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Nat Microbiol May 2024 PMID 38684911

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood.

Mathias Jensen, Linn Stenfelt, Jennifer Ricci Hagman, Michael Jakob Pichler, Julia Weikum, Tine Sofie Nielsen, Annika Hult, Jens Preben Morth, Martin L Olsson, Maher Abou Hachem

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Mentions

140
Peak: 13 in Apr 2024
across 7 sources since Apr 2024

Extended reach

28,787
potential audience

Total likes

84

Video views

405

Mentions per month

Apr 2024 – Jul 2024

Where it's discussed

  • News98 articles
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  • Blogs12 articles
  • Facebook5 posts
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  • Bluesky1 posts

AI synopsis

What people are saying

The collective responses reveal a generally enthusiastic reception, with statements like 'converts any blood group to universal donor' and 'targeting extended blood group antigens,' showcasing both support and interest in the potential healthcare implications. The tone is optimistic, emphasizing the 'significant impact' of the research in creating ABO-universal blood, which is seen as a breakthrough for transfusion medicine.

AgreementStrong agreement

Most participants express strong support or positive reactions, indicating high agreement with the significance of the research.

InterestHigh interest

Posts show high curiosity and enthusiasm, highlighting fascination with the potential medical advancements.

EngagementModerate engagement

The discussions involve referencing specific enzyme targets and implications, showing moderate depth in engagement.

ImpactHigh impact

Several discussions emphasize the transformative potential of this discovery, implying it could revolutionize blood transfusions.

Abstract in brief

  • The study explores how the gut bacteria Akkermansia muciniphila produces enzymes that can break down ABO blood group antigens on red blood cells, potentially enabling the conversion of blood types to universal Type O, which can be safely transfused to anyone.
  • Researchers identified specific enzymes that efficiently remove both A and B antigens, including their extended carbohydrate structures, improving blood compatibility with Type O plasma and reducing the risk of transfusion reactions.
  • Structural analysis of these enzymes revealed a new carbohydrate-binding module, highlighting the potential of gut bacteria as a source of novel enzymes for creating universal blood supplies for transfusions.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Huiluo Cao 曹慧荦
@hlcao · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiology https://t.co/7Wfl9so7Fu

Apr 30, 2024 · 31 likes · 13 shares · 2,828 followers View post →
Nomen Nescio
@dehammo · X

@mcdanka Msm da im hidrolizuju ugljene hidrate na antigenima, ali evo, to je ovo: https://t.co/0VUDhHvGCr

Apr 30, 2024 · 4 likes · 7,849 followers View post →
Yuta Sugiyama
@GNTocr3 · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood https://t.co/2Z6dX6pw5t

Apr 29, 2024 · 3 likes · 128 followers View post →
Alex Crits-Christoph
@acritschristoph.bsky.social · Bluesky

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood www.nature.com/articles/s41...

Apr 30, 2024 · 3 likes · 3 shares View post →
Nirmata
@En_formare · X

Gut bacteria enzyme converts any blood group to ‘universal donor’ O. Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood. Nat Microbiol (2024). https://t.co/e3pPMQRRre @NatureMicrobiol https://t.co/z5rp5KU5Qz

Apr 30, 2024 · 1 like · 1 share · 432 followers View post →
mateusz kogut
@kogut_mateusz · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood https://t.co/e2rouNzxza

May 7, 2024 · 1 like · 49 followers View post →

All mentions

Chabe
@chabe_mtzz · X

Abstract: https://t.co/6YwQ52bHjx

May 13, 2024 · 668 followers View post →
Ali Asif
@asif00663274 · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

May 10, 2024 · 13 shares · 322 followers View post →
mateusz kogut
@kogut_mateusz · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood https://t.co/e2rouNzxza

May 7, 2024 · 1 like · 49 followers View post →
zhanghengguo
@HengguoZhang · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

May 4, 2024 · 13 shares · 18 followers View post →
Michelle Fitzmaurice
@DrMFitzmaurice · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

May 2, 2024 · 13 shares · 757 followers View post →
Andy_Weeble_Weaver
@AndrewW66619812 · X

The paper in "Nature Microbiology" the above "Science Alert" article is based upon, & links to: “'Akkermansia muciniphila' exoglycosidases target extended blood group antigens to generate ABO-universal blood” via "Nature Briefing Microbiology" 2/2 https://t.co/oApQBIF0OH

May 2, 2024 · 4,322 followers View post →
Caitlin Marie Tygart
@caitlintygart · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiology https://t.co/9dtS6Tpgwg

May 1, 2024 · 33 followers View post →
XiaoTao JIANG
@Titus12629950 · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

May 1, 2024 · 13 shares · 371 followers View post →
Swift
@r3dblueb0lt · X

RT @En_formare: Gut bacteria enzyme converts any blood group to ‘universal donor’ O. Akkermansia muciniphila exoglycosidases target exten…

Apr 30, 2024 · 1 share · 12 followers View post →
Georgy Leonov
@leonov_ge · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 1,126 followers View post →
Nirmata
@En_formare · X

Gut bacteria enzyme converts any blood group to ‘universal donor’ O. Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood. Nat Microbiol (2024). https://t.co/e3pPMQRRre @NatureMicrobiol https://t.co/z5rp5KU5Qz

Apr 30, 2024 · 1 like · 1 share · 432 followers View post →
Franklin Nobrega
@NobregaFL · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 2,417 followers View post →
Filipe Carvalho (NOW AT
@ffchc84 · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 258 followers View post →
tmtsq
@tmtsq121571 · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 51 followers View post →
iMeta
@iMetaScience · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 2,867 followers View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @hlcao: Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiolo…

Apr 30, 2024 · 13 shares · 3,522 followers View post →
Huiluo Cao 曹慧荦
@hlcao · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiology https://t.co/7Wfl9so7Fu

Apr 30, 2024 · 31 likes · 13 shares · 2,828 followers View post →
Alex Crits-Christoph
@acritschristoph.bsky.social · Bluesky

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood www.nature.com/articles/s41...

Apr 30, 2024 · 3 likes · 3 shares View post →
Nomen Nescio
@dehammo · X

@mcdanka Msm da im hidrolizuju ugljene hidrate na antigenima, ali evo, to je ovo: https://t.co/0VUDhHvGCr

Apr 30, 2024 · 4 likes · 7,849 followers View post →
Yuta Sugiyama
@GNTocr3 · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood https://t.co/2Z6dX6pw5t

Apr 29, 2024 · 3 likes · 128 followers View post →
よし兄　Yoshi
@aminfield · X

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood | Nature Microbiology https://t.co/m06OvDevA4

Apr 29, 2024 · 57 followers View post →