In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulated hair growth signatures. https://t.co/tgGQ6ve5Jt https://t.co/ev66HxEvTY
Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia.
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Sep 2024 – Jan 2025Where it's discussed
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X / Twitter19 posts
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News9 articles
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YouTube2 videos
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Reddit2 posts
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Bluesky1 posts
AI synopsis
What people are saying
The discussions show strong interest and moderate agreement, with comments citing findings like metformin’s ability to downregulate fibrosis, and posts describing the research as potentially transformative, using enthusiastic language like 'wonders' and 'potential.' The tone and content reflect a mix of curiosity, support, and anticipation of real-world application.
Most discussions acknowledge the potential benefits of low-dose metformin for hair loss linked to CCCA, showing general support.
Posts demonstrate high curiosity about the research, with mentions of its promising effects and new insights into treatment options.
Responders reference specific data, such as gene expression changes and potential for reversing fibrosis, indicating thoughtful engagement.
Many believe this research could influence future treatments for scarring alopecia and related fibrosis, indicating a moderate but meaningful impact.
Abstract in brief
- Central centrifugal cicatricial alopecia (CCCA) primarily affects Black women and is characterized by scarring that leads to hair loss; conventional treatments focus on inflammation rather than the underlying fibrotic issues.
- A study was conducted to assess the effects of low-dose oral metformin, an antidiabetic drug with antifibrotic properties, on clinical symptoms and gene expression in CCCA patients unresponsive to standard treatments.
- Results from 12 participants showed that after at least 6 months of metformin treatment, many experienced symptom improvement and some showed hair regrowth, with gene analysis indicating beneficial changes in pathways related to skin and hair development.
Top posts
Most liked on X and Blueskyhttps://t.co/aSBFLYixI3
In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. https://t.co/1bXGpZO88B #ccca #scarringalopecia https://t.co/BZQg6ZofB1
Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall
JAMA Dermatolに掲載された瘢痕性脱毛に対するメトホルミン投与に関する研究。少数例での探索的な介入+transcriptomics。 脱毛症は苦手意識があったので詳しくないのだけど、1-2年前ならさっぱりだった内容も今なら頭に入ってくるし、お手本になるかもなと。 https://t.co/RT2KinNItK #皮膚科
@doc4care September 4, 2024 "Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia" These findings suggest that low-dose metformin may reverse the fibrotic transcriptional signature in CCCA and promote hair regrowth, indicating its potential as a
All mentions
Top 20 Hair Research Studies of 2024 Overview
Dr Donovan reviews the 20 most influential hair research studies published in 2024, focusing on novel treatments and safety evaluations. This yearly review highlights advancements in hair loss therapies, including…
Low-Dose Metformin's Impact on CCCA Treatment Insights
This episode explores a study from JAMA Dermatology examining low-dose metformin's effects on Central Centrifugal Cicatricial Alopecia. The findings suggest potential benefits in symptom improvement and gene expression…
JAMA Dermatolに掲載された瘢痕性脱毛に対するメトホルミン投与に関する研究。少数例での探索的な介入+transcriptomics。 脱毛症は苦手意識があったので詳しくないのだけど、1-2年前ならさっぱりだった内容も今なら頭に入ってくるし、お手本になるかもなと。 https://t.co/RT2KinNItK #皮膚科
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
RT @JAMADerm: In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulat…
In a case series of central centrifugal cicatricial alopecia, low-dose oral metformin downregulated profibrosis and upregulated hair growth signatures. https://t.co/tgGQ6ve5Jt https://t.co/ev66HxEvTY
Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia - https://t.co/Jp86n2OedO
In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. youtu.be/K3VT8qYFWDg?... #ccca #scarringalopecia
In this week’s Evidence Based Hair podcast, I discuss oral metformin and its role in treating central centrifugal cicatricial alopecia. https://t.co/1bXGpZO88B #ccca #scarringalopecia https://t.co/BZQg6ZofB1
RT @drdaviperezmeza: https://t.co/aSBFLYhZSv
https://t.co/aSBFLYhZSv
Source: Bao A, Qadri A, Gadre A, et al. Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia. JAMA Dermatol. Published online September 4, 2024. doi:10.1001/jamadermatol.2024.3062 Link to article: https://t.co/9B1in7wRC6
Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia - https://t.co/th0RPbkpBC
@doc4care September 4, 2024 "Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia" These findings suggest that low-dose metformin may reverse the fibrotic transcriptional signature in CCCA and promote hair regrowth, indicating its potential as a
RT @KrischanWolf: Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall
Neue Wunder aus der #Metformin-Küche: nun auch gegen Haarausfall
RT @drdaviperezmeza: https://t.co/aSBFLYixI3
https://t.co/aSBFLYixI3