Am J Psychiatry July 2024 PMID 38946271

A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression.

Christopher Rohde, Søren Dinesen Østergaard, Oskar Hougaard Jefsen

Mentions

37
Peak: 32 in Jul 2024
across 3 sources since Jul 2024

Extended reach

113,133
potential audience

Total likes

113

Video views

291

Mentions per month

Jul 2024 – Oct 2025

Where it's discussed

  • X / Twitter34 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

Discussions highlight the study's conclusion that the risk of antidepressant-induced mania is limited, with comments like 'negligible risk' and references to detailed methodology. Some responses, like 'You don’t say?', convey a tone of skepticism or mild sarcasm, indicating a nuanced engagement where participants recognize the significance but also question the scope of the findings.

AgreementModerate agreement

Most discussions acknowledge the study's findings that antidepressants are unlikely to induce mania, indicating general agreement with the publication.

InterestModerate interest

Participants show moderate interest, as evidenced by references to the study’s methodology and implications, but some responses are dismissive or minimally engaged.

EngagementModerate engagement

Several posts analyze or question aspects of the research, such as its scope and limitations, demonstrating moderate engagement.

ImpactModerate impact

The discussions reflect an awareness of the potential influence of the findings on clinical practices and perceptions regarding bipolar disorder treatment.

Abstract in brief

  • This study used observational data from Danish health records to compare the risk of mania in bipolar depression patients treated with antidepressants versus those not treated, finding no significant increase in mania risk due to antidepressants over a one-year period.
  • The analysis accounted for various factors and included different patient groups, such as those on mood stabilizers and those not, but still found no strong evidence that antidepressants significantly raise the risk of mania or bipolar depression recurrence.
  • Overall, the findings suggest that concerns about antidepressant-induced mania may be less than previously thought, highlighting the need for more research to improve treatment approaches for bipolar depression.

Top posts

Most liked on X and Bluesky
Chris Aiken, MD
@chrisaikenmd · X

Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipolar: https://t.co/EppESpwLFV However, they only looked at hospitalized cases, and did not separate bipolar I from II. https://t.co/86lKF5oRd7

Jul 2, 2024 · 97 likes · 25 shares · 8,488 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

A Nationwide Target Trial Emulation Assessing the Risk of #Antidepressant-Induced #Mania Among Patients With #Bipolar #Depression | American Journal of Psychiatry https://t.co/LkEqkP5VGI

Jul 1, 2024 · 6 likes · 2 shares · 2,278 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

A register-based study shows that potential mania-inducing effect of antidepressants among patients with bipolar depression may be limited. https://t.co/txmH3kc012 https://t.co/fsHemZxrIb

Jul 8, 2024 · 5 likes · 2 shares · 11,606 followers View post →
P
@psychopharmacol · X

retro OL study: The risk of antidepressant-induced mania is negligible for individuals with bipolar depression (HRR=1.08; 0.72–1.61), with or without a mood-stabilizing agent (1.16; 0.63–2.13 and 1.16; 0.65–2.07, respectively) https://t.co/nirMcNgIoK

Jul 6, 2024 · 2 likes · 569 followers View post →
Antidep Effects
@antidepeffects · X

"Dr. Rohde has received funding from the Danish Diabetes Academy, the Lundbeck Foundation (grant R358-2020-2342), and the Novo Nordisk Foundation (grant NNF17SA0031406) and received the 2020 Lundbeck Foundation Talent Prize. https://t.co/yhEiGdxc26

Nov 10, 2024 · 2 likes · 269 followers View post →
Robert Howard
@ProfRobHoward · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 18,278 followers View post →

All mentions

Antidep Effects
@antidepeffects · X

"Dr. Rohde has received funding from the Danish Diabetes Academy, the Lundbeck Foundation (grant R358-2020-2342), and the Novo Nordisk Foundation (grant NNF17SA0031406) and received the 2020 Lundbeck Foundation Talent Prize. https://t.co/yhEiGdxc26

Nov 10, 2024 · 2 likes · 269 followers View post →
Lisa Brown, PhD
@DocLBrown2 · X

You don’t say? “These findings suggest that the risk of antidepressant-induced mania is negligible…” https://t.co/hElnxoTlRF

Sep 10, 2024 · 598 followers View post →
Sean Lynch
@SeanLynchMD · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 9, 2024 · 25 shares · 52 followers View post →
Radhouane Fakhfakh
@fakhfakhr · X

