PubHawk
Arthritis Rheumatol June 2024 PMID 38272846

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial.

Karen H Costenbader, Nancy R Cook, I-Min Lee, Jill Hahn, Joseph Walter, Vadim Bubes, Gregory Kotler, Nicole Yang, Sonia Friedman, Erik K Alexander, JoAnn E Manson

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Mentions

34
Peak: 9 in Feb 2024
across 3 sources since Jan 2024

Extended reach

225,855
potential audience

Total likes

3,374

Video views

35,502

Mentions per month

Jan 2024 – Oct 2025

Where it's discussed

  • X / Twitter30 posts
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect a balanced mix of curiosity and critical thought, with participants referencing key points such as the fading effect of vitamin D after cessation, versus the persistent benefit of omega-3 fatty acids. The tone varies from scientific to skeptical, with phrases like 'dissipated' and 'sustained effect' highlighting nuances in the findings, and terms like 'significant' and 'potential' emphasizing recognition of impact.

AgreementModerate agreement

Most social discussions acknowledge the findings, with some highlighting the differential long-term effects of vitamin D and omega-3 fatty acids, suggesting a moderate agreement with the study's conclusions.

InterestHigh interest

Posts demonstrate curiosity about the study’s implications, including mentions of specific outcomes, such as the sustained benefit of omega-3s, indicating high interest.

EngagementModerate engagement

Several discussions reference the methodology and long-term implications, showing meaningful engagement, while some dismiss the findings or only briefly mention them.

ImpactModerate impact

Participants seem to perceive the study as having moderate impact, with some posts emphasizing the importance of sustained effects and potential shifts in autoimmune disease prevention strategies.

Abstract in brief

  • The VITAL trial found that vitamin D supplementation significantly reduced the incidence of autoimmune diseases during the study period, but this protective effect disappeared two years after stopping the supplement.
  • Omega-3 fatty acids showed a non-significant trend towards reducing autoimmune disease risk, and their protective effects persisted into the post-intervention period.
  • Continued monitoring revealed that, two years after the trial ended, only omega-3 fatty acids maintained a sustained reduction in autoimmune disease incidence, while vitamin D's effects had faded.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Donald Thomas, MD
@lupuscyclopedia · X

Jul 19, 2025 · 18 likes · 5 shares · 5,733 followers View post →
Brady Holmer
@B_Holmer · X

Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind, Placebo‐Controlled Trial - Costenbader - Arthritis & Rheumatology - Wiley Online Library https://t.co/ziWZtZZJ6C

Feb 29, 2024 · 14 likes · 5 shares · 26,597 followers View post →
ACR_Journals
@ACR_Journals · X

Top 10 widely viewed in A&R #7 - Vitamin D and Marine n3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial https://t.co/77HdzU7JLx https://t.co/qq8gZ7v7QC

Dec 25, 2024 · 9 likes · 1 share · 14,057 followers View post →
Sergey Minaev
@sminaev2015 · X

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial - PubMed https://t.co/Jor8LLWLpN

Mar 26, 2024 · 6 likes · 1 share · 31,498 followers View post →
ACR_Journals
@ACR_Journals · X

VITAL Autoimmune Disease Prevention Trial results at 2 years AFTER end of 5.3 years of randomized intervention: vitamin D vs. placebo HR 0.98 (0.83-1.17); omega-3 fatty acids vs. placebo HR 0.83 (0.70-0.99); both HR 0.83 (0.66-1.05) In A&R https://t.co/iH9Rvq7iwA @karen_kc123 https://t.co/vAi4j9ZIhh

Jan 30, 2024 · 6 likes · 5 shares · 14,057 followers View post →
ACR_Journals
@ACR_Journals · X

Rheum Research in Brief Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Trial Completion In A&R https://t.co/iH9Rvq7iwA Figures: Adjusted cumulative incidence curves for autoimmune disease https://t.co/GKzP6qSMUP

May 3, 2024 · 2 likes · 2 shares · 14,057 followers View post →

All mentions

Silvia Suárez
@SilviaPorto88 · X

RT @lupuscyclopedia:

Jul 21, 2025 · 5 shares · 270 followers View post →
Ricardo Bedón
@ricardo_bedon · X

RT @lupuscyclopedia:

Jul 20, 2025 · 5 shares · 1,499 followers View post →
george demirakos
@georgedemirakos · X

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Jul 19, 2025 · 5 shares · 985 followers View post →
Ali
@mirheum · X

RT @lupuscyclopedia:

Jul 19, 2025 · 5 shares · 119 followers View post →
LESAI_Agent
@LESAI_bot · X

RT @lupuscyclopedia:

Jul 19, 2025 · 5 shares · 860 followers View post →
Donald Thomas, MD
@lupuscyclopedia · X

Jul 19, 2025 · 18 likes · 5 shares · 5,733 followers View post →
Nouf Al hemmadi
@NoufAhmedAlham2 · X

RT @ACR_Journals: Top 10 widely viewed in A&R #7 - Vitamin D and Marine n3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Yea…

