Br J Psychiatry December 2023 PMID 38108319

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial.

Colleen Loo, Nick Glozier, David Barton, Bernhard T Baune, Natalie T Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B Mitchell

Mentions

48
Peak: 13 in Jul 2023
across 5 sources since Jul 2023

Extended reach

353,175
potential audience

Total likes

4,861

Video views

190,151

Mentions per month

Jul 2023 – Oct 2025

Where it's discussed

  • X / Twitter34 posts
  • News8 articles
  • Reddit3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions showcase a strong interest and deep engagement with the research, as evidenced by phrases like 'ketamine wins big' and references to specific trial results such as remission rates, indicating enthusiasm for the potential of ketamine as an effective treatment. The tone and context reflect a recognition of the study's importance, with many emphasizing its promising results and possible influence on future depression therapies.

AgreementModerate agreement

Most discussions support the findings of the study, emphasizing its positive results and potential clinical implications, evidenced by comments like 'Ketamine Wins Big' and mentions of promising trial outcomes.

InterestHigh interest

There is a high level of curiosity, as participants refer to multiple studies, dosing details, and comparisons to existing treatments, indicating they find the research relevant and worth exploring.

EngagementHigh engagement

Many discussions delve into details about the methodology and implications, with references to specific trial results and citations, showing deep involvement in understanding the topic.

ImpactHigh impact

Several posts highlight the trial’s significance, considering it a potential breakthrough in treating resistant depression and calling it a 'game changer,' thus perceiving high impact on mental health treatments.

Abstract in brief

  • The study tested the safety and effectiveness of a 4-week course of repeated subcutaneous racemic ketamine injections for treatment-resistant depression, comparing fixed and flexible dosing to midazolam as a control.
  • Results showed that flexible-dose ketamine was significantly more effective than midazolam in inducing remission of depression, while fixed-dose ketamine did not show a significant difference.
  • The treatment was generally safe and well tolerated, with manageable side effects like temporary blood pressure increases and psychotomimetic effects, indicating that subcutaneous ketamine could be a practical option for managing treatment-resistant depression.]

Top posts

Most liked on X and Bluesky
Health Nerd
@GidMK · X

Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule with up to 2x the dose showed a fairly large improvement https://t.co/nh4fnmsKqo

Jul 17, 2023 · 36 likes · 5 shares · 74,573 followers View post →
Dr Dilara Bahceci
@DilaraB_PhD · X

⭐ In case you missed it: Generic #ketamine was confirmed to be an effective #antidepressant in people with treatment-resistant #depression. An Australian, @NHMRC-funded, phase 3 trial by @UNSW @georgeinstitute @blackdoginst et al.

Jul 18, 2023 · 15 likes · 1 share · 1,594 followers View post →
Psychedelic Alpha
@Psyched_Alpha · X

Researchers in Australia Demonstrate Efficacy of Ketamine for Treatment-Resistant Depression Over a 4-week Treatment Course "..the proportional increase in remission comparing favourably to that of studies of intranasal esketamine.." https://t.co/Dbeyza12u8

Jul 14, 2023 · 8 likes · 1 share · 20,727 followers View post →
Mark Anderson
@MarkHAnderson59 · X

@7NewsMelbourne Why say its linked to mental illness? We are currently using it in trials to treat resistant depression: https://t.co/tK3RsodvPM There are a good number of studies showing that it has positive effects on mental illness. https://t.co/tK3RsodvPM https://t.co/3FA5ANQJO9

Jan 7, 2024 · 4 likes · 1 share · 1,241 followers View post →
BJPsych Journals
@TheBJPsych · X

#BJPsych Most Downloaded goes to ‘Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial’ by Colleen Loo et al Read the article: https://t.co/sWyOA1HTiI https://t.co/j9uObxmFpv

Jun 17, 2024 · 2 likes · 13,386 followers View post →
#TheSpiderHunter - Black History Is Important!
@Arthur59611540 · X

@Rahmami2585 @MaeWilbon @ChrisTurne83916 @drtessporess @YouTube Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/C4GFbFuzXh via @YouTube

