Nat Aging January 2024 PMID 38195725

Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles.

Betty M Tijms, Ellen M Vromen, Olav Mjaavatten, Henne Holstege, Lianne M Reus, Sven van der Lee, Kirsten E J Wesenhagen, Luigi Lorenzini, Lisa Vermunt, Vikram Venkatraghavan, Niccoló Tesi, Jori Tomassen, Anouk den Braber, Julie Goossens, Eugeen Vanmechelen

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180
Peak: 62 in Jan 2024
across 6 sources since Jan 2024

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AI synopsis

What people are saying

The discussions highlight the significance of the research by mentioning specific subtypes identified in the study, such as those related to neuronal hyperplasticity and immune activation. Phrases like 'very interesting paper' and 'future potential for a more personalized approach' convey excitement and optimism about how these findings could reshape treatment methodologies for Alzheimer's, clearly indicating a strong sentiment towards the publication's relevance.

AgreementStrong agreement

The majority of discussions praise the findings, indicating strong support for the publication's conclusions.

InterestHigh interest

Participants show high curiosity about the molecular subtypes and their implications for Alzheimer's disease treatment.

EngagementModerate engagement

While most discussions reflect interest, they tend to stay at a surface level without diving deeply into the specifics of the research methods.

ImpactHigh impact

Many express confidence in the potential for these findings to influence future Alzheimer's research and treatment strategies.

Abstract in brief

  • Researchers analyzed cerebrospinal fluid in Alzheimer's disease (AD) patients to identify five molecular subtypes based on protein levels, using mass spectrometry on 1,058 proteins.
  • Each subtype corresponds to distinct molecular processes, including neuronal hyperplasticity, immune activation, RNA dysregulation, choroid plexus dysfunction, and blood-brain barrier impairment.
  • These subtypes are associated with specific genetic risk factors and differ in clinical outcomes, emphasizing the importance of understanding molecular heterogeneity for developing personalized treatment strategies for AD.

Top posts

Most liked on X and Bluesky
Nature Aging
@NatureAging · X

Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures. https://t.co/iAUnFHu1eH

Jan 15, 2024 · 91 likes · 23 shares · 18,650 followers View post →
Morgan Fairchild
@morgfair · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/dyoyzBcTSB

Jan 9, 2024 · 30 likes · 2 shares · 180,543 followers View post →
Sean Kennelly
@SPKennelly · X

Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/IvIWyLyoiw

Jan 10, 2024 · 18 likes · 7 shares · 2,539 followers View post →
thmonk
@thmonk_pf · X

CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3. RNA制御不全 4. 脈絡叢機能不全 5. BBB機能障害 Open Access #Alzheimers #CSF #papers https://t.co/drgOORLE6z https://t.co/E1B4S90gAB

Jan 12, 2024 · 14 likes · 4 shares · 1,633 followers View post →
Nat Vilor-Tejedor
@natvilortejedor · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Jan 9, 2024 · 9 likes · 2 shares · 1,579 followers View post →
BioMassSpec
@realBioMassSpec · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles #NatCommun #MassSpec https://t.co/RUPQjyWTfj

Jan 10, 2024 · 8 likes · 1 share · 5,995 followers View post →

All mentions

thmonk
@thmonk_pf · X

こちらはADのCSF大規模proteomicsで5つの分子的subtypeを同定 1.神経可塑性亢進 2.自然免疫活性化 3.RNA調節不全 4.脈絡叢機能不全 5.BBB機能不全 各subtypeは特定のAD遺伝的risk変異と関連し臨床的転帰/生存時間/脳萎縮patternも異なる #subtype #Alzheimers #papers https://t.co/drgOORLE6z https://t.co/1XnffovPfu

Mar 4, 2025 · 1,633 followers View post →
Scott Williams
@scottmwilliams9 · X

We need to pick apart heterogeneity in complex diseases to better prevent and treat. Bigger numbers may muddy waters Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct g… https://t.co/qBnIRWZK4r

Oct 7, 2024 · 858 followers View post →
@Neuro_AI
@NeuroAI_Nexus · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles @NatureAging https://t.co/B1DYqJk2AH

Mar 2, 2024 · 4,846 followers View post →
Pon|食と健康
@PonNutr · X

脳脊髄液のプロテオミクス解析を行ったところ、5つのクラスターに分類され、アルツハイマーとの関連が認められたというNature Agingの論文 脊髄液のプロテオミクスってたまに聞くけど、すごいことしてるなーといつも思います https://t.co/PzkqvLBIQi

