June 2024 PMID 38916891

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial.

Manish Kumar Jha, Samuel T Wilkinson, Kamini Krishnan, Katherine A Collins, Gerard Sanacora, James Murrough, Fernando Goes, Murat Altinay, Amy Aloysi, Ali Asghar-Ali, Brian Barnett, Lee Chang, Sara Costi, Donald Malone, Sina Nikayin

Mentions

40
Peak: 11 in Mar 2025
across 6 sources since Jun 2024

Extended reach

137,387
potential audience

Total likes

69

Video views

60

Mentions per month

Jun 2024 – Mar 2025

Where it's discussed

  • X / Twitter19 posts
  • News11 articles
  • Blogs4 articles
  • Facebook3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The collective discussions show a focus on the comparative effectiveness of ketamine and ECT, with posts citing specific data like depression score improvements and patient suitability, using tone and terminology that indicate both support and curiosity about clinical implications and nuanced results.

AgreementModerate agreement

Most discussions recognize that ketamine shows comparable or better outcomes than ECT, with some emphasizing its effectiveness, indicating general support for the study's findings.

InterestModerate interest

Posts demonstrate moderate curiosity, referencing specific results like improvements in depression scores and highlighting particular patient groups, which suggests a decent level of engagement.

EngagementModerate engagement

Several users reference detailed aspects such as patient preferences, clinical features, and statistical outcomes, showing a thoughtful and analytical approach.

ImpactModerate impact

The discussions highlight the potential for changing treatment approaches, especially favoring ketamine in certain cases, reflecting a recognition of meaningful implications.

Abstract in brief

  • The ELEKT-D trial explored whether intravenous ketamine is as effective as ECT for patients with treatment-resistant depression (TRD), finding that ketamine is noninferior to ECT in this group.
  • This secondary analysis aimed to identify which clinical features might predict better outcomes with either ketamine or ECT in treating TRD.
  • The study involved 365 participants from five U.S. medical centers, comparing treatment responses based on various baseline factors, such as depression severity and cognitive function, using advanced statistical methods.

Top posts

Most liked on X and Bluesky
Chris Aiken, MD
@chrisaikenmd · X

Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://t.co/F3wQyQFhpV 2. Patient preference skewed the results in favor of ketamine: https://t.co/Fmt1KAdSGO Also, psychosis excluded, and responds better to ECT. https://t.co/BDbnk9qSEh

Mar 29, 2025 · 59 likes · 10 shares · 8,242 followers View post →
Dr. Carl Hindy
@DrCarlHindy · X

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial - PubMed https://t.co/iPnBmnmrFS

Jun 28, 2024 · 3 likes · 33,258 followers View post →
Chris Aiken, MD
@chrisaikenmd.bsky.social · Bluesky

Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases pubmed.ncbi.nlm.nih.gov/38916891 2. Patient preference skewed the results in favor of ketamine: pubmed.ncbi.nlm.nih.gov/40049091 Also, psychosis excluded, and responds better to ECT.

Mar 29, 2025 · 3 likes · 2 shares View post →
Deutsches Ärzteblatt
@Dt_Aerzteblatt · X

Bei moderater bis schwerer Depression besser Ketamin als EKT: Dallas – Im Fachblatt JAMA Network Open (2024; DOI: 10.1001/jamanetworkopen.2024.17786) berichten US-Forschende, an welchen Merkmalen man Patienten mit… https://t.co/vmPFVKrx8U #JAMANetworkOpen #NEJM https://t.co/Af8lFoyjqN

Jul 12, 2024 · 1 like · 35,082 followers View post →
Andrey Ostrovsky, MD, FAAP
@AndreyOstrovsky · X

Study: Ketamine more effective than ECT for depression treatment. Well done @BrianBarnettMD ! https://t.co/3KPTnnViwL @JAMA_current

Jun 28, 2024 · 1 like · 1 share · 8,854 followers View post →
JAMA Network Open
@JAMANetworkOpen · X

Greater improvement in depression was observed w/ IV ketamine among outpatients with nonpsychotic Treatment Resistant Depression (TRD) who had moderately severe or severe depression, suggesting these patients may consider ketamine over ECT for TRD. https://t.co/h2u5dQnhGh

Jun 25, 2024 · 25,128 followers View post →

All mentions

David Medina
@davimedinTwits · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 31, 2025 · 10 shares · 112 followers View post →
Anna Bazydło
@a_bazydloMD · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 31, 2025 · 10 shares · 5,479 followers View post →
MJP
@_Mywonderfulife · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 30, 2025 · 10 shares · 652 followers View post →
Carlat Psychiatry
@CarlatPsych · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 30, 2025 · 10 shares · 8,031 followers View post →
Chris Aiken, MD
@chrisaikenmd.bsky.social · Bluesky

Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases pubmed.ncbi.nlm.nih.gov/38916891 2. Patient preference skewed the results in favor of ketamine: pubmed.ncbi.nlm.nih.gov/40049091 Also, psychosis excluded, and responds better to ECT.

