Breast Cancer Res Treat July 2024 PMID 38653905

Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis.

Rowan T Chlebowski, Aaron K Aragaki, Kathy Pan, Joanne E Mortimer, Karen C Johnson, Jean Wactawski-Wende, Meryl S LeBoff, Sayeh Lavasani, Dorothy Lane, Rebecca A Nelson, JoAnn E Manson

Mentions

27
Peak: 17 in May 2024
across 3 sources since Apr 2024

Extended reach

276,930
potential audience

Total likes

292

Video views

4,109

Mentions per month

Apr 2024 – Aug 2025

Where it's discussed

  • X / Twitter23 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The discussions demonstrate high engagement through references to statistics like a 22% reduction in breast cancer risk and citations of the meta-analysis involving over 14,000 women. Words such as 'great news' and phrases like 'shatters misconception' convey excitement and impact, illustrating a consensus that this research could significantly influence understanding and treatment practices.

AgreementStrong agreement

Most discussions strongly support the findings, emphasizing the protective effect of estrogen therapy on breast cancer risk.

InterestHigh interest

The posts show high interest, highlighting new research and emphasizing its significance for women’s health.

EngagementHigh engagement

Many comments reference specific studies, statistics, and implications, indicating deep engagement with the topic.

ImpactHigh impact

The overall tone suggests that these findings could influence clinical practices and public perceptions about hormone replacement therapy.

Abstract in brief

  • The meta-analysis of 10 randomized trials involving over 14,000 participants indicates that estrogen alone significantly reduces the incidence of breast cancer, with a combined relative risk of about 0.77.
  • Some smaller trials and specific formulations like estradiol also showed a similar protective effect, with relative risks around 0.63 to 0.65.
  • This finding contrasts with some cohort studies and previous research, but overall, the evidence from randomized clinical trials supports that estrogen alone therapy can lower breast cancer risk.]

Top posts

Most liked on X and Bluesky
Amy B. Killen MD
@KillenMd · X

Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10 randomized trials. https://t.co/5BWyPvqJ5P

May 23, 2024 · 23 likes · 7 shares · 6,848 followers View post →
Rewriting midlife and menopause
@MenoScandal · X

Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a meta analysis of randomised controlled trials and found a 23% REDUCTION in risk of breast cancer. https://t.co/W41rBE6zlm

May 24, 2024 · 4 likes · 4 shares · 10,947 followers View post →
Dr. Lynn Fynn-derella
@Fynnderella1 · X

@lairdwd2 @MarbleBenjamin @EricawithaC13 @MartyMakary @US_FDA HRT isn’t necessarily bad. What dark sides have you seen? I get what you’re saying but it’s an important topic. https://t.co/CGonKBVP5a

Mar 25, 2025 · 3 likes · 224,592 followers View post →
magicmalt
@MayaTalP · X

@rutihersh @liti_gilad @ArielaGoesFake תבדקי קצת מחקרים חדשים. חלקם מראים אפילו ירידה בסיכון לסרטן. למשל המטא-אנליזה הזו. לגבי היתרונות הם כה משכנעים שאני בעד לכל מי שיכולה. https://t.co/Dt4E8yResu

Aug 9, 2025 · 1 like · 2,234 followers View post →
trainerrueben
@trainerrueben · X

https://t.co/OZXAuSdfKs

May 31, 2024 · 1 like · 951 followers View post →
trainerrueben
@trainerrueben · X

Conclusion: The totality of randomized clinical trial evidence supports a conclusion that estrogen-alone use significantly reduces breast cancer incidence. https://t.co/9EH6UvdY1d 2024

May 23, 2024 · 1 like · 950 followers View post →

All mentions

magicmalt
@MayaTalP · X

@rutihersh @liti_gilad @ArielaGoesFake תבדקי קצת מחקרים חדשים. חלקם מראים אפילו ירידה בסיכון לסרטן. למשל המטא-אנליזה הזו. לגבי היתרונות הם כה משכנעים שאני בעד לכל מי שיכולה. https://t.co/Dt4E8yResu

Aug 9, 2025 · 1 like · 2,234 followers View post →
Dr. Lynn Fynn-derella
@Fynnderella1 · X

