June 2024 PMID 38701785

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis.

Thomas Mortimer, Valentina M Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B Koronowski, Paul Petrus, Carolina M Greco, Stephen Forrow

Mentions

58
Peak: 21 in May 2024
across 6 sources since May 2024

Extended reach

310,747
potential audience

Total likes

79

Video views

1,179

Mentions per month

May 2024 – Jul 2025

Where it's discussed

  • News27 articles
  • X / Twitter22 posts
  • YouTube3 videos
  • Blogs3 articles
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions reflect a positive and engaged attitude, with posts emphasizing the importance of the study, such as descriptions of the epidermal circadian clock's role in tissue homeostasis and its potential to influence treatments. Words like 'thrilled,' 'integrates,' and 'guarantees' convey enthusiasm and recognition of scientific importance, indicating a strong interest and acknowledgment of the study's potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some expressing excitement about its implications for skin health.

InterestHigh interest

Posts demonstrate high interest, often highlighting the novelty and potential applications of the circadian clock in skin physiology.

EngagementModerate engagement

Participants are engaging beyond basic mentions, referencing related concepts like brain-skin axes and circadian regulation, showing moderate deep involvement.

ImpactModerate impact

The tone suggests that the findings are seen as potentially influential for future research and medical approaches, though not universally deemed transformative.

Abstract in brief

  • The study explores how the skin's epidermal circadian clock interacts with signals from the brain to maintain daily tissue balance, using a simplified mouse model with only two main clock components.
  • The epidermal clock plays a key gatekeeping role by integrating signals from the brain and selectively overriding feeding-related signals to ensure proper timing of cell cycle and DNA replication in skin cells.
  • Overall, the research highlights a crucial function of peripheral circadian clocks in safeguarding tissue health by coordinating internal and external cues to regulate daily physiological processes.

Top posts

Most liked on X and Bluesky
Müge Atalay
@MugeeAtalay · X

I am thrilled to share our new paper on “The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis” now out in @CellStemCell Read more in this: https://t.co/DmBelvM7Fm @AznarLab @IRBBarcelona

May 5, 2024 · 21 likes · 1 share · 228 followers View post →
htw
@heniek_htw · X

The epidermal #circadian clock integrates and subverts brain signals to guarantee #skin homeostasis https://t.co/RLeiraGrYe https://t.co/cC6ovqsAbt

May 3, 2024 · 11 likes · 3 shares · 11,258 followers View post →
FrezzaLab
@FrezzaLab · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis: Cell Stem Cell https://t.co/9SfjobqWf7

May 4, 2024 · 9 likes · 2 shares · 26,997 followers View post →
BowTiedBiotech
@BowTiedBiotech · X

Brain / Skin Axis: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis This one is quite interesting - we recently were pitched an approach to optimize PD-1 dosing around circadian rhythms. This paper suggest ECM skin maintenance https://t.co/2Ql9eHoxrY

May 4, 2024 · 8 likes · 1 share · 20,541 followers View post →
Cell Stem Cell
@CellStemCell · X

Online Now! The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/atuM2FZhWG #stemcells

May 7, 2024 · 4 likes · 1 share · 58,416 followers View post →
Agingdoc
@agingdoc1 · X

@EricTopol @justsaysinmice & from The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Peripheral clock inputs are required for full-epidermal daily physiology➡️The epidermal clock gates brain clock signals to ensure tissue health."

May 2, 2024 · 3 likes · 41,311 followers View post →

All mentions

Cell Stem Cell
@cp-cellstemcell.bsky.social · Bluesky

Research highlight from Cell Stem Cell: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis www.cell.com/cell-stem-ce...

