Nat Aging March 2024 PMID 38267706

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.

Corina Amor, Inés Fernández-Maestre, Saria Chowdhury, Yu-Jui Ho, Sandeep Nadella, Courtenay Graham, Sebastian E Carrasco, Emmanuella Nnuji-John, Judith Feucht, Clemens Hinterleitner, Valentin J A Barthet, Jacob A Boyer, Riccardo Mezzadra, Matthew G Wereski, David A Tuveson

Mentions

161
Peak: 44 in Jan 2024
across 7 sources since Sep 2023

Extended reach

521,546
potential audience

Total likes

189

Video views

579

Mentions per month

Sep 2023 – Jul 2025

Where it's discussed

  • News78 articles
  • X / Twitter60 posts
  • Blogs12 articles
  • Facebook4 posts
  • YouTube3 videos
  • Reddit3 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Posts frequently praise the study as 'mind-blowing' and describe the therapy as a promising and potentially revolutionary intervention in aging. The tone is optimistic and excited, with expressions like 'Welcome to the future!' and references to long-lasting, prophylactic effects, illustrating high interest and perceived significance in the scientific and broader community.

AgreementStrong agreement

Most discussions express strong support and excitement for the study's findings, highlighting its potential importance in aging research.

InterestHigh interest

The discussions show a high level of curiosity and enthusiasm, with posters emphasizing the groundbreaking nature of the research.

EngagementHigh engagement

Many posts delve into details like long-term effects, method significance, and potential applications, indicating deep engagement.

ImpactHigh impact

Widespread acknowledgment of the research as a possible 'game changer' or advancing anti-aging therapy demonstrates perceived high impact.

Abstract in brief

  • The study discusses developing CAR T cells that target and eliminate senescent cells expressing uPAR, which accumulate with age and contribute to tissue decline.
  • These CAR T cells effectively improve physical fitness and metabolic health, such as better exercise capacity and glucose tolerance, in aging and high-fat diet mice.
  • A single dose of these CAR T cells provides long-lasting benefits, making this a promising long-term therapy for age-related metabolic problems.]

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B30oeIqI9U

Jan 26, 2024 · 31 likes · 5 shares · 30,528 followers View post →
Agingdoc
@agingdoc1 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 24, 2024 · 17 likes · 3 shares · 41,313 followers View post →
MinneBIO
@MinneBio · X

Prof Vegas team at Cold Spring Harbor Laboratory found that T cells can be reprogrammed to combat aging, with potential lifelong effects. These CAR T cells are capable of targeting senescent cells, which contribute to aging-related problems and diseases. https://t.co/LoXB18gDGu

Jan 28, 2024 · 16 likes · 3 shares · 421 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

Congratulations @corina_amor_MD! Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/p8Ku6Flj7B

Sep 30, 2023 · 14 likes · 1 share · 4,768 followers View post →
Burny - Effective Curiosity
@burny_tech · X

Yo @bryan_johnson great news! A One-and-Done Injection to Slow Aging? New Study in Mice Opens the Possibility Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction "Yet a new study led by Dr. Corina Amor Vegas at Cold Spring https://t.co/UWPgnVABT2 https://t.co/OQNAZaIjBx

Feb 5, 2024 · 13 likes · 19,153 followers View post →
Binod Dhakal
@bhemato · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/r1VrMd5fv4

Jan 24, 2024 · 13 likes · 2 shares · 1,701 followers View post →

All mentions

Regen Ranger
@RegenRanger · X

Mind-blowing!

Jul 28, 2025 · 1 like · 13 followers View post →
Regen Ranger
@RegenRanger · X

Mind-blowing! CAR-T cells engineered to destroy senescent "zombie" cells that drive aging. One injection improved glucose control 25%, exercise capacity 40%, lasting 15+ months!

Jul 28, 2025 · 1 like · 13 followers View post →
Regen Ranger
@RegenRanger · X

Mind-blowing!

