PubHawk
Circ Cardiovasc Imaging July 2024 PMID 39012946

Rapid Plaque Progression Is Independently Associated With Hyperglycemia and Low HDL Cholesterol in Patients With Stable Coronary Artery Disease: A PARADIGM Study.

Danilo Neglia, Chiara Caselli, Erica Maffei, Filippo Cademartiri, Antonella Meloni, Eduardo Bossone, Luca Saba, Sang-Eun Lee, Ji Min Sung, Daniele Andreini, Mouaz H Al-Mallah, Matthew J Budoff, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun

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Mentions

27
Peak: 14 in Jul 2024
across 2 sources since Jul 2024

Extended reach

298,202
potential audience

Total likes

8,650

Video views

206,510

Mentions per month

Jul 2024 – Oct 2025

Where it's discussed

  • X / Twitter23 posts
  • YouTube4 videos

AI synopsis

What people are saying

Discussions emphasize the significance of the findings, such as hyperglycemia and low HDL cholesterol driving plaque progression, with many users referencing specific data like 'rapid plaque progression' and praising the work’s methodology, tone, and potential impact on treatment strategies, which demonstrates strong support and active engagement with the research’s implications.

AgreementStrong agreement

Many discussions highlight the importance of the study’s findings, supporting its conclusions about risk factors like hyperglycemia and low HDL cholesterol.

InterestHigh interest

The participants show high interest, frequently referencing specific data points, such as plaque progression rates and risk factors, indicating active engagement.

EngagementHigh engagement

Posts compare the study with previous work, praise the methodology, and mention contributors, demonstrating deep engagement with the research.

ImpactHigh impact

Discussions emphasize the potential influence on clinical practices and future research, suggesting that the study could significantly shape understanding of coronary artery disease.

Abstract in brief

  • The study evaluated how various cardiometabolic risk factors, such as metabolic syndrome and individual factors like high fasting glucose and low HDL cholesterol, impact the progression of coronary plaque and the likelihood of major cardiovascular events in patients with stable coronary artery disease.
  • In a cohort of 1,200 patients followed over several years, 28% experienced rapid coronary plaque progression, identified primarily through increased atheroma volume, which indicates worsening arterial health.
  • The findings suggest that a combination of risk factors, particularly high blood sugar and blood pressure, significantly forecast both plaque progression and serious cardiovascular incidents, highlighting the importance of monitoring these factors in at-risk patients.
Read the full abstract

Top posts

Most liked on X and Bluesky
The Heart
@ZHeart11768530 · X

Jul 20, 2024 · 26 likes · 10 shares · 32,828 followers View post →
まいち
@maiti_86 · X

このように介入研究ではLDLと動脈硬化の因果関係を決定づけることはそもそも不可能である。 観察研究ではどのような結果になっているかといえば、こちらの論文の通り。 https://t.co/kwf3ujrxRY 4,260人の参加者でLDLと動脈硬化に相関がないことが示されている。最も大きな相関は高血糖+低HDL。 3/8 https://t.co/jnBdga06AJ

Apr 9, 2025 · 16 likes · 2 shares · 10,612 followers View post →
Dr. Filippo Cademartiri
@FCademartiri · X

RAPID PLAQUE PROGRESSION IS INDEPENDENTLY ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL CHOLESTEROL IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: A PARADIGM STUDY Neglia et al. Circulation: Cardiovascular Imaging Volume 17, Number 7 doi: 10.1161/CIRCIMAGING.123.016481 https://t.co/4LduvTReJ8

Jul 29, 2024 · 10 likes · 3 shares · 2,839 followers View post →
CircImaging
@CircImaging · X

In stable CAD, hyperglycemia & low HDL-C is associated with rapid Plaque Progression independently of other RFs, baseline plaque burden, and treatment @DaniloNeglia @Mumofsteel77 @FCademartiri @lucasabaITA @DAndreiniMD @almallahmo @BudoffMd @ChinnaiyanMD https://t.co/gt4B6ntAY8 https://t.co/zhbWIHUTlr

