Sci Transl Med June 2024 PMID 38838135

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.

Jian Liu, David A Copland, Alison J Clare, Mathias Gorski, Burt T Richards, Louis Scott, Sofia Theodoropoulou, Ursula Greferath, Katherine Cox, Gongyu Shi, Oliver H Bell, Kepeng Ou, Jenna Le Brun Powell, Jiahui Wu, Luis Martinez Robles

Mentions

217
Peak: 22 in Jun 2024
across 4 sources since Jun 2024

Extended reach

88,904
potential audience

Total likes

96

Video views

20

Mentions per month

Jun 2024 – Jul 2024

Where it's discussed

  • News192 articles
  • X / Twitter22 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions frequently praise the research, with phrases like 'great job' and 'incredible story,' and highlight its potential to treat age-related macular degeneration, showing excitement and recognition of significance. The tone and references to therapy and scientific advancement reflect strong enthusiasm and engagement.

AgreementStrong agreement

Most discussions show strong support for the research findings, highlighting the potential of IRAK-M as a therapeutic target.

InterestHigh interest

The enthusiasm for the study and its implications demonstrates high interest among participants.

EngagementModerate engagement

Posts include mentions of experimental results, collaborations, and future applications, indicating substantial engagement.

ImpactHigh impact

The emphasis on therapies for AMD and the potential breakthrough implications suggest high perceived impact.

Abstract in brief

  • * Research indicates that levels of IRAK-M decrease with age and oxidative stress, with genetic variants linked to a higher risk of developing AMD.
  • * Restoring IRAK-M in RPE cells shows promise in protecting against oxidative damage and retinal degeneration, indicating it could be a potential therapeutic avenue for AMD.

Top posts

Most liked on X and Bluesky
Andrew Dick
@andrewdick4 · X

Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cover to go with it. Big thanks to Kai. https://t.co/5CiXFBr8pZ https://t.co/8zF5s0hp9f

Jun 5, 2024 · 62 likes · 10 shares · 1,404 followers View post →
Michael F. Chiang, MD
@NEIDirector · X

From @BristolUni and Cirrus Technologies (UK): boosting levels of the protein IRAK-M in mice reduced retinal inflammation & slowed AMD progression. @andrewdick4 @MoranEyeCenter @UniMelb @ScienceTM: https://t.co/emVQJTdRpA https://t.co/BqfH9CDcuf

Jun 12, 2024 · 21 likes · 4 shares · 9,738 followers View post →
Sean Ku Wang
@SeanKuWang · X

Incredible story from @andrewdick4 and co on a noncomplement target for macular degeneration IRAK-M levels in the RPE decline with age and especially in AMD. Gene therapy restoring IRAK-M protects mice from retinal degeneration and may offer a new therapy https://t.co/XtPENfcyEh

Jun 5, 2024 · 9 likes · 507 followers View post →
Science Translational Medicine
@ScienceTM · X

Scientists find that a decline in #IRAKM in the retinal pigment epithelium is a risk factor for age-related macular degeneration in patients, and show replenishing IRAK-M reverses retinal degeneration and inflammation in mice. @andrewdick4 @Brms_Research https://t.co/Ay07DJGXud https://t.co/IyMDnllQdk

Jun 11, 2024 · 4 likes · 3 shares · 33,721 followers View post →
NEI
@NatEyeInstitute · X

RT @NEIDirector: From @BristolUni and Cirrus Technologies (UK): boosting levels of the protein IRAK-M in mice reduced retinal inflammation…

Jun 12, 2024 · 4 shares · 16,034 followers View post →
UCL Institute of Ophthalmology
@UCLeye · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 6, 2024 · 10 shares · 6,230 followers View post →

All mentions

UCL Open Science and Scholarship
@UCLopenscience · X

RT @ucylpay: UCL Discovery records 50 million d/loads! 'Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retin…

Jun 27, 2024 · 1 share · 2,848 followers View post →
Paul Ayris
@ucylpay · X

UCL Discovery records 50 million d/loads! 'Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration' by a writing team was the 50 millionth d/load! See https://t.co/Vncmy6JU1I for more! @UCLopenscience @profgeraintrees @AnthonySmithVP https://t.co/uvPnsiQr5O

