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The group consistently praises the research's technological breakthroughs, such as gene modifications like hHMOX1 and hCD47, which reduce immune rejection, illustrating deep engagement. Phrases like 'game-changer' and references to clinical trials underscore the high-impact perception of this field's potential for transforming organ transplantation.
Most discussions express strong support and enthusiasm for the advancements in xenotransplantation, emphasizing the potential benefits and scientific progress.
Posts highlight significant interest, referencing detailed gene edits, immune responses, and clinical developments, suggesting high engagement with the topic.
Many discussions include citations of research articles, gene strategies, and upcoming podcasts, indicating active involvement and curiosity.
The discourse centers on groundbreaking clinical trials and the promising future of this technology, implying high potential influence on medicine and transplantation practices.
This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient. What is the #physiological basis for #xenotransplantation from genetically-modified pigs to humans? Read Peterson et al.
The team at United Therapeutics and their collaborators have just published the first comprehensive review of the history breakthroughs that led to xenotransplantation from pigs modified by genetic engineering. https://t.co/bVYWbqNatO
.@washingtonpost "FDA approves pig organ transplant trials for patients with kidney failure" https://t.co/tAtnGAdNFw features @physiolrev author Dr. Leigh Peterson
8. Physiological basis for xenotransplantation from genetically modified pigs to humans https://t.co/DrAL7yxJ8N
This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipient. What's the #physiological basis for #xenotransplantation from genetically-modified pigs to humans? Read Peterson et al. @physiolrev
Macrophages serve a key role in the identification and elimination of foreign cells in the innate immune system. Human transgene hCD47 is inserted into source pigs to make xenograft cells less susceptible to human macrophage phagocytosis. https://t.co/yY6Ay90Fbl 1/3 https://t.co/AJNHNmj8Th
Kim Solez discusses how AI xenotransplantation and ethical considerations are accelerating efforts to address organ shortages, potentially saving millions annually and expanding transplant capabilities through…
Scientists are developing genetically modified pigs to enable successful organ transplants into humans, with recent clinical trials demonstrating promising progress in pig-to-human heart transplants and potential for…
Scientists have developed advanced technologies like genetic engineering and cloning to make pig organs suitable for transplanting into humans. Recent clinical trials with pig-to-human heart transplants demonstrate…
As a result, insertion of hHMOX1 into source pigs could be beneficial in promoting survival of xenografts by reducing cellular apoptosis and tissue damage. https://t.co/yY6Ay90Fbl 3/3 https://t.co/vpC3GFow7z
RT @UTHRMed: Macrophages serve a key role in the identification and elimination of foreign cells in the innate immune system. Human transge…
Macrophages serve a key role in the identification and elimination of foreign cells in the innate immune system. Human transgene hCD47 is inserted into source pigs to make xenograft cells less susceptible to human macrophage phagocytosis. https://t.co/yY6Ay90Fbl 1/3 https://t.co/AJNHNmj8Th
Two human anticoagulant genes, hTHBD and hPROCR, have been inserted into source pigs to improve xenotransplantation compatibility in humans. https://t.co/yY6Ay90Fbl 1/5 https://t.co/TtNbKkG5Dz
Expression of human complement regulatory proteins hCD46 and hCD55 in the xenograft inhibit recipient complement system activation and prevent rejection. This is achieved through insertion of hCD46 and hCD55 genes in source pigs. https://t.co/yY6Ay90Fbl 2/2 https://t.co/PgMwMXk5qc
For more information on other gene edits, check out this review article: https://t.co/yY6Ay90Fbl 2/2 https://t.co/MOdIB9uRhD
RT @con_nectinder: 8. Physiological basis for xenotransplantation from genetically modified pigs to humans https://t.co/DrAL7yxJ8N
8. Physiological basis for xenotransplantation from genetically modified pigs to humans https://t.co/DrAL7yxJ8N
Inactivation of the CMAH and B4GALNT2genes in the source pig is thought to decrease the chance of xenograft rejection in humans. https://t.co/yY6Ay90Fbl 5/5 https://t.co/8zCbeKlTbf
Please be sure to revisit our account in the future for more information on the role of other gene edits. https://t.co/yY6Ay90Fbl 4/4 https://t.co/CwerXgCA1j
