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BMJ Evid Based Med July 2024 PMID 38684374

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies.

Zilong Bian, Lijuan Wang, Rong Fan, Jing Sun, Lili Yu, Meihong Xu, Paul R H J Timmers, Xia Shen, James F Wilson, Evropi Theodoratou, Xifeng Wu, Xue Li

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Mentions

260
Peak: 18 in May 2024
across 6 sources since Apr 2024

Extended reach

375,108
potential audience

Total likes

69

Video views

191

Mentions per month

Apr 2024 – May 2025

Where it's discussed

  • News197 articles
  • X / Twitter47 posts
  • Blogs9 articles
  • Facebook4 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Several posts emphasize the idea that a healthy lifestyle can significantly mitigate genetic predisposition, with phrases like 'can add five years to life' and 'lifestyle is more important than genes' being frequently mentioned. The positive tone and clear emphasis on actionable insights contribute to an overall optimistic sentiment about the research's implications for longevity.

AgreementModerate agreement

Many discussions reflect a positive reception towards the conclusions of the study, highlighting a general consensus.

InterestHigh interest

There is strong curiosity about the implications of genetic and lifestyle interactions on lifespan, as evidenced by a high volume of posts.

EngagementModerate engagement

While some posts share links and summaries, deeper conversations about specific findings were less frequent, indicating moderate engagement.

ImpactHigh impact

Several commenters stress the importance of the study's findings for public health and personal lifestyle choices, indicating a belief in its significant impact.

Abstract in brief

  • The study aimed to explore how genetic factors and lifestyle choices influence lifespan, using data from the UK Biobank involving 353,742 adults of European ancestry, tracked over a median duration of nearly 13 years.
  • Participants were classified into lifespan risk categories based on genetic predispositions and lifestyle scores, with significant findings showing higher mortality rates for those genetically predisposed to shorter lifespans and those following unhealthy lifestyles.
  • Results indicated that individuals with both a genetic tendency towards a short lifespan and an unfavorable lifestyle had over double the risk of dying compared to those with a long lifespan and favorable lifestyle, highlighting the combined impact of genetics and lifestyle on health outcomes.
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Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies https://t.co/1FKxR6X3L8

Apr 30, 2024 · 14 likes · 1 share · 30,641 followers View post →
Jeremy Farrar
@JeremyFarrar · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies. ⁦@uk_biobank⁩ https://t.co/k2D3kyUJUW

Apr 30, 2024 · 9 likes · 4 shares · 76,074 followers View post →
Carlos Piñeiro Diaz
@carpydia · X

Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies https://t.co/k4ZybHmDYf

Jun 26, 2024 · 9 likes · 7 shares · 2,533 followers View post →
NOMIX
@NOMIX_AI · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies #longevity #healthspan #rejuvenation https://t.co/pp20rk7EuL

May 3, 2024 · 7 likes · 3 shares · 596 followers View post →
William B. Grant, PhD
@wbgrant2 · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple co… https://t.co/JFXwl3VwCa

May 1, 2024 · 5 likes · 2 shares · 6,119 followers View post →
Reiner 
@erlesen · X

The optimal combination of healthy lifestyles could convey better benefits for a longer lifespan, regardless of genetic background https://t.co/0cssNebDAs Der Lebensstil ist wichtiger als die Gene: eine neue Datenanalyse bestätigt es https://t.co/EGj1uhVNYx

Jun 2, 2024 · 4 likes · 1 share · 7,863 followers View post →

All mentions

BMJ Evidence-Based Medicine
@BMJ_EBM · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies Original research by Zilong Bian et al. Link: https://t.co/HjJquDoZvA https://t.co/W4W5vaHfCM

Jul 23, 2024 · 12,364 followers View post →
BMJ Evidence-Based Medicine
@BMJ_EBM · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies Original research by Zilong Bian et al. Link: https://t.co/HjJquDoZvA https://t.co/gOOAqysQNP

Jul 17, 2024 · 1 like · 12,364 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 15, 2024 · 4 shares · 2,823 followers View post →
PTSD JEDI
@ptsdjedi · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 12, 2024 · 4 shares · 8,976 followers View post →
Pawel Zagozdzon
@zagozdzon · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 12, 2024 · 4 shares · 210 followers View post →
Dr Jessica Otte, CCFP, FCFP
@LessIsMoreMed · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 11, 2024 · 4 shares · 6,057 followers View post →
BMJ Evidence-Based Medicine
@BMJ_EBM · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies Original research by Zilong Bian et al. Link: https://t.co/HjJquDoZvA https://t.co/iiyKVsF45K