Jul 28, 2025 · 1 like · 13 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/wqIRwwL0oT

Jun 17, 2025 · 2,061 followers View post →
المنتدى العربي العلمي
@safonline_org · X

المرجع: https://t.co/PH5kIeokoo #السكري #الشيخوخة #السمنة https://t.co/m95Ay08bFu

Apr 26, 2025 · 1 like · 348 followers View post →
Keon Jung
@just_kyunjung · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/oujHrVjVP7

Oct 26, 2024 · 2 likes · 4,865 followers View post →
Living Drugs
@LivingDrugsFilm · X

RT @XX62: 『Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction』 Nature Aging  24 Janu…

Mar 20, 2024 · 1 share · 105 followers View post →
Alex
@AlexAlexicumd · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/uqwjUVWeqI

Mar 11, 2024 · 1 like · 49 followers View post →
Miguel A. Luna-Calvo
@lunacalvo · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/fhVwrnCWtJ

Mar 10, 2024 · 6,567 followers View post →
Yoshihisa Okazaki
@XX62 · X

『Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction』 Nature Aging  24 January 2024 CAR-Tパイオニアの一人Michel Sadelain研究室 NEJM,NatureにCAR-T自己免疫疾患治療成績の論文が掲載された CAR-T本領発揮のアンチエイジング治療 https://t.co/3sI8N0kCJY

Mar 2, 2024 · 3 likes · 1 share · 2,280 followers View post →
Miguel A. Luna-Calvo
@lunacalvo · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/fhVwrnCWtJ

Feb 11, 2024 · 1 like · 6,567 followers View post →
Orlando_uy
@Orlando_uy · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. https://t.co/b4GpkF4LwS

Feb 10, 2024 · 1 like · 690 followers View post →
Paul Coen
@CoenPM · X

Healthspan game changer?? "Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction." https://t.co/9QCi7OZ8oz

Feb 7, 2024 · 3 likes · 1,324 followers View post →
Burny - Effective Curiosity
@burny_tech · X

@bryan_johnson Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/409CHET0MZ

Feb 5, 2024 · 19,153 followers View post →
Burny - Effective Curiosity
@burny_tech · X

Yo @bryan_johnson great news! A One-and-Done Injection to Slow Aging? New Study in Mice Opens the Possibility Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction "Yet a new study led by Dr. Corina Amor Vegas at Cold Spring https://t.co/UWPgnVABT2 https://t.co/OQNAZaIjBx

Feb 5, 2024 · 13 likes · 19,153 followers View post →
Orlando_uy
@Orlando_uy · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. https://t.co/b4GpkF5jmq

Jan 31, 2024 · 690 followers View post →
Papa
@BigNasty_75 · X

Welcome to the Future! We’re going to end up with Immortality before Reparations

Jan 31, 2024 · 890 followers View post →
Aging Papers
@PapersAging · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/4f7GEWoZuC

Jan 30, 2024 · 16 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction [aka senolytic therapy based on CAR T cells targeting the senescence-associated protein urokinase plasminogen activator receptor (uPAR)] https://t.co/PkjMDyQyeL

Jan 30, 2024 · 4 likes · 4,736 followers View post →
Johan Van Weyenbergh
@johanvawe · X

RT @MinneBio: Prof Vegas team at Cold Spring Harbor Laboratory found that T cells can be reprogrammed to combat aging, with potential lifel…

Jan 29, 2024 · 3 shares · 4,743 followers View post →
Naiem Hossain
@Naiem661125 · X

RT @MinneBio: Prof Vegas team at Cold Spring Harbor Laboratory found that T cells can be reprogrammed to combat aging, with potential lifel…

Jan 29, 2024 · 3 shares · 38 followers View post →
Hao Yin
@HaoYin20 · X

RT @MinneBio: Prof Vegas team at Cold Spring Harbor Laboratory found that T cells can be reprogrammed to combat aging, with potential lifel…

