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Am J Psychiatry April 2024 PMID 38419496

N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm.

Yongqing Hou, Haishuo Xia, Tianbao He, Bohua Zhang, Guiping Qiu, Antao Chen

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Mentions

7
Peak: 3 in Apr 2024
across 2 sources since Mar 2024

Extended reach

38,837
potential audience

Total likes

3

Video views

1,434

Mentions per month

Mar 2024 – Aug 2024

Where it's discussed

  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight appreciation for the researchers' efforts to identify neurobiological markers, with phrases like 'pushing the needle' and 'potential as a prognostic biomarker,' indicating a positive reception and recognition of the study's significance in early psychosis detection. The tone emphasizes both support and curiosity about clinical applications, reflecting moderate yet impactful engagement with the research.

AgreementStrong agreement

Most posts praise the research for advancing understanding of early psychosis indicators, indicating strong alignment with its findings.

InterestModerate interest

The discussion shows moderate interest, particularly around the potential of N2 as a biomarker, but not deeply in technical details.

EngagementModerate engagement

Comments suggest some engagement with the concept, like recognizing its significance, but limited in critical analysis or new insights.

ImpactHigh impact

Posts imply that the findings could influence future early intervention strategies, highlighting the study's importance in the field.

Abstract in brief

  • The study investigated how youths with psychosis risk syndrome (PRS) respond to visual stimuli using EEG during a three-stimulus oddball task, finding that they had reduced N2 brain response amplitudes compared to healthy controls, especially in those who later converted to psychosis.
  • Among those with PRS, reduced N2 amplitudes at baseline were most pronounced in participants whose condition progressed to full psychosis within 12 months, suggesting N2 could predict clinical outcomes like conversion or remission.
  • The findings indicate that deficits in attention-related brain responses (specifically N2 amplitudes) are linked to the risk of developing psychosis and could serve as useful biomarkers for prognosis, even though no significant differences were observed in P3 responses.
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Top posts

Most liked on X and Bluesky
Journals of The American Psychiatric Association
@APAPubJournals · X

N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm Yongqing Hou, Ph.D., et al. https://t.co/fSJNBTauow

Apr 19, 2024 · 1 like · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

N2 amplitude shows potential as a prognostic biomarker of clinical outcome among youths with psychosis risk syndrome. https://t.co/PyqllORga6 https://t.co/TT2wzHvWqL

Mar 5, 2024 · 1 like · 1 share · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

2. “N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm,” by Yongqing Hou, Ph.D., et al. 2/4 https://t.co/fSJNBTauow

Apr 12, 2024 · 11,606 followers View post →
Mike Gara
@garami53 · X

RT @APAPubJournals: N2 amplitude shows potential as a prognostic biomarker of clinical outcome among youths with psychosis risk syndrome. h…

Mar 5, 2024 · 1 share · 1,734 followers View post →

All mentions

Arjun Nanda, MD
@arjunknanda · X

Link to original study and commentary, and hats off to the researchers for pushing the needle on early psychosis intervention. https://t.co/S01BWXfVfI https://t.co/xoL5XPM6G0

Apr 23, 2024 · 848 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm Yongqing Hou, Ph.D., et al. https://t.co/fSJNBTauow

Apr 19, 2024 · 1 like · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

2. “N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm,” by Yongqing Hou, Ph.D., et al. 2/4 https://t.co/fSJNBTauow

Apr 12, 2024 · 11,606 followers View post →
Mike Gara
@garami53 · X

RT @APAPubJournals: N2 amplitude shows potential as a prognostic biomarker of clinical outcome among youths with psychosis risk syndrome. h…

Mar 5, 2024 · 1 share · 1,734 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

N2 amplitude shows potential as a prognostic biomarker of clinical outcome among youths with psychosis risk syndrome. https://t.co/PyqllORga6 https://t.co/TT2wzHvWqL

Mar 5, 2024 · 1 like · 1 share · 11,606 followers View post →