Dec 25, 2024 · 1 share · 1,282 followers View post →
ACR_Journals
@ACR_Journals · X

Top 10 widely viewed in A&R #7 - Vitamin D and Marine n3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial https://t.co/77HdzU7JLx https://t.co/qq8gZ7v7QC

Dec 25, 2024 · 9 likes · 1 share · 14,057 followers View post →
James Bogash, DC
@drbogash · X

@Maccspider @kevinfolta @dr_andrealove OK. Vitamin D / EFAs on autoimmunity. https://t.co/PLFcMGavDN

Oct 3, 2024 · 393 followers View post →
Daniel H Solomon
@DanielHSolomon · X

RT @ACR_Journals: June A&R Editor's Pick

May 31, 2024 · 1 share · 2,243 followers View post →
ACR Journals
@acr-journals.bsky.social · Bluesky

June A&R Editor's Pick Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Trial Completion

May 31, 2024 View post →
ACR_Journals
@ACR_Journals · X

June A&R Editor's Pick

May 31, 2024 · 2 likes · 1 share · 14,057 followers View post →
Daniel H Solomon
@DanielHSolomon · X

RT @ACR_Journals: Rheum Research in Brief Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After…

May 5, 2024 · 2 shares · 2,243 followers View post →
franz otaiza
@reumaven · X

RT @ACR_Journals: Rheum Research in Brief Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After…

May 5, 2024 · 2 shares · 743 followers View post →
ACR_Journals
@ACR_Journals · X

Rheum Research in Brief Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Trial Completion In A&R https://t.co/iH9Rvq7iwA Figures: Adjusted cumulative incidence curves for autoimmune disease https://t.co/GKzP6qSMUP

May 3, 2024 · 2 likes · 2 shares · 14,057 followers View post →
Justin Root
@JustinRoot · X

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Do… https://t.co/oOGFy844A5

Apr 2, 2024 · 316 followers View post →
Ken Gusler
@kgusler · X

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial - PubMed: https://t.co/FIxCz5zD5r

Mar 26, 2024 · 20,012 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial https://t.co/1E629OYcg9 #science #health #vitamin #marine #fatty #acids

Mar 26, 2024 · 331 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @sminaev2015: Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Bl…

Mar 26, 2024 · 1 share · 31,498 followers View post →
Sergey Minaev
@sminaev2015 · X

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial - PubMed https://t.co/Jor8LLWLpN

Mar 26, 2024 · 6 likes · 1 share · 31,498 followers View post →
Danijel
@MiocanDanijel · X

RT @B_Holmer: Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind…

Feb 29, 2024 · 5 shares · 1,117 followers View post →
boti
@botibop · X

RT @B_Holmer: Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind…

Feb 29, 2024 · 5 shares · 159 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

RT @B_Holmer: Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind…

Feb 29, 2024 · 5 shares · 1,054 followers View post →
Dan Patrick
@mdpatrick · X

RT @B_Holmer: Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind…

Feb 29, 2024 · 5 shares · 2,030 followers View post →
Brady Holmer
@B_Holmer · X

Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double‐Blind, Placebo‐Controlled Trial - Costenbader - Arthritis & Rheumatology - Wiley Online Library https://t.co/ziWZtZZJ6C

Feb 29, 2024 · 14 likes · 5 shares · 26,597 followers View post →
Frank Paul Mora
@InTime_49 · X

"Two years after trial termination, vitamin D 2000 IU/day's protective effects dissipated, but 1000 mg/day n-3 fatty acids had a sustained effect in reducing AD incidence." Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention https://t.co/t3mt9PLsLH

Feb 18, 2024 · 405 followers View post →
NutshellNutritionUK
@uk_nutshell · X

https://t.co/ZLX7WQw3mb

Feb 9, 2024 · 98 followers View post →
TiroSEEN
@TiroSEEN · X

Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion - Costenbader - Arthritis & Rheumatology - Wiley Online Library https://t.co/sUwcEL3Hon

Feb 9, 2024 · 2 likes · 1,585 followers View post →
Dra_Reuma
@Dra_Reuma · X

RT @ACR_Journals: VITAL Autoimmune Disease Prevention Trial results at 2 years AFTER end of 5.3 years of randomized intervention: vitamin D…

Jan 30, 2024 · 5 shares · 208 followers View post →
ACR_Journals
@ACR_Journals · X

VITAL Autoimmune Disease Prevention Trial results at 2 years AFTER end of 5.3 years of randomized intervention: vitamin D vs. placebo HR 0.98 (0.83-1.17); omega-3 fatty acids vs. placebo HR 0.83 (0.70-0.99); both HR 0.83 (0.66-1.05) In A&R https://t.co/iH9Rvq7iwA @karen_kc123 https://t.co/vAi4j9ZIhh

Jan 30, 2024 · 6 likes · 5 shares · 14,057 followers View post →
Orlando_uy
@Orlando_uy · X

Vitamin D and Marine n‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion https://t.co/NjgSxGfcVh

Jan 30, 2024 · 694 followers View post →