RT @UTHRMed: For more information on why these gene edits may decrease the human immune response to xenografts, see this review article: ht…
For more information on why these gene edits may decrease the human immune response to xenografts, see this review article: https://t.co/yY6Ay90Fbl 5/5 https://t.co/GQuG2kNlQW
For more information on immunological considerations in xenotransplantation, see this review article: https://t.co/yY6Ay90Fbl 7/7 https://t.co/AsGhUsDGOt
"Physiological Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review" Peterson L, Yacoub MH, Ayares D, Yamada K, Eisenson D, Griffith BP, Mohiuddin MM, Eyestone W, Venter JC, Smolenski RT, Rothblatt M. Physiol Rev 2024-03-2２ https://t.co/i7Y68npjho https://t.co/jdN8EmaUQf
RT @physiolrev: .@washingtonpost "FDA approves pig organ transplant trials for patients with kidney failure" https://t.co/tAtnGAdNFw featu…
RT @physiolrev: .@washingtonpost "FDA approves pig organ transplant trials for patients with kidney failure" https://t.co/tAtnGAdNFw featu…
.@washingtonpost "FDA approves pig organ transplant trials for patients with kidney failure" https://t.co/tAtnGAdNFw features @physiolrev author Dr. Leigh Peterson
https://t.co/SksVjQ9obY.
To get the most out of this game-changer, we recommend "Physiological basis for xenotransplantation from genetically modified pigs to humans" + author interview podcast! doi.org/10.1152/phys...
To get the most out of this game-changer, we recommend "Physiological basis for xenotransplantation from genetically modified pigs to humans" + author interview podcast! https://t.co/5BJfvRrMb9 https://t.co/ApsyKRrRvT
RT @LeonDonnelly18: @darcwood Dr Martine Rothblatt's Revivicor/United Therapeutics use Alpha Genesis 'non-human primates' as human substitu…
@darcwood David Ayares’s research while affiliated with United Therapeutics Corporation and other places https://t.co/t5An1wDH8k Physiological basis for xenotransplantation from genetically modified pigs to humans https://t.co/R6cG36tLSl https://t.co/EgpYZFIWYf https://t.co/i4Nkw4SCm4
@darcwood Dr Martine Rothblatt's Revivicor/United Therapeutics use Alpha Genesis 'non-human primates' as human substitutes for xenotransplantation/xenotransfusion tests using his human-pig hybrids. Risk of pandemic. https://t.co/EgpYZFIp8H https://t.co/H0o1TtxJFk https://t.co/R6cG36te2N https://t.co/blykI0wDoH
Podcast *coming soon* on this important Review! Physiological Basis for #Xenotransplantation from Genetically-Modified Pigs to Humans Peterson et al. https://t.co/beMoqeTcCD https://t.co/DQ6NFS356l
See a review article that describes the physiological basis of xenotransplantation of organs from genetically modified pigs to humans. Now available at @physiolrev. https://t.co/yUSezNSbAu https://t.co/uu08lZJPFV
RT @APSPublications: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipi…
RT @APSPublications: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipi…
RT @physiolrev: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient.…
RT @JCVenterInst: The team at United Therapeutics and their collaborators have just published the first comprehensive review of the history…
RT @JCVenterInst: The team at United Therapeutics and their collaborators have just published the first comprehensive review of the history…
The team at United Therapeutics and their collaborators have just published the first comprehensive review of the history breakthroughs that led to xenotransplantation from pigs modified by genetic engineering. https://t.co/bVYWbqNatO
RT @physiolrev: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient.…
Timely review: Basis for Xenotransplantation from Genetically-Modified Pigs to Humans: A Review | Physiological Reviews https://t.co/CZ6CZU7N1y
RT @APSPublications: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipi…
RT @physiolrev: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient.…
RT @physiolrev: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient.…
RT @physiolrev: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient.…
RT @APSPublications: This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipi…
This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited pig #kidney to a living recipient. What's the #physiological basis for #xenotransplantation from genetically-modified pigs to humans? Read Peterson et al. @physiolrev
This week doctors @MassGeneralNews performed the 1st transplant of a genetically edited #pig #kidney to a living recipient. What is the #physiological basis for #xenotransplantation from genetically-modified pigs to humans? Read Peterson et al.