JCO Precis Oncol August 2024 PMID 39102632

Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers.

Thejus Jayakrishnan, Yasmine Baca, Joanne Xiu, Mehrie Patel, Benjamin A Weinberg, Emil Lou, Jashodeep Datta, Moh'd Khushman, Pat Gulhati, Sanjay Goel, Tiago Biachi de Castria, Vaia Florou, Kanika G Nair, Suneel D Kamath, Alok A Khorana

Download social card

Mentions

29
Peak: 28 in Aug 2024
across 2 sources since Aug 2024

Extended reach

68,877
potential audience

Total likes

60

Video views

27

Mentions per month

Aug 2024 – Sep 2024

Where it's discussed

  • X / Twitter28 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several posts praise the publication for identifying molecular differences in early-onset biliary tract cancers, calling it 'game-changing' and emphasizing the discovery of targetable alterations. The tone, filled with enthusiasm and references to collaborative efforts, indicates a high level of interest and perceived significance, although the overall impact is viewed as promising but still unfolding.

AgreementModerate agreement

Most discussions highlight support and praise for the research, emphasizing its importance and potential clinical impact, as seen in phrases like 'outstanding work' and 'congratulations.'

InterestHigh interest

The posts demonstrate high curiosity, especially around the implications of molecular differences and targeted therapies for early-onset cases, indicated by words like 'exciting' and 'significant.'

EngagementHigh engagement

Many comments go beyond surface-level appreciation, mentioning specifics such as genetic markers like FGFR2 fusion, and expressing enthusiasm about future applications and research collaborations.

ImpactModerate impact

The discussions reflect a perception that this publication could influence clinical approaches and personalized treatments, though some posts suggest it’s still early to judge the full impact.

Abstract in brief

  • The study investigates the molecular characteristics of early-onset biliary tract cancer (eoBTC) compared to average-onset biliary tract cancer (aoBTC) using data from 5,587 patients, with a focus on understanding biological differences and treatment implications.
  • Findings showed that eoBTC has a higher prevalence of certain genetic fusions, specifically the FGFR2 fusion, and distinct immune marker profiles compared to aoBTC, suggesting that eoBTC may have unique biological traits.
  • The median overall survival rate was better for eoBTC (16.5 months) compared to aoBTC (13.3 months), highlighting the significance of genetic testing for personalized treatment options in eoBTC patients.

Top posts

Most liked on X and Bluesky
Emil Lou, MD, PhD, FACP
@cancerassassin1 · X

Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this work: "Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers." https://t.co/7P33iWslN1 https://t.co/lvJrUtgq2F

Aug 6, 2024 · 34 likes · 12 shares · 6,953 followers View post →
JCO Precision Oncology
@JCOPO_ASCO · X

Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https://t.co/ECsAGfuPa9 @thejusjay @aakonc #gicsm

Aug 12, 2024 · 11 likes · 5 shares · 5,307 followers View post →
Thejus Jayakrishnan
@ThejusJay · X

For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contribution @SKamath_MD @kgnairmd @VaiaFlorou @BiachiTiago @khushmanmd @DrJashDatta @cancerassassin1 @benweinbergmd DrPatGulhati & DrSanjayGoel @RutgersCancer

Aug 13, 2024 · 10 likes · 5 shares · 1,134 followers View post →
Tiago Biachi
@BiachiTiago · X

Outstanding work @tejus_sawjiani ! Early onset cholangio with higher incidence of targetable alterations! Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers | JCO Precision Oncology https://t.co/uGOFDgzaU1

Aug 6, 2024 · 4 likes · 2,710 followers View post →
Oscar Tahuahua
@OscarTahuahua · X

Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers | JCO Precision Oncology https://t.co/cwwKhIe5s1 https://t.co/6vKqF1fdag

Aug 12, 2024 · 1 like · 1,371 followers View post →
Shaalan Beg MD MBA FASCO
@ShaalanBeg · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 7, 2024 · 12 shares · 7,269 followers View post →

All mentions

Mehrie H Patel, MBBS
@MehrieHPatel · X

RT @JCOPO_ASCO: Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https…

Aug 19, 2024 · 5 shares · 493 followers View post →
Vaia Florou, MD
@VaiaFlorou · X

RT @ThejusJay: For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contrib…

Aug 14, 2024 · 5 shares · 184 followers View post →
Jash Datta, MD
@DrJashDatta · X

