Acta Crystallogr F Struct Biol Commun October 2024 PMID 39259139

Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microscopy.

Stefania Hanau, John R Helliwell

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Peak: 20 in Oct 2024

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The overall tone highlights excitement about the detailed structural insights provided by the publication, with terms like 'wide-ranging discussion,' 'topical review,' and mentions of specific structures, which demonstrate active engagement. The references to technical methods and potential biomedical applications reflect a strong interest and recognition of the work's importance.

AgreementModerate agreement

Most discussions acknowledge the scientific value of the structural studies and their potential applications, reflecting general agreement with the publication's significance.

InterestHigh interest

Posts express high interest in the detailed analysis of the enzyme's 3D structures, referencing specific techniques like X-ray crystallography and electron cryo-microscopy.

EngagementModerate engagement

Discussions include references to interviews and structural data, indicating a moderate level of engagement centered around understanding the methodologies and implications.

ImpactModerate impact

The mentions of breakthrough applications in drug development and biotechnology suggest the audience perceives moderate to high potential impact.

Abstract in brief

Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway, and its structure has been studied extensively through X-ray crystallography and electron cryomicroscopy, with several structures available in the Protein Data Bank.
The differences between human G6PD and parasite G6PD can be used to develop targeted drugs for infections like malaria and leishmaniasis, and G6PD also serves as a marker and potential target in various cancers.
F-dependent G6PD (FGD) from microbes like Mycobacterium tuberculosis has significant biotechnological applications in biocatalysis and bioremediation, making it a promising target for disease treatment and industrial processes.]

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Structural Insights into Glucose-6-Phosphate Dehydrogenase and Its Biomedical Applications

This video discusses the extensive structural studies of G6PD using crystallography and cryomicroscopy. It highlights differences between human and parasite G6PD for drug development, G6PD's role in cancer, and…

International Union of Crystallography · Oct 28, 2024 225 views

Structural Insights into Glucose-6-Phosphate Dehydrogenase and Its Applications

This video covers the structural studies of G6PD, a key enzyme in the pentose phosphate pathway, highlighting its 3D structures obtained via crystallography and cryomicroscopy. It discusses implications for drug…

International Union of Crystallography · Oct 29, 2024 57 views

Analio Dugarte

@analioj · X

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Nov 16, 2024 · 6 shares · 2,180 followers View post →

Structural Biology

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RT @ActaCrystF: A new edition of 'Interviews with Authors': @ActaCrystF Section Editors Jon Agirre, Cristy Nonato and @markvanraaij and Com…

Oct 31, 2024 · 4 shares · 3,024 followers View post →

Roberto Steiner

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RT @ActaCrystF: A new edition of 'Interviews with Authors': @ActaCrystF Section Editors Jon Agirre, Cristy Nonato and @markvanraaij and Com…

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Structural Biology Communications

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RT @ActaCrystF: A new edition of 'Interviews with Authors': @ActaCrystF Section Editors Jon Agirre, Cristy Nonato and @markvanraaij and Com…

Oct 30, 2024 · 4 shares · 1,651 followers View post →

Kutand Alkım Bayer

@kutandalkim · X

RT @HelliwellJohn: @ActaCrystF Try this weblink for my interview (video and audio) with the Acta Cryst F Main Editors:- https://t.co/4VeX…

Oct 29, 2024 · 2 shares · 651 followers View post →

Kutand Alkım Bayer

@kutandalkim · X

RT @ActaCrystF: A new edition of 'Interviews with Authors': @ActaCrystF Section Editors Jon Agirre, Cristy Nonato and @markvanraaij and Com…

Oct 29, 2024 · 4 shares · 651 followers View post →

Kutand Alkım Bayer

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Oct 29, 2024 · 6 shares · 651 followers View post →

Structural Biology Communications

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Brice Kauffmann

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RT @HelliwellJohn: @ActaCrystF Try this weblink for my interview (video and audio) with the Acta Cryst F Main Editors:- https://t.co/4VeX…

Oct 29, 2024 · 2 shares · 888 followers View post →

John R Helliwell

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@ActaCrystF Try this weblink for my interview (video and audio) with the Acta Cryst F Main Editors:- https://t.co/4VeXcS7MXk @IUCr

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Structural Chemistry

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John R Helliwell

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Structural Biology Communications

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IUCr

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Yue Lab at Newcastle

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RT @ActaCrystF: This topical review focuses on 13 X-ray crystal structures and five electron cryo-microscopy structures of glucose-6-phosph…

Oct 14, 2024 · 3 shares · 1,002 followers View post →

John R Helliwell

@HelliwellJohn · X

RT @ActaCrystF: This topical review focuses on 13 X-ray crystal structures and five electron cryo-microscopy structures of glucose-6-phosph…

Oct 14, 2024 · 3 shares · 1,872 followers View post →

Kutand Alkım Bayer

@kutandalkim · X

RT @ActaCrystF: This topical review focuses on 13 X-ray crystal structures and five electron cryo-microscopy structures of glucose-6-phosph…

Oct 14, 2024 · 3 shares · 651 followers View post →

Structural Biology Communications

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Oct 14, 2024 · 5 likes · 3 shares · 1,651 followers View post →

Kutand Alkım Bayer

@kutandalkim · X

RT @ActaCrystF: Hanau and Helliwell: Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microsc…

Sep 17, 2024 · 2 shares · 651 followers View post →

Kutand Alkım Bayer

@kutandalkim · X

RT @ActaCrystF: Hanau and Helliwell: Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microsc…

Sep 12, 2024 · 2 shares · 651 followers View post →

Structural Biology Communications

@actacrystf.iucr.org · Bluesky

Sep 11, 2024 · 1 share View post →

Structural Biology Communications

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Sep 11, 2024 · 2 likes · 2 shares · 1,651 followers View post →

Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microscopy.

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Structural Insights into Glucose-6-Phosphate Dehydrogenase and Its Biomedical Applications

Structural Insights into Glucose-6-Phosphate Dehydrogenase and Its Applications