The overall tone reflects moderate agreement and curiosity, with several comments referencing the detailed neuroimaging methods and the significance of brain connectivity in ADHD, such as mentions of the amygdala-cortex links and large datasets; the tone is analytical and cautious, recognizing both the study's contributions and its limitations.
AgreementModerate agreement
Most comments acknowledge the study's findings on brain connectivity related to ADHD, with some questioning the broader implications or relevance, indicating a moderate level of support.
InterestHigh interest
Discussions express high curiosity about the neural mechanisms and the significance of the findings, especially with mentions of complex brain regions and studies involving large participant numbers.
EngagementModerate engagement
Participants reference specific aspects such as the increased connectivity between the amygdala and cortex, and the use of large neuroimaging datasets, showing a genuine interest and some analysis beyond surface-level reactions.
ImpactModerate impact
While some posts highlight the study's contribution to understanding ADHD's neural basis, they acknowledge the small effect sizes and ongoing debates, suggesting moderate perceived impact on diagnosis or treatment approaches.
Abstract in brief
A mega-analysis of six neuroimaging datasets investigated the relationship between ADHD and subcortico-cortical connectivity, involving 1,696 youths with ADHD and 6,737 control subjects.
The study found that youths with ADHD exhibited increased connectivity between striatal seeds and various brain regions, particularly the caudate, and also between the amygdala and dorsal anterior cingulate cortex.
Although these results support links between ADHD and brain connectivity, the effect sizes were small, suggesting that resting-state subcortico-cortical circuits may not fully explain the complexities of ADHD pathology.
Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibilité à la récompense.
Étude d'imagerie sur plus de 8000 participants.
-Oui, vous avez bien lu, huit mille!
https://t.co/49pF2trWNs
Mar 26, 2024 · 37 likes · 12 shares · 2,390 followersView post →
JL
Jesse Luke
@RealJesseLuke · X
N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections.
https://t.co/veDt6rs4IO
Mar 14, 2024 · 31 likes · 7 shares · 2,245 followersView post →
YS
Yann Le Strat
@YannLe_Strat · X
Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dans le #TDAH.
Importance de la connectivité amygdale-cortex frontal médian, qui explique peut-être les pb émotionels dans le #TDAH.
https://t.co/4YsYPMQsHp
Jun 12, 2024 · 17 likes · 8 shares · 2,390 followersView post →
AA
American Psychiatric Association
@APApsychiatric · X
Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/UmH7xCFzKC https://t.co/jDtfJvrAcQ
Mar 20, 2024 · 16 likes · 2 shares · 178,395 followersView post →
PJ
Pan Janek
@psych_janek · X
"Resting-State Connectivity" to pomiar korelacji w aktywności struktur mózgu w MRI podczas gdy osoba nie wykonuje żadnych zadań. Porównanie takich wzorców u osób z ADHD vs. zdrowe osoby, na dużej próbie, ujawnia zmiany w pętlach czołowo-podkorowych. https://t.co/GDEBPjJXKD
Mar 14, 2024 · 9 likes · 1 share · 310 followersView post →
American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses a meta-analysis of 243 fMRI studies highlighting shared and disorder-specific neural patterns in ADHD and autism, focusing on brain activity…
This mega-analysis of six neuroimaging datasets examined brain connectivity differences in youth with ADHD, highlighting increased connectivity between subcortical and cortical regions, though effect sizes remain small…
https://t.co/ojA9EIB5EI
Here is the study itself.
What is it about PhDs at the National Institutes of health that isn't credible? Is this study also lacking independence and validity?
Glad to see it doesn't seem to be appearing on the bio thus far today. What say you, Grok?
RT @Sverige2019: @NatalieBurea Adhd är mer än uppmärksamhet & uppe i varv. Gjorts flertal scanningar & studier efter de som referas till.…
Nov 14, 2024 · 1 share · 1,517 followersView post →
N
Normalisera
@Sverige2019 · X
@NatalieBurea Adhd är mer än uppmärksamhet & uppe i varv. Gjorts flertal scanningar & studier efter de som referas till.
Här en studie från 2024, 10.000 personer & uppdelade i de som har adhd vs de utan diagnoser. Annorlunda hjärnstruktur bla
https://t.co/tcu1h13MAZ https://t.co/6N0RhY0KEz
Nov 14, 2024 · 1 share · 1,517 followersView post →
RH
Rupa Health
@Rupa_Health · X
@fizzbee4 Please see this for citation DOI: 10.1176/appi.ajp.20230026
3. “Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts,” by Luke J. Norman, Ph.D., et al. 3/4
https://t.co/7zoGppfhzq
Jun 28, 2024 · 3 likes · 1 share · 11,606 followersView post →
B
Blanch
@BlancaTripp · X
Subcortico-Cortical Dysconnectivity in #ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/Iog4AZM1xT
3. “Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts,” by Luke J. Norman, Ph.D., et al. 3/4
https://t.co/7zoGppfhzq
Wichtig im Dt. Ärzteblatt:
"Die Frage nach den genauen Ursachen der vermuteten Entwicklungsstörung bleibt weiter unbeantwortet."
https://t.co/RpaFe6dUQ3
Original:
https://t.co/G7CKHHdaNh
> Steve Biddulph: 'Kinder sind genau so unruhig, wie wenig ihnen Eltern inneren Halt bieten.'
RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…
Jun 12, 2024 · 8 shares · 1,493 followersView post →
FC
Florence CL
@FlorenceCLTL · X
RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…
Jun 12, 2024 · 8 shares · 316 followersView post →
MS
mini scarabée
@miniscarabee · X
RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…
Jun 12, 2024 · 8 shares · 1,114 followersView post →
HT
HyperSupers TDAH
@TDAHyperSupers · X
RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…
Jun 12, 2024 · 8 shares · 3,074 followersView post →
FD
Frederic Danel
@Frederic_Danel · X
RT @YannLe_Strat: Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dan…
Jun 12, 2024 · 8 shares · 334 followersView post →
YS
Yann Le Strat
@YannLe_Strat · X
Éditorial à propos d'un important article dont nous avons discuté ici sur les altérations de connectivités cérébrales dans le #TDAH.
Importance de la connectivité amygdale-cortex frontal médian, qui explique peut-être les pb émotionels dans le #TDAH.
https://t.co/4YsYPMQsHp
Jun 12, 2024 · 17 likes · 8 shares · 2,390 followersView post →
E
Emily
@TigerTownDream · X
@HonestYPTweets It's also a complex pathophysiology, meaning the disordered physiological processes associated with disease or injury. It's a physical issue with connectivity within the brain that can be helped by medication. MacArthur is wrong here.
https://t.co/MWLoBksYhQ
@JennMGreenberg Here's an article published on 03/14/2024 in The American Journal of Psychiatry about a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity you might find interesting.
https://t.co/MWLoBksYhQ
"and structures in the frontal area of the brain involved in attention and control of unwanted behaviors".
https://t.co/mOzGvtJ5Jm
https://t.co/MWLoBksYhQ
2/2
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 27, 2024 · 12 shares · 442 followersView post →
GF
Garance FdG
@AnneGarancefdg · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 100 followersView post →
AV
Armelle Vautrot
@ArmelleV26 · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 4,090 followersView post →
NH
Nathalia Le Hen
@NathaliaLeHen · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 2,835 followersView post →
ᗩ
ᗩᑎᗩïS
@AnaisHeilig · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 615 followersView post →
AP
alias.patm
@MarcouxPatrici2 · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 75 followersView post →
FD
Frederic Danel
@Frederic_Danel · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 334 followersView post →
P
PORCHE
@AgPorche · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 3,438 followersView post →
OS
ombeline.bsky.social
@ombeline_beline · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 237 followersView post →
SP
Serenity #PreventionSuicide
@SerenityArvak · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 599 followersView post →
SR
SApsy progressiste universalité républicaine
@hadrienromain · X
RT @YannLe_Strat: Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibil…
Mar 26, 2024 · 12 shares · 547 followersView post →
YS
Yann Le Strat
@YannLe_Strat · X
Dans le #TDAH, il y a une augmentation de connectivité entre le striatum et cortex, une boucle impliquée dans la sensibilité à la récompense.
Étude d'imagerie sur plus de 8000 participants.
-Oui, vous avez bien lu, huit mille!
https://t.co/49pF2trWNs
Mar 26, 2024 · 37 likes · 12 shares · 2,390 followersView post →
AA
American Psychiatric Association
@APApsychiatric · X
Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/UmH7xCFzKC https://t.co/jDtfJvrAcQ
Mar 20, 2024 · 16 likes · 2 shares · 178,395 followersView post →
AI
Adult ADHD India
@adultADHDindia · X
Largest study to date on changes in subcortico-cortical connectivity in ADHD. The brain regions showing altered connectivity align with fronto-striatal models of the disorder (small effect). Still don’t explain everything about ADHD.
https://t.co/eUmAhOvWcN https://t.co/DJfLFooan7
Analysis of brain images from youths with #ADHD found heightened connectivity between structures in the brain involved in learning and emotion + structures in the frontal area of the brain involved in control of unwanted behaviors. @Luke_J_Norman https://t.co/8mQ0RmUJ6Q https://t.co/WC9cIFT8i2
Mar 18, 2024 · 2 likes · 1 share · 11,606 followersView post →
RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections.
http…
Mar 14, 2024 · 7 shares · 2,718 followersView post →
AN
Akshay Nair
@DrAkshayNair · X
RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections.
http…
Mar 14, 2024 · 7 shares · 778 followersView post →
LF
Lady Clairey Fairy
@arienmaia · X
https://t.co/M33LW89m71
Mar 14, 2024 · 2 likes · 1,277 followersView post →
DD
Dr Hannah Durand
@DurandHannah · X
Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/6nCZUiFpQ7
RT @RealJesseLuke: N=9980 neuroimaging of ADHD provides strong support of neuroscientific hypotheses of relevant neural connections.
http…
Mar 14, 2024 · 7 shares · 402 followersView post →
JL
Jesse Luke
@RealJesseLuke · X
@DrEvans_Health @BettyBlue168 Open access: https://t.co/veDt6rs4IO
Mar 14, 2024 · 2 likes · 2,245 followersView post →
DM
Diagnostic Brain Medicine
@BrainDiagMed · X
A recent study reveals fascinating links between ADHD and subcortico-cortical connectivity in youth. Despite small effect sizes, these findings deepen our understanding of ADHD's neural underpinnings. Discover more about this complex disorder!
"Resting-State Connectivity" to pomiar korelacji w aktywności struktur mózgu w MRI podczas gdy osoba nie wykonuje żadnych zadań. Porównanie takich wzorców u osób z ADHD vs. zdrowe osoby, na dużej próbie, ujawnia zmiany w pętlach czołowo-podkorowych. https://t.co/GDEBPjJXKD
Mar 14, 2024 · 9 likes · 1 share · 310 followersView post →
IT
Iban tripiana
@ibants · X
Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts | American Journal of Psychiatry https://t.co/iSURLz7Qta
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