Jan 28, 2024 · 3 shares · 12,204 followers View post →
MinneBIO
@MinneBio · X

Prof Vegas team at Cold Spring Harbor Laboratory found that T cells can be reprogrammed to combat aging, with potential lifelong effects. These CAR T cells are capable of targeting senescent cells, which contribute to aging-related problems and diseases. https://t.co/LoXB18gDGu

Jan 28, 2024 · 16 likes · 3 shares · 421 followers View post →
Victoria VALPARAISO
@Orange_Atomique · X

RT @AgingBiology: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B3…

Jan 28, 2024 · 5 shares · 182 followers View post →
Jason Murphy
@jasemurphy.bsky.social · Bluesky

...apparently they can also kill senescent cells that are one of the big contributors to ageing! Such an exciting technology. pubmed.ncbi.nlm.nih.gov/38267706/

Jan 28, 2024 · 2 likes View post →
João Paulo Pelúzio
@PeLuzZIo_ · X

RT @AgingBiology: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B3…

Jan 27, 2024 · 5 shares · 55 followers View post →
Alexander M. Wolf
@AlexanderMWolf7 · X

@davidasinclair @corina_amor_MD And I also thank the authors for showing the weight data (even though weight data for the animals of Fig. 6 is missing). This paper will be an instant classic & will be cited for decades to come as showing the benefits of senescent cell elimination. https://t.co/FU4nkdYYs2

Jan 27, 2024 · 1 like · 349 followers View post →
Beatriz Suarez
@beasuarezalv · X

RT @AgingBiology: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B3…

Jan 27, 2024 · 5 shares · 110 followers View post →
Boris Carikeo
@BCarikeo · X

RT @AgingBiology: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B3…

Jan 27, 2024 · 5 shares · 672 followers View post →
medicalnews
@medicalnews20 · X

https://t.co/zDbfn69wik CAR-T Therapy: Lifelong Clearance of Aging Cells Slows Aging Process. On Jan 24, Corina Amor and her team at Cold Spring Harbor Laboratory published a study titled "Prophylactic and long-lasting efficacy of senolytic CAR T cells against.... #antiaging

Jan 27, 2024 · 1 like · 1,169 followers View post →
USFQ-Biotecnología
@UsfqB · X

⛲Lee el artículo completo aquí

Jan 26, 2024 · 2 likes · 455 followers View post →
Beatriz Martin Antonio
@Beatriz15995013 · X

RT @Zapata_Lab_IIBm: Impressive! T cells rule! https://t.co/qeUB4ZzJ2P

Jan 26, 2024 · 1 share · 136 followers View post →
Masaaki Yokoyama
@MYOKOYAMA11 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/akEgxSOPjz

Jan 26, 2024 · 1 like · 47 followers View post →
BitFuturist
@BitFuturist · X

RT @AgingBiology: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B3…

Jan 26, 2024 · 5 shares · 1,167 followers View post →
Sanna Madan
@SannaMadan · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction @NatureAging https://t.co/JPsvPwGJDl

Jan 26, 2024 · 2 likes · 1,130 followers View post →
Aging Science News
@AgingBiology · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/B30oeIqI9U

Jan 26, 2024 · 31 likes · 5 shares · 30,528 followers View post →
BowTiedBiotech
@BowTiedBiotech · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 26, 2024 · 5 likes · 20,541 followers View post →
Zapata lab IIBm
@Zapata_Lab_IIBm · X

Impressive! T cells rule! https://t.co/qeUB4ZzJ2P

Jan 26, 2024 · 2 likes · 1 share · 106 followers View post →
Agnostic
@Agnosticum8 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/klBRqCO2RK

Jan 25, 2024 · 285 followers View post →
Richard Kollen
@nuclearball · X

RT @agingdoc1: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 25, 2024 · 3 shares · 2,192 followers View post →
BiopharmaTrend
@BiopharmaTrend · X

