October 2024 PMID 38856086

Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial.

Michael J Li, Brendon Chau, Thomas Belin, Thomas Carmody, Manish K Jha, Elise N Marino, Madhukar Trivedi, Steven J Shoptaw

Mentions

43
Peak: 9 in Jun 2024
across 4 sources since Jun 2024

Extended reach

31,226
potential audience

Total likes

15

Video views

138

Mentions per month

Jun 2024 – Nov 2024

Where it's discussed

  • News26 articles
  • X / Twitter12 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions convey overall support and curiosity about the research, with examples like mentions of the 27% increase in negative tests and phrases like 'bold discoveries' and 'significantly reduce' reflecting a tone of optimism and importance. The tone and word choices suggest a recognition of the study's relevance in advancing treatments for methamphetamine use disorder.

AgreementModerate agreement

Most discussions endorse the positive results and potential of the combined treatment, with many highlighting the significant reduction in methamphetamine use shown in the trial.

InterestModerate interest

The posts demonstrate moderate interest, as they focus on sharing study outcomes and highlighting their importance, but lack detailed critical analysis or personal insights.

EngagementModerate engagement

Participants reference specific data points such as increases in negative test results and mention the significance of treatment duration, indicating a moderate level of in-depth engagement.

ImpactModerate impact

The discussion emphasizes the potential impact of the treatment as a notable development in addiction medicine, suggesting it could influence future treatment protocols.

Abstract in brief

  • The ADAPT2 trial studied the effects of combined naltrexone and bupropion (NTXBUPN) on reducing methamphetamine use over 12 weeks, showing that those on NTXBUPN had a significantly higher likelihood of testing negative for methamphetamine than those on placebo.
  • Participants receiving NTXBUPN in stage 1 continued to improve in stage 2, with a 92% increase in the chance of testing negative for methamphetamine, adding to an overall 27% increase over 12 weeks, while the placebo group showed a smaller 11.4% increase.
  • The results indicate that extended-release naltrexone plus bupropion could be an effective treatment to reduce methamphetamine use, as evidenced by significant differences in drug test outcomes between the treatment and placebo groups during the trial.

Top posts

Most liked on X and Bluesky
Addiction Journal
@AddictionJrnl · X

For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional reductions in MA use up to 12 weeks. Read the full study by Michael Li @uclaFM and colleagues here https://t.co/HfjGeR3MZa https://t.co/TklAsrINy6

Jun 17, 2024 · 11 likes · 5 shares · 15,014 followers View post →
P
@psychopharmacol · X

ADAPT-2 trial: People with methamphetamine UD receiving treatment with naltrexone + bupropion XL showed a greater increase in their probability of testing negative for MA after 12-week vs. placebo (15.8%: P=0.006) https://t.co/KHANNOD36r

Jun 21, 2024 · 3 likes · 575 followers View post →
AliAdyb-Bear
@AlyAdybBear · X

Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT‐2 trial - Li - Addiction - Wiley Online Library https://t.co/xgwxqQGekU

Jul 9, 2024 · 1 like · 1 share · 1,427 followers View post →
InterCoast Colleges
@CareersOnTarget · X

**Bold Discoveries in Battling Meth Use Disorder:** The latest ADAPT-2 trial shows that NTX + BUPN treatments significantly reduce methamphetamine use over 12 weeks compared to placebo.

Jun 17, 2024 · 4,839 followers View post →
ISSUP
@issupnet · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 4,008 followers View post →
Your Ally Foundation, Inc
@ally_foundation · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 1,542 followers View post →

All mentions

Anja Busse
@un_anja · X

RT @AlyAdybBear: Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT‐2 trial - Li - Ad…

Jul 10, 2024 · 1 share · 1,070 followers View post →
AliAdyb-Bear
@AlyAdybBear · X

Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT‐2 trial - Li - Addiction - Wiley Online Library https://t.co/xgwxqQGekU

Jul 9, 2024 · 1 like · 1 share · 1,427 followers View post →
UCLA CHIPTS
@CHIPTS · X

A recent publication by CHIPTS very own CP Core Scientist Dr. Michael Li on the “Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial," was highlighted on @UCLAHealth news. Read here: https://t.co/37fQ98hPZD https://t.co/0T7qN2BTFW

Jul 2, 2024 · 529 followers View post →
P
@psychopharmacol · X

ADAPT-2 trial: People with methamphetamine UD receiving treatment with naltrexone + bupropion XL showed a greater increase in their probability of testing negative for MA after 12-week vs. placebo (15.8%: P=0.006) https://t.co/KHANNOD36r

Jun 21, 2024 · 3 likes · 575 followers View post →
TOXIDROGAS UN
@ToxidrogasUN · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 422 followers View post →
InterCoast Colleges
@CareersOnTarget · X

**Bold Discoveries in Battling Meth Use Disorder:** The latest ADAPT-2 trial shows that NTX + BUPN treatments significantly reduce methamphetamine use over 12 weeks compared to placebo.

Jun 17, 2024 · 4,839 followers View post →
Maria.
@MariaToxCli · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 93 followers View post →
Your Ally Foundation, Inc
@ally_foundation · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 1,542 followers View post →
Anja Busse
@un_anja · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 1,070 followers View post →
ISSUP
@issupnet · X

RT @AddictionJrnl: For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional…

Jun 17, 2024 · 5 shares · 4,008 followers View post →
Addiction Journal
@AddictionJrnl · X

For people with methamphetamine (MA) use disorder, treatment with NTX-BUPN beyond 6 weeks is associated with additional reductions in MA use up to 12 weeks. Read the full study by Michael Li @uclaFM and colleagues here https://t.co/HfjGeR3MZa https://t.co/TklAsrINy6

Jun 17, 2024 · 11 likes · 5 shares · 15,014 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

New Post: Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial https://t.co/kT4oFspRf5

Jun 12, 2024 · 435 followers View post →