Ann Intern Med August 2024 PMID 38950403

Medication-Induced Weight Change Across Common Antidepressant Treatments : A Target Trial Emulation Study.

Joshua Petimar, Jessica G Young, Han Yu, Sheryl L Rifas-Shiman, Matthew F Daley, William J Heerman, David M Janicke, W Schuyler Jones, Kristina H Lewis, Pi-I D Lin, Carly Prentice, John W Merriman, Sengwee Toh, Jason P Block

Mentions

264
Peak: 42 in Jul 2024
across 6 sources since Jul 2024

Extended reach

618,301
potential audience

Total likes

96

Video views

354

Mentions per month

Jul 2024 – Oct 2025

Where it's discussed

  • News191 articles
  • X / Twitter57 posts
  • Blogs8 articles
  • Facebook3 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

In the discussions, users frequently mention the implications of the study in practical terms, such as 'Will I gain weight?!' reflecting their concern before starting antidepressants. Several posts highlight bupropion as a 'correct answer' for those worried about weight gain, emphasizing its potential benefits. The choice of words like 'important question' and phrases that suggest a transformational insight indicate a strong engagement with the topic, contributing to the overall high sentiment around the article.

AgreementStrong agreement

The majority of discussions reflect a strong consensus on the findings of the study regarding weight changes associated with different antidepressants, particularly highlighting the benefits of bupropion.

InterestHigh interest

Participants show high curiosity, as evidenced by multiple posts referencing study findings and elaborating on different medications and their impacts on weight.

EngagementHigh engagement

Many discussions dive into details about particular antidepressants and their effects, showing a deeper level of investigation and personal connection to the topic.

ImpactHigh impact

The discussions indicate that there is a strong belief in the significance of the study's findings in informing treatment options and addressing patient concerns about weight gain.

Abstract in brief

  • This study compares weight changes among patients prescribed different first-line antidepressants over a 24-month period using electronic health records from 2010 to 2019 across multiple U.S. health systems.
  • Researchers found that several antidepressants, such as escitalopram, paroxetine, and duloxetine, led to greater weight gain compared to sertraline, while bupropion was associated with weight loss.
  • The analysis highlighted that escitalopram, paroxetine, and duloxetine increased the likelihood of gaining at least 5% of baseline weight, whereas bupropion significantly reduced that risk.

Top posts

Most liked on X and Bluesky
David Arterburn, MD, MPH
@davearterburn · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Internal Medicine @jasonpblock and colleagues https://t.co/BVXgaPnGxB

Jul 2, 2024 · 12 likes · 5 shares · 2,233 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

Jul 1, 2024 · 9 likes · 3 shares · 1,783 followers View post →
EARLの医学&AIノート
@EARL_med_tw · X

Jul 18, 2024 · 8 likes · 2 shares · 148,053 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: A target trial emulation study found #bupropion was consistently associated with the least weight gain among 8 first-line #antidepressant treatments. https://t.co/fcdmuJ0UJf https://t.co/ICa9ZYaB0w

Feb 10, 2025 · 7 likes · 3 shares · 72,487 followers View post →
Dr. Mick
@mickael_sp · X

Jul 9, 2024 · 7 likes · 2 shares · 6,935 followers View post →
Dr Sudhir Kumar MD DM
@hyderabaddoctor · X

Correct answer is: Bupropion (Ref: https://t.co/zToWIkQsAa) (Note: Please follow your psychiatrist's advice regarding the choice, dose and duration of antidepressants)

Jul 6, 2024 · 6 likes · 1 share · 96,781 followers View post →

All mentions

Aluanas
@Aluanas4 · X

@naoparfait The study for anyone interested in the numbers: https://t.co/K9M8e46upO

Oct 4, 2025 · 12 followers View post →
David Arterburn, MD, MPH
@davearterburn · X

RT @AnnalsofIM: From the Annals ‘Spotlight on 2024’ collection: A target trial emulation study found #bupropion was consistently associated…

Feb 10, 2025 · 3 shares · 2,233 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @AnnalsofIM: From the Annals ‘Spotlight on 2024’ collection: A target trial emulation study found #bupropion was consistently associated…