Feb 7, 2024 · 8 likes · 2,626 followers View post →
Korthlab
@Korthlab_HHU · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles "These results indicate molecular heterogeneity in AD" https://t.co/9nkys7uivn

Jan 26, 2024 · 1 like · 2,119 followers View post →
Maria Gonçalves
@Maria_CBG · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 23, 2024 · 23 shares · 122 followers View post →
Cathy McHale
@Cathymch7 · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/fj0wEb93WG

Jan 20, 2024 · 1 like · 962 followers View post →
CayoCornelio
@CayoCornelio · X

RT @metodologica_cl:

Jan 18, 2024 · 1 share · 2,478 followers View post →
Researching the Brain
@Brain_Database · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/LcEV9Acoj3

Jan 18, 2024 · 1,037 followers View post →
Alexis R. | METODOLOGICA_CL
@metodologica_cl · X

Jan 16, 2024 · 2 likes · 1 share · 3,807 followers View post →
Aging and Disease
@ISOAD2018 · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 16, 2024 · 23 shares · 89 followers View post →
thmonk
@thmonk_pf · X

RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…

Jan 16, 2024 · 4 shares · 1,633 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/ffmrqTj538

Jan 16, 2024 · 2 likes · 2,525 followers View post →
Hui Hong
@honghui2021 · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 16, 2024 · 23 shares · 34 followers View post →
Orlando_uy
@Orlando_uy · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/EHzTpH89Wq

Jan 16, 2024 · 1 like · 692 followers View post →
Carola Radulescu
@carola_izabela · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 16, 2024 · 23 shares · 415 followers View post →
Christophe Trivalle
@CTrivalle · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/h3bopG01HQ

Jan 16, 2024 · 8,284 followers View post →
Beatriz Escobar-Doncel
@BeatrizEscDon · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 16, 2024 · 23 shares · 247 followers View post →
RG
@ritu_achaLA · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 16, 2024 · 23 shares · 18 followers View post →
priya joseph
@ayirpelle · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 4,900 followers View post →
PharmaDecisions LLC
@PharmaDecisions · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 452 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 704 followers View post →
Seungho Oh @seunghooh@genomic.social
@dancewithsun · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 98 followers View post →
Paneni Lab
@PaneniLab · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 219 followers View post →
Christina Ramelow, MS, (she/her)
@ChristinaRamel1 · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 617 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/GpQMJLcCuM

Jan 15, 2024 · 358 followers View post →
Sahba Ferdowsi DO (conciergedoc)
@DrFerdowsi · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 9,642 followers View post →
JYChoi_Neuroloscientist
@ChoiJunYoung20 · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 23 followers View post →
Shoutang WANG
@ShoutangW · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 360 followers View post →
john morley
@drjohnmorley · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 8,322 followers View post →
Mychael Lourenco
@mvlourenco · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 3,022 followers View post →
Andrey Chursov, Ph.D.
@per4mancehacker · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 56 followers View post →
István Fodor
@fodor_i · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 545 followers View post →
Caleb Moulema
@CalebMoulema · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 227 followers View post →
Fasina Opeyemi
@flashope · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 334 followers View post →
Dr. Axel Montagne, PhD
@AxL_Montagne · X

RT @NatureAging: Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hype…

Jan 15, 2024 · 23 shares · 3,993 followers View post →
Nature Aging
@NatureAging · X

Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures. https://t.co/iAUnFHu1eH

Jan 15, 2024 · 91 likes · 23 shares · 18,650 followers View post →
Terra Rara
@Terra_Rara · X

DESCOBERTA REVOLUCIONÁRIA REVELA CINCO VARIANTES DISTINTAS DE ALZHEIMER https://t.co/jUnoj7Q8Jz Credibilidade: 989 #Alzheimer As 5 variantes parecem diferir na forma como afetam o cérebro e na forma como respondem ao tratamento. Leia mais em: https://t.co/9LvmhIrJHd https://t.co/njyvkyBXxl

Jan 12, 2024 · 348 followers View post →
Keita Hiraga
@NEUR0TRAVELER · X

RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…

Jan 12, 2024 · 4 shares · 93 followers View post →
もりはるし
@hmori_tky · X

RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…

Jan 12, 2024 · 4 shares · 961 followers View post →
KSK@neuropsychiatry
@ksktkht8 · X

