New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and meclizine (mTORC1 inhibitor) extended mouse lifespan. Five compounds didn’t, including fisetin - the first senolytic tested so far. https://t.co/Lw2Vml7nL9
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
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Dec 2023 – Nov 2025Where it's discussed
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AI synopsis
What people are saying
The discussions emphasize the positive effects of astaxanthin and meclizine, with comments like 'astaxanthin extended lifespan by 12%' and 'meclizine by 8%' echoing across various posts. Others raised points about the importance of negative results, stating 'publishing negative results is equally important,' which showcases the thoughtful consideration of research outcomes. The tone is generally optimistic and inquisitive, suggesting a recognition of the article's relevance and potential impact on health and longevity.
Most discussions express a favorable view of the findings, particularly regarding astaxanthin and meclizine.
Users show high curiosity about the implications of the study, especially concerning longevity.
While some posts discuss the methods, others raise questions and share insights, reflecting moderate engagement.
Several users highlight the publication's potential significance for future research and health advancements.
Abstract in brief
- In a study using genetically diverse UM-HET3 mice, the Nrf2 activator astaxanthin (Asta) increased male lifespan by 12%, while the mTORC1 inhibitor meclizine (Mec) raised it by 8%.
- Both treatments began at 12 months of age and neither significantly affected body weight, although females showed lower weights with Asta and Mec.
- Five additional compounds tested, including fisetin and dimethyl fumarate, did not lead to significant increases in lifespan, suggesting the need for further investigation into sex-specific aging effects and optimal dosages.
Top posts
Most liked on X and BlueskyAstaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/gid7wHwnCI https://t.co/g3bZo4jcTW
Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negative result of 2024 was the ITP study showing that a senolytic (fisetin) does not extend lifespan in genetically diverse mice. 4/4 https://t.co/Lw2Vml7VAH
One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate to a potential human lifespan increase of 9 years—9 healthy years. Impressive: https://t.co/0HT1sEBYje
Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18IZd Fisetin: same. In fact, it didn’t even clear senescent cells which is the mechanism by which it’s said to increase lifespan! https://t.co/5tVTrLeyO3
Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version
All mentions
Effects of Daily Astaxanthin Supplementation on Skin Health and Aging
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Astaxanthin's Potential Benefits for Dementia: A Clinical Review
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Astaxanthin and Longevity: Scientific Insights and Potential Benefits
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Natürlicher Sonnenschutz vom Feinsten!
Astaxanthin's Impact on Brain Health and Longevity in Mice
This video discusses the role of coconut oil as a brain fuel and the disappointing studies around it. It also highlights astaxanthin's potential benefits, showing improved lifespan in male mice and its efficiency…
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Study Finds Popular Longevity Supplements Show No Benefits
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Astaxanthin Increases Lifespan by 12% in New Study Findings
In a groundbreaking study, astaxanthin was shown to extend lifespan by 12% in genetically diverse UM-HET3 male mice. This video explores the science behind astaxanthin, its optimal dosage, and the significant results…
Die 3 besten Supplements für den Sommer - Mangelgefahr!
First Supplement To Show Greater Than 10% Life Extension In ITP History
【話題のサプリメント】驚くべき効果を持つ、アスタキサンチンについて医師が徹底解説します。
The Astaxanthin Quest: Cracking Longevity
Astaxanthin Safety and Benefits for Anti-Aging and Health Enhancement
Astaxanthin is a powerful antioxidant that offers cellular protection, reduces inflammation, and supports healthy aging. This video explores how it works, its benefits for athletes, and safety considerations for optimal…
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@Longevity_EDU The Inteventions Testing Program (ITP) also showed it extended the male mouse lifespan by 12%. https://t.co/DlkTYmo0Qf
If you are a male mouse, Meclizine and Astaxanthin can extend lifespan by ~10%. https://t.co/uNdBrmoZ3L
@NHAunleashed Vitamin #2: Astaxanthin https://t.co/d51bTl9DW8
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
RT @jpsenescence: Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negati…
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/U1vlHK2ALA
Last but not least - because publishing negative results is often overlooked yet it is equally important - the top negative result of 2024 was the ITP study showing that a senolytic (fisetin) does not extend lifespan in genetically diverse mice. 4/4 https://t.co/Lw2Vml7VAH
RT @jpsenescence: @KarlPfleger Hmm, do senolytics increase lifespan? I've seen some smaller studies suggest they do but in the ITP they did…
@KarlPfleger Hmm, do senolytics increase lifespan? I've seen some smaller studies suggest they do but in the ITP they didn't: https://t.co/Lw2Vml7nL9
For more details, check out the full study: https://t.co/suKKn4czHm
@Ketogenic_EU @siimland Ref; https://t.co/nckOIffkqO
@siimland Why not astaxanthin for antioxidant defence, given the recent longevity study on male mice? https://t.co/9ilzdpCqqL
RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…
RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…
RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…
RT @NOMIX_AI: Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic…
Astaxanthin and meclizine extend lifespan in mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan #longevity #healthspan #rejuvenation https://t.co/55cNyS9AUl
RT @LammingLab: Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.
