Changes in the intestinal microbiota of individuals with non-alcoholic fatty liver disease based on sequencing: An updated systematic review and meta-analysis.

Abstract in brief

• The study systematically reviewed and meta-analyzed data up to March 2023 to examine how the diversity and abundance of gut microbiota differ between individuals with nonalcoholic fatty liver disease (NAFLD) and healthy people, finding that NAFLD patients generally have reduced microbiota diversity and altered bacterial populations.
• Specifically, the research showed that in people with NAFLD, beneficial bacteria like Ruminococcus, Faecalibacterium, and Coprococcus are decreased, while potentially harmful bacteria like Escherichia are increased, indicating a dysbiosis or imbalance in gut bacteria may be linked to NAFLD.
• The findings suggest that increasing microbial diversity and adjusting the abundance of certain bacteria might help improve NAFLD, highlighting the potential of microbiota-targeted strategies for managing the disease.