Pain November 2024 PMID 38809314

RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing.

Asta Arendt-Tranholm, Juliet M Mwirigi, Theodore J Price

Mentions

22
Peak: 7 in Nov 2023
across 4 sources since Nov 2023

Extended reach

302,307
potential audience

Total likes

46

Video views

332

Mentions per month

Nov 2023 – May 2025

Where it's discussed

  • X / Twitter13 posts
  • Bluesky4 posts
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall sentiment demonstrates strong support and enthusiasm for the research, with mentions of its impact on understanding nerve function and pain mechanisms, exemplified by phrases like 'impact of PacBio sequencing' and calls to explore the publication in reputable journals. The words used, such as 'highlight,' 'discover,' and 'impact,' convey high interest and perceived importance, fostering a sense of advancement in pain research.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, emphasizing its novelty and importance for pain research and RNA isoform analysis.

InterestHigh interest

Posts show high interest by highlighting the potential implications and inviting others to learn about the findings.

EngagementModerate engagement

Participants actively share resources like seminars and articles, indicating a moderate level of engagement and curiosity.

ImpactHigh impact

The focus on the groundbreaking methods and discoveries suggests the community perceives this work as having a substantial influence on the field.

Abstract in brief

  • The study used longread sequencing to identify and validate over 19,500 protein-coding isoforms in human dorsal root ganglia, revealing many previously unknown splice variants, especially in pain-related genes like ASIC3, MRGPRX1, and HNRNPK.
  • Researchers found unique splicing events, such as excision of part of the 5' untranslated region (UTR) in ASIC3, incorporation of an additional exon in MRGPRX1, and new splice sites in HNRNPK, which could impact gene regulation and function.
  • The study also confirmed a nerve-specific splicing event in the WNK1 gene linked to painless peripheral neuropathy, providing insights into how genetic mutations contribute to nerve pain disorders, and offering a valuable resource for understanding nerve function at the RNA level.

Top posts

Most liked on X and Bluesky
bioRxiv Neuroscience
@biorxiv_neursci · X

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/oDEfO2iX9G #biorxiv_neursci

Nov 1, 2023 · 20 likes · 3 shares · 60,029 followers View post →
SPARC.science
@sparc_science · X

@UTDPainCenter @UTDPainLab @asta_at @BBSutdallas The article that interprets this data was published today in @PAINthejournal : checkout "RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing" at https://t.co/HbNwFTHGtw.

May 29, 2024 · 5 likes · 502 followers View post →
IASP
@IASPpain · X

Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/tF36CJ1hVq https://t.co/Pw8YF2CxdJ

Nov 1, 2024 · 4 likes · 2 shares · 22,729 followers View post →
bioRxiv
@biorxivpreprint · X

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/rks3lwROWv #bioRxiv

Nov 1, 2023 · 2 likes · 137,332 followers View post →
IASP
@IASPpain · X

Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/tF36CJ1hVq https://t.co/HuuT49ODGg

Nov 1, 2024 · 2 likes · 22,729 followers View post →
SPARC
@sparc.science · Bluesky

Attending the 2025 PNS Annual Meeting?

May 19, 2025 · 2 likes · 1 share View post →

All mentions

SPARC
@sparc.science · Bluesky

Attending the 2025 PNS Annual Meeting?

May 19, 2025 · 2 likes · 1 share View post →
SPARC
@sparc.science · Bluesky

ICYMI: The seminar "Uncover Novel RNA Isoforms in Pain Research" featuring Dr. Asta Arendt Tranholm (#UTDallas) is now available. Learn about the impact of PacBio sequencing on somatosensation and nociception. Watch here: youtu.be/feTELX_tDAw?... #PainResearch #SeminarSeries #SPARC

Apr 21, 2025 · 1 like View post →
Sociedad Española del Dolor
@Sedolor · X

#PaintheJournal RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing  https://t.co/4dnw11gXGm https://t.co/ARSG8Ft3h0

Nov 11, 2024 · 14,197 followers View post →
PAIN Journal
@PAINthejournal · X

Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/DvNgO3InEy https://t.co/ZVY4lHGMbi

Nov 1, 2024 · 1 like · 18,773 followers View post →
North American Pain School
@NAPainSchool · X

RT @IASPpain: Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UT…

Nov 1, 2024 · 2 shares · 2,961 followers View post →
IASP
@IASPpain · X

Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/tF36CJ1hVq https://t.co/HuuT49ODGg

Nov 1, 2024 · 2 likes · 22,729 followers View post →
SANDRAJOHNSTON
@sandra04850184 · X

RT @PAINthejournal: Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing”…

Nov 1, 2024 · 1 share · 952 followers View post →
IASP
@IASPpain · X

Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/tF36CJ1hVq https://t.co/Pw8YF2CxdJ

Nov 1, 2024 · 4 likes · 2 shares · 22,729 followers View post →
PAIN Journal
@PAINthejournal · X

Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/DvNgO3InEy https://t.co/osDpcmel3J

Nov 1, 2024 · 1 like · 1 share · 18,773 followers View post →
SPARC.science
@sparc_science · X

@UTDPainCenter @UTDPainLab @asta_at @BBSutdallas The article that interprets this data was published today in @PAINthejournal : checkout "RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing" at https://t.co/HbNwFTHGtw.

May 29, 2024 · 5 likes · 502 followers View post →
Alex Chamessian
@achamess · X

RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…

Nov 2, 2023 · 3 shares · 2,744 followers View post →
Olivia Davis
@livdavis117 · X

RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…

Nov 2, 2023 · 3 shares · 191 followers View post →
Clément Verkest
@clement_verkest · X

RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…

Nov 1, 2023 · 3 shares · 24 followers View post →
bioRxiv Neuroscience
@biorxiv-neursci.bsky.social · Bluesky

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://www.biorxiv.org/content/10.1101/2023.10.28.564535v1

Nov 1, 2023 · 1 like · 1 share View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://www.biorxiv.org/content/10.1101/2023.10.28.564535v1

Nov 1, 2023 View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/oDEfO2iX9G #biorxiv_neursci

Nov 1, 2023 · 20 likes · 3 shares · 60,029 followers View post →
bioRxiv
@biorxivpreprint · X

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/rks3lwROWv #bioRxiv

Nov 1, 2023 · 2 likes · 137,332 followers View post →