RT @APAPubJournals: A register-based study shows that potential mania-inducing effect of antidepressants among patients with bipolar depres…

Jul 8, 2024 · 2 shares · 896 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 8, 2024 · 25 shares · 11,606 followers View post →
Mike Gara
@garami53 · X

RT @APAPubJournals: A register-based study shows that potential mania-inducing effect of antidepressants among patients with bipolar depres…

Jul 8, 2024 · 2 shares · 1,734 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

A register-based study shows that potential mania-inducing effect of antidepressants among patients with bipolar depression may be limited. https://t.co/txmH3kc012 https://t.co/fsHemZxrIb

Jul 8, 2024 · 5 likes · 2 shares · 11,606 followers View post →
P
@psychopharmacol · X

retro OL study: The risk of antidepressant-induced mania is negligible for individuals with bipolar depression (HRR=1.08; 0.72–1.61), with or without a mood-stabilizing agent (1.16; 0.63–2.13 and 1.16; 0.65–2.07, respectively) https://t.co/nirMcNgIoK

Jul 6, 2024 · 2 likes · 569 followers View post →
Trends in Psychiatry
@TrendsPsych · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 3, 2024 · 25 shares · 551 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 380 followers View post →
jieuni
@_withjieun · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 86 followers View post →
Claudio Arriagada ™
@DonArriagada · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 141 followers View post →
Raymond Lam
@DrRaymondLam · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 2,122 followers View post →
reic
@reic46252450 · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 805 followers View post →
Radhouane Fakhfakh
@fakhfakhr · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 896 followers View post →
Kelly B. Ahern, M.D.
@Kelly_Bee22 · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 195 followers View post →
Antimetaphysik Metaphysik Aktion
@ElPoderDeNu · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 366 followers View post →
Carlat Psychiatry
@CarlatPsych · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 8,079 followers View post →
Robert Howard
@ProfRobHoward · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 18,278 followers View post →
a MAN in NEAD
@aMANinNEAD · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 575 followers View post →
Ryan Logan
@wickedneuro · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 2,959 followers View post →
Austin Lam
@austinaldenlam · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 1,084 followers View post →
Yeyo Minutti
@YeyoMinutti · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 173 followers View post →
Dr. Jessica Giddens DNP (nurse)
@DrJGiddensRN · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 2,757 followers View post →
Utpal Tiwari ( B-ve)
@tripathi_utpal · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 1,862 followers View post →
M
@micmicmic1 · X

A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression - PubMed https://t.co/1dj1xTrxCx

Jul 2, 2024 · 1,615 followers View post →
Iván Morales
@ivanmoralesm_ · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 380 followers View post →
Oriveros19
@clubordeportes · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 171 followers View post →
Edilberto Peña
@Edilberto_pena · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 17,865 followers View post →
A Punk Rock Future
@APunkRockFuture · X

RT @chrisaikenmd: Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipol…

Jul 2, 2024 · 25 shares · 1,333 followers View post →
Chris Aiken, MD
@chrisaikenmd · X

Antidepressants did not cause mania (or prevent #depression) in this 1 year observational study of 979 people with #bipolar: https://t.co/EppESpwLFV However, they only looked at hospitalized cases, and did not separate bipolar I from II. https://t.co/86lKF5oRd7

Jul 2, 2024 · 97 likes · 25 shares · 8,488 followers View post →
『NY午前0時 美術館は眠らない』配信開始!/岩渕潤子
@tawarayasotatsu · X

RT @Luke_629: A Nationwide Target Trial Emulation Assessing the Risk of #Antidepressant-Induced #Mania Among Patients With #Bipolar #Depres…

Jul 2, 2024 · 2 shares · 10,647 followers View post →
Kei Matoba
@mkei_psycho · X

RT @Luke_629: A Nationwide Target Trial Emulation Assessing the Risk of #Antidepressant-Induced #Mania Among Patients With #Bipolar #Depres…

Jul 1, 2024 · 2 shares · 192 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

A Nationwide Target Trial Emulation Assessing the Risk of #Antidepressant-Induced #Mania Among Patients With #Bipolar #Depression | American Journal of Psychiatry https://t.co/LkEqkP5VGI

Jul 1, 2024 · 6 likes · 2 shares · 2,278 followers View post →
A07250539_WEB | PDF | Bipolar Disorder | Major Depressive ...
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