Mar 1, 2024 · 2 likes · 4,119 followers View post →

All mentions

Neil Stillman
@NEILStllmn · X

Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/GoBSUkf4i9 via @YouTube

Oct 26, 2025 · 1 like · 676 followers View post →
Sexy Brain TV
@SexyBrainTV1 · X

https://t.co/LDK9tkww6g

Feb 15, 2025 · 36 followers View post →
Bovenator
@Leonard_Bvg · X

@MagicMinder @NilsVirago @IsarJesus https://t.co/E1KhzgHvBf

Dec 25, 2024 · 4 followers View post →
SRLibProblems
@srlibproblems.bsky.social · Bluesky

What about these? doi: 10.1192/bjp.2023.79 doi: 10.1176/appi.ajp.2018.18070834 doi: 10.1177/0269881118760660 doi: 10.1192/bjp.2018.196

Sep 3, 2024 · 1 like View post →
BJPsych Journals
@TheBJPsych · X

#BJPsych Most Downloaded goes to ‘Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial’ by Colleen Loo et al Read the article: https://t.co/sWyOA1HTiI https://t.co/j9uObxmFpv

Jun 17, 2024 · 2 likes · 13,386 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial | The British Journal of Psychiatry | Cambridge Core https://t.co/pmPHrC2NZV

May 30, 2024 · 358 followers View post →
sara fournier
@sarafou37790797 · X

@francoislegault @JustinTrudeau @POTUS @Eminem Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/gdd1dg4qez via @YouTube Legalise heavy drugs

Mar 13, 2024 · 27 followers View post →
#TheSpiderHunter - Black History Is Important!
@Arthur59611540 · X

@Rahmami2585 @MaeWilbon @ChrisTurne83916 @drtessporess @YouTube Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/C4GFbFuzXh via @YouTube

Mar 1, 2024 · 2 likes · 4,119 followers View post →
D P
@DreamPedestrian · X

@TatiGrebennique https://t.co/shTXa4aSlA https://t.co/5dAL35LfSB

Feb 7, 2024 · 1 share · 37 followers View post →
⟊ʞɏᒪɘ ∴ ȺⱤϻ$₮ⱤØ₦₲⟁
@TheMedicineWolf · X

Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/aqQo6JMNF1

Feb 7, 2024 · 19,850 followers View post →
Joshua
@MindOfJoshua_ · X

Spravato vs. Seroquel: Ketamine Wins Big in Head-to-Head Depression Battle https://t.co/US6BBnzNIt via @YouTube

Feb 7, 2024 · 1,956 followers View post →
Gaetano Lardieri
@EntheoG108 · X

https://t.co/iOy98vsBnB

Jan 18, 2024 · 172 followers View post →
PSYCSpotlight
@PSYC_Spot · X

A Phase III trial, found that a 4-week course of subcutaneous ketamine was more effective than midazolam in treating treatment-resistant depression, with a remission rate of 19.6% compared to 2.0% in the flexible-dose cohort. https://t.co/WotnmNkIeX

Jan 10, 2024 · 2 likes · 3,029 followers View post →
Gaetano Lardieri
@EntheoG108 · X

https://t.co/iOy98vsBnB

Jan 10, 2024 · 172 followers View post →
Mark Anderson
@MarkHAnderson59 · X

RT @MarkHAnderson59: @7NewsMelbourne Why say its linked to mental illness? We are currently using it in trials to treat resistant depress…

Jan 7, 2024 · 1 share · 1,241 followers View post →
Mark Anderson
@MarkHAnderson59 · X

@7NewsMelbourne Why say its linked to mental illness? We are currently using it in trials to treat resistant depression: https://t.co/tK3RsodvPM There are a good number of studies showing that it has positive effects on mental illness. https://t.co/tK3RsodvPM https://t.co/3FA5ANQJO9

Jan 7, 2024 · 4 likes · 1 share · 1,241 followers View post →
P
@psychopharmacol · X

RCT: Twice-weekly SC racemic ketamine, 0.5–0.9 mg/kg, was more efficacious than midazolam after 4 weeks (remission rate - MADRS OR=12.1; 2.1–69.2), but not different when fixed doses of 0.5 mg(kg were used (1.3; 0.2–8.2). Ketamine was well tolerated https://t.co/BEzchHUsCP https://t.co/pVCoU8RG6s

