The discussions frequently cite the study's findings about Numts accumulating in the brain and fibroblasts, with phrases like 'an impressive finding' and 'a new type of jumping gene' conveying curiosity and significance. The tone, rich with scientific references and technical terms, indicates a strong interest and engagement with the content's potential impact on understanding aging and genetic evolution.
AgreementModerate agreement
Many discussions recognize the prevalence and significance of mitochondrial DNA transfers, indicating general support for the article’s findings.
InterestHigh interest
The discussions consistently emphasize mitochondria, aging, and cellular mechanisms, reflecting high curiosity toward the scientific implications.
EngagementModerate engagement
Participants discuss the research methods, potential biological impacts, and evolutionary aspects, showing moderate to deep engagement.
ImpactModerate impact
While the discussions highlight the importance of the findings, they mainly speculate on implications rather than demonstrating immediate societal or medical impacts.
Abstract in brief
Somatic nuclear mitochondrial DNA insertions, called Numts, are common in the human brain and tend to increase with age, especially in brain areas like the dorsolateral prefrontal cortex.
The study found that individuals who died younger or had no cognitive impairment had more Numts, suggesting a link between Numt accumulation and earlier mortality or brain health.
Experimental evidence from human fibroblast cells showed that Numts gradually accumulate over time at a rate of about one every 13 days, and factors like mitochondrial DNA instability can accelerate this process.]
In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus, changing the nuclear genomic sequence. One interpretation of this is that bioenergetic defects help accelerate evolution.
https://t.co/EqZ8GdCNc0 https://t.co/Rvg38ts3AZ
Feb 6, 2025 · 72 likes · 14 shares · 26,446 followersView post →
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts https://t.co/1VGxHe47lL #biorxiv_genomic
Feb 5, 2023 · 13 likes · 3 shares · 11,973 followersView post →
MM
Madam Mitochondria
@Madam_Mito · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts | bioRxiv https://t.co/msf8ezc50y
Feb 8, 2023 · 10 likes · 4 shares · 10,894 followersView post →
HW
Hansi WEISSENSTEINER
@whansi · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts #preprint https://t.co/Yb6IWbRWWG
Feb 7, 2023 · 9 likes · 2 shares · 549 followersView post →
T
thmonk
@thmonk_pf · X
ヒト脳/体細胞のmitchondria DNAの核genome挿入(Numts)を調べたところ、脳、特に前頭前野でNumtが高頻度に蓄積し若年死亡と関連
小脳と比較しDLPFCでNumtが5.5倍
Numtは老化や種々の表現型に関与する新たなゲノム変異となる可能性
OA
#mitchondria
#aging
#papers
https://t.co/cqdjvwqjy2 https://t.co/7X6vxt4Ixy
Aug 27, 2024 · 8 likes · 1 share · 1,672 followersView post →
These worms played a crucial role in the evolution of complex life on Earth. Recent discoveries also include new dinosaur species in China and insights into whale hunting abilities.
Somatic nuclear mitochondrial DNA insertions, called Numts, are common in the human brain and tend to increase with age, especially in areas like the dorsolateral prefrontal cortex. The study links Numt accumulation…
@arubikscube Everything's coming up mitochondria
"Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain" https://t.co/LlylvhbUIy
"The social nature of mitochondria" https://t.co/iFwCFmtEJp
"Mitochondrial origins of the pressure to sleep" https://t.co/coj92FVtE2
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
May 13, 2025 · 84 shares · 2,170 followersView post →
H
Hypersane
@hypersane24 · X
@Madam_Mito @OutlawsPoetic The linked tweet in the quote looks pretty interesting but the account is "Protected" so I can't read it.
Anyway if you're really into mitochondria have you seen these papers yet?
https://t.co/ItDFFKOhWr
https://t.co/0IDGcYGinC
RT @MitoPsychoBio: In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus…
Feb 6, 2025 · 14 shares · 1,226 followersView post →
A
ASHZEN
@ASHZEN17 · X
RT @MitoPsychoBio: In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus…
Feb 6, 2025 · 14 shares · 5,249 followersView post →
FE
Fibelius.eth
@MycelFi · X
RT @MitoPsychoBio: In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus…
Feb 6, 2025 · 14 shares · 3,528 followersView post →
ID
Iain Campbell, Ph.D.
@IainCampbellPhD · X
RT @MitoPsychoBio: In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus…
Feb 6, 2025 · 14 shares · 6,924 followersView post →
P
P123
@P1231032850 · X
RT @MitoPsychoBio: In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus…
Feb 6, 2025 · 14 shares · 3,428 followersView post →
MP
Martin Picard
@MitoPsychoBio · X
In human cells with mitochondrial defects, we have seen an accelerated rate of mitochondrial DNA transfer to the nucleus, changing the nuclear genomic sequence. One interpretation of this is that bioenergetic defects help accelerate evolution.