Jul 11, 2024 · 2 likes · 4 shares · 12,364 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 9, 2024 · 2 shares · 2,823 followers View post →
Ferdinand Saraiva
@FGSaraiva · X

RT @BMJ_EBM: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studie…

Jul 6, 2024 · 2 shares · 107 followers View post →
BMJ Evidence-Based Medicine
@BMJ_EBM · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies Original research by Zilong Bian et al. Link: https://t.co/HjJquDoZvA https://t.co/khLdjXLiCB

Jul 5, 2024 · 2 likes · 2 shares · 12,364 followers View post →
trombo.info
@tromboinfo · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 27, 2024 · 7 shares · 1,586 followers View post →
Carlos Gomez
@cmgomezVIAJANTE · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 27, 2024 · 7 shares · 195 followers View post →
Manu Morales Sánchez
@Manugrillo2 · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 27, 2024 · 7 shares · 2,139 followers View post →
Pacientes SEMERGEN
@PacientSemergen · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 27, 2024 · 7 shares · 8,952 followers View post →
Sandra Tapia
@mi_otrotuit · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 26, 2024 · 7 shares · 772 followers View post →
SEMERGEN_CV
@SEMERGEN_CV · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 26, 2024 · 7 shares · 2,036 followers View post →
amalia garcia souto
@sabela11n · X

RT @carpydia: Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition,…

Jun 26, 2024 · 7 shares · 4,818 followers View post →
Carlos Piñeiro Diaz
@carpydia · X

Un estilo de vida saludable puede contrarrestar la genética en un 60% y añadir cinco años a la vida Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies https://t.co/k4ZybHmDYf

Jun 26, 2024 · 9 likes · 7 shares · 2,533 followers View post →
Reiner 
@erlesen · X

RT @erlesen: The optimal combination of healthy lifestyles could convey better benefits for a longer lifespan, regardless of genetic backgr…

Jun 7, 2024 · 1 share · 7,863 followers View post →
Reiner
@erlangen.bsky.social · Bluesky

The optimal combination of healthy lifestyles could convey better benefits for a longer lifespan, regardless of genetic background pubmed.ncbi.nlm.nih.gov/38684374/ Der Lebensstil ist wichtiger als die Gene: eine neue Datenanalyse bestätigt es www.derstandard.at/story/300000...

Jun 2, 2024 View post →
Reiner 
@erlesen · X

The optimal combination of healthy lifestyles could convey better benefits for a longer lifespan, regardless of genetic background https://t.co/0cssNebDAs Der Lebensstil ist wichtiger als die Gene: eine neue Datenanalyse bestätigt es https://t.co/EGj1uhVNYx

Jun 2, 2024 · 4 likes · 1 share · 7,863 followers View post →
Johns Hopkins Frailty Science #FrailtyFighter
@FrailtyScience · X

RT @WHOCenterFrailt: Genetic and lifestyle factors in "Genetic Predisposition, Modifiable Lifestyles, and Their Joint Effects on Human Life…

May 7, 2024 · 1 share · 2,269 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Genetic Predisposition, Modifiable Lifestyles, and Their Joint Effects on Human Lifespan: Evidence from Multiple Cohort Stud…

May 6, 2024 · 1 share · 133 followers View post →
OMS Centre Collaborateur pour la Fragilité
@CentreOMSfragil · X

Facteurs génétiques et mode de vie dans "Genetic Predisposition, Modifiable Lifestyles, and Their Joint Effects on Human Lifespan: Evidence from Multiple Cohort Studies." @SSRN https://t.co/nOvQP91JY2 @brunovellas @SoutoPhilipe @LaSFGG

May 6, 2024 · 576 followers View post →
WHO Collaborating Center for Frailty
@WHOCenterFrailt · X

Genetic and lifestyle factors in "Genetic Predisposition, Modifiable Lifestyles, and Their Joint Effects on Human Lifespan: Evidence from Multiple Cohort Studies." @SSRN https://t.co/F7fZhKo9pf @brunovellas @RollandYves2

