EMBO Rep July 2024 PMID 38816514

Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication.

Pasqualino de Antonellis, Veronica Ferrucci, Marco Miceli, Francesca Bibbo, Fatemeh Asadzadeh, Francesca Gorini, Alessia Mattivi, Angelo Boccia, Roberta Russo, Immacolata Andolfo, Vito Alessandro Lasorsa, Sueva Cantalupo, Giovanna Fusco, Maurizio Viscardi, Sergio Brandi

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Mentions

Peak: 4 in Jun 2024

across 3 sources since May 2024

Extended reach

31,559

potential audience

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Mentions per month

May 2024 – Feb 2025

Where it's discussed

X / Twitter5 posts
Blogs2 articles
YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a cautious interest with references to the study's potential, as seen in comments about the non-toxic caloxin-derivative and its role in reducing infection, conveying a moderate yet meaningful engagement that recognizes the study's possible significance without extensive debate or critique.

AgreementModerate agreement

Most discussions are supportive or neutral towards the study, indicating general alignment with its findings.

InterestModerate interest

Participants show moderate curiosity, mentioning specific compounds like PI-7 and referencing potential implications.

EngagementModerate engagement

Comments include responses to the study's relevance and safety, demonstrating some depth of discussion.

ImpactModerate impact

The posts suggest that the research could influence future treatments or understanding of COVID-19, though not overwhelmingly so.

Abstract in brief

ATP2B1 plays a crucial role in regulating calcium export and maintaining calcium homeostasis, which is linked to the replication of SARS-CoV-2.
A compound called PI-7, derived from caloxin, lowers intracellular calcium levels and decreases SARS-CoV-2 infection without causing toxicity.
The study also identifies a rare variant of ATP2B1 linked to more severe COVID-19 outcomes, with the mechanism involving the PI3K/Akt pathway and inhibiting certain calcium pump expression, demonstrating PI-7's potential as a prophylactic treatment against COVID-19.

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All mentions

Role of ATP2B1 in Regulating Calcium and SARS-CoV-2 Replication

This study explores how ATP2B1 controls calcium levels in infected cells, impacting SARS-CoV-2 replication. It highlights a compound called PI-7 that reduces viral infection by lowering calcium, offering potential for…

Massimo Zollo · Jun 8, 2024 33 views

D3Rahanne

@D3Rahanne · X

@ThingsHiddenn FOX rings an alert, hope not related. https://t.co/AqmJp6EDCX https://t.co/mZ3Ll6Ekoe

Feb 18, 2025 · 26 followers View post →

圧到的に成長したぬーとりあはかぴばらと区別できないですわ（極悪令嬢・圧ヌ一ちゃん）

@piyota0 · X

RT @infdisease_news: Researchers demonstrated that a nontoxic caloxin-derivative compound

Jun 5, 2024 · 2 shares · 2,770 followers View post →

EMBO Reports

@emboreports · X

RT @infdisease_news: Researchers demonstrated that a nontoxic caloxin-derivative compound

Jun 5, 2024 · 2 shares · 15,887 followers View post →

Immunology of Infectious Disease News

@infdisease_news · X

Researchers demonstrated that a nontoxic caloxin-derivative compound

Jun 4, 2024 · 8 likes · 2 shares · 12,656 followers View post →

Massimo Zollo

@e9514c04b940481 · X

https://t.co/qJyulU9Ipg

May 31, 2024 · 175 followers View post →