Feb 10, 2025 · 3 shares · 2,463 followers View post →
Alison S Liu
@suhsun32 · X

RT @AnnalsofIM: From the Annals ‘Spotlight on 2024’ collection: A target trial emulation study found #bupropion was consistently associated…

Feb 10, 2025 · 3 shares · 128 followers View post →
Annals of Int Med
@AnnalsofIM · X

From the Annals ‘Spotlight on 2024’ collection: A target trial emulation study found #bupropion was consistently associated with the least weight gain among 8 first-line #antidepressant treatments. https://t.co/fcdmuJ0UJf https://t.co/ICa9ZYaB0w

Feb 10, 2025 · 7 likes · 3 shares · 72,487 followers View post →
おくさん/OKUSUN
@Astella6174 · X

抗うつ薬と体重変化https://t.co/iGanenV5NR

Nov 5, 2024 · 1,185 followers View post →
P
@psychopharmacol · X

retro cohort study: Estimated 6-month weight gain was higher for escitalopram (MD=0.41 kg), paroxetine (0.37 kg), duloxetine (0.34 kg), venlafaxine (0.17 kg), and citalopram (0.12 kg) vs. sertraline https://t.co/A9cLgzJojM

Aug 30, 2024 · 1 like · 575 followers View post →
Lisa Nelson
@Lisa_198709 · X

RT @AnnalsofIM: Trending on https://t.co/HQyUgwV2bm: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Tri…

Aug 15, 2024 · 3 shares · 1,146 followers View post →
Mathijs C. Bunck
@1900b · X

RT @AnnalsofIM: Trending on https://t.co/HQyUgwV2bm: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Tri…

Aug 9, 2024 · 3 shares · 192 followers View post →
Jason Block
@jasonpblock · X

RT @AnnalsofIM: Trending on https://t.co/HQyUgwV2bm: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Tri…

Aug 9, 2024 · 3 shares · 830 followers View post →
Annals of Int Med
@AnnalsofIM · X

Trending on https://t.co/HQyUgwV2bm: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: https://t.co/6GmD867J71 https://t.co/KLIgiwywX4

Aug 9, 2024 · 4 likes · 3 shares · 72,487 followers View post →
ArkansasACP
@ArkansasACP · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study https://t.co/ovxjnu1fjN

Aug 5, 2024 · 293 followers View post →
IllinoisACP
@IllinoisACP · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study https://t.co/WIZU7Pz9DB

Aug 5, 2024 · 638 followers View post →
IndianaACP
@AcpIndiana · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study https://t.co/naQB7jurE7

Aug 5, 2024 · 315 followers View post →
ACPNewMexico
@ACPNewMexico · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study https://t.co/p94l4pWcyq

Aug 5, 2024 · 120 followers View post →
علي بن
@AMGALI0 · X

المصدر https://t.co/z3QlZ5a5tu

Aug 4, 2024 · 213 followers View post →
Revista MFAndalucia
@RevistaMFSamfyc · X

Cambios de peso inducidos por medicación a lo largo de los tratamientos con antidepresivos comunes: estudio por ensayo de emulación del objetivo https://t.co/Uj8qxIwDs1 PMID 38950403

Jul 29, 2024 · 723 followers View post →
Medicine Daily
@medidaily · X

Which #Antidepressants Cause the Most #WeightGain? A new study revealed that #escitalopram, #paroxetine, and #duloxetine were associated with higher risk of gaining weight, whereas #bupropion showed the least. #AnnalsofInternalMedicine https://t.co/K6rUtn5QgM

Jul 23, 2024 · 7 followers View post →
C☻Chihiro
@oki_13_love · X

RT @EARL_med_tw:

Jul 18, 2024 · 2 shares · 53 followers View post →
ほふほふSHIRO
@Aes3215M · X

RT @EARL_med_tw:

Jul 18, 2024 · 2 shares · 128 followers View post →
EARLの医学&AIノート
@EARL_med_tw · X

Jul 18, 2024 · 8 likes · 2 shares · 148,053 followers View post →
drvin33
@drvin33 · X

RT @hyderabaddoctor: Correct answer is: Bupropion (Ref: https://t.co/zToWIkQsAa) (Note: Please follow your psychiatrist's advice regardin…

Jul 14, 2024 · 1 share · 592 followers View post →
Muhammad Umar Kamal, MD, ABOM-D, FACP
@Muk5332 · X

