Cardiovasc Diabetol August 2024 PMID 39182114

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial.

Javier Donate-Correa, Carla M Ferri, Carmen Mora-Fernández, Nayra Pérez-Delgado, Ainhoa González-Luis, Juan F Navarro-González

Mentions

11
Peak: 8 in Aug 2024
across 2 sources since Aug 2024

Extended reach

70,237
potential audience

Total likes

51

Video views

5,432

Mentions per month

Aug 2024 – Sep 2024

Where it's discussed

  • X / Twitter9 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a general agreement on the promising effects of pentoxifylline, with posts emphasizing its role in reducing inflammation and slowing atherosclerosis, such as mentions of higher Klotho levels and better carotid artery health. The tone is optimistic but straightforward, indicating moderate engagement among medical communities interested in advancements for diabetic and CKD patient care.

AgreementModerate agreement

Most discussions recognize the positive findings of the study, emphasizing benefits like reduced atherosclerosis progression and increased Klotho gene expression.

InterestModerate interest

Participants show moderate interest, as they highlight key results and potential clinical relevance but do not delve deeply into methodological details.

EngagementModerate engagement

There is some engagement with the content, including sharing positive reactions and referencing specific outcomes like inflammation reduction.

ImpactModerate impact

The social discussions suggest that the findings could influence clinical practice, highlighting PTF's potential for improving cardiovascular health in high-risk patients.

Abstract in brief

  • Pentoxifylline (PTF) helps slow down the progression of subclinical atherosclerosis in patients with type 2 diabetes and chronic kidney disease by reducing inflammation and increasing protective proteins like Klotho.
  • The study showed that patients treated with PTF experienced better outcomes, including healthier carotid artery thickness (CIMT) and higher Klotho levels, which are linked to improved cardiovascular health.
  • Overall, PTF appears to be a promising treatment to reduce cardiovascular risks in this high-risk patient group, acting through mechanisms involving decreased inflammation and enhanced protective gene expression.

Top posts

Most liked on X and Bluesky
Javier Donate-Correa, PhD
@Javi_Donate · X

Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients with diabetes and CKD, a beneficial effect related to Klotho gene expression. https://t.co/8Qcti1Wrjs @SaludISCIII @SENefrologia @SanidadGobCan @ITB_ULL

Aug 26, 2024 · 8 likes · 4 shares · 103 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 ... - https://t.co/gm9WpLkfcf #GoogleAlerts

Aug 25, 2024 · 1 like · 32,279 followers View post →
S.E.N. Nefrología
@SENefrologia · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 27, 2024 · 4 shares · 21,905 followers View post →
Jose Luis Górriz
@jlgorriz · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 27, 2024 · 4 shares · 8,597 followers View post →
Shoaib Alam
@ShoaibAlamKhat2 · X

Pentoxifylline slows atherosclerosis progression in diabetic kidney disease patients by boosting Klotho gene expression and reducing inflammation!

Aug 28, 2024 · 913 followers View post →
manuel macia heras
@mmacia25 · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 26, 2024 · 4 shares · 808 followers View post →

All mentions

Grupo Medicable
@GrupoMedicable · X

Los médicos están abiertos a recibir información comercial de productos y servicios que les han aportado información para su práctica diaria. NOTIMED. La pentoxifilina podría reducir riesgo cardiovascular en pacientes con diabetes y enfermedad renal. https://t.co/3rAYELNDQS

Sep 9, 2024 · 1 followers View post →
Shoaib Alam
@ShoaibAlamKhat2 · X

Pentoxifylline slows atherosclerosis progression in diabetic kidney disease patients by boosting Klotho gene expression and reducing inflammation!

Aug 28, 2024 · 913 followers View post →
Jose Luis Górriz
@jlgorriz · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 27, 2024 · 4 shares · 8,597 followers View post →
S.E.N. Nefrología
@SENefrologia · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 27, 2024 · 4 shares · 21,905 followers View post →
Samantha Morais Armas
@samanthama12913 · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 26, 2024 · 4 shares · 158 followers View post →
manuel macia heras
@mmacia25 · X

RT @Javi_Donate: Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients…

Aug 26, 2024 · 4 shares · 808 followers View post →
Javier Donate-Correa, PhD
@Javi_Donate · X

Happy to share the results of this clinical trial in which pentoxifylline reduced atherosclerosis progression in patients with diabetes and CKD, a beneficial effect related to Klotho gene expression. https://t.co/8Qcti1Wrjs @SaludISCIII @SENefrologia @SanidadGobCan @ITB_ULL

Aug 26, 2024 · 8 likes · 4 shares · 103 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 ... - https://t.co/gm9WpLkfcf #GoogleAlerts

Aug 25, 2024 · 1 like · 32,279 followers View post →
Hari Saini
@docharisaini · X

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial https://t.co/No88rO3X8l

Aug 24, 2024 · 2 followers View post →