Here is a link to an article, which is called "Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction" https://t.co/830OYaTkX2

Jan 25, 2024 · 824 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 25, 2024 · 3 shares · 41,313 followers View post →
Feyza Engin
@EnginLaboratory · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/JXW1VDi6aM

Jan 25, 2024 · 12 likes · 1,764 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Amor C, Fernández-Maestre I, Chowdhury S, et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging. 2024. doi: 10.1038/s43587-023-00560-5 https://t.co/ebYAbTtyRZ

Jan 25, 2024 · 2 likes · 15,705 followers View post →
ShorterLab
@ShorterLab · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction: https://t.co/I8ye2VzBYD

Jan 25, 2024 · 1 like · 12,026 followers View post →
AG_Hays 2
@hays_ag · X

@WmHaseltine I've looked forward to CAR-T fruit 4 10 yrs From @CSHL (where as child spent many hours"playing"(sorting seeds) 4 Barbara McClintock) https://t.co/xC0P5SO1IP "Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction"

Jan 25, 2024 · 1 like · 256 followers View post →
Desi Veleva
@Desi_Veleva24 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/YZJqqwWYSH

Jan 25, 2024 · 1 like · 202 followers View post →
サイエンスあれこれ
@sarekore · X

した。また、高齢マウスに投与した場合は若返り効果もありました。さらに、これらすべての利点は、一切の副作用を伴いませんでした。Nature Aging誌https://t.co/mSB5JMbqFw

Jan 25, 2024 · 922 followers View post →
INSPIRE Platform - IHU HealthAge
@INSPIREPlatfor1 · X

For long-term preventive effects ? "Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction." Nat Aging (2024). https://t.co/Uc2id8tyl3 @isaperarnau @brunovellas @RestoreInstitut @InfinityTLS @I2mcT

Jan 25, 2024 · 1 like · 674 followers View post →
Markus Y. Mapara
@BMT_updates · X

RT @bhemato: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https…

Jan 24, 2024 · 2 shares · 517 followers View post →
Rahul Banerjee, MD, FACP
@RahulBanerjeeMD · X

RT @bhemato: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https…

Jan 24, 2024 · 2 shares · 11,129 followers View post →
Binod Dhakal
@bhemato · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/r1VrMd5fv4

Jan 24, 2024 · 13 likes · 2 shares · 1,701 followers View post →
Amirhossein Nayeri Rad
@amirhosseinnr · X

RT @agingdoc1: Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 24, 2024 · 3 shares · 92 followers View post →
Jeremy Farrar
@JeremyFarrar · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/zqdKFbl7lB

Jan 24, 2024 · 76,141 followers View post →
Nutriop Longevity
@nutriop · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/ylBvIooZng

Jan 24, 2024 · 79 followers View post →
Bruno Vellas
@brunovellas · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction | Nature Aging https://t.co/t78J3uHR1Y

Jan 24, 2024 · 1 like · 2,565 followers View post →
Agingdoc
@agingdoc1 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Jan 24, 2024 · 17 likes · 3 shares · 41,313 followers View post →
john morley
@drjohnmorley · X

Amor, C., Fernández-Maestre, I., Chowdhury, S. et al. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging (2024). https://t.co/r6Vr1K7Uu4

Jan 24, 2024 · 8,324 followers View post →
Agingdoc
@agingdoc1 · X

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/opsz5pcfAT @researchsquare https://t.co/2N5nCOD2Nm

Oct 18, 2023 · 6 likes · 41,313 followers View post →
Antonei B Csoka, PhD
@abcsoka · X

RT @MattYousefzadeh: Congratulations @corina_amor_MD! Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related…

Sep 30, 2023 · 1 share · 113,145 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

Congratulations @corina_amor_MD! Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction https://t.co/p8Ku6Flj7B

Sep 30, 2023 · 14 likes · 1 share · 4,768 followers View post →