May 6, 2024 · 2 likes · 1 share · 3,195 followers View post →
Agingdoc
@agingdoc1 · X

Genetic Predisposition, Modifiable Lifestyles, and Their Joint Effects on Human Lifespan: Evidence from Multiple Cohort Studies

May 6, 2024 · 2 likes · 1 share · 41,729 followers View post →
Vitamin D.
@Vitamin34662D · X

RT @wbgrant2: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple co… https://…

May 4, 2024 · 2 shares · 3,512 followers View post →
Roger Blackwell
@rogerablackwell · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies https://t.co/4vRtuOCWDk

May 4, 2024 · 2,305 followers View post →
Datarella
@Datarella · X

RT @NOMIX_AI: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studi…

May 3, 2024 · 3 shares · 1,930 followers View post →
BIOCOACH
@BIOCOACHAPP · X

RT @NOMIX_AI: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studi…

May 3, 2024 · 3 shares · 144 followers View post →
michaelreuter
@michaelreuter · X

RT @NOMIX_AI: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studi…

May 3, 2024 · 3 shares · 4,298 followers View post →
NOMIX
@NOMIX_AI · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies #longevity #healthspan #rejuvenation https://t.co/pp20rk7EuL

May 3, 2024 · 7 likes · 3 shares · 596 followers View post →
Nick Krontiris
@nick_krontiris · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies (open access) https://t.co/E89Du9gRrU

May 3, 2024 · 19,103 followers View post →
Cardio MILONE
@CardioMILONE · X

[Healthy Life Style] “Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies“. + Info: https://t.co/AWgcrxBDwt #CardioMILONE #HealthyLifeStyle https://t.co/2nbC2Cc1IP

May 2, 2024 · 3 likes · 159 followers View post →
Shahin.
@Shahin20634947 · X

RT @wbgrant2: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple co… https://…

May 2, 2024 · 2 shares · 25,130 followers View post →
桶屋　猫之介
@diccogiale21 · X

RT @norionakatsuji: 元論文→ Bian Z, Wang L, Fan R, et al. Genetic predisposition, modifiable lifestyles, and their joint effects on human life…

May 2, 2024 · 1 share · 357 followers View post →
William B. Grant, PhD
@wbgrant2 · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple co… https://t.co/JFXwl3VwCa

May 1, 2024 · 5 likes · 2 shares · 6,119 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Bian Z, Wang L, Fan R, et al. Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies. BMJ Eviden-bas Med. 2024. doi: 10.1136/bmjebm-2023-112583 https://t.co/6DVejpnP5G

May 1, 2024 · 1 like · 1 share · 15,695 followers View post →
PeterLX
@PL_GX44 · X

RT @AgingBiology: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort s…

May 1, 2024 · 1 share · 162 followers View post →
July
@JulySeEs · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies | BMJ Evidence-Based Medicine https://t.co/68yCjklXij

Apr 30, 2024 · 17,574 followers View post →
Aging Science News
@AgingBiology · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies https://t.co/1FKxR6X3L8

Apr 30, 2024 · 14 likes · 1 share · 30,641 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort stud…

Apr 30, 2024 · 1 share · 573 followers View post →
Heather Ferguson
@drheatherferg · X

RT @JeremyFarrar: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort s…

Apr 30, 2024 · 4 shares · 3,231 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies.  FREE article. https://t.co/xOdDsrgfp8

Apr 30, 2024 · 2 likes · 1 share · 2,068 followers View post →
Tara Weeramanthri
@TWeeramanthri · X

RT @JeremyFarrar: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort s…

Apr 30, 2024 · 4 shares · 516 followers View post →
Jenny Briggs
@jennyldb · X

RT @JeremyFarrar: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort s…

Apr 30, 2024 · 4 shares · 1,332 followers View post →
Adelina ComasHerrera
@AdelinaCoHe · X

RT @JeremyFarrar: Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort s…

Apr 30, 2024 · 4 shares · 6,024 followers View post →
Jeremy Farrar
@JeremyFarrar · X

Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies. ⁦@uk_biobank⁩ https://t.co/k2D3kyUJUW

Apr 30, 2024 · 9 likes · 4 shares · 76,074 followers View post →