May 2024 PMID 38742535

Bleeding Risk in Patients Receiving Omega-3 Polyunsaturated Fatty Acids: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Mustafa Javaid, Kadhim Kadhim, Bilal Bawamia, Timothy Cartlidge, Mohamed Farag, Mohammad Alkhalil

Mentions

48
Peak: 7 in Oct 2025
across 7 sources since May 2024

Extended reach

77,506
potential audience

Total likes

51

Video views

284

Mentions per month

May 2024 – Dec 2025

Where it's discussed

  • Instagram17 posts
  • X / Twitter10 posts
  • Facebook9 posts
  • Reddit7 posts
  • YouTube2 videos
  • News2 articles
  • Blogs1 articles

AI synopsis

What people are saying

The discussions emphasize that the meta-analysis provides convincing evidence that omega-3 PUFAs are generally safe regarding bleeding risk, with phrases like 'not associated with increased bleeding' and mentions of specific RR values (e.g., 1.09). Words like 'support,' 'confirm,' and 'significant' underscore their belief in the study’s impact on clinical practice, and references to sample sizes and detailed statistical results demonstrate a high level of engagement and interest.

AgreementStrong agreement

Most discussions express strong support for the article's conclusion that omega-3 PUFAs do not significantly increase bleeding risk, citing meta-analyses and clinical trial data.

InterestHigh interest

Participants show high interest, referencing specific study results, such as RR values and safety implications, indicating engagement with the research findings.

EngagementModerate engagement

Comments include interpretations of the statistical data and implications for clinical practice, demonstrating thoughtful engagement, though some are brief or summary-like.

ImpactHigh impact

The discussions highlight the importance of these findings for medical professionals and patients, suggesting a meaningful influence on understanding omega-3 supplement safety and clinical decision-making.

Abstract in brief

  • The meta-analysis of 11 clinical trials with over 120,000 patients found that taking omega-3 PUFAs generally does not increase the overall risk of bleeding, including severe events like hemorrhagic strokes.
  • A higher dose of purified eicosapentaenoic acid (EPA) may slightly raise the risk of bleeding by about 50%, but the actual increase in bleeding incidents remains small and possibly not clinically significant.
  • The increased bleeding risk associated with high-dose EPA is linked to the dose itself, not to the use of other medications like antiplatelet drugs, suggesting that the safety concern is primarily dose-dependent.]

Top posts

Most liked on X and Bluesky
Hospimex
@Scimexx · X

@med_amargado @td_patty https://t.co/OytB2tVQm9 Según este metanálisis del 2024 del JAHA no lo incrementan: “Omega‐3 PUFAs were not associated with increased bleeding risk. Patients receiving high‐dose purified EPA may incur additional bleeding risk, although its clinical significance is very modest”

Apr 17, 2025 · 13 likes · 18 followers View post →
JAHA
@JAHA_AHA · X

Patients receiving omega‐3 polyunsaturated fatty acids do not have an increased bleeding risk. #AHAJournals @Kadhimad @MoFFarag https://t.co/cgyqERiSCr https://t.co/8YU4MDLDNQ

Jun 17, 2024 · 9 likes · 3 shares · 31,633 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials | Journal of the American Heart Association https://t.co/wFhx7iITjQ

Jul 11, 2024 · 2 likes · 32,177 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【ω3-PUFAは出血リスク増やさず:RCTメタ解析/ JAHA】 ω3-PUFA検討のRCT 11報 [120643例] 併合:「出血イベント」RRは対照群に比べ.1.09 [95%CI 091-1.31]。「脳出血」や「頭蓋内出血」「消化管出血」もリスク増加は認めず。なおEPAでは用量依存性の出血リスク増加を観察。 https://t.co/b9wMhfuBco https://t.co/n089e0PmHv

May 15, 2024 · 2 likes · 4,946 followers View post →
ぽん@
@pharma_pon · X

オメガ-3多価不飽和脂肪酸を投与する患者における出血リスク:無作為化臨床試験の系統的レビューとメタ分析-PubMed https://t.co/LJlWpw4g3r

