February 2024 PMID 38427922

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data.

Levente Lippenszky, Kathleen F Mittendorf, Zoltán Kiss, Michele L LeNoue-Newton, Pablo Napan-Molina, Protiva Rahman, Cheng Ye, Balázs Laczi, Eszter Csernai, Neha M Jain, Marilyn E Holt, Christina N Maxwell, Madeleine Ball, Yufang Ma, Margaret B Mitchell

Mentions

10
Peak: 6 in Apr 2024
across 4 sources since Mar 2024

Extended reach

19,976
potential audience

Total likes

5

Video views

18

Mentions per month

Mar 2024 – Nov 2024

Where it's discussed

  • X / Twitter5 posts
  • LinkedIn2 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The group of discussions showcases enthusiasm and recognition of the study's significance, with phrases like 'innovative approach' and 'personalizing treatment,' reflecting high interest and belief in substantial clinical impact. Comments referencing the integration of routine clinical data and AI models underscore the depth of engagement, emphasizing the potential revolution in cancer treatment and decision-making.

AgreementModerate agreement

Most discussions acknowledge the value of the research and its potential to improve personalized treatment, showing moderate support.

InterestHigh interest

Posts express high curiosity about the AI models and their clinical applications, indicating strong interest.

EngagementHigh engagement

Many comments reference specific aspects like EHR data, predictive models, and implications for cancer immunotherapy, demonstrating deep engagement.

ImpactHigh impact

Discussions highlight the importance of this research in advancing precision medicine and patient outcomes, reflecting high perceived impact.

Abstract in brief

  • The study developed machine learning models using electronic health record data to predict serious immune-related side effects (like hepatitis, colitis, pneumonitis) and one-year survival in cancer patients treated with immune checkpoint inhibitors, aiming to personalize treatment risks and benefits.
  • The models, built with data from over 2200 patients, showed reasonably strong predictive performance, with AUC scores around 0.73-0.75, and require no extra data collection beyond routine clinical records.
  • This research is innovative because it provides a way to assess individual patient risks and outcomes based solely on existing EHR data, which can help improve clinical decision-making and trial designs for cancer immunotherapy.]

Top posts

Most liked on X and Bluesky
Prof Jeffrey S Morris
@jsm2334 · X

Interesting article presenting an AI based model to predict response to and toxicity from immunotherapy for cancer patients developed by Vanderbilt researchers and GE Healthcare https://t.co/1qMPfsVrQX

Apr 23, 2024 · 3 likes · 14,394 followers View post →
JCO Clinical Cancer Informatics
@JCOCCI_ASCO · X

New #ML models use #EHR data to predict risks & outcomes for patient w/ #cancer on #immunotherapy. Aimed at personalizing treatment by predicting immunotoxicities like hepatitis, colitis & pneumonitis plus survival. ➡️https://t.co/Sfy8bCK6LS @GEHealthCare @VUMChealth https://t.co/etdLmq6CIO

Apr 25, 2024 · 1 like · 4,581 followers View post →
Vali Barsan, MD
@vbarsan · X

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data | JCO Clinical Cancer Informatics https://t.co/PwxgSHpztv

May 10, 2024 · 1 like · 575 followers View post →
たん
@tanko_nonnon · X

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data | JCO Clinical Cancer Informatics https://t.co/QuF3V2dwFy

Apr 6, 2024 · 258 followers View post →

All mentions

Vali Barsan, MD
@vbarsan · X

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data | JCO Clinical Cancer Informatics https://t.co/PwxgSHpztv

May 10, 2024 · 1 like · 575 followers View post →
JCO Clinical Cancer Informatics
@JCOCCI_ASCO · X

New #ML models use #EHR data to predict risks & outcomes for patient w/ #cancer on #immunotherapy. Aimed at personalizing treatment by predicting immunotoxicities like hepatitis, colitis & pneumonitis plus survival. ➡️https://t.co/Sfy8bCK6LS @GEHealthCare @VUMChealth https://t.co/etdLmq6CIO

Apr 25, 2024 · 1 like · 4,581 followers View post →
Prof Jeffrey S Morris
@jsm2334 · X

Interesting article presenting an AI based model to predict response to and toxicity from immunotherapy for cancer patients developed by Vanderbilt researchers and GE Healthcare https://t.co/1qMPfsVrQX

Apr 23, 2024 · 3 likes · 14,394 followers View post →
Anthony F Provenzano, MD, FASCO
@drpro2011 · X

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data | JCO Clinical Cancer Informatics https://t.co/NlDk769gOW

Apr 21, 2024 · 110 followers View post →
たん
@tanko_nonnon · X

Prediction of Effectiveness and Toxicities of Immune Checkpoint Inhibitors Using Real-World Patient Data | JCO Clinical Cancer Informatics https://t.co/QuF3V2dwFy

Apr 6, 2024 · 258 followers View post →
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News

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