Jul 29, 2025 · 1 share View post →
Kursad Turksen
@kursadturksen · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/u4rwqCi3DT

Jun 10, 2024 · 231 followers View post →
Shook Lab
@ShookLab · X

RT @CellStemCell: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/Zso2lkGLg1

Jun 6, 2024 · 3 shares · 237 followers View post →
Duuamene Nyimanu, PhD
@DuuameneNyimanu · X

RT @CellStemCell: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/Zso2lkGLg1

Jun 6, 2024 · 3 shares · 108 followers View post →
Cell Stem Cell
@CellStemCell · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/Zso2lkGLg1

Jun 6, 2024 · 1 like · 3 shares · 58,416 followers View post →
Walko Lab
@walko_lab · X

RT @CellStemCell: Online Now! The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.c…

May 7, 2024 · 1 share · 554 followers View post →
Cell Stem Cell
@CellStemCell · X

Online Now! The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis https://t.co/atuM2FZhWG #stemcells

May 7, 2024 · 4 likes · 1 share · 58,416 followers View post →
Kursad Turksen
@kursadturksen · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis: Cell Stem Cell https://t.co/KFbmFjo5VO

May 7, 2024 · 231 followers View post →
IRB Barcelona
@IRBBarcelona · X

RT @MugeeAtalay: I am thrilled to share our new paper on “The epidermal circadian clock integrates and subverts brain signals to guarantee…

May 5, 2024 · 1 share · 20,899 followers View post →
Müge Atalay
@MugeeAtalay · X

I am thrilled to share our new paper on “The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis” now out in @CellStemCell Read more in this: https://t.co/DmBelvM7Fm @AznarLab @IRBBarcelona

May 5, 2024 · 21 likes · 1 share · 228 followers View post →
nike
@wot_mikey · X

RT @FrezzaLab: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis: Cell Stem Cell https://t.…

May 4, 2024 · 2 shares · 464 followers View post →
Vega Shah
@dr_alphalyrae · X

RT @BowTiedBiotech: Brain / Skin Axis: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis T…

May 4, 2024 · 1 share · 18,706 followers View post →
Brian Ferguson
@viropractor · X

RT @FrezzaLab: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis: Cell Stem Cell https://t.…

May 4, 2024 · 2 shares · 3,903 followers View post →
FrezzaLab
@FrezzaLab · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis: Cell Stem Cell https://t.co/9SfjobqWf7

May 4, 2024 · 9 likes · 2 shares · 26,997 followers View post →
BowTiedBiotech
@BowTiedBiotech · X

Brain / Skin Axis: The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis This one is quite interesting - we recently were pitched an approach to optimize PD-1 dosing around circadian rhythms. This paper suggest ECM skin maintenance https://t.co/2Ql9eHoxrY

May 4, 2024 · 8 likes · 1 share · 20,541 followers View post →
IRB Barcelona
@IRBBarcelona · X

while the work on the coordination between the central clock and skin peripheral clock has been released in @CellStemCell (

May 4, 2024 · 1 like · 20,899 followers View post →
CJara
@cjarao1 · X

RT @heniek_htw: The epidermal #circadian clock integrates and subverts brain signals to guarantee #skin homeostasis https://t.co/RLeiraGrYe…

May 3, 2024 · 3 shares · 19 followers View post →
Meltem Weger
@MeltemWeger · X

RT @heniek_htw: The epidermal #circadian clock integrates and subverts brain signals to guarantee #skin homeostasis https://t.co/RLeiraGrYe…

May 3, 2024 · 3 shares · 123 followers View post →
UPF Medicine and Life Sciences
@UPFbiomed · X

8/

May 3, 2024 · 3,006 followers View post →
htw
@heniek_htw · X

The epidermal #circadian clock integrates and subverts brain signals to guarantee #skin homeostasis https://t.co/RLeiraGrYe https://t.co/cC6ovqsAbt

May 3, 2024 · 11 likes · 3 shares · 11,258 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis. https://t.co/c53j6yuBdt

May 3, 2024 · 2,061 followers View post →
IRB Barcelona
@IRBBarcelona · X

while the work on the coordination between the central clock and skin peripheral clock has been released in @CellStemCell (

May 3, 2024 · 2 likes · 20,899 followers View post →
Agingdoc
@agingdoc1 · X

@EricTopol @justsaysinmice & from The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Peripheral clock inputs are required for full-epidermal daily physiology➡️The epidermal clock gates brain clock signals to ensure tissue health."

May 2, 2024 · 3 likes · 41,311 followers View post →