Eur J Pharmacol October 2024 PMID 39084452

Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity.

Vilém Charvát, Anna Strnadová, Aneta Myšková, David Sýkora, Miroslava Blechová, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská, Andrea Pačesová

Mentions

13
Peak: 5 in Aug 2024
across 7 sources since Aug 2024

Extended reach

8,026
potential audience

Total likes

15

Video views

581

Mentions per month

Aug 2024 – Sep 2024

Where it's discussed

  • X / Twitter3 posts
  • News3 articles
  • YouTube2 videos
  • Blogs2 articles
  • Bluesky1 posts
  • Facebook1 posts
  • Instagram1 posts

AI synopsis

What people are saying

The discussions reflect a generally positive stance towards the research, with comments like 'Lipidized analogues show neuroprotective potential,' indicating interest in the therapeutic promise. The tone is informative rather than highly emotive, emphasizing the scientific implications without extensive critique, which explains the moderate scores in interest and impact.

AgreementModerate agreement

Most posts acknowledge the positive findings of the research, recognizing its potential benefits for treating obesity and neurodegenerative diseases.

InterestModerate interest

Discussions show moderate interest, with some posts highlighting the significance of lipidized analogs and their neuroprotective effects, but few delve deeply into technical details.

EngagementNeutral engagement

The level of engagement appears neutral overall, with some posts sharing the study's core findings but limited active debate or critical analysis.

ImpactModerate impact

Participants seem to see the research as potentially impactful, particularly in addressing obesity and neurodegeneration, though the overall discourse remains somewhat preliminary.

Abstract in brief

  • This study explores lipidized versions of the neuropeptide CART, which is known to suppress appetite and regulate neuroprotection, showing that these analogues can help reduce obesity and protect brain cells in mouse models, especially those with diet-induced issues like obesity and prediabetes.
  • The lipidized analogues demonstrated stronger binding, increased stability, and were more effective at preventing harmful tau protein changes associated with neurodegeneration, compared to non-lipid versions, indicating they could help with both metabolic and neurodegenerative conditions.
  • Specifically, the analog palm2SSCART61102 was effective in lowering weight, food intake, and tau pathology while boosting brain cell growth, suggesting it could be a promising candidate for treating obesity and related neurodegenerative diseases like Alzheimer's.]

Top posts

Most liked on X and Bluesky
IOCB Prague
@IOCBPrague · X

#research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: https://t.co/rpny5CRdzy https://t.co/9tUVOLnnVm

Aug 13, 2024 · 1 like · 1 share · 4,752 followers View post →
Jovita Mezquita Pla
@JovitaMezquita · X

CART actua reduïnt els #agregatsTau, responsables de la mort #neuronal en l’Alzheimer.  Publicat al European Journal of Pharmacology 2024. Charvát V, Strnadová A, Myšková A, et al. Euro J Pharmacol. 2024; 980:176864. doi: 10.1016/j.ejphar.2024.176864

Sep 2, 2024 · 1 like · 653 followers View post →
Czech Academy of Sciences
@CzechAcademy · X

RT @IOCBPrague: #research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show a…

Aug 13, 2024 · 1 share · 1,967 followers View post →
IOCB Prague
@iocbprague.bsky.social · Bluesky

#research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: doi.org/10.1016/j.ej... @iocbprague.bsky.social

Aug 13, 2024 View post →

All mentions

Jovita Mezquita Pla
@JovitaMezquita · X

CART actua reduïnt els #agregatsTau, responsables de la mort #neuronal en l’Alzheimer.  Publicat al European Journal of Pharmacology 2024. Charvát V, Strnadová A, Myšková A, et al. Euro J Pharmacol. 2024; 980:176864. doi: 10.1016/j.ejphar.2024.176864

Sep 2, 2024 · 1 like · 653 followers View post →
IOCB Prague
@iocbprague.bsky.social · Bluesky

#research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: doi.org/10.1016/j.ej... @iocbprague.bsky.social

Aug 13, 2024 View post →
Czech Academy of Sciences
@CzechAcademy · X

RT @IOCBPrague: #research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show a…

Aug 13, 2024 · 1 share · 1,967 followers View post →
IOCB Prague
@IOCBPrague · X

#research Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: https://t.co/rpny5CRdzy https://t.co/9tUVOLnnVm

Aug 13, 2024 · 1 like · 1 share · 4,752 followers View post →
Vilém Charvát, Dr Andrea Pačesová, Dr Lenka Maletínská [IMAGE ...
News

10.1016/j.ejphar.2024.176864. Keywords. /Life sciences/Physiology/Nutritional physiology; /Health and medicine/Diseases and disorders/Neurological disorders ...

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DOI: 10.1016/j.ejphar.2024.176864. linkinghub.elsevier.com/retrie … ii/S0014299924005533. 免责声明. 本公众号上的医疗信息仅作为信息资源提供与 ...

Aug 23, 2024 View →
Brain-protective molecules by IOCB Prague
Blogs

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Blogs

doi.org/10.1016/j.ejphar.2024.176864. Be the first to rate this article. Posted in: Medical Science News | Medical Research News | Medical ...

Aug 21, 2024 View →
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News

J. Pharmacol. 2024, 980. https://doi.org/10.1016/j.ejphar.2024.176864. IOCB Prague / The Institute of Organic Chemistry and Biochemistry of ...

Aug 21, 2024 View →
Skupina Dr. Lenky Maletínské z našeho ústavu vyvinula látku z ...
Facebook

... J. Pharmacol. 2024, 980, DOI: 10.1016/j.ejphar.2024.176864 #chemie #uochb #ceskaveda Akademie věd České republiky. Log in ·

Aug 21, 2024 View →
Skupina Dr. Lenky Maletínské z našeho ústavu vyvinula látku z ...
Instagram

... induced obesity. Eur. J. Pharmacol. 2024, 980, DOI: 10.1016/j.ejphar.2024.176864 #chemie #uochb #ceskaveda @akademievedcr".

Aug 21, 2024 View →