RT @davearterburn: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Inte…

Jul 11, 2024 · 5 shares · 375 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Internal Medicine: Vol 0, No 0 https://t.co/g7y8BM23XK

Jul 9, 2024 · 2 likes · 1,294 followers View post →
Walter Arruda
@woleschkoa · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Internal Medicine: Vol 0, No 0 https://t.co/CT2U2RvOrf

Jul 9, 2024 · 1 like · 54 followers View post →
Adrien Catteau
@AdrienCatteau · X

RT @mickael_sp:

Jul 9, 2024 · 2 shares · 85 followers View post →
milodo
@sadlergo · X

RT @mickael_sp:

Jul 9, 2024 · 2 shares · 284 followers View post →
Dr. Mick
@mickael_sp · X

Jul 9, 2024 · 7 likes · 2 shares · 6,935 followers View post →
Orlando_uy
@Orlando_uy · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study. https://t.co/KBjfzX4gev

Jul 8, 2024 · 1 like · 693 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @pinacol: 【RCT模倣研究】セルトラリンと比較して、エスシタロプラム、パロキセチン、デュロキセチン、ベンラファキシンおよびシタロプラムはより大きな体重増加が見込まれた。フルオキセチンは同様の体重増加をブプロピオンはより小さな体重増加が見込まれた。 #ペ読 htt…

Jul 7, 2024 · 1 share · 1,783 followers View post →
pinacol
@pinacol · X

【RCT模倣研究】セルトラリンと比較して、エスシタロプラム、パロキセチン、デュロキセチン、ベンラファキシンおよびシタロプラムはより大きな体重増加が見込まれた。フルオキセチンは同様の体重増加をブプロピオンはより小さな体重増加が見込まれた。 #ペ読 https://t.co/HFdx5pjqGE

Jul 7, 2024 · 2 likes · 1 share · 1,616 followers View post →
Dr Sudhir Kumar MD DM
@hyderabaddoctor · X

Correct answer is: Bupropion (Ref: https://t.co/zToWIkQsAa) (Note: Please follow your psychiatrist's advice regarding the choice, dose and duration of antidepressants)

Jul 6, 2024 · 6 likes · 1 share · 96,781 followers View post →
Salud juntos
@alfonso_casi · X

Cambio de peso inducido por medicamentos en tratamientos antidepresivos comunes: Se encontraron pequeñas diferencias en el cambio de peso medio entre 8 antidepresivos de primera línea, y el bupropión mostró consistentemente el menor aumento de peso,... https://t.co/NZVCBPsXAl

Jul 6, 2024 · 8,568 followers View post →
Arjun Nanda, MD
@arjunknanda · X

https://t.co/x7jt3LEYpf

Jul 5, 2024 · 851 followers View post →
がたいがでかい
@gataigadekai · X

RT @ichiipsy: ブプロピオンは日本では一般的でないけれど、体重増加については害が少ないそうだ。 Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target T…

Jul 5, 2024 · 2 shares · 414 followers View post →
NICKEL
@NZ90_NZ98 · X

RT @ichiipsy: ブプロピオンは日本では一般的でないけれど、体重増加については害が少ないそうだ。 Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target T…

Jul 5, 2024 · 2 shares · 141 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

ブプロピオンは日本では一般的でないけれど、体重増加については害が少ないそうだ。 Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Internal Medicine: Vol 0, No 0 https://t.co/FcRphIN2pX

Jul 5, 2024 · 5 likes · 2 shares · 78,977 followers View post →
Arjun Nanda, MD
@arjunknanda · X

https://t.co/x7jt3LEYpf

Jul 5, 2024 · 851 followers View post →
npnicolereina ♥️
@Whatsyourcause · X

https://t.co/HeaPNdCuJh Will I gain weight?! This is a very important question for a lot of patients prior to initiation of anti-depressant medication

Jul 3, 2024 · 3,308 followers View post →
Hmmm...
@HmmmNiceee · X

Researchers compared weight change across 8 common antidepressants for patients starting treatment. Study shows differences in weight, with bupropion consistently causing the least weight gain. Findings provide strong evidence on expected weight changes … https://t.co/pkxV8sGjdZ

Jul 3, 2024 · 340 followers View post →
Zubair Khan, MD, FACP, CMQ
@zubairkhan254 · X

