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Cell Metab July 2024 PMID 38959864

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease.

Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica D Ewald, Jason C Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F Spigelman, Jocelyn E Manning Fox, James Lyon, Leanne Beet

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Mentions

57
Peak: 19 in Jul 2024
across 6 sources since May 2023

Extended reach

144,875
potential audience

Total likes

433

Video views

31,980

Mentions per month

May 2023 – Oct 2024

Where it's discussed

  • X / Twitter24 posts
  • News23 articles
  • Blogs4 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

Discussions reflect overall enthusiasm and recognition of the study's potential, with examples such as references to how proteomic markers may predict individual responses and the mention of implications for personalized healthcare. The tone is generally positive and forward-looking, highlighting appreciation for the scientific advancements presented.

AgreementModerate agreement

Most discussions acknowledge the importance and validity of the study, emphasizing how it advances understanding of insulin response heterogeneity.

InterestHigh interest

Participants show high curiosity about the implications, referencing proteomic predictors and personalized nutrition strategies.

EngagementModerate engagement

Comments often discuss specific methods, such as proteomics and multiomics analyses, indicating moderate but meaningful engagement.

ImpactModerate impact

The tone suggests that the research could influence future studies and clinical approaches, hinting at moderate perceived significance.

Abstract in brief

  • The study examined how insulin secretion varies among individuals, including those with type 2 diabetes, in response to different nutrients like glucose, amino acids, and fatty acids, finding that most islets had the strongest response to glucose.
  • Some donors' islets showed unusually high responses to amino acids or fatty acids compared to glucose, indicating heterogeneity in nutrient responsiveness, which was analyzed using multiomics techniques to identify molecular markers.
  • Researchers also tested stem cell-derived islets, finding they responded to fats but not to carbohydrates or proteins, suggesting these cells might be less mature, and highlighting the potential for personalized nutritional strategies based on insulin response profiles.]
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Top posts

Most liked on X and Bluesky
Cell Metabolism
@Cell_Metabolism · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEuD3 https://t.co/oK2uqNsWI4

Jul 5, 2024 · 20 likes · 5 shares · 53,910 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t.co/wmH7S8m3KG

Jul 2, 2024 · 15 likes · 4 shares · 6,450 followers View post →
Richard Sever
@cshperspectives · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/KnTTTyvoae

Jun 8, 2023 · 3 likes · 20,070 followers View post →
Islet Biology Lab - UMH
@isletbiologylab · X

Kolic et al. compared insulin secretion responses to carbohydrate, protein, and fat in human islets from donors with and without #T2D and defined the transcriptomic and proteomic mechanisms that underlie the variation in response to each macronutrient. https://t.co/mySYnsfDdn https://t.co/81Sc8Dehb3

Jul 2, 2024 · 3 likes · 1,158 followers View post →
medRxiv
@medrxivpreprint · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/zYUJEx10sB #medRxiv

May 28, 2023 · 17,457 followers View post →
Dr Mazen Ghaith
@mm_ghaith · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 7, 2024 · 5 shares · 2,826 followers View post →

All mentions

Jin Feng
@JinnnFeng · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease: Cell Metabolism https://t.co/Muc21oMdD9

Aug 26, 2024 · 35 followers View post →
Free56
@Free5620 · X

https://t.co/nsPD3Ef5dU

Aug 18, 2024 · 198 followers View post →
CNELM
@CNELM1 · X

https://t.co/UnuSQfzVQE A new study has shed new light on how different macronutrients might affect insulin secretion, suggesting that insulin secretion in response to nutrients may be more complex and individualized than previously believed. https://t.co/hQKSE5Xdtj

Aug 17, 2024 · 924 followers View post →
Emmy Vänman
@EmmyVanman · X

https://t.co/CgSSDsPk74

Jul 19, 2024 · 26 followers View post →
Clippie
@von_herren · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease: Cell Metabolism https://t.co/oEtssezfEH

Jul 14, 2024 · 114 followers View post →
Dr Mazen Ghaith
@mm_ghaith · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 7, 2024 · 5 shares · 2,826 followers View post →
Shiva Shankar S
@BioShankar · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 6, 2024 · 5 shares · 162 followers View post →
Lum Lab
@lum_lab · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 6, 2024 · 5 shares · 1,204 followers View post →
YU TAHARA
@YUTAHARA6 · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 5, 2024 · 5 shares · 313 followers View post →
BillOckham
@BillOccham0 · X

RT @Cell_Metabolism: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEu…

Jul 5, 2024 · 5 shares · 585 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/PUlLrtEuD3 https://t.co/oK2uqNsWI4

Jul 5, 2024 · 20 likes · 5 shares · 53,910 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease Cell Press https://t.co/RI4hb7E1Jf

Jul 3, 2024 · 2,569 followers View post →
Mourad Ferdaoussi
@mferdaoussi · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease - ScienceDirect https://t.co/hfEHMDWomc

Jul 3, 2024 · 298 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease: Cell Metabolism https://t.co/ODetT5XM7V

Jul 3, 2024 · 360 followers View post →
Hannah Fang PhD
@HanFang_Hannah · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease: Cell Metabolism https://t.co/SdZMWkj0SL

Jul 3, 2024 · 78 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

RT @Brunorm84: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t…

Jul 3, 2024 · 4 shares · 879 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @Brunorm84: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t…

Jul 3, 2024 · 4 shares · 1,467 followers View post →
Sai P Pydi
@saip_pydi · X

RT @Brunorm84: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t…

Jul 3, 2024 · 4 shares · 651 followers View post →
nike
@wot_mikey · X

RT @Brunorm84: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t…

Jul 2, 2024 · 4 shares · 476 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease @Cell_Metabolism https://t.co/wmH7S8m3KG

Jul 2, 2024 · 15 likes · 4 shares · 6,450 followers View post →
Islet Biology Lab - UMH
@isletbiologylab · X

Kolic et al. compared insulin secretion responses to carbohydrate, protein, and fat in human islets from donors with and without #T2D and defined the transcriptomic and proteomic mechanisms that underlie the variation in response to each macronutrient. https://t.co/mySYnsfDdn https://t.co/81Sc8Dehb3

Jul 2, 2024 · 3 likes · 1,158 followers View post →
BillOckham
@BillOccham0 · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease | medRxiv https://t.co/eFY0IBLfHH

Jun 20, 2023 · 585 followers View post →
Richard Sever
@cshperspectives · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/KnTTTyvoae

Jun 8, 2023 · 3 likes · 20,070 followers View post →
medRxiv
@medrxivpreprint · X

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://t.co/zYUJEx10sB #medRxiv

May 28, 2023 · 17,457 followers View post →