PubHawk
JAMA Psychiatry December 2024 PMID 39230883

Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis.

Jared T Hinkle, Marianna Graziosi, Sandeep M Nayak, David B Yaden

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Mentions

38
Peak: 20 in Sep 2024
across 5 sources since Sep 2024

Extended reach

290,414
potential audience

Total likes

1,273

Video views

32,318

Mentions per month

Sep 2024 – Jun 2025

Where it's discussed

  • X / Twitter26 posts
  • News5 articles
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The posts often cite specific aspects of the study, such as its systematic approach and findings about safety, with tone reflecting curiosity and caution, like 'learning a lot' and discussions about standards for adverse event reporting, demonstrating meaningful engagement and interest in the article's implications.

AgreementModerate agreement

Most comments recognize the findings of the article, especially noting the general safety of psychedelics in research settings like 'generally well tolerated' and 'no serious adverse events in healthy participants.'

InterestHigh interest

Discussions show high interest by referencing the methodology and implications, such as learning how to report adverse events and emphasizing the importance of safety monitoring.

EngagementHigh engagement

Many posts delve into details, sharing their thoughts on the significance of the review, raising questions about heterogeneity and safety standards, indicating thoughtful engagement.

ImpactModerate impact

The content suggests the article influences perceptions about the safety of psychedelics, with some posts highlighting its role in guiding clinical practices and safety reporting, though overall impact feels moderate.

Abstract in brief

  • This systematic review and meta-analysis examines the risks associated with classic psychedelics like LSD, psilocybin, DMT, and 5MeODMT in clinical and research settings to ensure safe application as use expands.
  • The study analyzed data from 214 studies involving over 114,000 participants, focusing on adverse events such as serious adverse events (SAEs) and nonserious adverse events (NSAEs), including those requiring medical or psychiatric intervention.
  • Results showed that no SAEs occurred in healthy individuals, but about 4% of participants with pre-existing neuropsychiatric conditions experienced SAEs like worsening depression, suicidal behavior, psychosis, or convulsions.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Julie Holland, MD
@BellevueDoc · X

Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 8, 2024 · 19 likes · 5 shares · 14,446 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical trials. Eg learning the standards for how to report them ie comprehensively. https://t.co/4xEW6kqQiX https://t.co/9sqfPvvsuJ

Dec 30, 2024 · 17 likes · 4 shares · 65,118 followers View post →
内田裕之 (Hiroyuki Uchida)
@Uchida_Keio_Psy · X

精神展開剤（サイケデリックス）の有害事象に関するメタ解析。精神展開剤は忍容性が総じて高いものの、今後も慎重に有害事象を観察しましょう、という内容 Adverse Events in Studies of Classic Psychedelics https://t.co/Qg6X4WDsNP

Sep 9, 2024 · 14 likes · 2 shares · 547 followers View post →
JAMA Psychiatry
@JAMAPsych · X

In this systematic review and meta-analysis, classic psychedelics were generally well tolerated in clinical or research settings according to the existing literature, although SAEs did occur. https://t.co/iDIsru3NwM https://t.co/HkSqYqXDdS

Sep 4, 2024 · 8 likes · 6 shares · 56,635 followers View post →
David B. Yaden
@ExistWell · X

This project was led by @jaredhinkle4, an MD/PhD interested in trying to get an objective picture of the safety profile of classic psychedelics, w/ support from myself, Marianna Graziosi @MariannaGrazz and Sandeep Nayak @sdpnayak. It's available here: https://t.co/parJozr22L

Sep 6, 2024 · 6 likes · 7,185 followers View post →
P
@psychopharmacol · X

MA: classic psychedelics were generally well tolerated in clinical or research settings. However, there was significant heterogeneity in the quality of AE monitoring and reporting https://t.co/4c1Pyc4MBG

Sep 10, 2024 · 2 likes · 575 followers View post →

All mentions

David B. Yaden
@ExistWell · X

RT @RCarhartHarris: Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical tri…

Jan 4, 2025 · 4 shares · 7,185 followers View post →
Tripepsych
@Tripepsych · X

RT @RCarhartHarris: Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical tri…

Dec 30, 2024 · 4 shares · 819 followers View post →
El Drey
@ElDrey72 · X

RT @RCarhartHarris: Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical tri…

Dec 30, 2024 · 4 shares · 29 followers View post →
Centre for Psychedelic Research
@Imperial_PRG · X

RT @RCarhartHarris: Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical tri…

Dec 30, 2024 · 4 shares · 19,138 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

Thought this was good. I learned a lot re how to report AEs after moving from healthy P imaging studies to clinical trials. Eg learning the standards for how to report them ie comprehensively. https://t.co/4xEW6kqQiX https://t.co/9sqfPvvsuJ

Dec 30, 2024 · 17 likes · 4 shares · 65,118 followers View post →
M
@micmicmic1 · X

Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network https://t.co/GblWjdWBHH

Dec 5, 2024 · 1,622 followers View post →
ForensicPsyMD
@ForensicPsyMD · X

Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network https://t.co/C05AfMgPaA