Mar 29, 2025 · 3 likes · 2 shares View post →
George Kirov
@GeorgeKirov1 · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 29, 2025 · 10 shares · 1,091 followers View post →
gabafeitina
@gabrielbasto_ · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 29, 2025 · 10 shares · 99 followers View post →
Agnes Ayton
@AgnesAyton · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 29, 2025 · 10 shares · 7,393 followers View post →
Francois Kazour
@francoiskazour · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 29, 2025 · 10 shares · 987 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @chrisaikenmd: Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://…

Mar 29, 2025 · 10 shares · 383 followers View post →
Chris Aiken, MD
@chrisaikenmd · X

Re-analyzing the trial that found ECT=ketamine in TRD, we learn: 1. ECT better for severe or hospitalized cases https://t.co/F3wQyQFhpV 2. Patient preference skewed the results in favor of ketamine: https://t.co/Fmt1KAdSGO Also, psychosis excluded, and responds better to ECT. https://t.co/BDbnk9qSEh

Mar 29, 2025 · 59 likes · 10 shares · 8,242 followers View post →
Lifeline Interventional Therapeutics
@litketamine · X

https://t.co/wzJ35QLhSN An amazing article showing efficacy of IV Ket vs ECT.

Jan 6, 2025 · 2 followers View post →
Amad Elia
@AmadElia77 · X

@the_sigh_op2 Here’s one that contradicts that: https://t.co/a1lK7vyUkk

Nov 11, 2024 · 773 followers View post →
Deutsches Ärzteblatt
@Dt_Aerzteblatt · X

Bei moderater bis schwerer Depression besser Ketamin als EKT: Dallas – Im Fachblatt JAMA Network Open (2024; DOI: 10.1001/jamanetworkopen.2024.17786) berichten US-Forschende, an welchen Merkmalen man Patienten mit… https://t.co/vmPFVKrx8U #JAMANetworkOpen #NEJM https://t.co/Af8lFoyjqN

Jul 12, 2024 · 1 like · 35,082 followers View post →
Arturo Carballo
@artcarballo7 · X

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression https://t.co/DESq7JiS3F

Jun 30, 2024 · 171 followers View post →
Ajiman
@Ajiman1 · X

RT @AndreyOstrovsky: Study: Ketamine more effective than ECT for depression treatment. Well done @BrianBarnettMD ! https://t.co/3KPTnnViwL…

Jun 28, 2024 · 1 share · 808 followers View post →
Dr. Carl Hindy
@DrCarlHindy · X

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial - PubMed https://t.co/iPnBmnmrFS

Jun 28, 2024 · 3 likes · 33,258 followers View post →
Andrey Ostrovsky, MD, FAAP
@AndreyOstrovsky · X

Study: Ketamine more effective than ECT for depression treatment. Well done @BrianBarnettMD ! https://t.co/3KPTnnViwL @JAMA_current

Jun 28, 2024 · 1 like · 1 share · 8,854 followers View post →
P
@psychopharmacol · X

Post Hoc Analysis: > improvement (QIDS-SR16) was observed with IV ketamine vs. ECT among outpatients (−8.4 vs −6.2 points) with moderately severe or severe (−7.7 vs −5.6 points) nonpsychotic TRD https://t.co/eYhx6EKZT9 https://t.co/r3XVetGN6M

Jun 27, 2024 · 575 followers View post →
JAMA Network Open
@JAMANetworkOpen · X

Greater improvement in depression was observed w/ IV ketamine among outpatients with nonpsychotic Treatment Resistant Depression (TRD) who had moderately severe or severe depression, suggesting these patients may consider ketamine over ECT for TRD. https://t.co/h2u5dQnhGh

Jun 25, 2024 · 25,128 followers View post →