Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures. https://t.co/iAUnFHu1eH
Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles.
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Jan 2024 – Mar 2025Where it's discussed
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The discussions highlight the significance of the research by mentioning specific subtypes identified in the study, such as those related to neuronal hyperplasticity and immune activation. Phrases like 'very interesting paper' and 'future potential for a more personalized approach' convey excitement and optimism about how these findings could reshape treatment methodologies for Alzheimer's, clearly indicating a strong sentiment towards the publication's relevance.
The majority of discussions praise the findings, indicating strong support for the publication's conclusions.
Participants show high curiosity about the molecular subtypes and their implications for Alzheimer's disease treatment.
While most discussions reflect interest, they tend to stay at a surface level without diving deeply into the specifics of the research methods.
Many express confidence in the potential for these findings to influence future Alzheimer's research and treatment strategies.
Abstract in brief
- Researchers analyzed cerebrospinal fluid in Alzheimer's disease (AD) patients to identify five molecular subtypes based on protein levels, using mass spectrometry on 1,058 proteins.
- Each subtype corresponds to distinct molecular processes, including neuronal hyperplasticity, immune activation, RNA dysregulation, choroid plexus dysfunction, and blood-brain barrier impairment.
- These subtypes are associated with specific genetic risk factors and differ in clinical outcomes, emphasizing the importance of understanding molecular heterogeneity for developing personalized treatment strategies for AD.
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Most liked on X and BlueskyCerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/dyoyzBcTSB
Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/IvIWyLyoiw
CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3. RNA制御不全 4. 脈絡叢機能不全 5. BBB機能障害 Open Access #Alzheimers #CSF #papers https://t.co/drgOORLE6z https://t.co/E1B4S90gAB
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles #NatCommun #MassSpec https://t.co/RUPQjyWTfj
All mentions
Alzheimer: A Descoberta das 5 Variantes
2024最新資料 阿滋海默五種亞型|RayMediLife #自然療法 #養生 #健康生活 #代謝緩慢 #糖尿病 #減肥 #低碳水 #低脂肪 #斷食
こちらはADのCSF大規模proteomicsで5つの分子的subtypeを同定 1.神経可塑性亢進 2.自然免疫活性化 3.RNA調節不全 4.脈絡叢機能不全 5.BBB機能不全 各subtypeは特定のAD遺伝的risk変異と関連し臨床的転帰/生存時間/脳萎縮patternも異なる #subtype #Alzheimers #papers https://t.co/drgOORLE6z https://t.co/1XnffovPfu
We need to pick apart heterogeneity in complex diseases to better prevent and treat. Bigger numbers may muddy waters Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct g… https://t.co/qBnIRWZK4r
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles @NatureAging https://t.co/B1DYqJk2AH
脳脊髄液のプロテオミクス解析を行ったところ、5つのクラスターに分類され、アルツハイマーとの関連が認められたというNature Agingの論文 脊髄液のプロテオミクスってたまに聞くけど、すごいことしてるなーといつも思います https://t.co/PzkqvLBIQi
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles "These results indicate molecular heterogeneity in AD" https://t.co/9nkys7uivn
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/fj0wEb93WG
RT @metodologica_cl:
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/LcEV9Acoj3
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…
Open Access UCL Research: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/ffmrqTj538
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/EHzTpH89Wq
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/h3bopG01HQ
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/GpQMJLcCuM
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…
Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures. https://t.co/iAUnFHu1eH
DESCOBERTA REVOLUCIONÁRIA REVELA CINCO VARIANTES DISTINTAS DE ALZHEIMER https://t.co/jUnoj7Q8Jz Credibilidade: 989 #Alzheimer As 5 variantes parecem diferir na forma como afetam o cérebro e na forma como respondem ao tratamento. Leia mais em: https://t.co/9LvmhIrJHd https://t.co/njyvkyBXxl
RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…
RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…
RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3. RNA制御不全 4. 脈絡叢機能不全 5. BBB機能障害 Open Access #Alzheimers #CSF #papers https://t.co/drgOORLE6z https://t.co/E1B4S90gAB
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/bKGquJGLot
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/O8FP9QEnVu
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
RT @realBioMassSpec: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…
RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…
RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…
RT @natvilortejedor: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…
Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/IvIWyLyoiw
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles #NatCommun #MassSpec https://t.co/RUPQjyWTfj
RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…
RT @morgfair: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic ris…
RT @morgfair: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic ris…
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/dyoyzBcTSB
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/Y8rFRreeBt
RT @natvilortejedor: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…
{Fighting Stigma} Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular ...: Genetic, brain tissue proteomics and gene expression studies indicated that many different pathophysiological processes are associated with… https://t.co/GUqqTGEOlP
Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles