Cancer Cell June 2024 PMID 38759656

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy.

Marit J van Elsas, Jim Middelburg, Camilla Labrie, Jessica Roelands, Gaby Schaap, Marjolein Sluijter, Ruxandra Tonea, Vitalijs Ovcinnikovs, Katy Lloyd, Janine Schuurman, Samantha J Riesenfeld, Thomas F Gajewski, Noel F C C de Miranda, Thorbald van Hall, Sjoerd H van der Burg

Mentions

86
Peak: 69 in Jun 2024
across 3 sources since May 2024

Extended reach

447,894
potential audience

Total likes

239

Video views

126

Mentions per month

May 2024 – Dec 2024

Where it's discussed

  • X / Twitter75 posts
  • YouTube9 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect a high level of agreement and excitement about the research's importance, with many posts emphasizing the role of M1-like macrophages and T cells in therapeutic efficacy, often describing the findings as crucial for advancing cancer treatment strategies. The tone suggests a recognition of the study's potential to impact clinical practice significantly, using phrases like 'critical for therapy,' 'game changer,' and 'key to improving outcomes.'

AgreementStrong agreement

All discussions strongly affirm the article's findings, emphasizing the critical role of T cells and macrophages in immunotherapy success.

InterestHigh interest

The discussions indicate high interest, with repeated mentions of the mechanisms and significance described in the publication.

EngagementHigh engagement

Many contributions reference specific cellular interactions and implications, showing deep engagement with the research details.

ImpactHigh impact

Participants view this research as highly impactful, highlighting its potential to influence future cancer therapies and clinical approaches.

Abstract in brief

  • The study shows that in cancer immunotherapy, activated CD8 T cells help recruit and activate specific M1-like macrophages, which are essential for clearing tumors in mice, through CCR5 signaling.
  • When exposed to signals from T cells and tumor lysates, nonpolarized macrophages become tumor-killing M1-like macrophages, and similar macrophages are found in human tumors, especially in patients responding to immune checkpoint therapy.
  • Effective cancer treatment relies on the coordinated action of CD8 T cells and macrophages; disrupting this cooperation with therapies that broadly target macrophages could hinder treatment success.]

Top posts

Most liked on X and Bluesky
Cancer Cell
@Cancer_Cell · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy https://t.co/u9zgFJWIBv https://t.co/BI9z6bgAWQ

Jun 11, 2024 · 229 likes · 75 shares · 72,149 followers View post →
The Innovation Oncology
@InnovOncology · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy @Cancer_Cell https://t.co/vAbbwe5oDf https://t.co/3cQEFPU3qf

May 23, 2024 · 7 likes · 4 shares · 2,853 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 254,027 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 32,533 followers View post →
Farouk J.M Mokwa
@Farouk_Mokwa · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 11,423 followers View post →
Mwaura Robert
@MwauraRobert2 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 9,589 followers View post →

All mentions

Wollen_k
@wollen1987 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 19, 2024 · 75 shares · 211 followers View post →
Janella L Ulloa
@JUlloa_PHD_MPH · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy: Cancer Cell https://t.co/03JrUAWCGo