Jun 27, 2024 · 1 share · 2,522 followers View post →
Lian-Wang Guo
@lian_guo · X

RT @NEIDirector: From @BristolUni and Cirrus Technologies (UK): boosting levels of the protein IRAK-M in mice reduced retinal inflammation…

Jun 12, 2024 · 4 shares · 120 followers View post →
NEI
@NatEyeInstitute · X

RT @NEIDirector: From @BristolUni and Cirrus Technologies (UK): boosting levels of the protein IRAK-M in mice reduced retinal inflammation…

Jun 12, 2024 · 4 shares · 16,034 followers View post →
Michael F. Chiang, MD
@NEIDirector · X

From @BristolUni and Cirrus Technologies (UK): boosting levels of the protein IRAK-M in mice reduced retinal inflammation & slowed AMD progression. @andrewdick4 @MoranEyeCenter @UniMelb @ScienceTM: https://t.co/emVQJTdRpA https://t.co/BqfH9CDcuf

Jun 12, 2024 · 21 likes · 4 shares · 9,738 followers View post →
Amy
@amyward3112 · X

RT @ScienceTM: Scientists find that a decline in #IRAKM in the retinal pigment epithelium is a risk factor for age-related macular degenera…

Jun 11, 2024 · 3 shares · 151 followers View post →
Eve Beavers
@espacetimeCO · X

RT @ScienceTM: Scientists find that a decline in #IRAKM in the retinal pigment epithelium is a risk factor for age-related macular degenera…

Jun 11, 2024 · 3 shares · 898 followers View post →
Science Translational Medicine
@ScienceTM · X

Scientists find that a decline in #IRAKM in the retinal pigment epithelium is a risk factor for age-related macular degeneration in patients, and show replenishing IRAK-M reverses retinal degeneration and inflammation in mice. @andrewdick4 @Brms_Research https://t.co/Ay07DJGXud https://t.co/IyMDnllQdk

Jun 11, 2024 · 4 likes · 3 shares · 33,721 followers View post →
Dr. Marcus Karlstetter
@MKarlstetterPhD · X

Jun 10, 2024 · 548 followers View post →
Dr. Marcus Karlstetter
@MKarlstetterPhD · X

Jun 10, 2024 · 548 followers View post →
Lisa Hill
@Neuroscience_Dr · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 7, 2024 · 10 shares · 2,138 followers View post →
Elfride De Baere
@elfridedebaere · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 6, 2024 · 10 shares · 1,651 followers View post →
Siegfried Wagner
@sktywagner · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 6, 2024 · 10 shares · 1,030 followers View post →
Giulia De Rossi
@GDR_tweets · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 6, 2024 · 10 shares · 1,175 followers View post →
UCL Institute of Ophthalmology
@UCLeye · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 6, 2024 · 10 shares · 6,230 followers View post →
Sean Ku Wang
@SeanKuWang · X

Incredible story from @andrewdick4 and co on a noncomplement target for macular degeneration IRAK-M levels in the RPE decline with age and especially in AMD. Gene therapy restoring IRAK-M protects mice from retinal degeneration and may offer a new therapy https://t.co/XtPENfcyEh

Jun 5, 2024 · 9 likes · 507 followers View post →
Xiaowu Gu
@XiaowuGu · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 5, 2024 · 10 shares · 1,555 followers View post →
Phage Papers
@Phage_Papers · X

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration https://t.co/im09K1hCRQ

Jun 5, 2024 · 647 followers View post →
Danny Saban
@SabanLab · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 5, 2024 · 10 shares · 2,117 followers View post →
Prof. Roxanne Crosby-Nwaobi RN PhD FRCN
@CrosbyNwaobi · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 5, 2024 · 10 shares · 1,331 followers View post →
Dr Lola Solebo
@lolaeyedoc · X

RT @andrewdick4: Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cove…

Jun 5, 2024 · 10 shares · 1,726 followers View post →
Andrew Dick
@andrewdick4 · X

Well done to an amazing and super fun lab team and collaborators and thanks to the funders - great job Jian and front cover to go with it. Big thanks to Kai. https://t.co/5CiXFBr8pZ https://t.co/8zF5s0hp9f

Jun 5, 2024 · 62 likes · 10 shares · 1,404 followers View post →