Am J Psychiatry June 2024 PMID 38476041

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts.

Luke J Norman, Gustavo Sudre, Jolie Price, Philip Shaw

Mentions

83
Peak: 31 in Mar 2024
across 8 sources since Mar 2024

Extended reach

314,665
potential audience

Total likes

131

Video views

3,498

Mentions per month

Mar 2024 – Aug 2025

Where it's discussed

  • X / Twitter55 posts
  • News9 articles
  • Reddit8 posts
  • Facebook5 posts
  • YouTube2 videos
  • Instagram2 posts
  • LinkedIn1 posts
  • Blogs1 articles

AI synopsis

What people are saying

The overall tone reflects moderate agreement and curiosity, with several comments referencing the detailed neuroimaging methods and the significance of brain connectivity in ADHD, such as mentions of the amygdala-cortex links and large datasets; the tone is analytical and cautious, recognizing both the study's contributions and its limitations.

AgreementModerate agreement

Most comments acknowledge the study's findings on brain connectivity related to ADHD, with some questioning the broader implications or relevance, indicating a moderate level of support.

InterestHigh interest

Discussions express high curiosity about the neural mechanisms and the significance of the findings, especially with mentions of complex brain regions and studies involving large participant numbers.

EngagementModerate engagement

Participants reference specific aspects such as the increased connectivity between the amygdala and cortex, and the use of large neuroimaging datasets, showing a genuine interest and some analysis beyond surface-level reactions.

ImpactModerate impact

While some posts highlight the study's contribution to understanding ADHD's neural basis, they acknowledge the small effect sizes and ongoing debates, suggesting moderate perceived impact on diagnosis or treatment approaches.

Abstract in brief

  • A mega-analysis of six neuroimaging datasets investigated the relationship between ADHD and subcortico-cortical connectivity, involving 1,696 youths with ADHD and 6,737 control subjects.
  • The study found that youths with ADHD exhibited increased connectivity between striatal seeds and various brain regions, particularly the caudate, and also between the amygdala and dorsal anterior cingulate cortex.
  • Although these results support links between ADHD and brain connectivity, the effect sizes were small, suggesting that resting-state subcortico-cortical circuits may not fully explain the complexities of ADHD pathology.

Top posts

Most liked on X and Bluesky
Yann Le Strat
@YannLe_Strat · X

Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibilité à la récompense. Étude d'imagerie sur plus de 8000 participants. -Oui, vous avez bien lu, huit mille! https://t.co/49pF2trWNs

Mar 26, 2024 · 37 likes · 12 shares · 2,390 followers View post →
Jesse Luke
@RealJesseLuke · X

N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. https://t.co/veDt6rs4IO

Mar 14, 2024 · 31 likes · 7 shares · 2,245 followers View post →
Yann Le Strat
@YannLe_Strat · X

Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dans le #TDAH. Importance de la connectivité amygdale-cortex frontal médian, qui explique peut-être les pb émotionels dans le #TDAH. https://t.co/4YsYPMQsHp

Jun 12, 2024 · 17 likes · 8 shares · 2,390 followers View post →
American Psychiatric Association
@APApsychiatric · X

Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/UmH7xCFzKC https://t.co/jDtfJvrAcQ

Mar 20, 2024 · 16 likes · 2 shares · 178,395 followers View post →
Pan Janek
@psych_janek · X

"Resting-State Connectivity" to pomiar korelacji w aktywności struktur mózgu w MRI podczas gdy osoba nie wykonuje żadnych zadań. Porównanie takich wzorców u osób z ADHD vs. zdrowe osoby, na dużej próbie, ujawnia zmiany w pętlach czołowo-podkorowych. https://t.co/GDEBPjJXKD

Mar 14, 2024 · 9 likes · 1 share · 310 followers View post →
NeuroClass
@neuroclass1 · X

Apr 13, 2024 · 8 likes · 1 share · 10,094 followers View post →

All mentions

Sαfiα Biαncα
@safiabsmith1 · X

https://t.co/ojA9EIB5EI Here is the study itself. What is it about PhDs at the National Institutes of health that isn't credible? Is this study also lacking independence and validity? Glad to see it doesn't seem to be appearing on the bio thus far today. What say you, Grok?

Jan 3, 2025 · 366 followers View post →
Normalisera
@Sverige2019 · X

RT @Sverige2019: @NatalieBurea Adhd är mer än uppmärksamhet & uppe i varv. Gjorts flertal scanningar & studier efter de som referas till.…

Nov 14, 2024 · 1 share · 1,517 followers View post →
Normalisera
@Sverige2019 · X

@NatalieBurea Adhd är mer än uppmärksamhet & uppe i varv. Gjorts flertal scanningar & studier efter de som referas till. Här en studie från 2024, 10.000 personer & uppdelade i de som har adhd vs de utan diagnoser. Annorlunda hjärnstruktur bla https://t.co/tcu1h13MAZ https://t.co/6N0RhY0KEz

Nov 14, 2024 · 1 share · 1,517 followers View post →
Rupa Health
@Rupa_Health · X

@fizzbee4 Please see this for citation DOI: 10.1176/appi.ajp.20230026

Jul 11, 2024 · 3,537 followers View post →
American Neuropsychiatric Association (ANPA)
@anpadirect · X

RT @APAPubJournals: 3. “Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts,” by Luke J. Norman…

Jul 9, 2024 · 1 share · 1,217 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

3. “Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts,” by Luke J. Norman, Ph.D., et al. 3/4 https://t.co/7zoGppfhzq

Jun 28, 2024 · 3 likes · 1 share · 11,606 followers View post →
Blanch
@BlancaTripp · X

Subcortico-Cortical Dysconnectivity in #ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/Iog4AZM1xT

Jun 25, 2024 · 1,232 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

3. “Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts,” by Luke J. Norman, Ph.D., et al. 3/4 https://t.co/7zoGppfhzq

Jun 21, 2024 · 11,606 followers View post →
Lehrer Felten
@MichaelFelten2 · X

Wichtig im Dt. Ärzteblatt: "Die Frage nach den genauen Ursachen der vermuteten Entwicklungsstörung bleibt weiter unbeantwortet." https://t.co/RpaFe6dUQ3 Original: https://t.co/G7CKHHdaNh > Steve Biddulph: 'Kinder sind genau so unruhig, wie wenig ihnen Eltern inneren Halt bieten.'

Jun 21, 2024 · 1 like · 468 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts Luke J. Norman, Ph.D., et al. https://t.co/o4eAPxZ3vu

Jun 14, 2024 · 11,606 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 13, 2024 · 8 shares · 2,835 followers View post →
Charles Carrere
@charlescarrere · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 300 followers View post →
CFHTB
@CCfhtb · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 37 followers View post →
Nathalie Couture
@Nat33_ · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 1,493 followers View post →
Florence CL
@FlorenceCLTL · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 316 followers View post →
mini scarabée
@miniscarabee · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 1,114 followers View post →
HyperSupers TDAH
@TDAHyperSupers · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 3,074 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…

Jun 12, 2024 · 8 shares · 334 followers View post →
Yann Le Strat
@YannLe_Strat · X

Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dans le #TDAH. Importance de la connectivité amygdale-cortex frontal médian, qui explique peut-être les pb émotionels dans le #TDAH. https://t.co/4YsYPMQsHp

Jun 12, 2024 · 17 likes · 8 shares · 2,390 followers View post →
Emily
@TigerTownDream · X

@HonestYPTweets It's also a complex pathophysiology, meaning the disordered physiological processes associated with disease or injury. It's a physical issue with connectivity within the brain that can be helped by medication. MacArthur is wrong here. https://t.co/MWLoBksYhQ

May 2, 2024 · 602 followers View post →
Emily
@TigerTownDream · X

@JennMGreenberg Here's an article published on 03/14/2024 in The American Journal of Psychiatry about a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity you might find interesting. https://t.co/MWLoBksYhQ

May 2, 2024 · 602 followers View post →
Emily
@TigerTownDream · X

"and structures in the frontal area of the brain involved in attention and control of unwanted behaviors". https://t.co/mOzGvtJ5Jm https://t.co/MWLoBksYhQ 2/2

May 1, 2024 · 1 like · 602 followers View post →
Dyz̶er Nihil ψ
@Dyzer_Nihil · X

RT @neuroclass1:

Apr 13, 2024 · 1 share · 1,402 followers View post →
NeuroClass
@neuroclass1 · X

Apr 13, 2024 · 8 likes · 1 share · 10,094 followers View post →
François
@Aephage · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 27, 2024 · 12 shares · 442 followers View post →
Garance FdG
@AnneGarancefdg · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 100 followers View post →
Armelle Vautrot
@ArmelleV26 · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 4,090 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 2,835 followers View post →
ᗩᑎᗩïS
@AnaisHeilig · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 615 followers View post →
alias.patm
@MarcouxPatrici2 · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 75 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 334 followers View post →
PORCHE
@AgPorche · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 3,438 followers View post →
ombeline.bsky.social
@ombeline_beline · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 237 followers View post →
Serenity #PreventionSuicide
@SerenityArvak · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 599 followers View post →
SApsy progressiste universalité républicaine
@hadrienromain · X

RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…

Mar 26, 2024 · 12 shares · 547 followers View post →
Yann Le Strat
@YannLe_Strat · X

Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibilité à la récompense. Étude d'imagerie sur plus de 8000 participants. -Oui, vous avez bien lu, huit mille! https://t.co/49pF2trWNs

Mar 26, 2024 · 37 likes · 12 shares · 2,390 followers View post →
American Psychiatric Association
@APApsychiatric · X

Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/UmH7xCFzKC https://t.co/jDtfJvrAcQ

Mar 20, 2024 · 16 likes · 2 shares · 178,395 followers View post →
Adult ADHD India
@adultADHDindia · X

Largest study to date on changes in subcortico-cortical connectivity in ADHD. The brain regions showing altered connectivity align with fronto-striatal models of the disorder (small effect). Still don’t explain everything about ADHD. https://t.co/eUmAhOvWcN https://t.co/DJfLFooan7

Mar 18, 2024 · 541 followers View post →
Luke Norman
@Luke_J_Norman · X

RT @APAPubJournals: Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved…

Mar 18, 2024 · 1 share · 758 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/8mQ0RmUJ6Q https://t.co/WC9cIFT8i2

Mar 18, 2024 · 2 likes · 1 share · 11,606 followers View post →
Mumfi3
@Mumfi_3 · X

@GarryPNolan @AlchemyAmerican https://t.co/tKDIU5RzSy

Mar 17, 2024 · 453 followers View post →
Nils Kroemer
@cornu_copiae · X

RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. http…

Mar 14, 2024 · 7 shares · 2,718 followers View post →
Akshay Nair
@DrAkshayNair · X

RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. http…

Mar 14, 2024 · 7 shares · 778 followers View post →
Lady Clairey Fairy
@arienmaia · X

https://t.co/M33LW89m71

Mar 14, 2024 · 2 likes · 1,277 followers View post →
Dr Hannah Durand
@DurandHannah · X

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/6nCZUiFpQ7

Mar 14, 2024 · 1,544 followers View post →
Phunky Pharmacology
@phunky_pharm · X

RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. http…

Mar 14, 2024 · 7 shares · 402 followers View post →
Jesse Luke
@RealJesseLuke · X

@DrEvans_Health @BettyBlue168 Open access: https://t.co/veDt6rs4IO

Mar 14, 2024 · 2 likes · 2,245 followers View post →
Diagnostic Brain Medicine
@BrainDiagMed · X

A recent study reveals fascinating links between ADHD and subcortico-cortical connectivity in youth. Despite small effect sizes, these findings deepen our understanding of ADHD's neural underpinnings. Discover more about this complex disorder!

Mar 14, 2024 · 9 followers View post →
Adult ADHD India
@adultADHDindia · X

RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. http…

Mar 14, 2024 · 7 shares · 541 followers View post →
Gar McGuigan
@gar_mcguigan · X

RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. http…

Mar 14, 2024 · 7 shares · 422 followers View post →
Jesse Luke
@RealJesseLuke · X

N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections. https://t.co/veDt6rs4IO

Mar 14, 2024 · 31 likes · 7 shares · 2,245 followers View post →
ifo
@SniezekOZZP · X

RT @psych_janek: "Resting-State Connectivity" to pomiar korelacji w aktywności struktur mózgu w MRI podczas gdy osoba nie wykonuje żadnych…

Mar 14, 2024 · 1 share · 191 followers View post →
Pan Janek
@psych_janek · X

"Resting-State Connectivity" to pomiar korelacji w aktywności struktur mózgu w MRI podczas gdy osoba nie wykonuje żadnych zadań. Porównanie takich wzorców u osób z ADHD vs. zdrowe osoby, na dużej próbie, ujawnia zmiany w pętlach czołowo-podkorowych. https://t.co/GDEBPjJXKD

Mar 14, 2024 · 9 likes · 1 share · 310 followers View post →
Iban tripiana
@ibants · X

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/iSURLz7Qta

Mar 13, 2024 · 393 followers View post →
Ken Gusler
@kgusler · X

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts: https://t.co/Velp50i43c

Mar 13, 2024 · 1 like · 19,971 followers View post →
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