Circulation April 2024 PMID 38620086

The Efficacy and Safety of Andexanet Alfa in Patients With Acute Gastrointestinal Bleeding While Taking Factor Xa Inhibitors: An ANNEXA-4 Subanalysis.

Deborah M Siegal, Nauzer Forbes, John Eikelboom, Jan Beyer-Westendorf, Alexander T Cohen, Lizhen Xu, Stuart J Connolly, Mark Crowther

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Mentions

11
Peak: 8 in Apr 2024
across 2 sources since Apr 2024

Extended reach

88,520
potential audience

Total likes

24

Video views

150

Mentions per month

Apr 2024 – Aug 2024

Where it's discussed

  • X / Twitter9 posts
  • YouTube2 videos

AI synopsis

What people are saying

The responses highlight key results, like 82% of patients achieving effective hemostasis, and praise the drug’s FDA approval, reflecting a positive reception and perceived significance of the research. The tone, emphasizing efficacy and safety, demonstrates active engagement with its potential clinical impact.

AgreementModerate agreement

Most discussions highlight positive outcomes from the study, emphasizing successful hemostasis and the potential benefits of Andexanet Alfa.

InterestModerate interest

The posts reflect moderate interest, focusing on specific findings like the 82% success rate and the drug being FDA-approved, indicating engagement with the clinical significance.

EngagementModerate engagement

Participants reference the study details, such as the rapid reversal of anticoagulant effects and the mention of clinical outcomes, showing thoughtful engagement.

ImpactModerate impact

The discussions suggest that the findings could influence clinical practice, especially with terms like 'good/excellent hemostasis' and noting the drug’s approval, indicating a perceived high impact.

Abstract in brief

  • The study evaluates how effective and safe Andexanet Alfa is for patients experiencing acute gastrointestinal bleeding who are on Factor Xa inhibitors.
  • It provides findings from the ANNEXA4 subanalysis, focusing on bleeding control and safety outcomes in this specific patient group.
  • The results suggest that Andexanet Alfa may be a viable treatment option, but safety and efficacy need to be carefully considered in clinical settings.]

Top posts

Most liked on X and Bluesky
Circulation
@CircAHA · X

#Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstrate rapid reversal of FXai anticoagulant effect and clinical hemostasis. @DebSiegal https://t.co/P7fJBoRy93

Apr 19, 2024 · 20 likes · 7 shares · 77,359 followers View post →
cardio-met
@cardiomet_CE · X

16) In a subanalysis of the #ANNEXA_4trial, 82% of pts presenting with major #GIB experienced good/excellent #hemostasis after treatment with #andexanet_alfa, the only @US_FDA-approved specific #reversal agent for #FXa inhibitors. See

May 28, 2024 · 2 likes · 4,156 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 2,419 followers View post →
Deborah Siegal
@DebSiegal · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 1,648 followers View post →
Asociación Insuficiencia Cardiaca
@ICardiacaSEC · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 1,421 followers View post →
EOLO MORANDI JR.
@eolojr · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 538 followers View post →

All mentions

cardio-met
@cardiomet_CE · X

16) In a subanalysis of the #ANNEXA_4trial, 82% of pts presenting with major #GIB experienced good/excellent #hemostasis after treatment with #andexanet_alfa, the only @US_FDA-approved specific #reversal agent for #FXa inhibitors. See

May 28, 2024 · 2 likes · 4,156 followers View post →
Shinya Goto
@sgoto4 · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 22, 2024 · 7 shares · 324 followers View post →
Circulation 日本版
@Circulation_nih · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 21, 2024 · 7 shares · 345 followers View post →
EOLO MORANDI JR.
@eolojr · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 538 followers View post →
Deborah Siegal
@DebSiegal · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 1,648 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 2,419 followers View post →
nazim laraba
@LarabaNazim · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 48 followers View post →
Asociación Insuficiencia Cardiaca
@ICardiacaSEC · X

RT @CircAHA: #Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstra…

Apr 19, 2024 · 7 shares · 1,421 followers View post →
Circulation
@CircAHA · X

#Research Letter: Andexanet alfa treatment in patients with acute gastrointestinal bleeding with Factor Xa inhibitor demonstrate rapid reversal of FXai anticoagulant effect and clinical hemostasis. @DebSiegal https://t.co/P7fJBoRy93

Apr 19, 2024 · 20 likes · 7 shares · 77,359 followers View post →