J Physiol Biochem May 2024 PMID 38175501

Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults: the FIT-AGEING study.

Ginés Navarro-Lomas, Abel Plaza-Florido, Alejandro De-la-O, Manuel J Castillo, Francisco J Amaro-Gahete

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Mentions

9
Peak: 3 in Sep 2024
across 2 sources since Jan 2024

Extended reach

34,976
potential audience

Total likes

1,489

Video views

33,308

Mentions per month

Jan 2024 – Sep 2025

Where it's discussed

  • X / Twitter7 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions demonstrate cautious interest and light engagement, with posts supporting the connection between exercise and heart health, such as mentions of breathing techniques and physiological responses, highlighting a general curiosity about implementing these findings rather than deep scientific debate.

AgreementModerate agreement

Most discussions express support or neutral acknowledgment of the study's findings, indicating general agreement or curiosity rather than disagreement.

InterestModerate interest

The posts show moderate interest, with some users sharing related topics like breathing techniques, but few delve deeply into the specifics of the research.

EngagementNeutral engagement

Comments are mostly brief and limited to sharing links or mentioning related figures, reflecting surface-level engagement.

ImpactModerate impact

The collective tone suggests an acknowledgement of the study's relevance, though without extensive debate or critical analysis, indicating a moderate perceived impact.

Abstract in brief

  • This study found that exercise-induced increases in plasma SKlotho levels are linked to improvements in heart rate variability, specifically showing increased vagal influence and decreased sympathetic activity in sedentary middle-aged adults.
  • Initially, SKlotho levels were not related to heart rate or variability measures, but after a 12-week exercise program, changes in SKlotho correlated with beneficial changes in autonomic nervous system markers.
  • Different exercise interventions, including moderate activity, high-intensity interval training, and whole-body electromyostimulation, all contributed to these changes, suggesting exercise can modulate SKlotho and promote better heart health in middle-aged adults.

Top posts

Most liked on X and Bluesky
Journal of Physiology and Biochemistry
@JPBY_official · X

#Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults https://t.co/6b9JwF42xA @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/Cma1aRSkLx

May 9, 2025 · 3 likes · 398 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

#Exercise-induced changes in plasma S-#Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults https://t.co/6b9JwF42xA @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/mgkttDTFZO

Sep 22, 2025 · 2 likes · 1 share · 398 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/6b9JwF4An8 https://t.co/4J31cgPyEc

Jun 12, 2024 · 1 like · 398 followers View post →
TLiverman
@liverman_t · X

@PeterDiamandis Huberman teaches a physiologic sigh to induce vagal tone on the move or at table. Richard Gervitz, the father of biofeedback, discovered that breathing 6 breaths per minute

Jan 17, 2024 · 1 like · 43 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults [...] @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/6b9JwF4An8 https://t.co/juYOuLIjVX

Sep 9, 2024 · 1 share · 398 followers View post →
Pilar Lostao
@LostaoPilar · X

RT @JPBY_official: #Exercise-induced changes in plasma S-#Klotho levels are associated with the obtained enhancements of heart rate variabi…

Sep 23, 2025 · 1 share · 13 followers View post →

All mentions

Pilar Lostao
@LostaoPilar · X

RT @JPBY_official: #Exercise-induced changes in plasma S-#Klotho levels are associated with the obtained enhancements of heart rate variabi…

Sep 23, 2025 · 1 share · 13 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

#Exercise-induced changes in plasma S-#Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults https://t.co/6b9JwF42xA @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/mgkttDTFZO

Sep 22, 2025 · 2 likes · 1 share · 398 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

#Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults https://t.co/6b9JwF42xA @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/Cma1aRSkLx

May 9, 2025 · 3 likes · 398 followers View post →
Pilar Lostao
@LostaoPilar · X

RT @JPBY_official: Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variabili…

Sep 10, 2024 · 1 share · 13 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults [...] @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/6b9JwF4An8 https://t.co/juYOuLIjVX

Sep 9, 2024 · 1 share · 398 followers View post →
Journal of Physiology and Biochemistry
@JPBY_official · X

Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults @CanalUGR @agorafacmed @HumanLab_iMUDS @UCIrvine @UCIMedSchool @CIBER_OBN @ibsGRANADA https://t.co/6b9JwF4An8 https://t.co/4J31cgPyEc

Jun 12, 2024 · 1 like · 398 followers View post →
TLiverman
@liverman_t · X

@PeterDiamandis Huberman teaches a physiologic sigh to induce vagal tone on the move or at table. Richard Gervitz, the father of biofeedback, discovered that breathing 6 breaths per minute

Jan 17, 2024 · 1 like · 43 followers View post →