J Immunother Cancer May 2024 PMID 38719544

Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial.

Yandong He, Xuhong Huang, Xiaoxia Li, Hongwei Liu, Min Liu, Junjia Tao, Yuanzhou Shan, Hafiz Khuram Raza, Yanqiu Liu, Wenting Zhong, Xue-Ping Cao, Yuan-Yuan Yang, Ruimei Li, Xian-Long Fang, Kang-Jian Zhang

Download social card

Mentions

18
Peak: 9 in May 2024
across 4 sources since May 2024

Extended reach

49,260
potential audience

Total likes

23

Video views

185

Mentions per month

May 2024 – Jul 2024

Where it's discussed

  • X / Twitter12 posts
  • News3 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a balanced view, with posts praising the initial safety profile and promising response rates, as evidenced by phrases like 'recently published' and mentions of 'preliminary efficacy.' The tone indicates a respectful acknowledgment of the study's significance, while questions about further research imply a cautious optimism rather than overstatement of impact.

AgreementModerate agreement

Most discussions recognize the positive preliminary results of YSCH-01, indicating general agreement on the promising safety and efficacy data.

InterestModerate interest

The interest level is moderate, with posters showing curiosity about the trial, its authors, and the potential significance of the findings.

EngagementModerate engagement

The engagement is moderate, as several posts mention specific details about the study, authors, and related articles, showing some depth of discussion.

ImpactModerate impact

The perceived impact is relatively modest, as the discussions focus on early-stage results and the importance of further research rather than immediate clinical application.

Abstract in brief

  • The study investigated the safety and preliminary effectiveness of YSCH01, a recombinant LIFN adenovirus, in patients with advanced solid tumors, using a two-phase approach involving dose escalation and expansion, with no severe toxicities observed.
  • The trial enrolled 14 patients, primarily with lung, breast, or melanoma cancers, and found an overall response rate of approximately 27% with a median progression-free survival of about 5 months and overall survival around 8.6 months.
  • While initial results are promising, showing disease control and reductions in tumor size, further research is needed to confirm the safety and efficacy of YSCH01 in larger clinical trials.]

Top posts

Most liked on X and Bluesky
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial https://t.co/StsmsGkpQ9 https://t.co/mFxfGnmCvh

May 7, 2024 · 10 likes · 4 shares · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Xueping Cao from Shanghai Yuansong Biotechnology Co is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/6 https://t.co/qcQnswBJG5

Jun 28, 2024 · 4 likes · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Here’s a closer look at recent #JITC article “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial” by @DrHKRaza from @Amgen @DaiichiSankyoUS @cgoncology @Oncolytics @virogin. 1/10 https://t.co/82z7DnWHC4

May 17, 2024 · 3 likes · 2 shares · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Yanqiu Liu (@handle) from Shanghai Yuansong Biotechnology Co. is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/6 https://t.co/r1ifojM6Nz

Jun 11, 2024 · 3 likes · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Dr. Hafiz Khuram Raza (@DrHKRaza) from Shanghai Yuansong Biotechnology Co is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/5 https://t.co/yh6AlelqyC

Jun 19, 2024 · 2 likes · 9,309 followers View post →
Dechao Feng
@DechaoF · X

RT @jitcancer: New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initia…

May 7, 2024 · 4 shares · 942 followers View post →

All mentions

Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Xueping Cao from Shanghai Yuansong Biotechnology Co is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/6 https://t.co/qcQnswBJG5

Jun 28, 2024 · 4 likes · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Dr. Hafiz Khuram Raza (@DrHKRaza) from Shanghai Yuansong Biotechnology Co is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/5 https://t.co/yh6AlelqyC

Jun 19, 2024 · 2 likes · 9,309 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Yanqiu Liu (@handle) from Shanghai Yuansong Biotechnology Co. is co-author of “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial,” recently published in #JITC! 1/6 https://t.co/r1ifojM6Nz

Jun 11, 2024 · 3 likes · 9,309 followers View post →
Hafiz Khuram Raza
@DrHKRaza · X

RT @jitcancer: Here’s a closer look at recent #JITC article “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tum…

May 19, 2024 · 2 shares View post →
YMED-X
@YmedX269 · X

RT @jitcancer: Here’s a closer look at recent #JITC article “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tum…

May 17, 2024 · 2 shares · 229 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Here’s a closer look at recent #JITC article “Preliminary Efficacy and Safety of YSCH-01 in Patients with Advanced Solid Tumors: An Investigator-Initiated Trial” by @DrHKRaza from @Amgen @DaiichiSankyoUS @cgoncology @Oncolytics @virogin. 1/10 https://t.co/82z7DnWHC4

May 17, 2024 · 3 likes · 2 shares · 9,309 followers View post →
Phage Papers
@Phage_Papers · X

Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial https://t.co/U610ltzsp0

May 9, 2024 · 647 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @jitcancer: New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initia…

May 8, 2024 · 4 shares · 572 followers View post →
Hafiz Khuram Raza
@DrHKRaza · X

RT @jitcancer: New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initia…

May 7, 2024 · 4 shares View post →
Aging and Disease
@ISOAD2018 · X

RT @jitcancer: New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initia…

May 7, 2024 · 4 shares · 89 followers View post →
Dechao Feng
@DechaoF · X

RT @jitcancer: New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initia…

May 7, 2024 · 4 shares · 942 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial https://t.co/StsmsGkpQ9 https://t.co/mFxfGnmCvh

May 7, 2024 · 10 likes · 4 shares · 9,309 followers View post →