Dev Cell January 2024 PMID 38101412

D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder.

Chetanchandra S Joshi, Arnold M Salazar, Caihong Wang, Marianne M Ligon, Rayvanth R Chappidi, Bisiayo E Fashemi, Paul A Felder, Amy Mora, Sandra L Grimm, Cristian Coarfa, Indira U Mysorekar

Mentions

20
Peak: 4 in Dec 2023
across 5 sources since Dec 2023

Extended reach

48,029
potential audience

Total likes

32

Video views

381

Mentions per month

Dec 2023 – Aug 2024

Where it's discussed

  • X / Twitter10 posts
  • News4 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Posts reflect a strong interest in the topic, with references to the mechanisms involved, such as autophagy and inflammation, and even mentions of the publication's potential to reverse bladder aging. The tone varies from curiosity to cautious optimism, with discussions centered around the significance of D-Mannose as a possible therapy and the article's contribution to urology research, demonstrating both engagement and recognition of its potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some expressing curiosity or cautious optimism about D-Mannose's potential benefits.

InterestHigh interest

Many posts are highly interested, referencing the research directly and highlighting its potential implications for bladder health and aging.

EngagementModerate engagement

Participants engage by sharing related articles, discussing mechanisms like autophagy and inflammation, and expressing positive opinions about the research's relevance.

ImpactModerate impact

While some recognize the potential therapeutic impact, the overall tone suggests awareness rather than immediate widespread application or revolutionary change.

Abstract in brief

  • The study shows that aging in female mice leads to impaired cellular health in the bladder's lining, including accumulation of damaged lysosomes, increased oxidative stress, and signs of cell aging, which results in urothelial cell loss and higher susceptibility to urinary tract infections (UTIs).
  • Aged mice exhibit increased inflammation and cell death driven by NLRP3 inflammasome and pyroptosis, worsening bladder dysfunction and infection risk, with cells showing a senescence-associated secretory phenotype (SASP).
  • Treatment with D-mannose, a natural sugar, helps reverse these aging-related issues by improving cell cleanup processes (autophagy), reducing inflammation, and decreasing cell shedding, suggesting it could be used as a therapy to combat age-related bladder problems.]

Top posts

Most liked on X and Bluesky
Developmental Cell
@Dev_Cell · X

Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder https://t.co/CSNOSWYxuq

Dec 14, 2023 · 10 likes · 3 shares · 39,235 followers View post →
CAIRIBU
@CAIRIBU1 · X

Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link: https://t.co/ggq8TdC0aV Discover other relevant articles to jump start your lit search HERE: https://t.co/Vlh8oWA2ri #Urology #MedTwitter https://t.co/INfWPWUmgO

Jan 10, 2024 · 3 likes · 2 shares · 355 followers View post →
Dr. Indira Mysorekar
@MysorekarLab · X

RT @CAIRIBU1: Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link:…

Jan 10, 2024 · 2 shares · 2,671 followers View post →
Dr. Indira Mysorekar
@MysorekarLab · X

RT @Dev_Cell: Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in…

Dec 18, 2023 · 3 shares · 2,671 followers View post →
Michael Neugent PhD
@MikeNeug · X

RT @CAIRIBU1: Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link:…

Jan 10, 2024 · 2 shares · 1,180 followers View post →
Michael Neugent PhD
@MikeNeug · X

RT @Dev_Cell: Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in…

Dec 14, 2023 · 3 shares · 1,180 followers View post →

All mentions

Mitigating Bladder Aging and UTI Risk with D-Mannose

Aging impairs bladder cellular health, increasing UTI vulnerability. This video examines how D-mannose helps reduce cellular senescence, inflammation, and cell shedding in the bladder, offering potential strategies for…

VHFILM · Aug 18, 2024 248 views
Ralph Turchiano
@RalphTurchiano · X

Reverse Bladder Aging with Mannose? Ep. 1202 AUG 2024 https://t.co/7JieMJoNRg via @YouTube Aging is often accompanied by a decline in organ function, and the urinary tract is no exception. This video explores how cellular aging within the bladder contributes to increased

Aug 18, 2024 · 128 followers View post →
Ralph Turchiano
@RalphTurchiano · X

Reverse Bladder Aging with Mannose? https://t.co/Lr8UnrdlP7 via @YouTube

Aug 10, 2024 · 128 followers View post →
Kidney Kaleidoscope
@KidneyKScope · X

D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. @Dev_Cell @MysorekarLab @BCMDeptMedicine https://t.co/0LZlivlHkA

Jan 19, 2024 · 40 followers View post →
Michael Neugent PhD
@MikeNeug · X

RT @CAIRIBU1: Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link:…

Jan 10, 2024 · 2 shares · 1,180 followers View post →
Dr. Indira Mysorekar
@MysorekarLab · X

RT @CAIRIBU1: Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link:…

Jan 10, 2024 · 2 shares · 2,671 followers View post →
CAIRIBU
@CAIRIBU1 · X

Have You Read This? Check out this article, written by CAIRIBU affiliated investigators, by clicking the link below! Link: https://t.co/ggq8TdC0aV Discover other relevant articles to jump start your lit search HERE: https://t.co/Vlh8oWA2ri #Urology #MedTwitter https://t.co/INfWPWUmgO

Jan 10, 2024 · 3 likes · 2 shares · 355 followers View post →
Bin Cao
@BinCaolabXMU · X

RT @Dev_Cell: Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in…

Dec 18, 2023 · 3 shares · 25 followers View post →
Dr. Indira Mysorekar
@MysorekarLab · X

RT @Dev_Cell: Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in…

Dec 18, 2023 · 3 shares · 2,671 followers View post →
Michael Neugent PhD
@MikeNeug · X

RT @Dev_Cell: Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in…

Dec 14, 2023 · 3 shares · 1,180 followers View post →
Developmental Cell
@Dev_Cell · X

Online now: D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder https://t.co/CSNOSWYxuq

Dec 14, 2023 · 10 likes · 3 shares · 39,235 followers View post →