Int J Mol Sci November 2023 PMID 38069031

Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation.

Konstantin Belov, Valery Brel, Valentina Sobornova, Irina Fedorova, Ilya Khodov

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Peak: 4 in Nov 2023

across 3 sources since Nov 2023

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14,165

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1,017

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Nov 2023 – Feb 2024

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What people are saying

The conversations focus on the findings related to fluorine's role in conformational behavior, with phrases like 'unlocking potential insights' and 'impact on anticancer activities,' reflecting high interest and appreciation for the study’s significance, while the tone remains professional and curious, emphasizing the scientific value of the research.

AgreementModerate agreement

Most discussions acknowledge and support the significance of the study, especially highlighting how fluorine affects molecular conformation.

InterestHigh interest

Posts show strong curiosity about how fluorine influences molecular structures and their biological activities.

EngagementModerate engagement

Comments involve referencing the methods used and potential implications, indicating moderate depth of interaction.

ImpactModerate impact

The discussions hint at the work's importance for future research in medicinal chemistry and structural analysis.

Abstract in brief

The study explores how fluorine atoms affect the shape (conformation) of 15Diaryl3Oxo14Pentadiene derivatives, which are organic compounds with a core structure including a pentadiene chain, aryl groups, and a ketone.
Using NMR spectroscopy and quantum chemical calculations, researchers examined how fluorine influences the distances between atoms and which conformers are most common, finding that nonfluorinated compounds have a mix of conformers, while fluorinated ones mainly adopt a specific conformer.
These structural differences caused by fluorine could be important for understanding the variations in anticancer activities seen in previous research, suggesting that conformation plays a role in their biological effects.]

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All mentions

Conformational Study of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives Using NMR Spectroscopy

Explore how fluorine atoms influence the structure of 1,5-diaryl-3-oxo-1,4-pentadiene derivatives through NMR spectroscopy and quantum calculations. The study highlights the impact of conformation on potential…

Ilya Khodov · Feb 7, 2024 926 views

Conformational Effects of Fluorine in Diaryl-Pentadiene Derivatives

Ilya Khodov · Feb 7, 2024 50 views

Conformational Analysis of Diaryl-3-Oxo-Pentadiene Derivatives Using NMR Techniques

Explore the conformational effects of fluorine atoms on 1,5-diaryl-3-oxo-1,4-pentadiene derivatives. Using NMR spectroscopy and quantum calculations, the study reveals structural differences influenced by fluorination…

Science of Molecules · Feb 8, 2024 42 views

Konstantin Belov

@Konstantin94484 · X

RT @FluidNmr:

Feb 1, 2024 · 3 shares · 10 followers View post →

Thorsten Maly (he/him)

@thmaly · X

Conformational Analysis of 1,5-Diaryl-3-Oxo-1,4-Pentadiene Derivatives: A Nuclear Overhauser Effect Spectroscopy Investigation #DNPNMR https://t.co/f1koP1ScWP

Jan 1, 2024 · 1 like · 1,597 followers View post →

IJMS MDPI

@IJMS_MDPI · X

RT @FluidNmr:

Nov 26, 2023 · 3 shares · 5,261 followers View post →

Magnetic Resonance News

@nmr900 · X

RT @IlyaKhodov: Our study, featured in @IJMS_MDPI, explores the impact of fluorine atoms on their conformational features ⚛️, unlocking pot…

Nov 24, 2023 · 3 shares · 6,114 followers View post →

Dr. Ilya Khodov

@IlyaKhodov · X

Our study, featured in @IJMS_MDPI, explores the impact of fluorine atoms on their conformational features ⚛️, unlocking potential insights into diverse anticancer activities.

Nov 24, 2023 · 5 likes · 3 shares · 37 followers View post →

Fluid State NMR

@FluidNmr · X

Nov 24, 2023 · 6 likes · 3 shares · 100 followers View post →