAyUZHu4N "In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test),"

Apr 14, 2024 · 3,957 followers View post →
Rene Sugar
@renesugar · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan ... #MECFS #LongCovid https://t.co/ErAyUZHu4N

Apr 14, 2024 · 5 likes · 1 share · 3,957 followers View post →
Nutriop Longevity
@nutriop · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used -… https://t.co/iqeGgAfMFY

Feb 28, 2024 · 78 followers View post →
alemac
@AleciaMacLeod24 · X

RT @bengreenfield: One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate t…

Jan 29, 2024 · 3 shares · 35 followers View post →
moussu romulien
@mousset_romain · X

RT @statto: Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18…

Jan 11, 2024 · 1 share · 57 followers View post →
Andrew Steele
@statto · X

Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18IZd Fisetin: same. In fact, it didn’t even clear senescent cells which is the mechanism by which it’s said to increase lifespan! https://t.co/5tVTrLeyO3

Jan 4, 2024 · 11 likes · 1 share · 12,387 followers View post →
Whole-istic Way
@whole_isticway · X

RT @bengreenfield: One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate t…

Dec 29, 2023 · 3 shares · 793 followers View post →
Ben Greenfield
@bengreenfield · X

One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate to a potential human lifespan increase of 9 years—9 healthy years. Impressive: https://t.co/0HT1sEBYje

Dec 29, 2023 · 32 likes · 3 shares · 94,874 followers View post →
Stan
@KanstantinS · X

@Sygdreas Very well summed up by @BradStanfieldMD in his video about Fisetin https://t.co/bVRAT3Fqdm

Dec 27, 2023 · 2 likes · 77 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

STOP Buying This Popular Supplement – New Study https://t.co/iVVuCSJ0O1 https://t.co/8U0yNamRgF

Dec 21, 2023 · 10 likes · 29,113 followers View post →
The Jackson Laboratory
@jacksonlab.bsky.social · Bluesky

Dec 15, 2023 View post →
The Jackson Laboratory
@jacksonlab · X

Dec 15, 2023 · 4 likes · 21,192 followers View post →
Orlando_uy
@Orlando_uy · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. https://t.co/y0kRvMTa40

Dec 12, 2023 · 1 like · 692 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

ITP latest findings: astaxanthin and meclizine extended mouse lifespan significantly. @LifespanIO https://t.co/5siXZcVk5S https://t.co/Stx5MQPwLF

Dec 11, 2023 · 691 followers View post →
Ken Gusler
@kgusler · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used: https://t.co/BQRtI9Z7q1

Dec 11, 2023 · 20,044 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@KeepFLFree2022 https://t.co/YJ1hELapRD

Dec 9, 2023 · 5 likes · 291,622 followers View post →
Andrew Steele
@statto · X

@AlexanderMWolf7 @PeterAttiaMD @aubreydegrey From the new ITP study: ‘Bodyweight was not significantly affected in males by the test agents. Late life weights were lower in females, but lifespan was not significantly affected in these females.’ People are aware of this and it’s not just CR! https://t.co/5tVTrLeyO3

Dec 8, 2023 · 3 likes · 12,387 followers View post →
Orlando_uy
@Orlando_uy · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. https://t.co/y0kRvMTa40

Dec 7, 2023 · 692 followers View post →
Rodney Samaan
@rsamaan · X

#Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses ⁦@PeterAttiaMD⁩ https://t.co/ayxsp2X1Z5

Dec 7, 2023 · 2,382 followers View post →
Healthier Friends
@HFriendsOrg · X

Winners and losers on ITP! https://t.co/DIQXteeQdx

Dec 7, 2023 · 14 followers View post →
tinytoeyy
@tinytoeyy · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 6, 2023 · 8 shares · 162 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

RT @Mah_abdellatif: The Nrf2 activator astaxanthin extends the median lifespan by 12%, whereas meclizine, an mTORC1 inhibitor, extends it b…

Dec 6, 2023 · 1 share · 6,435 followers View post →
Mahmoud Abdellatif
@Mah_abdellatif · X

The Nrf2 activator astaxanthin extends the median lifespan by 12%, whereas meclizine, an mTORC1 inhibitor, extends it by 8%, in male mice. https://t.co/cLl35E57BP

Dec 6, 2023 · 9 likes · 1 share · 625 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Astaxanthin and meclizine help male UM-HET3 mice live longer. But fisetin, SG1002, dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate don't affect lifespan in both male and female mice at the given doses and timings. @GeroScienceAGE https://t.co/5siXZcVk5S

Dec 6, 2023 · 2 likes · 691 followers View post →
Matt Kaeberlein
@mkaeberlein · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 5, 2023 · 11 shares · 29,598 followers View post →
Jiongming Lu
@LuJiongming · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 5, 2023 · 26 shares · 299 followers View post →
BioTrove Investments
@BiotroveInvest · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 5, 2023 · 18 shares · 433 followers View post →
น้องจุ๊บุ
@yayachacha7 · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 5, 2023 · 26 shares · 7 followers View post →
น้องจุ๊บุ
@yayachacha7 · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 5, 2023 · 8 shares · 7 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 5, 2023 · 11 shares · 291,622 followers View post →
CHANEL
@richdechanel · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 5, 2023 · 8 shares · 24 followers View post →
พี่ลินไทยเปย์
@MilinKittimaW · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 5, 2023 · 8 shares · 26,552 followers View post →
ริชเกิว โอลีฟเกิว
@navynblue · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 5, 2023 · 8 shares · 310 followers View post →
S U P R E A W
@Su_Praewy · X

RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB

Dec 5, 2023 · 8 shares · 254 followers View post →
The Longevist
@Dr_coachbear · X

Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB https://t.co/tyFylsF7WW

Dec 5, 2023 · 5 likes · 8 shares · 514,938 followers View post →
The Longevist
@Dr_coachbear · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 5, 2023 · 26 shares · 514,938 followers View post →
GeroScience
@GeroScienceAGE · X

Dec 4, 2023 · 7 likes · 3,632 followers View post →
Max Unfried
@MaxUnfried · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version

Dec 4, 2023 · 1 share · 3,854 followers View post →
Agingdoc
@agingdoc1 · X

Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version

Dec 4, 2023 · 10 likes · 1 share · 41,360 followers View post →
Chris Linnell
@ChrisPollyanna1 · X

Also unfortunately, fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate did not show a statistically significant change at the doses tested. 3/3 https://t.co/RZyf8aaxNG https://t.co/H7nwoik153

Dec 4, 2023 · 702 followers View post →
Simon Hill MSc, BSc
@theproof · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 4, 2023 · 11 shares · 34,142 followers View post →
Mark Patterson
@MarkGPatterson · X

Astaxanthin = 12% life extension in males. https://t.co/GuQX8R0hPJ

Dec 4, 2023 · 3,136 followers View post →
Dantalion
@Dantali84254624 · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 4, 2023 · 26 shares · 258 followers View post →
Vince Beltran, Ph.D.
@levin_beltran · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 4, 2023 · 18 shares · 11,760 followers View post →
Alex Janin
@AlexLJanin · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 4, 2023 · 11 shares · 10,380 followers View post →
Science Socks
@SocksScience · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 4, 2023 · 18 shares · 452 followers View post →
humanOS.me
@humanOS_me · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 4, 2023 · 11 shares · 9,664 followers View post →
CRISPR GLENN
@CrisprGlenn · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 4, 2023 · 26 shares · 2,646 followers View post →
Shahaf Peleg
@DocLarus · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 4, 2023 · 11 shares · 2,430 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 4, 2023 · 11 shares · 41,360 followers View post →
Mesha
@cosmautic · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 4, 2023 · 26 shares · 460 followers View post →
Boris Carikeo
@BCarikeo · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 4, 2023 · 18 shares · 669 followers View post →
Ove A. Vanebo
@vanebo · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 4, 2023 · 26 shares · 5,460 followers View post →
Maria Ermolaeva
@MariaErmolaev13 · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 4, 2023 · 18 shares · 2,152 followers View post →
Dimitri Villard
@DimitriVillard · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 4, 2023 · 26 shares · 253 followers View post →
Senpai
@kimchisushinasi · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 15 followers View post →
Fay
@fay90028966 · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 143 followers View post →
Govind Prakash
@drgovindprakash · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 244 followers View post →
Debbie @ Genetic Lifehacks
@GeneticLifehack · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 1,514 followers View post →
Sean Murphy
@book_sean · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 349 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 403 followers View post →
Dervis Salih
@DervisSalih1 · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 4,514 followers View post →
Alexei Maklakov
@AlexeiMaklakov · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 1,498 followers View post →
Anne McArdle
@Anne91011 · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 549 followers View post →
Marcio Brasileiro
@MarcioBrasilei3 · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 1,059 followers View post →
Dani ✌️
@danielsil44 · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 1,201 followers View post →
Simon Brežan MD
@BrezanSimonMD · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 783 followers View post →
Dr. Neil Paulvin
@NeilpDo · X

Article showing the antioxidant Astaxanthin and dizziness medicine Meclizine can increase longevity in animal studies. Astaxanthin does this as an antioxidant and a Meclizine acts through Mtor https://t.co/Cwj2qRalKv

Dec 3, 2023 · 1 like · 2,846 followers View post →
@drsimoncook.bsky.social
@DrSimonCook1 · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 1,234 followers View post →
genomicspark
@hexomics · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 90 followers View post →
Cellular Aging and Nutrition Laboratory
@Aging_CEU · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 3, 2023 · 11 shares · 402 followers View post →
SeattleFreeze☆Sheen
@SheenHunter · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 470 followers View post →
Aging Science News
@AgingBiology · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 30,508 followers View post →
Greenlandshark
@greenlandsharky · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 316 followers View post →
Lamming Lab
@LammingLab · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 5,835 followers View post →
Richard Harper
@harpersnotes · X

RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…

Dec 3, 2023 · 18 shares · 2,237 followers View post →
João Pedro de Magalhães
@jpsenescence · X

New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and meclizine (mTORC1 inhibitor) extended mouse lifespan. Five compounds didn’t, including fisetin - the first senolytic tested so far. https://t.co/Lw2Vml7nL9

Dec 3, 2023 · 79 likes · 18 shares · 18,175 followers View post →
Leo HA
@et_leonardo · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 231 followers View post →
frank
@frankwikson · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 28 followers View post →
Lt. Ice Eagle #USARMY
@PsyopLogician · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 6,545 followers View post →
Max Unfried
@MaxUnfried · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 3,854 followers View post →
Halixera
@halixera · X

RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…

Dec 3, 2023 · 26 shares · 1,549 followers View post →
Juhana Harju
@JuhanaHarju · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 3, 2023 · 11 shares · 1,689 followers View post →
Fay
@fay90028966 · X

RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…

Dec 3, 2023 · 11 shares · 143 followers View post →
Agingdoc
@agingdoc1 · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/gid7wHwnCI https://t.co/g3bZo4jcTW

Dec 3, 2023 · 61 likes · 11 shares · 41,360 followers View post →
Bradley John Willcox
@ProfBradWillcox · X

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl … https://t.co/CKrsTWYrlI

Dec 2, 2023 · 1 like · 68 followers View post →