Jul 19, 2024 · 9 likes · 5 shares · 3,766 followers View post →
John Gillespie
@DrGillespie_GP · X

@AdrianSotoMota Is that a progression around three times as fast as those with metabolic syndrome with suspected/CAD? https://t.co/M2DH3QzEsY

Apr 11, 2025 · 4 likes · 1,061 followers View post →
まいち
@maiti_86 · X

@NATROM https://t.co/kwf3ujrxRY こちらの研究でもプラークの進行はHigh FPGとLow HDL-Cと関連しており、High LDL-Cとは相関していない。 プラークとLDL-Cが相関しないのにLDL-C高値が心血管イベントの原因となるのはどのような機序か？ 明確に回答しなさい。 https://t.co/skBF15o9U9

Sep 21, 2024 · 3 likes · 10,612 followers View post →

All mentions

Zed
@zz_2141 · X

@Pl4ntbased @BudoffMd Should add Neglia et al 2024, from PARADIGM cohort. https://t.co/JcjXhmtmJe Annual median of delta NCPV was 0.61 mm3 for MetS negative and 1.51 mm3 for MetS positive patients with stable CAD..

Apr 19, 2025 · 106 followers View post →
Austin Dudzinski, PharmD, BCACP
@ApoDudz · X

@MattCalkinsMD @JoshJwageman @realDaveFeldman @lipo_fan @BrianLenzkes "The combination of high FPG with low HDL-C levels, which is very frequent in diabetes and prediabetic states, is a strong and independent determinant of rapid coronary plaque progression, outperforming other cardiometabolic risk factors." https://t.co/mKxDhOAuZK https://t.co/BM3zh4R4VT

Apr 15, 2025 · 3 likes · 782 followers View post →
Jesper Lundbom
@JesperLundbom · X

@MohammedAlo @richcollins @ifixhearts @POTUS @DrMakaryFDA @RobertKennedyJr @DrAseemMalhotra Plenty of studies support a protective role for HDL. Example below. https://t.co/SB57YREaKs

Apr 14, 2025 · 1 like · 184 followers View post →
John Gillespie
@DrGillespie_GP · X

@AdrianSotoMota Is that a progression around three times as fast as those with metabolic syndrome with suspected/CAD? https://t.co/M2DH3QzEsY

Apr 11, 2025 · 4 likes · 1,061 followers View post →
Tabatha
@araran100 · X

RT @maiti_86: このように介入研究ではLDLと動脈硬化の因果関係を決定づけることはそもそも不可能である。 観察研究ではどのような結果になっているかといえば、こちらの論文の通り。 https://t.co/kwf3ujrxRY 4,260人の参加者でLDLと動脈硬化に…

Apr 9, 2025 · 2 shares · 17,534 followers View post →
辻さとし（コロナは普通に治ります）
@Favorite_3776 · X

RT @maiti_86: このように介入研究ではLDLと動脈硬化の因果関係を決定づけることはそもそも不可能である。 観察研究ではどのような結果になっているかといえば、こちらの論文の通り。 https://t.co/kwf3ujrxRY 4,260人の参加者でLDLと動脈硬化に…

Apr 9, 2025 · 2 shares · 886 followers View post →
まいち
@maiti_86 · X

このように介入研究ではLDLと動脈硬化の因果関係を決定づけることはそもそも不可能である。 観察研究ではどのような結果になっているかといえば、こちらの論文の通り。 https://t.co/kwf3ujrxRY 4,260人の参加者でLDLと動脈硬化に相関がないことが示されている。最も大きな相関は高血糖+低HDL。 3/8 https://t.co/jnBdga06AJ

Apr 9, 2025 · 16 likes · 2 shares · 10,612 followers View post →
Austin Dudzinski, PharmD, BCACP
@ApoDudz · X

https://t.co/mKxDhOAuZK

Feb 25, 2025 · 1 like · 782 followers View post →
まいち
@maiti_86 · X

@NATROM https://t.co/kwf3ujrxRY こちらの研究でもプラークの進行はHigh FPGとLow HDL-Cと関連しており、High LDL-Cとは相関していない。 プラークとLDL-Cが相関しないのにLDL-C高値が心血管イベントの原因となるのはどのような機序か？ 明確に回答しなさい。 https://t.co/skBF15o9U9

