JCO Precis Oncol April 2024 PMID 38691816

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer.

Jacqueline A Shaw, Karen Page, Evie Wren, Elza C de Bruin, Ekaterina Kalashnikova, Robert Hastings, Rob McEwen, Eddie Zhang, Marc Wadsley, Emmanuel Acheampong, Derek Renner, Kelly L T Gleason, Bana Ambasager, Daniel Stetson, Daniel Fernandez-Garcia

Mentions

32
Peak: 27 in May 2024
across 4 sources since May 2024

Extended reach

79,505
potential audience

Total likes

71

Video views

45

Mentions per month

May 2024 – Jun 2024

Where it's discussed

  • X / Twitter27 posts
  • Facebook2 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions emphasize the high prognostic value of ctDNA testing, citing statistics such as the 88.2% sensitivity and the median lead time of 10 months before recurrence detection, which demonstrates both clinical interest and perceived impact. The tone and language, including terms like 'intriguing' and references to ongoing significant studies, highlight strong engagement and belief in the potential transformative impact of this research.

AgreementModerate agreement

Most discussions acknowledge the significant prognostic value of ctDNA testing, citing studies like the EBLIS study and emphasizing the importance of serial monitoring.

InterestHigh interest

Posts show high interest by referencing ongoing studies, potential clinical applications, and the technology's relevance for breast cancer management.

EngagementModerate engagement

Discussions include specific details like study design, recurrence rates, and potential treatment implications, indicating active engagement.

ImpactHigh impact

The collective tone suggests that this research could substantially influence future breast cancer diagnostics and patient management strategies.

Abstract in brief

  • This study shows that a personalized blood test called Signatera can detect residual breast cancer DNA (ctDNA) in patients' blood up to several months before clinical or radiologic signs of relapse, with a high sensitivity of 88.2%.
  • The presence of ctDNA after surgery is strongly linked to a higher risk of relapse and shorter survival, making it a useful prognostic tool for monitoring patients over a long-term follow-up period of up to 12 years.
  • Patients with hormone receptor-positive breast cancer who tested negative for ctDNA throughout follow-up generally experienced better outcomes, suggesting serial ctDNA testing may help guide early interventions and improve patient prognosis.]

Top posts

Most liked on X and Bluesky
Paolo Tarantino
@PTarantinoMD · X

EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + ctDNA, with median lead time of 10 mo. 5/122 pts w/o recurrence had false + ctDNA. Intriguing, though benefits still remain unclear. https://t.co/YBels0p9dF https://t.co/QXdxna4uxG

May 2, 2024 · 69 likes · 23 shares · 29,319 followers View post →
Katsuaki Maehara
@KatsuakiMaehara · X

術後ctDNA評価には強い予後予測価値があるという乳がんの長期フォローアップによる臨床研究報告。 論文を読んで頂けるとすぐにわかりますが、RFS、OSともに ctDNAが+と-でカプランマイヤーが明確に分かれています。 https://t.co/WnlHrwcjkv @JCOPO_ASCO #breast #liquidbiopsy @isliquidbiopsy

May 9, 2024 · 1 like · 2,980 followers View post →
Jose Fernando Moura, PhD
@FernandoOnco · X

Despite advancements, a lot to improve in ctDNA breast cancer https://t.co/VCXqbTZptb

May 2, 2024 · 1 like · 1,909 followers View post →
CParkMD
@CParkMD · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 21,110 followers View post →
ONCO BRUNO
@brunolarvol · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 3, 2024 · 23 shares · 7,283 followers View post →
Wendy Woodward MDPhD
@IBCradiation · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 3,937 followers View post →

All mentions

Amy Burkholder
@AmyBurkNews · X

Huge.

Jun 9, 2024 · 1,118 followers View post →
ほーくあい MD/PhD@Breast Oncology
@tkdmHawkeye · X

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer | JCO Precision Oncology https://t.co/fjjnlRpQpR

May 21, 2024 · 974 followers View post →
Katsuaki Maehara
@KatsuakiMaehara · X

術後ctDNA評価には強い予後予測価値があるという乳がんの長期フォローアップによる臨床研究報告。 論文を読んで頂けるとすぐにわかりますが、RFS、OSともに ctDNAが+と-でカプランマイヤーが明確に分かれています。 https://t.co/WnlHrwcjkv @JCOPO_ASCO #breast #liquidbiopsy @isliquidbiopsy

May 9, 2024 · 1 like · 2,980 followers View post →
Ricardo Villalobos V
@Rick_Villalobos · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 4, 2024 · 23 shares · 1,285 followers View post →
Niklas Klümper
@niklas_kluemper · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 3, 2024 · 23 shares · 1,392 followers View post →
e.acheampong
@imma_acheampong · X

For select cases with HR+ disease, decisions about treatment management might require serial monitoring despite the ctDNA-positive result. https://t.co/ycAQahQlPh #breastcancer #ctDNA #liquidbiopsies

May 3, 2024 · 172 followers View post →
ONCO BRUNO
@brunolarvol · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 3, 2024 · 23 shares · 7,283 followers View post →
Rɪᴏʏᴇ Aᴜꜱᴋ
@Polarbear900R · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 107 followers View post →
Kowalyszyn Ruben
@KowalyszynMD · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 808 followers View post →
Wendy Woodward MDPhD
@IBCradiation · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 3,937 followers View post →
Carlos Gonzalez
@DrMedOnco · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 1,004 followers View post →
CParkMD
@CParkMD · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 21,110 followers View post →
Lucid Health Consulting
@LucidHealthCon · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 384 followers View post →
Eriseld Krasniqi
@KrasniqiEriseld · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 643 followers View post →
Cancer Links
@LinksCancer · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 252 followers View post →
Living with Lobular Breast Cancer in Canada
@lobbccanada · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 755 followers View post →
A Nasser Nourallah. MD.FASCO
@a_nourallah · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 668 followers View post →
Jose Fernando Moura, PhD
@FernandoOnco · X

Despite advancements, a lot to improve in ctDNA breast cancer https://t.co/VCXqbTZptb

May 2, 2024 · 1 like · 1,909 followers View post →
Albert Grinshpun
@AlbertGrinshpun · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 273 followers View post →
El Niño Alex
@elAlexDutch · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 202 followers View post →
Dr Zachary Veitch
@z_veitch · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 574 followers View post →
silvia bernardos
@silviaBF013 · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 106 followers View post →
silvia bernardos
@silviaBF013 · X

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer | JCO Precision Oncology https://t.co/KuruRaaGvu

May 2, 2024 · 106 followers View post →
Damian Silbermins
@nos3as · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 169 followers View post →
Joel YR
@YnfaYr · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 118 followers View post →
Santiesteban
@s_santiesteban · X

RT @PTarantinoMD: EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + c…

May 2, 2024 · 23 shares · 846 followers View post →
Paolo Tarantino
@PTarantinoMD · X

EBLIS study: 156 pts with eBC followed for a median of 6.5y with Signatera testing Q6M. 30/34 pts that recurred had a + ctDNA, with median lead time of 10 mo. 5/122 pts w/o recurrence had false + ctDNA. Intriguing, though benefits still remain unclear. https://t.co/YBels0p9dF https://t.co/QXdxna4uxG

May 2, 2024 · 69 likes · 23 shares · 29,319 followers View post →