Jul 4, 2025 · 1 like · 991 followers View post →
株式会社サンクト
@sanct200301 · X

英国のフリーマン病院心臓胸部センターの研究者らの最新の包括的レビュー&メタ解析によると、オメガ3多価不飽和脂肪酸の摂取による出血リスクの増加は確認されなかったと報告しています。 https://t.co/6Rx6yTeEDs

Jul 18, 2024 · 1 like · 781 followers View post →

All mentions

ぽん@
@pharma_pon · X

オメガ-3多価不飽和脂肪酸を投与する患者における出血リスク:無作為化臨床試験の系統的レビューとメタ分析-PubMed https://t.co/LJlWpw4g3r

Jul 4, 2025 · 1 like · 991 followers View post →
Hospimex
@Scimexx · X

@med_amargado @td_patty https://t.co/OytB2tVQm9 Según este metanálisis del 2024 del JAHA no lo incrementan: “Omega‐3 PUFAs were not associated with increased bleeding risk. Patients receiving high‐dose purified EPA may incur additional bleeding risk, although its clinical significance is very modest”

Apr 17, 2025 · 13 likes · 18 followers View post →
株式会社サンクト
@sanct200301 · X

英国のフリーマン病院心臓胸部センターの研究者らの最新の包括的レビュー&メタ解析によると、オメガ3多価不飽和脂肪酸の摂取による出血リスクの増加は確認されなかったと報告しています。 https://t.co/6Rx6yTeEDs

Jul 18, 2024 · 1 like · 781 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials | Journal of the American Heart Association https://t.co/wFhx7iITjQ

Jul 11, 2024 · 2 likes · 32,177 followers View post →
Nidhi Rohatgi, MD, MS, SFHM
@nrohatgi2 · X

RT @JAHA_AHA: Patients receiving omega‐3 polyunsaturated fatty acids do not have an increased bleeding risk. #AHAJournals @Kadhimad @MoFFar…

Jun 17, 2024 · 3 shares · 368 followers View post →
Kadhim Kadhim
@Kadhimad · X

RT @JAHA_AHA: Patients receiving omega‐3 polyunsaturated fatty acids do not have an increased bleeding risk. #AHAJournals @Kadhimad @MoFFar…

Jun 17, 2024 · 3 shares · 406 followers View post →
Mohamed Farag
@MoFFarag · X

RT @JAHA_AHA: Patients receiving omega‐3 polyunsaturated fatty acids do not have an increased bleeding risk. #AHAJournals @Kadhimad @MoFFar…

Jun 17, 2024 · 3 shares · 799 followers View post →
JAHA
@JAHA_AHA · X

Patients receiving omega‐3 polyunsaturated fatty acids do not have an increased bleeding risk. #AHAJournals @Kadhimad @MoFFarag https://t.co/cgyqERiSCr https://t.co/8YU4MDLDNQ

Jun 17, 2024 · 9 likes · 3 shares · 31,633 followers View post →
SFC - Société Française de Cardiologie
@SFCardio · X

Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials

May 22, 2024 · 4,720 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【ω3-PUFAは出血リスク増やさず:RCTメタ解析/ JAHA】 ω3-PUFA検討のRCT 11報 [120643例] 併合:「出血イベント」RRは対照群に比べ.1.09 [95%CI 091-1.31]。「脳出血」や「頭蓋内出血」「消化管出血」もリスク増加は認めず。なおEPAでは用量依存性の出血リスク増加を観察。 https://t.co/b9wMhfuBco https://t.co/n089e0PmHv

May 15, 2024 · 2 likes · 4,946 followers View post →
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Dec 23, 2025 View →
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Dec 22, 2025 View →
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Dec 6, 2025 View →
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Sep 20, 2024 View →
Omega-3s: Meta-analysis finds no increase in bleeding risk
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Volume 13, Number 10, doi: 10.1161/JAHA.123.032390. “Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic ...

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Fish oil can cause internal bleeding and not good for those with ...
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