Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity.
The discussions reflect a generally positive stance towards the research, with comments like 'Lipidized analogues show neuroprotective potential,' indicating interest in the therapeutic promise. The tone is informative rather than highly emotive, emphasizing the scientific implications without extensive critique, which explains the moderate scores in interest and impact.
AgreementModerate agreement
Most posts acknowledge the positive findings of the research, recognizing its potential benefits for treating obesity and neurodegenerative diseases.
InterestModerate interest
Discussions show moderate interest, with some posts highlighting the significance of lipidized analogs and their neuroprotective effects, but few delve deeply into technical details.
EngagementNeutral engagement
The level of engagement appears neutral overall, with some posts sharing the study's core findings but limited active debate or critical analysis.
ImpactModerate impact
Participants seem to see the research as potentially impactful, particularly in addressing obesity and neurodegeneration, though the overall discourse remains somewhat preliminary.
Abstract in brief
This study explores lipidized versions of the neuropeptide CART, which is known to suppress appetite and regulate neuroprotection, showing that these analogues can help reduce obesity and protect brain cells in mouse models, especially those with diet-induced issues like obesity and prediabetes.
The lipidized analogues demonstrated stronger binding, increased stability, and were more effective at preventing harmful tau protein changes associated with neurodegeneration, compared to non-lipid versions, indicating they could help with both metabolic and neurodegenerative conditions.
Specifically, the analog palm2SSCART61102 was effective in lowering weight, food intake, and tau pathology while boosting brain cell growth, suggesting it could be a promising candidate for treating obesity and related neurodegenerative diseases like Alzheimer's.]
#research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: https://t.co/rpny5CRdzy https://t.co/9tUVOLnnVm
Aug 13, 2024 · 1 like · 1 share · 4,752 followersView post →
JP
Jovita Mezquita Pla
@JovitaMezquita · X
CART actua reduïnt els #agregatsTau, responsables de la mort #neuronal en l’Alzheimer.
Publicat al European Journal of Pharmacology 2024. Charvát V, Strnadová A, Myšková A, et al. Euro J Pharmacol. 2024; 980:176864. doi: 10.1016/j.ejphar.2024.176864
RT @IOCBPrague: #research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show a…
Aug 13, 2024 · 1 share · 1,967 followersView post →
IP
IOCB Prague
@iocbprague.bsky.social · Bluesky
#research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: doi.org/10.1016/j.ej...
@iocbprague.bsky.social
Scientists developed a new drug derived from a naturally occurring brain peptide, which suppresses appetite and shields the brain from Alzheimer's-related damage by reducing tau protein pathology, showing promise in…
Scientists led by Dr. Lenka Maletnsk developed a new compound derived from a natural brain peptide. It suppresses appetite and offers neuroprotection by reducing tau protein pathogenicity, potentially addressing obesity…
CART actua reduïnt els #agregatsTau, responsables de la mort #neuronal en l’Alzheimer.
Publicat al European Journal of Pharmacology 2024. Charvát V, Strnadová A, Myšková A, et al. Euro J Pharmacol. 2024; 980:176864. doi: 10.1016/j.ejphar.2024.176864
#research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: doi.org/10.1016/j.ej...
@iocbprague.bsky.social
RT @IOCBPrague: #research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show a…
Aug 13, 2024 · 1 share · 1,967 followersView post →
IP
IOCB Prague
@IOCBPrague · X
#research
Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity (Pačesová) - #EurJPharmacol: https://t.co/rpny5CRdzy https://t.co/9tUVOLnnVm
Aug 13, 2024 · 1 like · 1 share · 4,752 followersView post →
N
Vilém Charvát, Dr Andrea Pačesová, Dr Lenka Maletínská [IMAGE ...
News
10.1016/j.ejphar.2024.176864. Keywords. /Life sciences/Physiology/Nutritional physiology; /Health and medicine/Diseases and disorders/Neurological disorders ...