The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review.

Abstract in brief

• Alzheimer's disease (AD) is a leading cause of dementia affecting over 5 million people in the U.S., and current treatments mainly provide temporary symptom relief without stopping disease progression.
• Melatonin, a hormone produced by the pineal gland, has antioxidant and anti-inflammatory properties and has been researched extensively as a potential therapy for AD because it targets multiple mechanisms involved in the disease.
• Current evidence from cell and animal studies suggests melatonin's neuroprotective effects against AD, and clinical research shows promising results, but more rigorously designed trials are needed to confirm its ability to modify the disease itself.