June 2024 PMID 38906102

Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome.

Lisa Derosa, Valerio Iebba, Carolina Alves Costa Silva, Gianmarco Piccinno, Guojun Wu, Leonardo Lordello, Bertrand Routy, Naisi Zhao, Cassandra Thelemaque, Roxanne Birebent, Federica Marmorino, Marine Fidelle, Meriem Messaoudene, Andrew Maltez Thomas, Gerard Zalcman

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Mentions

Peak: 19 in Jun 2024

across 6 sources since Jun 2024

Extended reach

173,954

potential audience

Total likes

Video views

6,012

Mentions per month

Jun 2024 – May 2025

Where it's discussed

X / Twitter30 posts
News5 articles
Blogs4 articles
YouTube2 videos
Reddit2 posts
Bluesky1 posts

AI synopsis

What people are saying

Several discussions express enthusiasm about the novel approach for predicting immunotherapy outcomes, emphasizing terms like 'predictive tools,' 'diagnostic,' and 'rapid 21-bacteria-based test.' The tone varies from supportive to cautiously optimistic, and the inclusion of references to applications across different cancers underlines its perceived significance and potential impact on personalized treatment strategies.

AgreementModerate agreement

Most discussions show general support or neutral acknowledgment of the study, highlighting its significance in advancing cancer immunotherapy diagnostics.

InterestHigh interest

The discussions demonstrate high curiosity, with frequent references to the innovative scoring system, diagnostic potential, and translational applications.

EngagementModerate engagement

Posts often mention specific techniques like the 21-bacteria qPCR test and the implications for personalized medicine, indicating moderate to deep engagement.

ImpactModerate impact

Participants perceive the research as potentially transformative for clinical practice, although some express the need for further validation, suggesting a recognition of moderate impact.

Abstract in brief

The gut microbiota plays a significant role in how cancer patients respond to immune checkpoint inhibitors (ICIs), but there’s no clear definition of harmful dysbiosis.*
Researchers analyzed fecal samples from 245 non-small cell lung cancer (NSCLC) patients, identifying specific bacterial species groups associated with either resistance or response to ICIs, resulting in the creation of a topological score (TOPOSCORE).*
This TOPOSCORE was further validated in additional patient cohorts and transformed into a 21-bacterial probe set for qPCR scoring, suggesting it could serve as a dynamic tool for diagnosing intestinal dysbiosis and tailoring microbiota-focused treatments.*

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All mentions

Gut Microbiota Topology and Its Impact on Cancer Immunotherapy Response

This video explores how gut microbiota influences cancer patients' responses to immune checkpoint inhibitors, focusing on a new topological score derived from fecal microbiota analysis that aids in diagnosing dysbiosis…

김책임=대학원X바이오X박사멘토 · Jan 3, 2025 5,865 views

Gut Microbiome Profiling Guides Effective Cancer Immunotherapy Strategies

Researchers found that gut bacteria influence cancer drug responses, emphasizing the role of microbial communities in immunotherapy outcomes. The study introduces TOPOSCORE, a bacterial profile-based tool for predicting…

Science Wonders Unveiled · Jun 21, 2024 147 views

NatMalara MD, PhD

@natmalara · X

May 26, 2025 · 1,070 followers View post →

medicalnews

@medicalnews20 · X

https://t.co/s5ameExEW2 Gut Microbiome Topology Scoring Predicts Cancer Immunotherapy Efficacy. Researchers from France's ClinicObiome published a paper titled "Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome" in Cell..

Jul 29, 2024 · 1 like · 1,168 followers View post →

XiaoTao JIANG

@Titus12629950 · X