Clin Pharmacol Ther November 2024 PMID 39054656

Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ-Tetrahydrocannabinol Without Improving Its Analgesic Properties.

Andriy A Gorbenko, Jules A A C Heuberger, Linda E Klumpers, Marieke L de Kam, Pamela K Strugala, Saco J de Visser, Geert J Groeneveld

Mentions

41
Peak: 19 in Sep 2024
across 5 sources since Jul 2024

Extended reach

192,992
potential audience

Total likes

61

Video views

569

Mentions per month

Jul 2024 – Mar 2025

Where it's discussed

  • X / Twitter27 posts
  • News6 articles
  • Blogs4 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect a consensus that the study's results are significant, with posts stating that CBD actually increases THC effects rather than decreasing them, challenging prior assumptions. The tone indicates concern about how these findings affect both medicinal and recreational cannabis use, especially when considering over-the-counter products, as exemplified by phrases like 'more evidence against the 'CBD moderates the effects of THC' hypothesis' and noting the effects even at low doses, which enhances the perceived impact.

AgreementStrong agreement

Most discussions highlight that the study challenges the common belief that CBD mitigates THC effects, indicating strong agreement with the publication's findings.

InterestModerate interest

Participants show moderate curiosity, particularly about low doses of CBD and its interactions with THC, indicating some engagement but not overwhelming interest.

EngagementHigh engagement

Posts systematically reference the research, emphasizing its implications and details such as plasma concentrations and psychoactive effects, demonstrating deep engagement.

ImpactHigh impact

The discussions suggest the findings could significantly influence public perceptions and usage of CBD, highlighting notable implications for health and regulatory policies.

Abstract in brief

  • The study found that taking 450mg of CBD actually increased the psychoactive and adverse effects of THC, rather than reducing them.
  • CBD did not improve THC's pain-relieving (analgesic) properties at any dose tested.
  • Including CBD increased the levels of THC and its metabolite in the blood, which might explain the heightened psychoactive effects.

Top posts

Most liked on X and Bluesky
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

'Present findings do not support the use of CBD to reduce adverse effects of oral THC or enhance THC analgesia.' #cannabis #CBD https://t.co/Z9Bh1J7ES0

Nov 13, 2024 · 20 likes · 2 shares · 35,227 followers View post →
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive, and autonomous effects of THC (#CBD can increase serum levels of #cannabis by affecting liver enzymes.. https://t.co/OQqQO111b2

Sep 5, 2024 · 20 likes · 7 shares · 35,227 followers View post →
METODOLOGICA_CL
@metodologica_cl · X

Sep 4, 2024 · 10 likes · 6 shares · 3,803 followers View post →
Matt Wall (@mattwall.bsky.social)
@m_wall · X

More evidence against the "CBD moderates the effects of THC" hypothesis... Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Analgesic Properties https://t.co/Geh22nljsd

Jul 30, 2024 · 1 like · 1 share · 9,496 followers View post →
Deep Search Selections
@deepsearch420 · X

@Ericcannavet https://t.co/4URKZFsdnx

Dec 27, 2024 · 1 like · 527 followers View post →
Edward Chesney
@ed_chesney · X

Even a very low dose of CBD (30mg oral) can interact with THC. Interesting implications for over-the-counter CBD products. https://t.co/v4LjbYxihC

Jul 29, 2024 · 1 like · 275 followers View post →

All mentions

Deep Search Selections
@deepsearch420 · X

@Ericcannavet https://t.co/4URKZFsdnx

Dec 27, 2024 · 1 like · 527 followers View post →
José (Andaluz) ❤️
@JosAndaluz7 · X

Dec 19, 2024 · 190 followers View post →
José (Andaluz) ❤️
@JosAndaluz7 · X

Dec 18, 2024 · 190 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @Peter_Grinspoon: 'Present findings do not support the use of CBD to reduce adverse effects of oral THC or enhance THC analgesia.' #cann…

