Rev Cardiovasc Med August 2023 PMID 39076715

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Xinmin Li, Junzi Long, Qian Gao, Mengyang Pan, Jing Wang, Fangjie Yang, Yasu Zhang

Mentions

31
Peak: 10 in Jun 2024
across 5 sources since Aug 2023

Extended reach

457,483
potential audience

Total likes

5,558

Video views

218,943

Mentions per month

Aug 2023 – Dec 2025

Where it's discussed

  • X / Twitter26 posts
  • YouTube2 videos
  • TikTok1 posts
  • Reddit1 posts
  • News1 articles

AI synopsis

What people are saying

The overall tone reflects cautious interest, with comments like 'Positive effects on BP' and tips on artery health indicating some curiosity, while others critique study doses or question the real therapeutic value, highlighting uncertainty about its true impact and scientific consensus.

AgreementModerate agreement

Most posts acknowledge the publication's findings, though some, like Dr. Mike Hart, express skepticism about the dosage used in studies, suggesting moderate agreement overall.

InterestModerate interest

Posts show a moderate level of curiosity, with some sharing tips or summarizing findings, but others exhibit ambivalence or delay in forming opinions.

EngagementNeutral engagement

Engagement is varied; some posts share links or discuss dosing details, but many simply acknowledge the topic without deep analysis.

ImpactNeutral impact

The discussions indicate a limited immediate impact, as users express ongoing uncertainty about the clinical significance and mechanisms of Nattokinase.

Abstract in brief

  • This systematic review analyzed six clinical trials to assess how nattokinase, an enzyme from fermented soy, affects cardiovascular risk factors, finding that it can lower blood pressure and influence cholesterol levels.
  • Lower doses of nattokinase helped reduce total cholesterol, HDL, and LDL cholesterol, while higher doses increased total cholesterol but did not significantly change HDL or LDL levels.
  • Overall, nattokinase supplementation appeared safe with no significant adverse effects, although its impact on blood glucose and triglycerides was minimal or unclear.]

Top posts

Most liked on X and Bluesky
Paladin
@PaladinRood · X

Jun 12, 2024 · 45 likes · 8 shares · 60,437 followers View post →
Mike Hart, M.D
@drmikehart · X

The conclusions here on Nattokinase are not overly impressive due to low dosing in most studies. Effective dose = 10,800 FU/day. Most studies use 1000 - 3000 FU/day. Asprin 81mg and Vitamin K2 improve the response to Nattokinase. https://t.co/DBEx42TGLw https://t.co/QHbtIhfnNI

Aug 22, 2024 · 4 likes · 1 share · 66,560 followers View post →
Ford Brewer MD, MPH
@PrevMedHealth · X

How I Keep My Arteries Clean: Tip of the month: Nattokinase https://t.co/3n2PEPI2QJ via @YouTube

Aug 29, 2024 · 3 likes · 1,201 followers View post →
Art Assoiants
@aassoiants · X

@Mangan150 I looked into it too but verdict's still out it seems https://t.co/iwTRwQfwrf https://t.co/cnnlwSzBUA

May 16, 2024 · 2 likes · 1,125 followers View post →
floridanow1
@floridanow1 · X

@RareCoinsFTW

Dec 5, 2025 · 1 like · 80,519 followers View post →
Dr. Niccolo
@DrNiccollo · X

@ketofan1000 @jtsses @drpablocorral Does a systematic review of 23 of these studies work for you? https://t.co/yluZOszImT

Aug 15, 2025 · 1 like · 1,491 followers View post →

All mentions

floridanow1
@floridanow1 · X

@RareCoinsFTW

Dec 5, 2025 · 1 like · 80,519 followers View post →
Dr. Niccolo
@DrNiccollo · X

@ketofan1000 @jtsses @drpablocorral Does a systematic review of 23 of these studies work for you? https://t.co/yluZOszImT

Aug 15, 2025 · 1 like · 1,491 followers View post →
Danilift
@DT12300582892 · X

@thecryptomonk Nattokinase https://t.co/B5aZ2p5idD https://t.co/h8SEd31w8T et al. Positive effects on BP both Dys and sys

Apr 15, 2025 · 71 followers View post →
VooDoo17
@DumbocratD · X

@RealDrJaneRuby @bensmithlive

Feb 16, 2025 · 976 followers View post →
Divine Discontent
@TomTrampus · X

@KatjaSeruga @n1slovenija @SZgonik Presstitutka nagnusna, ali si v svojih kot grah velikih možganih sposobna predalati sporočilo teh treh znanstvenih objav? https://t.co/mpCfEzouh0 https://t.co/Y6h18KQdew https://t.co/p4kidRexTm

