JAMA Dermatol November 2024 PMID 39230880

Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia.

Aaron Bao, Aasheen Qadri, Aditi Gadre, Elizabeth Will, Dina Collins, Rexford Ahima, Lindsey A Bordone, Crystal Aguh

Mentions

33
Peak: 8 in Dec 2024
across 5 sources since Sep 2024

Extended reach

164,310
potential audience

Total likes

74

Video views

3,587

Mentions per month

Sep 2024 – Jan 2025

Where it's discussed

  • X / Twitter19 posts
  • News9 articles
  • YouTube2 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions show strong interest and moderate agreement, with comments citing findings like metformin’s ability to downregulate fibrosis, and posts describing the research as potentially transformative, using enthusiastic language like 'wonders' and 'potential.' The tone and content reflect a mix of curiosity, support, and anticipation of real-world application.

AgreementModerate agreement

Most discussions acknowledge the potential benefits of low-dose metformin for hair loss linked to CCCA, showing general support.

InterestHigh interest

Posts demonstrate high curiosity about the research, with mentions of its promising effects and new insights into treatment options.

EngagementModerate engagement

Responders reference specific data, such as gene expression changes and potential for reversing fibrosis, indicating thoughtful engagement.

ImpactModerate impact

Many believe this research could influence future treatments for scarring alopecia and related fibrosis, indicating a moderate but meaningful impact.

Abstract in brief

  • Central centrifugal cicatricial alopecia (CCCA) primarily affects Black women and is characterized by scarring that leads to hair loss; conventional treatments focus on inflammation rather than the underlying fibrotic issues.
  • A study was conducted to assess the effects of low-dose oral metformin, an antidiabetic drug with antifibrotic properties, on clinical symptoms and gene expression in CCCA patients unresponsive to standard treatments.
  • Results from 12 participants showed that after at least 6 months of metformin treatment, many experienced symptom improvement and some showed hair regrowth, with gene analysis indicating beneficial changes in pathways related to skin and hair development.

Top posts

Most liked on X and Bluesky
JAMA Dermatology
@JAMADerm · X

In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulated hair growth signatures. https://t.co/tgGQ6ve5Jt https://t.co/ev66HxEvTY

Dec 3, 2024 · 19 likes · 8 shares · 29,292 followers View post →
Lt Col Ret MD David Perez-Meza FISHRS ABHRS
@drdaviperezmeza · X

https://t.co/aSBFLYixI3

Sep 4, 2024 · 3 likes · 1 share · 861 followers View post →
Dr. Jeff Donovan,
@DonovanMedical · X

In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. https://t.co/1bXGpZO88B #ccca #scarringalopecia https://t.co/BZQg6ZofB1

Nov 25, 2024 · 2 likes · 3,477 followers View post →
Christian Wolf
@KrischanWolf · X

Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall

Sep 9, 2024 · 2 likes · 1 share · 2,488 followers View post →
Hide Miyachi
@HideMiyachi · X

JAMA Dermatolに掲載された瘢痕性脱毛に対するメトホルミン投与に関する研究。少数例での探索的な介入+transcriptomics。 脱毛症は苦手意識があったので詳しくないのだけど、1-2年前ならさっぱりだった内容も今なら頭に入ってくるし、お手本になるかもなと。 https://t.co/RT2KinNItK #皮膚科

Dec 3, 2024 · 2 likes · 166 followers View post →
TACT
@TactNowInfo · X

@doc4care September 4, 2024 "Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia" These findings suggest that low-dose metformin may reverse the fibrotic transcriptional signature in CCCA and promote hair regrowth, indicating its potential as a

Sep 18, 2024 · 1 like · 7,412 followers View post →

All mentions

Top 20 Hair Research Studies of 2024 Overview

Dr Donovan reviews the 20 most influential hair research studies published in 2024, focusing on novel treatments and safety evaluations. This yearly review highlights advancements in hair loss therapies, including…

Donovan Medical · Jan 3, 2025 2,937 views
Hide Miyachi
@HideMiyachi · X

JAMA Dermatolに掲載された瘢痕性脱毛に対するメトホルミン投与に関する研究。少数例での探索的な介入+transcriptomics。 脱毛症は苦手意識があったので詳しくないのだけど、1-2年前ならさっぱりだった内容も今なら頭に入ってくるし、お手本になるかもなと。 https://t.co/RT2KinNItK #皮膚科

Dec 3, 2024 · 2 likes · 166 followers View post →
Kevin McElwee
@ResearchHair · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 882 followers View post →
Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 13,641 followers View post →
tweetderma
@tweetderma · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 3,262 followers View post →
Lij Getachew sinegiorgis
@GetachewGirma15 · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 254 followers View post →
Luis González Torres
@LuisGonzle5510 · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 1,232 followers View post →
Marcelasaeblima.
@MarcelaSaebL · X

RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…

Dec 3, 2024 · 8 shares · 75,289 followers View post →
JAMA Dermatology
@JAMADerm · X

In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulated hair growth signatures. https://t.co/tgGQ6ve5Jt https://t.co/ev66HxEvTY

Dec 3, 2024 · 19 likes · 8 shares · 29,292 followers View post →
Dermatology Papers
@DermatologyPape · X

Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia - https://t.co/Jp86n2OedO

Nov 26, 2024 · 39 followers View post →
DonovanMedical - Dr. Jeff Donovan
@donovanmedical.bsky.social · Bluesky

In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. youtu.be/K3VT8qYFWDg?... #ccca #scarringalopecia

Nov 25, 2024 View post →
Dr. Jeff Donovan,
@DonovanMedical · X

In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. https://t.co/1bXGpZO88B #ccca #scarringalopecia https://t.co/BZQg6ZofB1

Nov 25, 2024 · 2 likes · 3,477 followers View post →
Perez-Meza Hair Institute
@PerezMezaHair · X

RT @drdaviperezmeza: https://t.co/aSBFLYhZSv

Nov 22, 2024 · 1 share · 25 followers View post →
Lt Col Ret MD David Perez-Meza FISHRS ABHRS
@drdaviperezmeza · X

https://t.co/aSBFLYhZSv

Nov 21, 2024 · 1 like · 1 share · 861 followers View post →
sk(in depth)
@skindepthderm · X

Source: Bao A, Qadri A, Gadre A, et al. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia. JAMA Dermatol. Published online September 4, 2024. doi:10.1001/jamadermatol.2024.3062 Link to article: https://t.co/9B1in7wRC6

Oct 5, 2024 · 1 like · 308 followers View post →
Ken Gusler
@kgusler · X

Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia - https://t.co/th0RPbkpBC

Sep 19, 2024 · 20,020 followers View post →
TACT
@TactNowInfo · X

@doc4care September 4, 2024 "Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia" These findings suggest that low-dose metformin may reverse the fibrotic transcriptional signature in CCCA and promote hair regrowth, indicating its potential as a

Sep 18, 2024 · 1 like · 7,412 followers View post →
Superkalifragilistin
@superkalifragi4 · X

RT @KrischanWolf: Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall

Sep 12, 2024 · 1 share · 883 followers View post →
Christian Wolf
@KrischanWolf · X

Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall

Sep 9, 2024 · 2 likes · 1 share · 2,488 followers View post →
#UnidosPorLaSalud
@PorSaludCuidate · X

RT @drdaviperezmeza: https://t.co/aSBFLYixI3

Sep 8, 2024 · 1 share · 208 followers View post →
Lt Col Ret MD David Perez-Meza FISHRS ABHRS
@drdaviperezmeza · X

https://t.co/aSBFLYixI3

Sep 4, 2024 · 3 likes · 1 share · 861 followers View post →