Sep 21, 2024 · 3 likes · 10,612 followers View post →
Mario E Napoles, MD
@MarioENapoles · X

RT @FCademartiri: RAPID PLAQUE PROGRESSION IS INDEPENDENTLY ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL CHOLESTEROL IN PATIENTS WITH STABLE C…

Jul 29, 2024 · 3 shares · 384 followers View post →
Jean Barahona
@JChrisBarahona · X

RT @FCademartiri: RAPID PLAQUE PROGRESSION IS INDEPENDENTLY ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL CHOLESTEROL IN PATIENTS WITH STABLE C…

Jul 29, 2024 · 3 shares · 321 followers View post →
Surenjav Chimed
@surenjav_ch · X

RT @FCademartiri: RAPID PLAQUE PROGRESSION IS INDEPENDENTLY ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL CHOLESTEROL IN PATIENTS WITH STABLE C…

Jul 29, 2024 · 3 shares · 203 followers View post →
Dr. Filippo Cademartiri
@FCademartiri · X

Study fulltext: https://t.co/541Ignb1AT Editorial fulltext: https://t.co/NLU4cx7WnO This is a great work from our team, and in particular from Danilo Neglia and Chiara Caselli with some help from my side and great help from Hyuk-Jae Chang and his team.

Jul 29, 2024 · 2,839 followers View post →
Dr. Filippo Cademartiri
@FCademartiri · X

RAPID PLAQUE PROGRESSION IS INDEPENDENTLY ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL CHOLESTEROL IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: A PARADIGM STUDY Neglia et al. Circulation: Cardiovascular Imaging Volume 17, Number 7 doi: 10.1161/CIRCIMAGING.123.016481 https://t.co/4LduvTReJ8

Jul 29, 2024 · 10 likes · 3 shares · 2,839 followers View post →
Ana Pau
@anapaulaacm · X

RT @ZHeart11768530:

Jul 20, 2024 · 10 shares · 157 followers View post →
juan ramon
@RamonTasmania · X

RT @ZHeart11768530:

Jul 20, 2024 · 10 shares · 96 followers View post →
Bayar Jaff
@JaffBayar · X

RT @ZHeart11768530:

Jul 20, 2024 · 10 shares · 605 followers View post →
Sintayehu Abebe
@sinta_gf · X

RT @ZHeart11768530:

Jul 20, 2024 · 10 shares · 453 followers View post →
The Heart
@ZHeart11768530 · X

Jul 20, 2024 · 26 likes · 10 shares · 32,828 followers View post →
Erwin Mulia
@ErwMulia · X

RT @CircImaging: In stable CAD, hyperglycemia & low HDL-C is associated with rapid Plaque Progression independently of other RFs, baseline…

Jul 19, 2024 · 5 shares · 392 followers View post →
Aloha Meave MD
@AlohaMeaveMD · X

RT @CircImaging: In stable CAD, hyperglycemia & low HDL-C is associated with rapid Plaque Progression independently of other RFs, baseline…

Jul 19, 2024 · 5 shares · 4,079 followers View post →
CircImaging
@CircImaging · X

In stable CAD, hyperglycemia & low HDL-C is associated with rapid Plaque Progression independently of other RFs, baseline plaque burden, and treatment @DaniloNeglia @Mumofsteel77 @FCademartiri @lucasabaITA @DAndreiniMD @almallahmo @BudoffMd @ChinnaiyanMD https://t.co/gt4B6ntAY8 https://t.co/zhbWIHUTlr

Jul 19, 2024 · 9 likes · 5 shares · 3,766 followers View post →
kogase
@puVZ2OqPcA66745 · X

Rapid Plaque Progression Is Independently Associated With Hyperglycemia and Low HDL Cholesterol in Patients With Stable Coronary Artery Disease: A PARADIGM Study | Circulation: Cardiovascular Imaging https://t.co/22arT4PT8h

Jul 17, 2024 · 7 followers View post →