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Cancer Res May 2024 PMID 38588411

Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy.

Sean Murphy, Sharif Rahmy, Dailin Gan, Guoqiang Liu, Yini Zhu, Maxim Manyak, Loan Duong, Jianping He, James H Schofield, Zachary T Schafer, Jun Li, Xuemin Lu, Xin Lu

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Mentions

56
Peak: 28 in Apr 2024
across 4 sources since Apr 2024

Extended reach

264,513
potential audience

Total likes

99

Video views

512

Mentions per month

Apr 2024 – May 2025

Where it's discussed

  • X / Twitter35 posts
  • News17 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Several discussions emphasize the significance of the research, using words like 'game changer' and 'overcome resistance,’ suggesting a notable potential impact. The tone varies from enthusiastic to analytical, with references to specific mechanisms such as histone deacytylase inhibition and immune landscape alterations, indicating deep interest and engagement. The frequent mention of combining diet with immune therapies underscores the perceived importance of this approach.

AgreementStrong agreement

Most discussions strongly support the potential of the ketogenic diet to enhance prostate cancer treatment, with phrases like 'game changer,' and 'overcome resistance,' indicating high endorsement.

InterestHigh interest

The widespread mention of diet, immune responses, and therapeutic strategies shows high curiosity and relevance, including technical terms like 'HDACi' and 'epigenetic landscape,' reflecting strong engagement.

EngagementHigh engagement

Many posts reference specific mechanisms and possible clinical applications, such as combining diets with immune checkpoint therapies, which demonstrates deep engagement and analysis.

ImpactModerate impact

Although some posts highlight the promising nature of the research, the overall tone suggests a belief in significant impact, but with cautious optimism; hence, a slightly lower impact score.

Abstract in brief

  • The study investigates how a ketogenic diet (KD), combined with other therapies, can improve the effectiveness of immune checkpoint blockade (ICB) therapy in treating resistant prostate cancer by changing the cancer's genetic and immune environment.
  • Researchers found that using a cyclic ketogenic diet and supplementing with ketone bodies like hydroxybutyrate, along with drugs that modify gene expression (HDAC inhibitors), can slow tumor growth and boost the immune response against cancer.
  • These interventions work by both making cancer cells more visible to the immune system and attracting immune cells to attack the tumor, suggesting dietary strategies could support immunotherapy in prostate cancer treatment.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Marcus Goncalves
@MarcusDGon · X

Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy | Cancer Research | American Association for Cancer Research https://t.co/T47mMKN4Ib

Apr 24, 2024 · 33 likes · 13 shares · 2,536 followers View post →
J P Fanton
@HealthyFellow · X

#Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkpoint blockade therapy https://t.co/pIPfe0ohxn @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @shashiiyengar @Mindzatwork @DrPalmquist @hormonedietdoc https://t.co/T4XcjLB0PJ

Apr 10, 2024 · 27 likes · 10 shares · 26,021 followers View post →
Dominic D'Agostino
@DominicDAgosti2 · X

Combining anti-PD1 + anti-CTLA4 antibodies + HDACi with a cyclic ketogenic diet for prostate cancer https://t.co/0IUzyJvwIz

Apr 11, 2024 · 18 likes · 3 shares · 77,979 followers View post →
P123
@P1231032850 · X

20

May 5, 2024 · 2 likes · 3,195 followers View post →
Rudolf Grams
@RudolfGrams · X

Die ketogene Diät: Ein Geheimnis im Kampf gegen Krebs? | Gesundheit und ... https://t.co/4LOPfLfj5l via @YouTube

Nov 5, 2024 · 2 likes · 317 followers View post →
Erich Acebedo
@AcebedoErichMD · X

Ketone body, beta-hydroxybutyrate which is an endogenous histone deacytylase inhibitor (HDACi) enhances the effect of Immune Checkpoint Blockade in prostate cancer. https://t.co/u1OQobEEqA

Apr 23, 2025 · 1 like · 311 followers View post →

All mentions

Decimus Septembris
@MSUalum2015 · X

@WhoIsTomLove @ScottAdamsSays @SBakerMD @DrSuzanneH7 Uh huh... https://t.co/jzEtW8hln8

May 22, 2025 · 332 followers View post →
Erich Acebedo
@AcebedoErichMD · X

Ketone body, beta-hydroxybutyrate which is an endogenous histone deacytylase inhibitor (HDACi) enhances the effect of Immune Checkpoint Blockade in prostate cancer. https://t.co/u1OQobEEqA

