JACC Clin Electrophysiol May 2024 PMID 38551548

Class 1C Antiarrhythmics for Premature Ventricular Complex Suppression in Nonischemic Cardiomyopathy With Implantable Cardioverter-Defibrillators.

Mohamad Raad, Haran Yogasundaram, Justice Oranefo, Gustavo Guandalini, Timothy Markman, Matthew Hyman, Robert Schaller, Gregory Supple, Rajat Deo, Saman Nazarian, Michael Riley, David Lin, Fermin Garcia, Sanjay Dixit, Andrew E Epstein

Mentions

33
Peak: 24 in Jun 2024
across 3 sources since Mar 2024

Extended reach

234,561
potential audience

Total likes

185

Video views

1,115

Mentions per month

Mar 2024 – Jul 2024

Where it's discussed

  • X / Twitter29 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Several discussions highlight the promising results, such as mentions of PVC suppression and increased ejection fraction, with phrases like 'exciting' and 'limited sample' indicating enthusiasm tempered by caution. The tone suggests a recognition of potential clinical significance, while also emphasizing the need for more extensive studies to confirm these initial findings.

AgreementModerate agreement

Most discussions acknowledge the publication's findings, with some emphasizing the positive effects of class 1C antiarrhythmics on PVC suppression and ventricular function, indicating general consensus or support.

InterestHigh interest

The discussions show high curiosity about the study, with many posts highlighting exciting or promising results, suggesting strong engagement from the audience interested in cardiac therapeutics.

EngagementModerate engagement

Posts often reference specific outcomes like LVEF improvements and PVC suppression, and some mention the need for larger studies, demonstrating active participation and analysis of the research details.

ImpactModerate impact

While the discussion recognizes potential benefits, most posts imply that the findings could influence future research and clinical practice, but they also note the limited sample size, suggesting moderate perceived impact.

Abstract in brief

  • PVCs are common in heart failure patients and can lead to worsened outcomes; class 1C antiarrhythmic drugs (AADs), while effective, have restricted use due to guidelines.
  • This study evaluated the safety and effectiveness of class 1C AADs (specifically flecainide and propafenone) in patients with nonischemic cardiomyopathy (NICM) who have implantable cardioverter-defibrillators (ICDs).
  • Results showed a significant reduction in PVC burden, improvement in left ventricular ejection fraction, and increased biventricular pacing percentage, with few safety concerns, suggesting class 1C AADs are beneficial for these patients, but more extensive research is necessary for definitive

Top posts

Most liked on X and Bluesky
JACC Journals
@JACCJournals · X

Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF and biventricular pacing percentage. In this limited sample, their use was safe. Larger studies are needed https://t.co/fMZfHz6wMa #JACCCEP #EPeeps #epICD https://t.co/wrtChulnlA

Jun 8, 2024 · 133 likes · 40 shares · 114,575 followers View post →
Heart Rhythm Society
@HRSonline · X

NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Complex Suppression in Nonischemic Cardiomyopathy With Implantable Cardioverter-Defibrillators

Jun 20, 2024 · 17 likes · 8 shares · 37,764 followers View post →
Nikhil Shah, MD
@NikhilShahMD · X

Exciting paper from Penn looking retrospectively (though small n) @ NICM pts w ICD on class Ic drugs for PVC suppression: ⬇️ PVCs ⬇️ sustained VT ⬆️ EF ⬆️ BiV pacing % https://t.co/kH4kwxQ8Cm

May 29, 2024 · 11 likes · 2 shares · 1,170 followers View post →
MEDNTD
@medntdj · X

Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF and biventricular pacing percentage. In this limited sample, their use was safe. Larger studies are needed https://t.co/FDSv2nyRVt #JACCCEP via @JACCJournals https://t.co/NXSaoVqVmK

Jun 9, 2024 · 2 likes · 910 followers View post →
Raviele Antonio
@drraviele · X

https://t.co/J7bMX3Swh8

Jun 24, 2024 · 23,345 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @NikhilShahMD: Exciting paper from Penn looking retrospectively (though small n) @ NICM pts w ICD on class Ic drugs for PVC suppression:…