@lairdwd2 @MarbleBenjamin @EricawithaC13 @MartyMakary @US_FDA HRT isn’t necessarily bad. What dark sides have you seen? I get what you’re saying but it’s an important topic. https://t.co/CGonKBVP5a

Mar 25, 2025 · 3 likes · 224,592 followers View post →
Dragon Slayer aKa Savage JE 20:9
@LashTania · X

Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis | Breast Cancer Research and Treatment https://t.co/W3C1i6VN8m

Dec 4, 2024 · 401 followers View post →
@Physichealth
@PhysicHealth · X

@Liz_ORiordan this is the polar opposite of what I see and hear in clinic and yet it’s being talked about today. I’d love to hear your thoughts on it? https://t.co/1obgyFRJi0

Jun 3, 2024 · 329 followers View post →
Yunique Medical
@Yunique_Medical · X

New findings reveal a 22% reduction in breast cancer with Estrogen Therapy, spanning over 14,000 women across randomized trials! This meta-analysis shatters the misconception of estrogen's link to breast cancer, marking a victory for women's health!

Jun 3, 2024 · 9 followers View post →
trainerrueben
@trainerrueben · X

Conclusion The totality of randomized clinical trial evidence supports a conclusion that estrogen-alone use significantly reduces breast cancer incidence. Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis Research Published: 23 April 2024

May 31, 2024 · 951 followers View post →
trainerrueben
@trainerrueben · X

https://t.co/OZXAuSdfKs

May 31, 2024 · 1 like · 951 followers View post →
millsjc67
@millsjc67 · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 26, 2024 · 7 shares · 1,450 followers View post →
Dadka1111
@Dadka1111 · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 24, 2024 · 7 shares · 22 followers View post →
Caroline
@Caroline2Cares · X

RT @MenoScandal: Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a…

May 24, 2024 · 4 shares · 141 followers View post →
alice smellie
@alicesmellie · X

RT @MenoScandal: Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a…

May 24, 2024 · 4 shares · 5,664 followers View post →
Nancy Sykes
@NancyOSykes · X

RT @MenoScandal: Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a…

May 24, 2024 · 4 shares · 442 followers View post →
Carol
@Carol76347048 · X

RT @MenoScandal: Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a…

May 24, 2024 · 4 shares · 75 followers View post →
Rewriting midlife and menopause
@MenoScandal · X

Great news from Breast Cancer Research and Treatment journal. They looked at 14,000 women who used estrogen-only HRT in a meta analysis of randomised controlled trials and found a 23% REDUCTION in risk of breast cancer. https://t.co/W41rBE6zlm

May 24, 2024 · 4 likes · 4 shares · 10,947 followers View post →
JustineGSwaab
@JustineGSwaab · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 23, 2024 · 7 shares · 2,060 followers View post →
Alexander Boldizar
@Boldizar · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 23, 2024 · 7 shares · 2,467 followers View post →
trainerrueben
@trainerrueben · X

Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis Rowan T Chlebowski et al. Breast Cancer Res Treat. 2024.

May 23, 2024 · 951 followers View post →
trainerrueben
@trainerrueben · X

Conclusion: The totality of randomized clinical trial evidence supports a conclusion that estrogen-alone use significantly reduces breast cancer incidence. https://t.co/9EH6UvdY1d 2024

May 23, 2024 · 1 like · 950 followers View post →
Dr. Indira Mysorekar
@MysorekarLab · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 23, 2024 · 7 shares · 2,668 followers View post →
Jake Perry
@ItsJakePerry · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 23, 2024 · 7 shares · 485 followers View post →
Dr Murphy WeightLoss
@TakeWeightOffMD · X

RT @KillenMd: Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10…

May 23, 2024 · 7 shares · 6,900 followers View post →
Amy B. Killen MD
@KillenMd · X

Estrogen therapy alone (without progestin) reduces breast cancer by 22% - findings of new 14,000+ person meta-analysis of 10 randomized trials. https://t.co/5BWyPvqJ5P

May 23, 2024 · 23 likes · 7 shares · 6,848 followers View post →
Professor Kefah Mokbel
@KefahMokbel · X

estrogen-alone use significantly reduces breast cancer incidence. https://t.co/SwCigNmbMP

Apr 24, 2024 · 1,133 followers View post →