Jun 17, 2024 · 58 followers View post →
Brigitte Elizabeth Delalleau Carcaterra
@CarcaterraS · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 15, 2024 · 75 shares · 30 followers View post →
KORGrok Lee
@hkleemd · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 13, 2024 · 75 shares · 122 followers View post →
Antonio Cembellin Prieto
@A_Cembellin_Pri · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 13, 2024 · 75 shares · 429 followers View post →
Joon Sang Lee
@JSLee198 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 42 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 32,533 followers View post →
Dr. Yasser Aldhamen
@AldhamenYasser · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 1,095 followers View post →
Leon
@Leon55164036 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 3 followers View post →
Bayar Jaff
@JaffBayar · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 604 followers View post →
Carlos González
@CarlosGlez1194 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 141 followers View post →
Xiangyue Zhang
@Xiangyue_CA · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 279 followers View post →
Dr.Hendri Wiyono,SpP
@drhendriwiyono · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 381 followers View post →
YMED-X
@YmedX269 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 229 followers View post →
Vivia Sthel
@vivia_sthel · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 202 followers View post →
Guezguez lab
@GuezguezL · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 1,413 followers View post →
Vivian Ortiz
@VivianOrtizMD · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 2,230 followers View post →
WALID ESKHITAR
@walidyx11 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 62 followers View post →
PENAs
@NagasawaPe787 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 36 followers View post →
ANDCS
@ANDCS_asso · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 340 followers View post →
Anny Velasquez Cruz
@AnnyVC19 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 182 followers View post →
Ken Xie
@CuriousKX · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 12, 2024 · 75 shares · 121 followers View post →
Giorgia Colombo
@judygilmore09 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 76 followers View post →
Julie Feldstein,MD
@feldstej · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 6,639 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 1,426 followers View post →
Pramila Krishnamurthy
@drpramilak · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 1,032 followers View post →
Chanhyeok Park
@chark729 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 6 followers View post →
Dr. Claire McCarthy (she/her)
@cemccarthy02 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 2,000 followers View post →
Memadayers
@Memadayers · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 176 followers View post →
juls
@luthor21 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 39 followers View post →
Deimar Perea Moreno
@DeimarPerea · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 479 followers View post →
Juan C. Nieto
@jc_nietos · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 422 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 254,027 followers View post →
PandaPalooza
@pandapalooza_59 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 142 followers View post →
kentontech
@kentontech · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 170 followers View post →
Dr.マローウ(プリンじゃない方)
@DrBMLNMMML · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 1,702 followers View post →
Olga Payar
@Olgapaval · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 87 followers View post →
Angelo Pirozzi
@angelopirozzi3 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 1,232 followers View post →
HeatWave
@Xarenoss1 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 80 followers View post →
Pouya Goleij
@pouya_gl · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 56 followers View post →
Vignesh Krishnamoorthy
@Vigneshkriish · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 152 followers View post →
feverfew
@feifeverfew · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 62 followers View post →
Ashwin Adrian Kallor
@AdrianKallor · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 136 followers View post →
Dieter
@Wuhle · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 474 followers View post →
Eliud FM
@efm_612 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 138 followers View post →
Valerie
@Valerie96104041 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 7,997 followers View post →
Eduardo Diogenes Fonseca, MD
@DrEduFonseca · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 548 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 1,322 followers View post →
Marinos Gkounes
@MarinosGkounes · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 164 followers View post →
harada pat
@harapatrick · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 145 followers View post →
ALI ALKHATHAM| د.علي الخثعمي
@ALKHATHAMI_ALI · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 935 followers View post →
nathalie corvaia
@NathalieCorvaia · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 21 followers View post →
J C O V
@CesarVindell · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 729 followers View post →
Dr Anthony Martin
@AMAinsight · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 916 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 8,810 followers View post →
Joshua's daddy
@Flutamide · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 340 followers View post →
Santiago Rendon-Marin
@santyrendonm · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 184 followers View post →
Ibn Misr Science
@IbnMisrScience · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 35 followers View post →
D.shahrin ahmed
@ahmedshahrin · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 2,696 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 97 followers View post →
Masoom Kasi
@masoomkassi · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 122 followers View post →
Farouk J.M Mokwa
@Farouk_Mokwa · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 11,423 followers View post →
Mwaura Robert
@MwauraRobert2 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 9,589 followers View post →
Santi Cabezas
@SantiCabezas1 · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 692 followers View post →
dec ⁽̨̡ ¨̮ ⁾̧̢ (slow)
@px_x_x · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 290 followers View post →
Dr. Wu
@QuinceyDr690 · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy: Cancer Cell https://t.co/evPYF5Osy4

Jun 11, 2024 · 2 followers View post →
Lovepreet Singh Chahal
@lovi27chahal · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 210 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @Cancer_Cell: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeuti…

Jun 11, 2024 · 75 shares · 574 followers View post →
Cancer Cell
@Cancer_Cell · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy https://t.co/u9zgFJWIBv https://t.co/BI9z6bgAWQ

Jun 11, 2024 · 229 likes · 75 shares · 72,149 followers View post →
Pat Adams
@PathologyPat · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy: Cancer Cell https://t.co/eMTM4lVtUK

May 29, 2024 · 1,511 followers View post →
Dechao Feng
@DechaoF · X

RT @InnovOncology: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeu…

May 23, 2024 · 4 shares · 945 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @InnovOncology: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeu…

May 23, 2024 · 4 shares · 574 followers View post →
YMED-X
@YmedX269 · X

RT @InnovOncology: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeu…

May 23, 2024 · 4 shares · 229 followers View post →
medic
@E329541 · X

RT @InnovOncology: Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeu…

May 23, 2024 · 4 shares · 82 followers View post →
The Innovation Oncology
@InnovOncology · X

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy @Cancer_Cell https://t.co/vAbbwe5oDf https://t.co/3cQEFPU3qf

May 23, 2024 · 7 likes · 4 shares · 2,853 followers View post →