May 30, 2024 · 2 shares · 11,713 followers View post →

All mentions

Alejandro Sánchez-Nadales, MD
@AlejandroSN21 · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jul 24, 2024 · 8 shares · 450 followers View post →
Brigham EP
@Brigham_EP · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 25, 2024 · 8 shares · 476 followers View post →
Raviele Antonio
@drraviele · X

https://t.co/J7bMX3Swh8

Jun 24, 2024 · 23,345 followers View post →
Martha G
@MGMayanrn · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 23, 2024 · 8 shares · 638 followers View post →
APHRS2024
@aphrs2024 · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 22, 2024 · 8 shares · 690 followers View post →
Deepthy "Dee" Varghese
@np_varghese · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 21, 2024 · 8 shares · 255 followers View post →
Prash Sanders
@PrashSanders · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 21, 2024 · 8 shares · 9,194 followers View post →
William H. Sauer, MD
@True_EP · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 20, 2024 · 8 shares · 8,413 followers View post →
David Chang, MD
@davidjchang7 · X

RT @HRSonline: NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Compl…

Jun 20, 2024 · 8 shares · 868 followers View post →
Heart Rhythm Society
@HRSonline · X

NEW EPISODE OF THE LEAD! [Ep. 66] A Discussion of Class 1C Antiarrhythmics for Premature Ventricular Complex Suppression in Nonischemic Cardiomyopathy With Implantable Cardioverter-Defibrillators

Jun 20, 2024 · 17 likes · 8 shares · 37,764 followers View post →
MEDNTD
@medntdj · X

Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF and biventricular pacing percentage. In this limited sample, their use was safe. Larger studies are needed https://t.co/FDSv2nyRVt #JACCCEP via @JACCJournals https://t.co/NXSaoVqVmK

Jun 9, 2024 · 2 likes · 910 followers View post →
Elena Vasti
@ecvasti · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 622 followers View post →
Dr Duncan Hogg
@drduncanhogg · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 1,306 followers View post →
Massimo Romano
@dottmasroman · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 356 followers View post →
Wissam Gharib
@aitawi1 · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 166 followers View post →
Angel Cueva Parra
@ACuevaParra · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 1,145 followers View post →
Alaa Rahhal
@AlaaRahhal13 · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 87 followers View post →
Jonathan Francois M.D
@jofrancois1 · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 110 followers View post →
Osama Bisht
@Obisht · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 6,408 followers View post →
Matthew S Glassy
@GlassyMatthew · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 241 followers View post →
Bhavya Varma, MD
@BhavyaVarma12 · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 984 followers View post →
Ahmed Teebi, MD MPH
@Teebi_MD · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 8,872 followers View post →
maldinilin
@maldinilin · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 96 followers View post →
Brian P. Rose, PA-C MPH AACC
@Brian_RosePA · X

RT @JACCJournals: Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF a…

Jun 8, 2024 · 40 shares · 311 followers View post →
JACC Journals
@JACCJournals · X

Class 1C antiarrhythmic drugs effectively suppressed PVCs in patients with NICM and ICDs, leading to increases in #LVEF and biventricular pacing percentage. In this limited sample, their use was safe. Larger studies are needed https://t.co/fMZfHz6wMa #JACCCEP #EPeeps #epICD https://t.co/wrtChulnlA

Jun 8, 2024 · 133 likes · 40 shares · 114,575 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @NikhilShahMD: Exciting paper from Penn looking retrospectively (though small n) @ NICM pts w ICD on class Ic drugs for PVC suppression:…

May 30, 2024 · 2 shares · 11,713 followers View post →
Maiwand Mirwais
@Maiwand66 · X

RT @NikhilShahMD: Exciting paper from Penn looking retrospectively (though small n) @ NICM pts w ICD on class Ic drugs for PVC suppression:…

May 30, 2024 · 2 shares · 965 followers View post →
Nikhil Shah, MD
@NikhilShahMD · X

Exciting paper from Penn looking retrospectively (though small n) @ NICM pts w ICD on class Ic drugs for PVC suppression: ⬇️ PVCs ⬇️ sustained VT ⬆️ EF ⬆️ BiV pacing % https://t.co/kH4kwxQ8Cm

May 29, 2024 · 11 likes · 2 shares · 1,170 followers View post →
Lê Văn Lắm
@levanlam95 · X

Class 1C Antiarrhythmics for Premature Ventricular Complex Suppression in Nonischemic Cardiomyopathy With Implantable Cardioverter-Defibrillators https://t.co/ndirVMT8PU

Mar 28, 2024 · 41 followers View post →