Nat Biomed Eng September 2024 PMID 39209948

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples.

Yannan Chen, Shradha Chauhan, Cheng Gong, Hannah Dayton, Cong Xu, Estanislao Daniel De La Cruz, Yu-Young Wesley Tsai, Malika S Datta, Gorazd B Rosoklija, Andrew J Dwork, J John Mann, Maura Boldrini, Kam W Leong, Lars E P Dietrich, Raju Tomer

Mentions

34
Peak: 22 in Aug 2024
across 3 sources since Aug 2024

Extended reach

37,305
potential audience

Total likes

74

Video views

2,616

Mentions per month

Aug 2024 – Nov 2024

Where it's discussed

  • X / Twitter19 posts
  • YouTube12 videos
  • News3 articles

AI synopsis

What people are saying

This collection of discussions overwhelmingly supports the publication, with posts calling it a 'game changer' and emphasizing its role in democratizing high-resolution imaging for biomedical research. The tone is optimistic and excited, especially when mentioning applications for brain studies and live sample imaging, demonstrating both enthusiasm and a recognition of its transformative potential.

AgreementStrong agreement

Most comments praise the development as a valuable innovation, emphasizing its affordability and versatility.

InterestHigh interest

Discussions reflect high curiosity about the technology's applications, especially in biomedical research and brain imaging.

EngagementModerate engagement

Some posts delve into technical details and potential uses, indicating active participation and deeper understanding.

ImpactHigh impact

Multiple posts highlight the significance of making high-resolution imaging more accessible, suggesting strong potential influence on the field.

Abstract in brief

  • Light-sheet fluorescence microscopy (LSFM) is effective for imaging cleared tissue and living samples, but traditional systems are expensive and difficult to scale.
  • The newly developed 'projected light-sheet microscopy' (pLSM) offers a low-cost and versatile alternative using consumer-grade components, optimized optics, and software-driven control for high-resolution imaging.
  • pLSM has been successfully tested for mapping mouse brains, analyzing human brain samples, and live imaging of bacterial biofilms, making high-resolution LSFM more accessible for biomedical research.

Top posts

Most liked on X and Bluesky
K SEIRIKI
@seiriki_ · X

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples | Nature Biomedical Engineering https://t.co/dsiUVHyle6

Sep 1, 2024 · 31 likes · 7 shares · 204 followers View post →
biophotonicat
@biophotonicat · X

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples (relevance: 97%) https://t.co/eTZW5KbmxW #biophotonics #biomedicaloptics

Aug 30, 2024 · 15 likes · 8 shares · 1,529 followers View post →
NIH Common Fund
@NIH_CommonFund · X

DYK research from a #NewInnovator award funded by our #NIHHighRisk Research Program enabled development of a low-cost #microscope that can image whole organs and live specimens? See how it can increase access to #3D imaging & its application to the #brain: https://t.co/6NGkDah6lO https://t.co/Fp9XPX8e1K

Nov 6, 2024 · 15,393 followers View post →
PurPurPurkinje
@tak_yamm · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,783 followers View post →
Matsukiblade
@matsukiblade · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,749 followers View post →
すぎちゃん / Y.Sugita
@yuo0y · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,581 followers View post →

All mentions

NIH Common Fund
@NIH_CommonFund · X

DYK research from a #NewInnovator award funded by our #NIHHighRisk Research Program enabled development of a low-cost #microscope that can image whole organs and live specimens? See how it can increase access to #3D imaging & its application to the #brain: https://t.co/6NGkDah6lO https://t.co/Fp9XPX8e1K

Nov 6, 2024 · 15,393 followers View post →
hr_wksh
@hr_wksh · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 2, 2024 · 7 shares · 2,501 followers View post →
Melike Nur Kaytaz
@KaytazNrMlk · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 2, 2024 · 7 shares · 43 followers View post →
成田
@nrinsushi · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 2, 2024 · 7 shares · 97 followers View post →
PurPurPurkinje
@tak_yamm · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,783 followers View post →
Matsukiblade
@matsukiblade · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,749 followers View post →
すぎちゃん / Y.Sugita
@yuo0y · X

RT @seiriki_: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples |…

Sep 1, 2024 · 7 shares · 2,581 followers View post →
K SEIRIKI
@seiriki_ · X

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples | Nature Biomedical Engineering https://t.co/dsiUVHyle6

Sep 1, 2024 · 31 likes · 7 shares · 204 followers View post →
biophotonicat
@biophotonicat · X

(rt) Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples https://t.co/eTZW5KbmxW #biophotonics #biomedicaloptics

Sep 1, 2024 · 1,529 followers View post →
J
@phy_6_ · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 31, 2024 · 8 shares · 32 followers View post →
Ahmed Ezat
@AhmedAdelEzat · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 31, 2024 · 8 shares · 88 followers View post →
afmmenchacalab
@afmmenchacalab · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 388 followers View post →
Christian Burns
@BurnsBioImaging · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 61 followers View post →
David J. Castillo-Cornejo PhD.
@davesnetvault · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 816 followers View post →
Kwasi
@Olu_GH · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 2,045 followers View post →
Panos Symvoulidis
@symvou · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 1,260 followers View post →
Ryuki Imamura
@bio_pypy · X

RT @biophotonicat: Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samp…

Aug 30, 2024 · 8 shares · 319 followers View post →
biophotonicat
@biophotonicat · X

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples (relevance: 97%) https://t.co/eTZW5KbmxW #biophotonics #biomedicaloptics

Aug 30, 2024 · 15 likes · 8 shares · 1,529 followers View post →
Olatunji Omisore
@ootsorewilly · X

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples https://t.co/rWB7Q0gVol

Aug 29, 2024 · 32 followers View post →