Oct 24, 2024 · 828 followers View post →
cacouteau
@cacouteau · X

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials https://t.co/w2MBNnj85O

Sep 9, 2024 · 2,847 followers View post →
Mikesherman
@Mikeshe63347211 · X

How I Keep My Arteries Clean: Tip of the month: Nattokinase https://t.co/97x4uofVa4 via @YouTube

Aug 29, 2024 · 620 followers View post →
Ford Brewer MD, MPH
@PrevMedHealth · X

How I Keep My Arteries Clean: Tip of the month: Nattokinase https://t.co/3n2PEPI2QJ via @YouTube

Aug 29, 2024 · 3 likes · 1,201 followers View post →
Menelaos
@Menelao16766603 · X

RT @drmikehart: The conclusions here on Nattokinase are not overly impressive due to low dosing in most studies. Effective dose = 10,800…

Aug 22, 2024 · 1 share · 25 followers View post →
Mike Hart, M.D
@drmikehart · X

The conclusions here on Nattokinase are not overly impressive due to low dosing in most studies. Effective dose = 10,800 FU/day. Most studies use 1000 - 3000 FU/day. Asprin 81mg and Vitamin K2 improve the response to Nattokinase. https://t.co/DBEx42TGLw https://t.co/QHbtIhfnNI

Aug 22, 2024 · 4 likes · 1 share · 66,560 followers View post →
Post-Buddhist Memes
@thepostbuddhist · X

@gregmushen https://t.co/MwsEzsiztn

Jul 13, 2024 · 1,098 followers View post →
laserplus
@laserplus4 · X

RT @PaladinRood:

Jul 7, 2024 · 8 shares · 49 followers View post →
Denise Profirio
@denise_profirio · X

RT @PaladinRood:

Jun 14, 2024 · 8 shares · 999 followers View post →
IZAH B PAVAO
@IzahPavao · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 453 followers View post →
Paola
@PaolaPedrosa4 · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 234 followers View post →
Eslí de Paula Andrade
@esli1971 · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 2,857 followers View post →
Lia Ma Souza
@liamariadesouza · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 1,466 followers View post →
Luis Luz
@luiscluz · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 5,640 followers View post →
T.F.G
@rushtfg · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 2,324 followers View post →
Elid@
@ElidaGo97465642 · X

RT @PaladinRood:

Jun 13, 2024 · 8 shares · 985 followers View post →
Mirian Garcia Siqueira Carneiro
@MirianGarciaSi1 · X

RT @PaladinRood:

Jun 12, 2024 · 8 shares · 1,499 followers View post →
Paladin
@PaladinRood · X

Jun 12, 2024 · 45 likes · 8 shares · 60,437 followers View post →
Art Assoiants
@aassoiants · X

@Mangan150 I looked into it too but verdict's still out it seems https://t.co/iwTRwQfwrf https://t.co/cnnlwSzBUA

May 16, 2024 · 2 likes · 1,125 followers View post →
Independent Mind Backup
@IndyGroupMedia · X

@lucindasan15671 @Truth_in_Number @sharkzfanz Why block me when I hadn’t responded?

Jan 13, 2024 · 24 followers View post →
Christian Tams MS RD LDN
@ChristianTams · X

@boydmyers Still a lot not known about the true therapeutic effects and underlying mechanisms, but no adverse effects really seen so might as well go for it. https://t.co/ozilTQoyAa https://t.co/A1d5Vtqzv4

Nov 2, 2023 · 1 like · 1,250 followers View post →
Reviews in Cardiovascular Medicine
@RCMjournal · X

#RCM-Vol. 24 No. 8

Aug 28, 2023 · 2,753 followers View post →
July 2025 Update: Nattokinase's Role in Fighting Inflammation and ...
News

doi:10.31083/j.rcm2408234. PMID: 39076715 PubMed. 9. Chiu HW, Chou CL, Lee KT, et al. Nattokinase attenuates endothelial inflammation through ...

Jul 14, 2025 View →
Principais Resultados Efeito sobre Lipídios Sanguíneos: A ... - TikTok
TikTok

... of Randomized Controlled Trials. Rev Cardiovasc Med. 2023; 24(8): 234. DOI: 10.31083/j.rcm2408234. #yakult #saude · som original · author · 9.

Jan 29, 2025 View →
Serrapeptase : r/Parkinsons
Reddit

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441630/ · https://www.imrpress.com/journal/RCM/24/8/10.31083/j.rcm2408234/htm · mudfud27. • 2y ago.

Jan 18, 2024 View →