RT @ThejusJay: For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contrib…

Aug 13, 2024 · 5 shares · 3,612 followers View post →
Moh’d khushman
@khushmanmd · X

RT @ThejusJay: For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contrib…

Aug 13, 2024 · 5 shares · 602 followers View post →
Hee Seung Lee
@hsleegioncology · X

RT @JCOPO_ASCO: Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https…

Aug 13, 2024 · 5 shares · 48 followers View post →
Gavin Strachan
@CCGav · X

RT @JCOPO_ASCO: Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https…

Aug 13, 2024 · 5 shares · 258 followers View post →
Milind Javle
@JavleMilind · X

RT @JCOPO_ASCO: Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https…

Aug 13, 2024 · 5 shares · 1,859 followers View post →
Emil Lou, MD, PhD, FACP
@cancerassassin1 · X

RT @ThejusJay: For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contrib…

Aug 13, 2024 · 5 shares · 6,953 followers View post →
Suneel Kamath MD
@SKamath_MD · X

RT @ThejusJay: For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contrib…

Aug 13, 2024 · 5 shares · 2,666 followers View post →
Thejus Jayakrishnan
@ThejusJay · X

For more details- https://t.co/XKwVmCByRI Thanks to experts @ClevelandClinic & across the country for their valuable contribution @SKamath_MD @kgnairmd @VaiaFlorou @BiachiTiago @khushmanmd @DrJashDatta @cancerassassin1 @benweinbergmd DrPatGulhati & DrSanjayGoel @RutgersCancer

Aug 13, 2024 · 10 likes · 5 shares · 1,134 followers View post →
Benjamin Weinberg, MD, FACP
@benweinbergmd · X

RT @JCOPO_ASCO: Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https…

Aug 12, 2024 · 5 shares · 2,813 followers View post →
Oscar Tahuahua
@OscarTahuahua · X

Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers | JCO Precision Oncology https://t.co/cwwKhIe5s1 https://t.co/6vKqF1fdag

Aug 12, 2024 · 1 like · 1,371 followers View post →
JCO Precision Oncology
@JCOPO_ASCO · X

Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers: https://t.co/ECsAGfuPa9 @thejusjay @aakonc #gicsm

Aug 12, 2024 · 11 likes · 5 shares · 5,307 followers View post →
Vaia Florou, MD
@VaiaFlorou · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 8, 2024 · 12 shares · 184 followers View post →
Madison Conces, MD
@MadisonConces · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 8, 2024 · 12 shares · 1,072 followers View post →
Joao Fogacci
@FogacciJoao · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 8, 2024 · 12 shares · 725 followers View post →
Benjamin Weinberg, MD, FACP
@benweinbergmd · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 7, 2024 · 12 shares · 2,813 followers View post →
Shaalan Beg MD MBA FASCO
@ShaalanBeg · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 7, 2024 · 12 shares · 7,269 followers View post →
Colm O'Rourke
@ColmJJORourke · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 7, 2024 · 12 shares · 548 followers View post →
Jash Datta, MD
@DrJashDatta · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 3,612 followers View post →
Tiago Biachi
@BiachiTiago · X

Outstanding work @tejus_sawjiani ! Early onset cholangio with higher incidence of targetable alterations! Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers | JCO Precision Oncology https://t.co/uGOFDgzaU1

Aug 6, 2024 · 4 likes · 2,710 followers View post →
UofU3i
@UofU3i · X

New 3i Investigator Article Alert!! Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers https://t.co/Z46xZPMMZ2

Aug 6, 2024 · 1,179 followers View post →
Smitha Krishnamurthi
@smitha42 · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 2,692 followers View post →
Pat Adams
@PathologyPat · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 1,516 followers View post →
Suneel Kamath MD
@SKamath_MD · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 2,666 followers View post →
Amanda Nizam, MD
@AmandaNizamMD · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 2,103 followers View post →
Alok Khorana, MD
@aakonc · X

RT @cancerassassin1: Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this wo…

Aug 6, 2024 · 12 shares · 5,076 followers View post →
Emil Lou, MD, PhD, FACP
@cancerassassin1 · X

Congratulations @ThejusJay @aakonc and multi-institutional collaborative team on publication in @JCOPO_ASCO of this work: "Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers." https://t.co/7P33iWslN1 https://t.co/lvJrUtgq2F

Aug 6, 2024 · 34 likes · 12 shares · 6,953 followers View post →