Dec 5, 2024 · 359 followers View post →
青井硝子@最高裁太郎
@garassan · X

RT @Uchida_Keio_Psy: 精神展開剤（サイケデリックス）の有害事象に関するメタ解析。精神展開剤は忍容性が総じて高いものの、今後も慎重に有害事象を観察しましょう、という内容 Adverse Events in Studies of Classic Psyched…

Sep 13, 2024 · 2 shares · 15,509 followers View post →
Tatsu Hirukawa / 蛭川立
@ininsui · X

RT @Uchida_Keio_Psy: 精神展開剤（サイケデリックス）の有害事象に関するメタ解析。精神展開剤は忍容性が総じて高いものの、今後も慎重に有害事象を観察しましょう、という内容 Adverse Events in Studies of Classic Psyched…

Sep 13, 2024 · 2 shares · 3,209 followers View post →
P
@psychopharmacol · X

MA: classic psychedelics were generally well tolerated in clinical or research settings. However, there was significant heterogeneity in the quality of AE monitoring and reporting https://t.co/4c1Pyc4MBG

Sep 10, 2024 · 2 likes · 575 followers View post →
Dr. Carl Hindy
@DrCarlHindy · X

Adverse Events in Studies of Classic Psychedelics. A Systematic Review and Meta-Analysis — JAMA Psychiatry https://t.co/7FFANBTNHb

Sep 10, 2024 · 33,180 followers View post →
Nicolas sapit
@NicolasSapit · X

RT @BellevueDoc: Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 10, 2024 · 5 shares · 155 followers View post →
Steven Glass, Psy.D./ Beyond the Journey
@StevenG41417579 · X

RT @BellevueDoc: Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 9, 2024 · 5 shares · 429 followers View post →
内田裕之 (Hiroyuki Uchida)
@Uchida_Keio_Psy · X

精神展開剤（サイケデリックス）の有害事象に関するメタ解析。精神展開剤は忍容性が総じて高いものの、今後も慎重に有害事象を観察しましょう、という内容 Adverse Events in Studies of Classic Psychedelics https://t.co/Qg6X4WDsNP

Sep 9, 2024 · 14 likes · 2 shares · 547 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

RT @BellevueDoc: Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 9, 2024 · 5 shares · 6,490 followers View post →
Henry Derevyanny (aka Jerry Christ)
@JerryLuMencken · X

RT @BellevueDoc: Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 8, 2024 · 5 shares · 285 followers View post →
Sir Gunjah LimpsAlot
@SLimpsalot · X

RT @BellevueDoc: Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 8, 2024 · 5 shares · 437 followers View post →
Julie Holland, MD
@BellevueDoc · X

Adverse events in studies of classic psychedelics: A systematic review and meta-analysis https://t.co/DCvfjP8SNX

Sep 8, 2024 · 19 likes · 5 shares · 14,446 followers View post →
George Dawson
@dawso007 · X

Open Access: neglected area of research relative to clinical practice Adverse Events in Studies of Classic Psychedelics https://t.co/9w5Ir5mCIL

Sep 6, 2024 · 1 like · 7,821 followers View post →
David B. Yaden
@ExistWell · X

This project was led by @jaredhinkle4, an MD/PhD interested in trying to get an objective picture of the safety profile of classic psychedelics, w/ support from myself, Marianna Graziosi @MariannaGrazz and Sandeep Nayak @sdpnayak. It's available here: https://t.co/parJozr22L

Sep 6, 2024 · 6 likes · 7,185 followers View post →
St Thomas Fan
@StThomasStan · X

Adverse Events in Studies of Classic Psychedelics Serious Adverse Events (SAE's) were reported for no healthy participants and only approximately 4% of participants with preexisting neuropsychiatric disorders. https://t.co/dqt9jdfV41

Sep 5, 2024 · 6,037 followers View post →
THERADELICS
@theradelics · X

Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis https://t.co/0E4qzKprgq https://t.co/g4DXMzCbE9

Sep 5, 2024 · 3,386 followers View post →
Katherine Cheung
@Katherine_Chg · X

RT @JAMAPsych: In this systematic review and meta-analysis, classic psychedelics were generally well tolerated in clinical or research sett…

Sep 4, 2024 · 6 shares · 427 followers View post →
(Sichu Lu(Sichu.Lu218@proton.me)
@lu_sichu · X

RT @JAMAPsych: In this systematic review and meta-analysis, classic psychedelics were generally well tolerated in clinical or research sett…

Sep 4, 2024 · 6 shares · 3,221 followers View post →
Michael Haichin
@MichaelHaichin · X

RT @JAMAPsych: In this systematic review and meta-analysis, classic psychedelics were generally well tolerated in clinical or research sett…

Sep 4, 2024 · 6 shares · 3,693 followers View post →
JAMA Psychiatry
@JAMAPsych · X

In this systematic review and meta-analysis, classic psychedelics were generally well tolerated in clinical or research settings according to the existing literature, although SAEs did occur. https://t.co/iDIsru3NwM https://t.co/HkSqYqXDdS

Sep 4, 2024 · 8 likes · 6 shares · 56,635 followers View post →