RT @thmonk_pf: CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3.…

Jan 12, 2024 · 4 shares · 4,270 followers View post →
Young Geris (irony intended)
@YoungGeris · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 12, 2024 · 7 shares · 5,168 followers View post →
thmonk
@thmonk_pf · X

CSF proteomicsによるAlzheimer病亜型分類 419ADと187健常例から1058蛋白を同定、clustering解析で5病型に分類 1. synapse可塑性障害:TREM2 R47Hに関係 2. 自然免疫免疫活性化 3. RNA制御不全 4. 脈絡叢機能不全 5. BBB機能障害 Open Access #Alzheimers #CSF #papers https://t.co/drgOORLE6z https://t.co/E1B4S90gAB

Jan 12, 2024 · 14 likes · 4 shares · 1,633 followers View post →
Frédéric Blanc
@BlancFrdric7 · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 12, 2024 · 7 shares · 941 followers View post →
Aging Papers
@PapersAging · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/bKGquJGLot

Jan 11, 2024 · 16 followers View post →
Gastón F Rodríguez
@GastonFRodrigu1 · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/O8FP9QEnVu

Jan 11, 2024 · 2 likes · 1,155 followers View post →
Desmond (Des) O'Neill
@Age_Matters · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 11, 2024 · 7 shares · 5,773 followers View post →
Weijie Huang
@weijiehuang18 · X

RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…

Jan 11, 2024 · 4 shares · 12 followers View post →
susan o reilly
@Susan0reilly_Wi · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 11, 2024 · 7 shares · 519 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @realBioMassSpec: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…

Jan 10, 2024 · 1 share · 578 followers View post →
Proustishere
@proustishere · X

RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…

Jan 10, 2024 · 4 shares · 55 followers View post →
Michael Wainberg
@michaelwainberg · X

RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…

Jan 10, 2024 · 4 shares · 647 followers View post →
Hanna-Maria Roitto
@RoittoHM · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 10, 2024 · 7 shares · 922 followers View post →
Dementia Trials Ireland
@DementiaTrials · X

RT @SPKennelly: Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cere…

Jan 10, 2024 · 7 shares · 1,805 followers View post →
Arcadi Navarro
@ANavarroFPM · X

RT @natvilortejedor: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…

Jan 10, 2024 · 2 shares · 562 followers View post →
Sean Kennelly
@SPKennelly · X

Very interesting paper that reflects the future potential of a more personalised approach to AD diagnosis + subtyping. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles. https://t.co/IvIWyLyoiw

Jan 10, 2024 · 18 likes · 7 shares · 2,539 followers View post →
BioMassSpec
@realBioMassSpec · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles #NatCommun #MassSpec https://t.co/RUPQjyWTfj

Jan 10, 2024 · 8 likes · 1 share · 5,995 followers View post →
Jose
@ahi_hay_alguien · X

RT @sha_zhiqiang: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic…

Jan 9, 2024 · 4 shares · 515 followers View post →
star gazer
@MountainsStars · X

RT @morgfair: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic ris…

Jan 9, 2024 · 2 shares · 2,323 followers View post →
Nicole Buggs
@NicoleBuggs3 · X

RT @morgfair: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic ris…

Jan 9, 2024 · 2 shares · 2,264 followers View post →
Morgan Fairchild
@morgfair · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles | Nature Aging https://t.co/dyoyzBcTSB

Jan 9, 2024 · 30 likes · 2 shares · 180,543 followers View post →
Zhiqiang Sha (@zhiqiangsha.bsky.social)
@sha_zhiqiang · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles https://t.co/Y8rFRreeBt

Jan 9, 2024 · 3 likes · 4 shares · 1,154 followers View post →
Journal of Translational Genetics and Genomics
@OfGenomics · X

RT @natvilortejedor: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct gene…

Jan 9, 2024 · 2 shares · 516 followers View post →
STIGMABASE
@stigmabase · X

{Fighting Stigma} Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular ...: Genetic, brain tissue proteomics and gene expression studies indicated that many different pathophysiological processes are associated with… https://t.co/GUqqTGEOlP

Jan 9, 2024 · 1,122 followers View post →
Nat Vilor-Tejedor
@natvilortejedor · X

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Jan 9, 2024 · 9 likes · 2 shares · 1,579 followers View post →