September 1979 PMID 384241

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial.

E T Creagan, C G Moertel, J R O'Fallon, A J Schutt, M J O'Connell, J Rubin, S Frytak

Mentions

16
Peak: 2 in Jul 2020
across 4 sources since Nov 2015

Extended reach

48,535
potential audience

Total likes

1,884

Video views

41,939

Mentions per month

Nov 2015 – Dec 2025

Where it's discussed

  • Facebook7 posts
  • X / Twitter6 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

The discussions reflect broad agreement with the study, citing historical trials like the Mayo Clinic's 1987 research and emphasizing the lack of benefit from high-dose vitamin C; words like 'no benefit' and phrases such as 'most rigorous' underscore the critical stance and reinforce the importance of the study’s findings, making the overall tone analytical and impactful.

AgreementStrong agreement

Most discussions clearly align with the study's conclusion that high-dose vitamin C offers no benefit for advanced cancer patients, reflecting a consensus of disagreement with claims of efficacy.

InterestModerate interest

The discussions show moderate interest, with many engaging in debates about methodology and past findings, but not expressing high curiosity or controversy.

EngagementModerate engagement

Comments reference specific studies and historical trials, indicating a reasonable depth of engagement, though not intensely detailed.

ImpactHigh impact

The discussions emphasize that the findings potentially change clinical perspectives, highlighting significant implications for medical practice and patient decisions.

Abstract in brief

  • A controlled double-blind study with 150 advanced cancer patients found no significant difference in symptoms, performance, or survival between those taking high-dose vitamin C (10g/day) and a placebo.
  • Both groups had similar patient characteristics, and median survival was around seven weeks, with survival curves overlapping.
  • The study concluded that high-dose vitamin C did not provide any therapeutic benefit for patients with advanced cancer.]

Top posts

Most liked on X and Bluesky
Jeremy Jones
@Jcj84Jeremy · X

@jgong15 @MayCho_MD @DrHendifar @mgfakih @marklewismd @guildsman @DrR_DUNNE @gabe_a_brooks @KristenCiombor @GIcancerDoc Perhaps my favorite series of trials and correspondences in the medical literature. Bottom line: no benefit. https://t.co/gNnERuEvcb

Nov 19, 2024 · 6 likes · 1,083 followers View post →
うろこ
@fjJQ2MvcDwKKyXp · X

https://t.co/3Ge5vkPhoF

Jul 23, 2020 · 4 likes · 1 share · 339 followers View post →
或いは、「」のオーナー涼花
@oryo_ka · X

RT @fjJQ2MvcDwKKyXp: https://t.co/3Ge5vkPhoF

Jul 23, 2020 · 1 share · 2,162 followers View post →
EAPCCT
@eapcct · X

Clinical trials conducted at the Mayo Clinic concluded that high-dose vitamin C was no better than placebo at treating cancer and that there was no benefit to high-dose vitamin C. https://t.co/UACByXN8HS 10/14

Aug 19, 2021 · 1,751 followers View post →
Leopoldo Santos-Neto
@leosantosIII · X

Contudo, esses dados nunca foram confirmados com metodologias mais rigorosas. Em 1987, o grupo de Oncologia da Mayo Clinic publicou dados mostrando que o uso de megadoses de vitamina C, nesse grupo de pacientes, aumentava a mortalidade. (

Nov 9, 2024 · 589 followers View post →
Leopoldo Santos-Neto
@leosantosIII · X

These data have never been confirmed using more rigorous methodologies. The Mayo Cancer Group published data in 1987 that showed that the use of megadoses of vitamin C in this group of patients produced increased mortality. https://t.co/Lqw3OcdCxr

Jan 21, 2023 · 589 followers View post →

All mentions

Jeremy Jones
@Jcj84Jeremy · X

@jgong15 @MayCho_MD @DrHendifar @mgfakih @marklewismd @guildsman @DrR_DUNNE @gabe_a_brooks @KristenCiombor @GIcancerDoc Perhaps my favorite series of trials and correspondences in the medical literature. Bottom line: no benefit. https://t.co/gNnERuEvcb

Nov 19, 2024 · 6 likes · 1,083 followers View post →
Leopoldo Santos-Neto
@leosantosIII · X

Contudo, esses dados nunca foram confirmados com metodologias mais rigorosas. Em 1987, o grupo de Oncologia da Mayo Clinic publicou dados mostrando que o uso de megadoses de vitamina C, nesse grupo de pacientes, aumentava a mortalidade. (

Nov 9, 2024 · 589 followers View post →
Leopoldo Santos-Neto
@leosantosIII · X

These data have never been confirmed using more rigorous methodologies. The Mayo Cancer Group published data in 1987 that showed that the use of megadoses of vitamin C in this group of patients produced increased mortality. https://t.co/Lqw3OcdCxr

Jan 21, 2023 · 589 followers View post →
EAPCCT
@eapcct · X

Clinical trials conducted at the Mayo Clinic concluded that high-dose vitamin C was no better than placebo at treating cancer and that there was no benefit to high-dose vitamin C. https://t.co/UACByXN8HS 10/14

Aug 19, 2021 · 1,751 followers View post →
或いは、「」のオーナー涼花
@oryo_ka · X

RT @fjJQ2MvcDwKKyXp: https://t.co/3Ge5vkPhoF

Jul 23, 2020 · 1 share · 2,162 followers View post →
うろこ
@fjJQ2MvcDwKKyXp · X

https://t.co/3Ge5vkPhoF

Jul 23, 2020 · 4 likes · 1 share · 339 followers View post →
Not Good, Up 25%
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Dec 8, 2025 View →
I started IV therapy high-dose vitamin C, along with my chemo for a ...
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Sep 5, 2025 View →
Where to order high-dose iv vitamin c for home use?
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Feb 8, 2025 View →
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doi: 10.1056/NEJM197909273011303. PMID 384241. ^ Moertel, CG; Fleming, TR; Creagan, ET; Rubin, J; O'Connell, MJ; Ames, MM (January 1985) ...

Sep 30, 2024 View →
Hi Steve & Pippa, I have seen some private treatments that may be ...
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Feb 21, 2023 View →
This article is now available in print. I am still asking if the ...
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Jan 8, 2023 View →
Australia has the highest rates of cancer in world. Do you ever ask ...
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org/doi/full/10.1056/NEJM197909273011303 Side effects. High doses of vitamin C are not toxic to healthy tissue; however, they can 'chelate' ...

Aug 23, 2019 View →
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News

Medline doi:10.1056/NEJM197909273011303. 29. C. G. Moertel, T. R. Fleming, E. T. Creagan, J. Rubin, M. J. O'Connell, M. M. Ames,. High-dose ...

Nov 5, 2015 View →