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BMC Endocr Disord September 2024 PMID 39350158

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies.

Katarzyna Nabrdalik, Mirela Hendel, Krzysztof Irlik, Hanna Kwiendacz, Igor Łoniewski, Tommaso Bucci, Uazman Alam, Gregory Y H Lip, Janusz Gumprecht, Karolina Skonieczna-Żydecka

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Mentions

13
Peak: 4 in Oct 2024
across 5 sources since Sep 2022

Extended reach

9,720
potential audience

Total likes

10

Video views

615

Mentions per month

Sep 2022 – Sep 2025

Where it's discussed

  • X / Twitter6 posts
  • Instagram3 posts
  • YouTube2 videos
  • Facebook1 posts
  • News1 articles

AI synopsis

What people are saying

Several discussions emphasize the importance of the research, with mentions of its relevance to clinical practice, such as improving patient outcomes by choosing better tolerated metformin formulations. The tone reflects curiosity and recognition of the study’s potential to affect treatment strategies, evidenced by phrases like 'new research' and emphasis on 'adverse events' which underline the study's significance.

AgreementModerate agreement

Most discussions acknowledge the relevance of the systematic review and its findings, indicating general support or acceptance.

InterestModerate interest

Participants show moderate interest, referencing the publication's implications for practice and highlighting new research with enthusiasm.

EngagementModerate engagement

Comments include references to specific aspects like the comparison between extended release and immediate release forms, showing a moderate level of detailed engagement.

ImpactModerate impact

The conversations suggest that the study could influence clinical considerations, especially regarding medication tolerability in patients.

Abstract in brief

  • Metformin, the most commonly prescribed medication for type 2 diabetes, is associated with gastrointestinal (GI) adverse events that can limit its use in patients.
  • A systematic review and meta-analysis of 21 studies aimed to determine the prevalence of these GI adverse events, finding that diarrhea (6.9%) and bloating (6.2%) were the most common issues.
  • Extended release (XR) metformin was shown to have lower incidences of GI issues, suggesting it's better tolerated than the immediate release (IR) formulation.
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Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials: Introduction Metformin is the… https://t.co/OzOt4zbCXQ #Endocrinology #Endo

Sep 14, 2022 · 2 likes · 1 share · 5,076 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

"Frontiers | Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials" @LHCH @LivHPartners @LJMU_Health : https://t.co/zXZ1kal9Q9 https://t.co/CzkhtiO4OF

Sep 14, 2022 · 1 like · 1,479 followers View post →
Health And Nutrition
@Nutrition_1M · X

References : •https://t.co/GmN3tL3RNF •https://t.co/3AWGIEtCRq •https://t.co/b8C95ebAFq

Jul 11, 2025 · 1 like · 434 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies https://t.co/gUfb8Q8JhV https://t.co/qEJpeXYJbN

Oct 25, 2024 · 1,479 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

RT @FrontEndocrinol: New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A syst…

Sep 14, 2022 · 1 share · 583 followers View post →
Grupo Medicable
@GrupoMedicable · X

En Conectimed creamos campañas en base al conocimiento aplicable a la práctica médica. NOTIMED. Efectos adversos gastrointestinales de la metformina en pacientes con diabetes mellitus tipo 2. https://t.co/bgs9HNKEOx #salud #medicos #ciencia #medicina #industriafarmaceutica

Oct 22, 2024 · 1 followers View post →

All mentions

Health And Nutrition
@Nutrition_1M · X

References : •https://t.co/GmN3tL3RNF •https://t.co/3AWGIEtCRq •https://t.co/b8C95ebAFq

Jul 11, 2025 · 1 like · 434 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies https://t.co/gUfb8Q8JhV https://t.co/qEJpeXYJbN

Oct 25, 2024 · 1,479 followers View post →
Grupo Medicable
@GrupoMedicable · X

En Conectimed creamos campañas en base al conocimiento aplicable a la práctica médica. NOTIMED. Efectos adversos gastrointestinales de la metformina en pacientes con diabetes mellitus tipo 2. https://t.co/bgs9HNKEOx #salud #medicos #ciencia #medicina #industriafarmaceutica

Oct 22, 2024 · 1 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

RT @FrontEndocrinol: New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A syst…

Sep 14, 2022 · 1 share · 583 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials: Introduction Metformin is the… https://t.co/OzOt4zbCXQ #Endocrinology #Endo

Sep 14, 2022 · 2 likes · 1 share · 5,076 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

"Frontiers | Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials" @LHCH @LivHPartners @LJMU_Health : https://t.co/zXZ1kal9Q9 https://t.co/CzkhtiO4OF

Sep 14, 2022 · 1 like · 1,479 followers View post →
Gastrointestinal Adverse Event | PDF | Diseases And Disorders ...
News

Nabrdalik et al. BMC Endocrine Disorders (2024) 24:206 BMC Endocrine Disorders. https://doi.org/10.1186/s12902-024-01727-w. SYSTEMATIC REVIEW ...

Sep 5, 2025 View →
Metformin is a medication that your doctor prescribes to lower your ...
Facebook

... •https://bmcendocrdisord.biomedcentral. com/articles/10.1186/s12902-024-01727-w. ncbi.nlm.nih.gov. Metformin. 2 wks. 3. Mitzi McPike.

Jul 11, 2025 View →
Diabetes Educator Nutritionist Pharmacist | Diana | Does ...
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... 10.1186/s12902-024-01727-w doi.org/10.1111/dom.12854 Disclaimer: @diabetespharmacist.dietitian page has been created with purpose to ...

Jun 24, 2025 View →
TWCM Trinity Medical Centre (Port Adelaide) | Say to one of our ...
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doi.org/10.1186/s12902-024-01727-w doi.org/10.1111/dom.12854 Disclaimer: @diabetespharmacist.dietitian page has been created with ...

Mar 4, 2025 View →
TWCM Trinity Medical Centre (Port Adelaide) | Those first few days ...
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doi.org/10.1186/s12902-024-01727-w doi.org/10.1111/dom.12854 Disclaimer: @diabetespharmacist.dietitian page has been created with ...

Jan 14, 2025 View →