https://t.co/EqZ8GdCNc0 https://t.co/Rvg38ts3AZ
Feb 6, 2025 · 72 likes · 14 shares · 26,446 followersView post →
MP
Martin Picard
@MitoPsychoBio · X
Original paper on Numts insertions in the human brain and cultured cells: https://t.co/EqZ8GdDl1y
Work by @kalpitark @ArthurZhou10 @ryan_e_mills
Jan 27, 2025 · 7 likes · 26,446 followersView post →
C
CMaxwell
@MitoFitNurse · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Jan 6, 2025 · 30 shares · 256 followersView post →
MW
MeiLing Wong
@its_meiling1 · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Nov 17, 2024 · 84 shares · 82 followersView post →
Ά
Άντζελα
@SouthernGemGal · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Oct 25, 2024 · 84 shares · 3,137 followersView post →
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Mart
@Mart23265574799 · X
RT @OACerebro:
Oct 13, 2024 · 13 shares · 50 followersView post →
OC
Oleg A. Chagin
@Oleg_A_Chagin · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PLOS Biology https://t.co/V4s4OlDC2v
Somewhat intriguingly mitochondria implant their own DNA into our chromosomes within our lifetimes - including in the brain! In particular, the frontal cortex where accumulation of mitochondrial DNA increases mortality https://t.co/WO8HxA4JVj
Oct 4, 2024 · 7 likes · 2 shares · 23,147 followersView post →
MR
Maria Robles
@RBioceutics · X
RT @Pluchinolab: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
htt…
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PLOS Biology https://t.co/7EIqijY6o2
"Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts"
Zhou W, Karan KR [..] Picard M, Mills RE.
PLoS Biology. 2024-08-22
https://t.co/TErQmIC6Uz
Sep 2, 2024 · 1 like · 1 share · 1,936 followersView post →
The study’s findings open the possibility that mito-nuclear horizontal gene transfer among human postmitotic tissues produces functionally relevant human Numts over timescales shorter than previously assumed. 19/19
https://t.co/nKe9ytKl5F https://t.co/zX7aAho5f2
درج DNA میتوکندری هستهای سوماتیک درمغز انسان به طور گستردهای مشاهده میشود و با گذر زمان در فیبروبلاستها تجمع میکند. این پدیده میتواند تأثیرات قابل توجهی بر عملکرد سلولی و سلامت بافتهاداشته باشد،و به درک بهتر فرآیندهای پیری و بیماریهای عصبی کمک کند.
https://t.co/cSKXqAFfdi
Aug 31, 2024 · 5 likes · 5,370 followersView post →
JS
Journal of Health and Rehabilitation Sciences
@journaljhrs · X
RT @EmLyWill: Basically, a new type of jumping gene! Mitochondrial DNA insertions into nuclear genome preferentially accumulate in brain ce…
Basically, a new type of jumping gene! Mitochondrial DNA insertions into nuclear genome preferentially accumulate in brain cells and other long-lived cells of the body. https://t.co/BPaaBtaQfF
Aug 31, 2024 · 3 likes · 1 share · 2,105 followersView post →
ヒト脳/体細胞のmitchondria DNAの核genome挿入(Numts)を調べたところ、脳、特に前頭前野でNumtが高頻度に蓄積し若年死亡と関連
小脳と比較しDLPFCでNumtが5.5倍
Numtは老化や種々の表現型に関与する新たなゲノム変異となる可能性
OA
#mitchondria
#aging
#papers
https://t.co/cqdjvwqjy2 https://t.co/7X6vxt4Ixy
Aug 27, 2024 · 8 likes · 1 share · 1,672 followersView post →
DD
Diane Dewhirst
@NJdoc · X
RT @EricTopol: A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis")…
Aug 26, 2024 · 30 shares · 20,507 followersView post →
SM
Sergey Minaev
@sminaev2015 · X
RT @sminaev2015: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PL…
Aug 26, 2024 · 4 shares · 31,489 followersView post →
PB
PLOS Biology
@PLOSBiology · X
#Eukaryogenesis entailed transfer of DNA from #mitochondria to nuclear genomes. @BrEUssMartin re a #PLOSBiology study of #Numtogenesis, extending this process to human somatic cells, correlating with #aging & disease. Primer: https://t.co/OUrC1I8bsl Paper: https://t.co/8s9lZxSOor https://t.co/zIOJ3EL7nX
Aug 26, 2024 · 2 likes · 102,099 followersView post →
KG
Ken Gusler
@kgusler · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts - https://t.co/x0wMsUbiow
RT @Madam_Mito: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts | bioRxiv…
Aug 26, 2024 · 4 shares · 10,894 followersView post →
PB
PLOS Biology
@PLOSBiology · X
#Eukaryogenesis entailed transfer of DNA from #mitochondria to nuclear genomes. @BrEUssMartin re a #PLOSBiology study of #Numtogenesis, extending this process to human somatic cells, correlating with #aging & disease. Primer: https://t.co/OUrC1I8bsl Paper: https://t.co/8s9lZxSOor https://t.co/B49vXBPlJA
Aug 26, 2024 · 4 likes · 102,099 followersView post →
DK
Dev Khanna
@CurieuxExplorer · X
RT @sminaev2015: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PL…
Aug 26, 2024 · 4 shares · 43,668 followersView post →
MC
MIC_CPH
@MIC_CPH · X
RT @sminaev2015: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PL…
Aug 26, 2024 · 4 shares · 4,004 followersView post →
DB
Dr.A.B.P.Ballal
@DrABPBallal · X
RT @sminaev2015: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PL…
Aug 26, 2024 · 4 shares · 1,783 followersView post →
SM
Sergey Minaev
@sminaev2015 · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PLOS Biology https://t.co/MtxC1hkoXh
Aug 26, 2024 · 7 likes · 4 shares · 31,489 followersView post →
H
Hmmm...