RT @LammingLab: Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.
Somehow missed this one: https://t.co/fu4PemBmKc Male-specific benefits of astaxanthin and meclizine on lifespan.
https://t.co/ErAyUZHu4N "while meclizine (Mec), an mTORC1 inhibitor, extended the male lifespan by 8% (p = 0.03)."
https://t.co/ErAyUZHu4N "In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test),"
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan ... #MECFS #LongCovid https://t.co/ErAyUZHu4N
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used -… https://t.co/iqeGgAfMFY
RT @bengreenfield: One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate t…
RT @statto: Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18…
Nicotinamide riboside: didn’t extend life in mice in the ITP, the gold standard of mouse lifespan studies. https://t.co/iGZpo18IZd Fisetin: same. In fact, it didn’t even clear senescent cells which is the mechanism by which it’s said to increase lifespan! https://t.co/5tVTrLeyO3
RT @bengreenfield: One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate t…
One form of astaxanthin extended the median lifespan by 12% with strong statistical significance. This could translate to a potential human lifespan increase of 9 years—9 healthy years. Impressive: https://t.co/0HT1sEBYje
@Sygdreas Very well summed up by @BradStanfieldMD in his video about Fisetin https://t.co/bVRAT3Fqdm
STOP Buying This Popular Supplement – New Study https://t.co/iVVuCSJ0O1 https://t.co/8U0yNamRgF
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. https://t.co/y0kRvMTa40
ITP latest findings: astaxanthin and meclizine extended mouse lifespan significantly. @LifespanIO https://t.co/5siXZcVk5S https://t.co/Stx5MQPwLF
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used: https://t.co/BQRtI9Z7q1
@KeepFLFree2022 https://t.co/YJ1hELapRD
@AlexanderMWolf7 @PeterAttiaMD @aubreydegrey From the new ITP study: ‘Bodyweight was not significantly affected in males by the test agents. Late life weights were lower in females, but lifespan was not significantly affected in these females.’ People are aware of this and it’s not just CR! https://t.co/5tVTrLeyO3
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. https://t.co/y0kRvMTa40
#Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses @PeterAttiaMD https://t.co/ayxsp2X1Z5
Winners and losers on ITP! https://t.co/DIQXteeQdx
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
RT @Mah_abdellatif: The Nrf2 activator astaxanthin extends the median lifespan by 12%, whereas meclizine, an mTORC1 inhibitor, extends it b…
The Nrf2 activator astaxanthin extends the median lifespan by 12%, whereas meclizine, an mTORC1 inhibitor, extends it by 8%, in male mice. https://t.co/cLl35E57BP
Astaxanthin and meclizine help male UM-HET3 mice live longer. But fisetin, SG1002, dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate don't affect lifespan in both male and female mice at the given doses and timings. @GeroScienceAGE https://t.co/5siXZcVk5S
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
RT @Dr_coachbear: Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB
Astaxanthin , meclizine สารสองชนิดที่เพิ่มอายุขัยในสัตว์ทดลองได้ 12% และ 8% https://t.co/1ynEsAaxYB https://t.co/tyFylsF7WW
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version
Astaxanthin and meclizine extend lifespan in UM HET3 male mice TikTok Teaser @YouTube Agingdoc Podcast Version
Also unfortunately, fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate did not show a statistically significant change at the doses tested. 3/3 https://t.co/RZyf8aaxNG https://t.co/H7nwoik153
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
Astaxanthin = 12% life extension in males. https://t.co/GuQX8R0hPJ
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
Article showing the antioxidant Astaxanthin and dizziness medicine Meclizine can increase longevity in animal studies. Astaxanthin does this as an antioxidant and a Meclizine acts through Mtor https://t.co/Cwj2qRalKv
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
RT @jpsenescence: New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and…
New paper from the @NIHAging Interventions Testing Program just out in @GeroScienceAGE Astaxanthin (Nrf2 inhibitor) and meclizine (mTORC1 inhibitor) extended mouse lifespan. Five compounds didn’t, including fisetin - the first senolytic tested so far. https://t.co/Lw2Vml7nL9
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @BradStanfieldMD: Major Lifespan News! From the Interventions Testing Program (mice): - Nrf2 activator astaxanthin extended the median…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
RT @agingdoc1: Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate,…
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used https://t.co/gid7wHwnCI https://t.co/g3bZo4jcTW
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl … https://t.co/CKrsTWYrlI