Nov 13, 2024 · 2 shares · 10,816 followers View post →
Normalisera
@Sverige2019 · X

RT @Peter_Grinspoon: 'Present findings do not support the use of CBD to reduce adverse effects of oral THC or enhance THC analgesia.' #cann…

Nov 13, 2024 · 2 shares · 1,447 followers View post →
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

'Present findings do not support the use of CBD to reduce adverse effects of oral THC or enhance THC analgesia.' #cannabis #CBD https://t.co/Z9Bh1J7ES0

Nov 13, 2024 · 20 likes · 2 shares · 35,227 followers View post →
AnonymousPharmacist
@anonymouspharmd · X

@marclanders https://t.co/DOsiGzaOxT I found this interesting, you probably will too!

Sep 24, 2024 · 3,791 followers View post →
Bruce Wagner
@BruceWagne73510 · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 6, 2024 · 7 shares · 3,541 followers View post →
Seretoninen
@JTFS84 · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 6, 2024 · 7 shares · 991 followers View post →
AnonymousPharmacist
@anonymouspharmd · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 5, 2024 · 7 shares · 3,791 followers View post →
Sara Payan
@SaraMPayan · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 5, 2024 · 7 shares · 1,232 followers View post →
Rutgers NJMS Addiction Medicine
@Rutgers_ADM · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 5, 2024 · 7 shares · 368 followers View post →
Sir Gunjah LimpsAlot
@SLimpsalot · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 5, 2024 · 7 shares · 441 followers View post →
Ward Wyatt
@wardwyatt_ · X

RT @Peter_Grinspoon: Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive…

Sep 5, 2024 · 7 shares · 10,093 followers View post →
Grinspoon -- Grinspoon on Drugs
@Peter_Grinspoon · X

Co-administration of 450 mg CBD did not reduce, but instead significantly increased subjective, psychomotor, cognitive, and autonomous effects of THC (#CBD can increase serum levels of #cannabis by affecting liver enzymes.. https://t.co/OQqQO111b2

Sep 5, 2024 · 20 likes · 7 shares · 35,227 followers View post →
Arturo Trostel
@XxTurok · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 200 followers View post →
Francisco Figueroa
@PanchoFigueroas · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 2,624 followers View post →
Ricardo Pino
@Ricardo_Pino1 · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 166 followers View post →
Carlos Andrés Rodríguez Fernández
@CARLITIOX · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 1,143 followers View post →
Kenita
@kenitafunk · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 2,109 followers View post →
CayoCornelio
@CayoCornelio · X

RT @metodologica_cl:

Sep 4, 2024 · 6 shares · 2,476 followers View post →
METODOLOGICA_CL
@metodologica_cl · X

Sep 4, 2024 · 10 likes · 6 shares · 3,803 followers View post →
CannaWorld
@cannaworldsite · X

RT @CannaWorld4: Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Anal…

Sep 4, 2024 · 1 share · 39,959 followers View post →
Canna World
@CannaWorld4 · X

Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Analgesic Properties https://t.co/3bF9On4ffU

Sep 4, 2024 · 1 share · 21,199 followers View post →
Ernesto de Bernardis, MD
@debe · X

RT @m_wall: More evidence against the "CBD moderates the effects of THC" hypothesis... Cannabidiol Increases Psychotropic Effects and Plas…

Jul 30, 2024 · 1 share · 886 followers View post →
Matt Wall (@mattwall.bsky.social)
@m_wall · X

More evidence against the "CBD moderates the effects of THC" hypothesis... Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Analgesic Properties https://t.co/Geh22nljsd

Jul 30, 2024 · 1 like · 1 share · 9,496 followers View post →
Edward Chesney
@ed_chesney · X

Even a very low dose of CBD (30mg oral) can interact with THC. Interesting implications for over-the-counter CBD products. https://t.co/v4LjbYxihC

Jul 29, 2024 · 1 like · 275 followers View post →