JAMA Psychiatry November 2024 PMID 39167392

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood.

Edward R Palmer, Isabel Morales-Muñoz, Benjamin I Perry, Steven Marwaha, Ella Warwick, Jack C Rogers, Rachel Upthegrove

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139
Peak: 92 in Aug 2024
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AI synopsis

What people are saying

In the discussions, several users emphasized the correlation between persistent inflammation and mental health disorders, particularly mentioning 'higher risk of serious mental health disorders, including psychosis and depression.' References to specific metrics, like CRP levels, and terms like 'chronic childhood illness as a marker for mental illness' contribute to a tone of urgency and seriousness, indicating a keen awareness of the publication's implications.

AgreementModerate agreement

Many discussions reflect support for the article's findings, with several users highlighting the connection between inflammation and mental health.

InterestHigh interest

Posts show a high level of interest in the topic, as participants are eager to share insights and findings from the research.

EngagementModerate engagement

There is a moderate depth of engagement, with some users referencing specific results and implications of the study.

ImpactHigh impact

Participants perceive the publication as having a significant impact on understanding mental health risks associated with inflammation.

Abstract in brief

  • Research indicates that ongoing low-grade inflammation may be a precursor to mental and physical health issues in adulthood, but most evidence has been limited to specific disorders or cross-sectional studies.
  • The study aimed to analyze inflammation patterns in children and adolescents using C-reactive protein (CRP) levels and assess their connections to mental and cardiometabolic health outcomes in early adulthood.
  • Out of 6,556 participants, three distinct inflammation trajectories were identified: persistently low, early peak at age 9, and late peak at age 17, with the early peak group showing a significantly higher risk for psychotic disorders.

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JAMA Psychiatry
@JAMAPsych · X

Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9, was associated with increased risk of developing psychosis disorder, severe depression, and higher levels of insulin resistance. https://t.co/k3zfV8OGAS

Aug 23, 2024 · 54 likes · 17 shares · 56,634 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9, was associated with increased risk of developing psychosis disorder, severe depression, and higher levels of insulin resistance. https://t.co/Flrf2hmHdm https://t.co/0yogts0bpo

Dec 2, 2024 · 43 likes · 17 shares · 56,634 followers View post →
Edward Palmer
@EdPalmer5 · X

Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood @CO90s @IMH_UoB https://t.co/l7LKGQ5J7o

Aug 21, 2024 · 31 likes · 7 shares · 359 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood” by Edward Palmer et al. JAMA Psychiatry https://t.co/bqbWPB65Xr 3/3

Aug 21, 2024 · 14 likes · 3 shares · 505,535 followers View post →
Outbreak Updates
@outbreakupdates · X

Low-grade persistent inflammation in early life is an important shared common factor for mental-physical comorbidity. https://t.co/XZZEldaBRY

Sep 30, 2024 · 7 likes · 100,799 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://t.co/5U01aUCRCT

Nov 7, 2024 · 2 likes · 71,732 followers View post →

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Ligaya Reyes (Nat)
@LigayaReyes8 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Jul 17, 2025 · 122 shares · 229 followers View post →
Dr. Paul Cottrell
@dr_cottrell · X

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://t.co/agAbnJuPz6 https://t.co/VrcxSNGgM1

Dec 11, 2024 · 10,327 followers View post →
Phil Anderson
@Dr_PhilAnderson · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Dec 2, 2024 · 17 shares · 3,870 followers View post →
Luis Fernando Gómez Gutiérrez.
@LuisFernandoGm6 · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Dec 2, 2024 · 17 shares · 1,764 followers View post →
Pablo Zapata, PhD
@JuanPablo_Zap · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Dec 2, 2024 · 17 shares · 754 followers View post →
Michele Santoni
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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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Dr Adriana G. Nevarez Flores
@Dr_GabyNevarez · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Dec 2, 2024 · 17 shares · 130 followers View post →
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@sandra04850184 · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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ほねたらこ
@lifelog_hone · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Dec 2, 2024 · 17 shares · 43 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9, was associated with increased risk of developing psychosis disorder, severe depression, and higher levels of insulin resistance. https://t.co/Flrf2hmHdm https://t.co/0yogts0bpo

Dec 2, 2024 · 43 likes · 17 shares · 56,634 followers View post →
Yasser Ad-Dab'bagh ياسر الدباغ
@yasseraddabbagh.bsky.social · Bluesky

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2822343?utm_source=twitter&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=110724

Nov 7, 2024 View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://t.co/5U01aUCRCT

Nov 7, 2024 · 2 likes · 71,732 followers View post →
Outbreak Updates
@outbreakupdates · X

Low-grade persistent inflammation in early life is an important shared common factor for mental-physical comorbidity. https://t.co/XZZEldaBRY

Sep 30, 2024 · 7 likes · 100,799 followers View post →
Marta Noya (Martouta)
@MartoutaTech · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Sep 1, 2024 · 122 shares · 1,124 followers View post →
Bina Pattel
@BinaPattel · X

INFLAMMATION DURING CHILDHOOD LINK ONSET OF MENTAL HEALTH ISSUES IN EARLY ADULTHOOD – NEW STUDY https://t.co/XOUeiWLK4K PERSISTENT RAISED INFLAMMATION – HIGHER RISK OF SERIOUS MENTAL HEALTH DISORDERS, INCLUDING PSYCHOSIS AND DEPRESSION IN EARLY ADULTHOOD https://t.co/3G24r7AZ15 https://t.co/0mE8C46CgH

Aug 31, 2024 · 36 followers View post →
Maysa
@MaysaFina_ · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 30, 2024 · 122 shares · 198 followers View post →
LindaJ
@IronLindaJ · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 30, 2024 · 122 shares · 878 followers View post →
Angelica Miriam Yañez Zubieta
@mompsiqstylist · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@SLimpsalot · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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blueranger buses
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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

