RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/oDEfO2iX9G #biorxiv_neursci
RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing.
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Nov 2023 – May 2025Where it's discussed
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X / Twitter13 posts
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Bluesky4 posts
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Facebook3 posts
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YouTube2 videos
AI synopsis
What people are saying
The overall sentiment demonstrates strong support and enthusiasm for the research, with mentions of its impact on understanding nerve function and pain mechanisms, exemplified by phrases like 'impact of PacBio sequencing' and calls to explore the publication in reputable journals. The words used, such as 'highlight,' 'discover,' and 'impact,' convey high interest and perceived importance, fostering a sense of advancement in pain research.
Most discussions acknowledge the significance of the research, emphasizing its novelty and importance for pain research and RNA isoform analysis.
Posts show high interest by highlighting the potential implications and inviting others to learn about the findings.
Participants actively share resources like seminars and articles, indicating a moderate level of engagement and curiosity.
The focus on the groundbreaking methods and discoveries suggests the community perceives this work as having a substantial influence on the field.
Abstract in brief
- The study used longread sequencing to identify and validate over 19,500 protein-coding isoforms in human dorsal root ganglia, revealing many previously unknown splice variants, especially in pain-related genes like ASIC3, MRGPRX1, and HNRNPK.
- Researchers found unique splicing events, such as excision of part of the 5' untranslated region (UTR) in ASIC3, incorporation of an additional exon in MRGPRX1, and new splice sites in HNRNPK, which could impact gene regulation and function.
- The study also confirmed a nerve-specific splicing event in the WNK1 gene linked to painless peripheral neuropathy, providing insights into how genetic mutations contribute to nerve pain disorders, and offering a valuable resource for understanding nerve function at the RNA level.
Top posts
Most liked on X and Bluesky@UTDPainCenter @UTDPainLab @asta_at @BBSutdallas The article that interprets this data was published today in @PAINthejournal : checkout "RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing" at https://t.co/HbNwFTHGtw.
Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/tF36CJ1hVq https://t.co/Pw8YF2CxdJ
RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/rks3lwROWv #bioRxiv
Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/tF36CJ1hVq https://t.co/HuuT49ODGg
Attending the 2025 PNS Annual Meeting?
All mentions
Longread Sequencing Reveals Novel RNA Isoforms in Human Dorsal Root Ganglia
Using longread sequencing, this study identifies over 19,500 protein-coding isoforms in human dorsal root ganglia, uncovering previously unknown variants that impact nerve function and pain regulation, and providing a…
Human Dorsal Root Ganglion RNA Isoform Landscape from Long-Read Sequencing
This study used long-read sequencing to identify over 19,500 protein-coding isoforms in human dorsal root ganglia, revealing novel splice variants, especially in pain-related genes, providing insights into nerve…
Attending the 2025 PNS Annual Meeting?
ICYMI: The seminar "Uncover Novel RNA Isoforms in Pain Research" featuring Dr. Asta Arendt Tranholm (#UTDallas) is now available. Learn about the impact of PacBio sequencing on somatosensation and nociception. Watch here: youtu.be/feTELX_tDAw?... #PainResearch #SeminarSeries #SPARC
#PaintheJournal RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing https://t.co/4dnw11gXGm https://t.co/ARSG8Ft3h0
Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/DvNgO3InEy https://t.co/ZVY4lHGMbi
RT @IASPpain: Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UT…
Check out articles like “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. in #PAIN https://t.co/tF36CJ1hVq https://t.co/HuuT49ODGg
RT @PAINthejournal: Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing”…
Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/tF36CJ1hVq https://t.co/Pw8YF2CxdJ
Now in #PAIN: “RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing” by @UTDpainlab et al. https://t.co/DvNgO3InEy https://t.co/osDpcmel3J
@UTDPainCenter @UTDPainLab @asta_at @BBSutdallas The article that interprets this data was published today in @PAINthejournal : checkout "RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing" at https://t.co/HbNwFTHGtw.
RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…
RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…
RT @biorxiv_neursci: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://…
RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://www.biorxiv.org/content/10.1101/2023.10.28.564535v1
RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://www.biorxiv.org/content/10.1101/2023.10.28.564535v1
RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/oDEfO2iX9G #biorxiv_neursci
RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing https://t.co/rks3lwROWv #bioRxiv