Apr 23, 2025 · 1 like · 311 followers View post →
Krishna Kannan
@Kannan9900 · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Dec 21, 2024 · 13 shares · 1,056 followers View post →
Vital Aging Lab | Dr. Lukas Morcinek
@vitalaginglab · X

https://t.co/LZQxJsdweq

Nov 7, 2024 · 1 like · 14 followers View post →
Rudolf Grams
@RudolfGrams · X

Die ketogene Diät: Ein Geheimnis im Kampf gegen Krebs? | Gesundheit und ... https://t.co/4LOPfLfj5l via @YouTube

Nov 5, 2024 · 2 likes · 317 followers View post →
EduX ⚛️
@Antonio_Baez · X

Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy https://t.co/D7DD1tRl3t #Research_bz #EduX #KetogenicDiet #ProstateCancer #Prostate

May 16, 2024 · 1,491 followers View post →
P123
@P1231032850 · X

20

May 5, 2024 · 2 likes · 3,195 followers View post →
Lyssiotis Lab
@LyssiotisLab · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 25, 2024 · 13 shares · 7,054 followers View post →
Helen Martirosova,PhD, MSc
@HMartirosova · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 25, 2024 · 13 shares · 86 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 572 followers View post →
Leave it to Beaver
@espacetimeNOT · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 1,192 followers View post →
SV Mathan
@MathanSivapar · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 301 followers View post →
Ranganath Muniyappa
@dr_muniyappa · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 1,091 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 12,803 followers View post →
Patrick
@pkamaukinyenje · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 715 followers View post →
DrDeaRoberts
@DrDeaRoberts · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 2,041 followers View post →
Johnny (find me on that other app)
@johnnyfreitag · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 430 followers View post →
K Dav-10
@kdscott10 · X

RT @MarcusDGon: Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint bl…

Apr 24, 2024 · 13 shares · 918 followers View post →
Marcus Goncalves
@MarcusDGon · X

Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy | Cancer Research | American Association for Cancer Research https://t.co/T47mMKN4Ib

Apr 24, 2024 · 33 likes · 13 shares · 2,536 followers View post →
the paper link
@the_paper_link · X

Trend up+7: Murphy S, ..., Lu X (Cancer Res) __Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy__ https://t.co/7jtZOv2Kkt

Apr 13, 2024 · 136 followers View post →
KetoMed
@KetoMed1 · X

RT @DominicDAgosti2: Combining anti-PD1 + anti-CTLA4 antibodies + HDACi with a cyclic ketogenic diet for prostate cancer https://t.co/0IUzy…

Apr 12, 2024 · 3 shares · 506 followers View post →
Mind Your Science!
@MindYourSci · X

RT @DominicDAgosti2: Combining anti-PD1 + anti-CTLA4 antibodies + HDACi with a cyclic ketogenic diet for prostate cancer https://t.co/0IUzy…

Apr 12, 2024 · 3 shares · 133 followers View post →
Best Health 4 You
@besthealthyou · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 11, 2024 · 10 shares · 522 followers View post →
David
@TheAlacritarian · X

RT @DominicDAgosti2: Combining anti-PD1 + anti-CTLA4 antibodies + HDACi with a cyclic ketogenic diet for prostate cancer https://t.co/0IUzy…

Apr 11, 2024 · 3 shares · 63 followers View post →
Dominic D'Agostino
@DominicDAgosti2 · X

Combining anti-PD1 + anti-CTLA4 antibodies + HDACi with a cyclic ketogenic diet for prostate cancer https://t.co/0IUzyJvwIz

Apr 11, 2024 · 18 likes · 3 shares · 77,979 followers View post →
#RaviVisvesvarayaSharadaPrasad #Telecom #InfoTech
@rvp · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 11, 2024 · 10 shares · 4,877 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 11, 2024 · 10 shares · 181 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 11, 2024 · 10 shares · 2,873 followers View post →
It is well with us
@kedem2134 · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 11, 2024 · 10 shares · 2,702 followers View post →
Vesper
@Silver_Lining76 · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 10, 2024 · 10 shares · 1,024 followers View post →
Lorraine Lanning
@Common_SenseCO · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 10, 2024 · 10 shares · 1,642 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 10, 2024 · 10 shares · 3,165 followers View post →
Made in the USA
@FiveFortySpin · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 10, 2024 · 10 shares · 198 followers View post →
Dr. Jay Wrigley
@hormonedietdoc · X

RT @HealthyFellow: #Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkp…

Apr 10, 2024 · 10 shares · 104,943 followers View post →
J P Fanton
@HealthyFellow · X

#Ketogenic #diet alters the #epigenetic & #immune landscape of #prostate #cancer to overcome resistance to immune checkpoint blockade therapy https://t.co/pIPfe0ohxn @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @shashiiyengar @Mindzatwork @DrPalmquist @hormonedietdoc https://t.co/T4XcjLB0PJ

Apr 10, 2024 · 27 likes · 10 shares · 26,021 followers View post →