RT @davearterburn: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Inte…

Jul 3, 2024 · 5 shares · 2,653 followers View post →
Drug Nutrition Interactions
@dninteractions · X

In a new study, antidepressants users had an adjusted rate ratio of 1.21 for >5% weight gain. Risk was elevated for at least 6 years follow-up. Escitalopram, paroxetine, and duloxetine users were 10%-15% more likely to gain weight compared to sertraline. https://t.co/MbX64Z5SBC https://t.co/Hv53o4nPCB

Jul 3, 2024 · 1 like · 107 followers View post →
Department of Population Medicine
@DeptPopMed · X

RT @davearterburn: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Inte…

Jul 3, 2024 · 5 shares · 1,272 followers View post →
田村綾子
@oosaka_tamura · X

RT @enango: 米国の8つの医療システムにおける2010~2019年までの電子カルテデータを用いた標的試験模倣(target trial emulation)では,うつ病の第一選択薬による推定6ヵ月体重増加は,服薬アドヒアランスは低かったものの,ブプロピオンが一貫して最…

Jul 3, 2024 · 1 share · 1,480 followers View post →
南郷 栄秀/Eishu NANGO, MD, PhD
@enango · X

米国の8つの医療システムにおける2010~2019年までの電子カルテデータを用いた標的試験模倣(target trial emulation)では,うつ病の第一選択薬による推定6ヵ月体重増加は,服薬アドヒアランスは低かったものの,ブプロピオンが一貫して最も体重増加が少なかった. https://t.co/NUnDvncAFi

Jul 3, 2024 · 3 likes · 1 share · 3,017 followers View post →
Department of Population Medicine
@DeptPopMed · X

RT @Pi_iDebbyLin: Our recent work investigated weight gain associated common antidepressants use. Check out the article here: https://t.co/…

Jul 3, 2024 · 1 share · 1,272 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

RT @davearterburn: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Inte…

Jul 2, 2024 · 5 shares · 9,552 followers View post →
Michael Cudworth, MD, FACS, DABS-FPD MBS
@mcudworth_MD · X

RT @davearterburn: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Inte…

Jul 2, 2024 · 5 shares · 1,196 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @3stars67664378:

Jul 2, 2024 · 3 shares · 1,783 followers View post →
Annals of Int Med
@AnnalsofIM · X

A target trial emulation study found bupropion was consistently associated with the least weight gain among 8 first-line antidepressant treatments. These findings could help guide treatment decisions for patients concerned about weight: https://t.co/6GmD867J71 https://t.co/DFYssNdR5F

Jul 2, 2024 · 2 likes · 72,487 followers View post →
Debby
@Pi_iDebbyLin · X

Our recent work investigated weight gain associated common antidepressants use. Check out the article here: https://t.co/HT7YPVSYdf

Jul 2, 2024 · 2 likes · 1 share · 166 followers View post →
David Arterburn, MD, MPH
@davearterburn · X

Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study: Annals of Internal Medicine @jasonpblock and colleagues https://t.co/BVXgaPnGxB

Jul 2, 2024 · 12 likes · 5 shares · 2,233 followers View post →
Department of Population Medicine
@DeptPopMed · X

Online now in @AnnalsofIM: a new study led by @DeptPopMed's Joshua Petimar adds rigorous evidence on expected weight gain across common first-line antidepressant treatments. Read what Dr. Petimar and team found: https://t.co/NLAnkPm9NU https://t.co/Mr1laQPvfM

Jul 2, 2024 · 2 likes · 1,272 followers View post →
@investigando
@rocatanho · X

Los principales antidepresivos inducen pocos cambios de peso, bupropion muestra la menor ganancia de peso, adhesión a medicamentos es baja, por lo que debe considerarse el aumento de peso cuando se inicien los antidepresivos #antidepressant #weight https://t.co/6xyyX1jqlx

Jul 2, 2024 · 399 followers View post →
kokohito222
@kokohito222 · X

RT @3stars67664378:

Jul 1, 2024 · 3 shares · 265 followers View post →
青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中!
@syuichiao89 · X

RT @3stars67664378:

Jul 1, 2024 · 3 shares · 8,603 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

Jul 1, 2024 · 9 likes · 3 shares · 1,783 followers View post →