@HmmmNiceee · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
https://t.co/r0T5Y3q6ya
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
https://www.byteseu.com/367178/
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts …
This is about genetics: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time !
An impressive finding with who knows what implications!
https://t.co/93ftHuBFB9
RT @EricTopol: A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis")…
Aug 25, 2024 · 30 shares · 5,402 followersView post →
RS
Richard S
@Richard01173388 · X
RT @EricTopol: A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis")…
Aug 24, 2024 · 30 shares · 170 followersView post →
RS
Richard Smith
@Richard79215390 · X
RT @EricTopol: A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis")…
Aug 24, 2024 · 30 shares · 229 followersView post →
?
|||||
@insurrealist · X
#PLOSBiology: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts https://t.co/lOQWo6tflX
Aug 24, 2024 · 1 like · 4,634 followersView post →
PD
Profesor Jonny E Duque
@ProfesorJonny · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 24, 2024 · 30 shares · 258 followersView post →
V
Viviana
@VivianAya93 · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 133 followersView post →
NA
Nithyanan Annamalai
@BlackSamrat · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 352 followersView post →
ZB
Zoomers of the Sunshine Coast, BC
@SCZoomers · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 316 followersView post →
LV
Lisa Vlad
@LisaVlad2 · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 103 followersView post →
SB
Samarpita Banerjee
@SamarpitaSB · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 63 followersView post →
KB
Kenneth Yaw Agyeman-Badu
@Kenzibit · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 1,617 followersView post →
AJ
AB Johnson
@Hijo_de_Juan · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 24, 2024 · 30 shares · 152 followersView post →
PF
Penelope Figtree
@PenelopeFigtree · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 2,245 followersView post →
TI
Transfinite Induktion
@Transfinit6981 · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 24, 2024 · 84 shares · 14 followersView post →
MH
Mingqi Han
@MingqiHan · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 24, 2024 · 30 shares · 111 followersView post →
TN
Thanh (Ricky) Nguyen
@ThanhNguyen_TNN · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 24, 2024 · 30 shares · 492 followersView post →
ST
Shima Taherkhani
@ShimaTaherkhani · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 23, 2024 · 30 shares · 350 followersView post →
LG
Longevity Global
@LongevityGL · X
RT @MitoPsychoBio: During evolution fragments of mitochondrial genome have been inserted into the nuclear genome - like viral pieces of DNA…
Aug 23, 2024 · 84 shares · 3,308 followersView post →
MC
Martin Correa
@martinrafco · X
RT @EricTopol: A surprise finding on the prevalence of mitochondrial DNA transfer to nucleus of brain cells (to form Numt, "numtogenesis")…
Aug 23, 2024 · 30 shares · 231 followersView post →
SM
Seiichi Mori
@seiichi_mori · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
https://t.co/NtU97n2r5j
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 23, 2024 · 30 shares · 6,648 followersView post →
NP
Nonia Pariente
@npariente · X
RT @PLOSBiology: A price for carrying our endosymbiont? Somatic nuclear #mitochondrial DNA (#Numt) insertions arise spontaneously and accum…
Aug 23, 2024 · 1 share · 4,554 followersView post →
FP
Facu Pacheco Polo
@FacundoPachec19 · X
RT @MitoPsychoBio: During evolution, pieces of mitochondrial genome have been integrated in the nuclear genome
We now find that this proce…
Aug 23, 2024 · 30 shares · 87 followersView post →
OC
Oleg A. Chagin
@Oleg_A_Chagin · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PLOS Biology https://t.co/V4s4OlE9S3
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts | PLOS Biology https://t.co/VkaNStQ3JL
Aug 23, 2024 · 3 likes · 4,786 followersView post →
DD
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts
https://t.co/4oyExPYPRo
RT @Madam_Mito: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts | bioRxiv…
Feb 22, 2024 · 4 shares · 10,894 followersView post →
I
IamMitochondria
@mitopapers · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts https://t.co/6s3uMII7k4 https://t.co/CEbuDFbnuX
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts https://t.co/jK1ZH6qXGf https://t.co/3HcFXSyhLg
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts https://t.co/1VGxHe47lL #biorxiv_genomic
Feb 5, 2023 · 13 likes · 3 shares · 11,973 followersView post →
B
bioRxiv
@biorxivpreprint · X
Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts https://t.co/crqWrVyTwj #bioRxiv
Feb 5, 2023 · 3 likes · 138,520 followersView post →
B
Полина Меньшова, Автор в Naked Science
Blogs
... 10.1371/journal.pbio.3002723 #sec007 (разделы Introduction и Discussion). Кроме того, в списке источников есть ссылки еще на несколько исследований именно ...