Dec 29, 2023 · 1 like · 574 followers View post →
Blossom
@blossomact · X

This trial evaluated the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. https://t.co/ECHYYoiuNJ

Dec 29, 2023 · 3,347 followers View post →
Social Anxiety Help
@AnxietyNews · X

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial https://t.co/iuz9nEOzbo

Dec 21, 2023 · 4,690 followers View post →
DogBot
@Dog_paper_bot · X

New dog paper! Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial https://t.co/Cgxnz2u7TI

Dec 20, 2023 · 69 followers View post →
GCH papers
@GCHpapers · X

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial https://t.co/XLg0IxUCmT

Dec 18, 2023 · 164 followers View post →
gchlthpapers
@gchlthpapers · X

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial https://t.co/7jgfdMPhMt

Dec 18, 2023 · 3 followers View post →
Paula Uros M
@paulaurosm · X

@PloederlM @RadoslawStupak Psychologists : psychiatry is dead... Researchers: continue everyday finding better treatments https://t.co/VOSrqFpZlJ

Aug 19, 2023 · 5 followers View post →
Leeds Interdisciplinary Mental Health Network
@LIMHRN · X

Promising results from @UNSW suggest that ketamine can be used as a new treatment option for severe treatment-resistant depression https://t.co/X1EU2a2shD

Jul 27, 2023 · 213 followers View post →
Ian Logan
@IanLoganDoes · X

RT @DilaraB_PhD: ⭐ In case you missed it: Generic #ketamine was confirmed to be an effective #antidepressant in people with treatment-resis…

Jul 18, 2023 · 1 share · 522 followers View post →
Dr Dilara Bahceci
@DilaraB_PhD · X

⭐ In case you missed it: Generic #ketamine was confirmed to be an effective #antidepressant in people with treatment-resistant #depression. An Australian, @NHMRC-funded, phase 3 trial by @UNSW @georgeinstitute @blackdoginst et al.

Jul 18, 2023 · 15 likes · 1 share · 1,594 followers View post →
Sarah
@SarahMya2000 · X

RT @GidMK: Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule…

Jul 18, 2023 · 5 shares · 1,761 followers View post →
Incontinent Philosophy
@antiark1 · X

RT @GidMK: Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule…

Jul 17, 2023 · 5 shares · 127 followers View post →
Heather McEwen
@HeatherMcEwen3 · X

RT @GidMK: Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule…

Jul 17, 2023 · 5 shares · 1,499 followers View post →
Rahisisi
@Hapankaalimehu · X

RT @GidMK: Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule…

Jul 17, 2023 · 5 shares · 448 followers View post →
Health Nerd
@GidMK · X

Pretty interesting RCT on ketamine for treatment-resistant depression - no benefit for low doses, but a revised dosing schedule with up to 2x the dose showed a fairly large improvement https://t.co/nh4fnmsKqo

Jul 17, 2023 · 36 likes · 5 shares · 74,573 followers View post →
gsr90
@rx_defi · X

Interesting use for Ketamine, besides Sedation & Anaesthesia. https://t.co/PWq9sIg7ZS https://t.co/cPHHah5F9r

Jul 17, 2023 · 187 followers View post →
Paul
@netfire4 · X

RT @Psyched_Alpha: Researchers in Australia Demonstrate Efficacy of Ketamine for Treatment-Resistant Depression Over a 4-week Treatment Co…

Jul 14, 2023 · 1 share · 1,141 followers View post →
Psychedelic Alpha
@Psyched_Alpha · X

Researchers in Australia Demonstrate Efficacy of Ketamine for Treatment-Resistant Depression Over a 4-week Treatment Course "..the proportional increase in remission comparing favourably to that of studies of intranasal esketamine.." https://t.co/Dbeyza12u8

Jul 14, 2023 · 8 likes · 1 share · 20,727 followers View post →
John Peters
@johnthejack · X

Study: Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial https://t.co/JAAdpcVibZ https://t.co/NwLbG7BSzN

Jul 14, 2023 · 4,903 followers View post →
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Reddit

... and effectiveness of subcutaneous administration: https://doi.org/10.1192/bjp.2023.79 · DuckWheelz. • 1y ago. I switched to subq six months ...

Sep 24, 2024 View →
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