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@JamieLarsH · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Aug 23, 2024 · 17 shares · 9,660 followers View post →
M
@micmicmic1 · X

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood | Adolescent Medicine | JAMA Psychiatry | JAMA Network https://t.co/aVVSVCbkIb

Aug 23, 2024 · 1,622 followers View post →
Agnes Ayton
@AgnesAyton · X

RT @JAMAPsych: Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9,…

Aug 23, 2024 · 17 shares · 7,381 followers View post →
JAMA Psychiatry
@JAMAPsych · X

Having persistently raised levels of inflammation as measured by CRP throughout childhood and adolescence, peaking at age 9, was associated with increased risk of developing psychosis disorder, severe depression, and higher levels of insulin resistance. https://t.co/k3zfV8OGAS

Aug 23, 2024 · 54 likes · 17 shares · 56,634 followers View post →
Debbie Hampton
@dlhampton · X

RT @Dra_TeraizaMesa: “Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood” by Edward Palmer…

Aug 23, 2024 · 1 share · 11,721 followers View post →
MeraltrTr
@MeraltrTr · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 23, 2024 · 122 shares · 989 followers View post →
Mrs M
@ShonaMorrison17 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 23, 2024 · 122 shares · 313 followers View post →
AliceInReality
@reality_alice · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@CounsellingSam · X

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@hopestardust20 · X

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The Health Matrix
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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XenaWarrior
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Aug 22, 2024 · 122 shares · 40,537 followers View post →
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@ENM1989 · X

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@lowrigriffiths_ · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 22, 2024 · 7 shares · 1,381 followers View post →
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@EllaAkman · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 87 followers View post →
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@DrJessieKeener · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 6,438 followers View post →
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@MarcyZgela · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 1,075 followers View post →
Dra. Teraiza Mesa R Cuenta Oficial ®
@Dra_TeraizaMesa · X

“Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood” by Edward Palmer et al. JAMA Psychiatry https://t.co/QsYL5ZPJCX… https://t.co/5k2TgVx72P

Aug 22, 2024 · 2 likes · 1 share · 9,069 followers View post →
WJW Mental Health Legal Fund
@wjwmhlf · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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Mind Your Science!
@MindYourSci · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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FT2D_Drew
@FT2D_DREW · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 5,709 followers View post →
Dr Ruby Tsang
@rubietsang · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 22, 2024 · 7 shares · 453 followers View post →
Paddy
@Paddy37927511 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 175 followers View post →
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@AndrewMcKune · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 1,896 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@PaulJSebastian · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 111 followers View post →
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@hkleemd · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 121 followers View post →
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@MarkusOfCoast · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 223 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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The Chronicles of Chris Young PSA scrub-your-hands
@YoungChris27040 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 5,800 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 585 followers View post →
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@selam_111 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 60 followers View post →
Petersen82
@pap1612 · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 213 followers View post →
Jonathan Rogers
@drjprogers · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 22, 2024 · 7 shares · 2,512 followers View post →
KindOfDesign
@kindofdesign · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 292 followers View post →
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@BenstherDf · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@dietamz · X

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@lulopson · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 454 followers View post →
Prof.dr Nikola Ilanković
@PIlankovic · X

Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://t.co/ImlBGsVKtk

Aug 22, 2024 · 1 like · 51 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 1,131 followers View post →
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@AlbertLakeElf · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 51 followers View post →
john williams
@wi_john · X

Chronic childhood illness a marker for mental illness, study shows - https://t.co/w6DAlD7Ruo https://t.co/WCL3qBK04Z

Aug 22, 2024 · 1 like · 3,173 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 22, 2024 · 122 shares · 956 followers View post →
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Aug 22, 2024 · 122 shares · 680 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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中武 壮以知
@soichinakatake · X

子供の頃に低レベルの慢性的な炎症が増加すると、成人初期での精神病性障害、重度のうつ病、およびインスリン抵抗性レベルの上昇のリスクが増加する可能性。 Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood https://t.co/fWvmk2Igze

Aug 21, 2024 · 138 followers View post →
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@KineticImpactRP · X

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@toothdoc3 · X

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@psi_001 · X

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@levsolonothan · X

RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 21, 2024 · 122 shares · 68 followers View post →
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@Richard79215390 · X

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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@_kabro_ · X

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Aug 21, 2024 · 3 shares · 332 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

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Aug 21, 2024 · 122 shares · 3,483 followers View post →
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RT @ChrisPalmerMD: High levels of inflammation throughout childhood and adolescence, peaking at age 9 years, are associated with an increas…

Aug 21, 2024 · 122 shares · 1,472 followers View post →
Dom Oliver
@Dom__Oliver · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 21, 2024 · 7 shares · 834 followers View post →
Laavanya Damodaran
@Laavanya_ · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 21, 2024 · 7 shares · 243 followers View post →
Dr Keri Wong
@DrKeriWong · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 21, 2024 · 7 shares · 2,184 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood” by Edward Palmer et al. JAMA Psychiatry https://t.co/bqbWPB65Xr 3/3

Aug 21, 2024 · 14 likes · 3 shares · 505,535 followers View post →
sally palmer
@sallypalmer50 · X

RT @EdPalmer5: Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Y…

Aug 21, 2024 · 7 shares · 9 followers View post →
Edward Palmer
@EdPalmer5 · X

Very excited to announce the publication of my first paper from PhD in @JAMAPsych entitled Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood @CO90s @IMH_UoB https://t.co/l7LKGQ5J7o

Aug 21, 2024 · 31 likes · 7 shares · 359 followers View post →