Trials October 2024 PMID 39354527

A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program.

Brad Stanfield, Matt Kaeberlein, Brian Leroux, Julie Jones, Ruth Lucas, Bruce Arroll

Mentions

31
Peak: 25 in Oct 2024
across 3 sources since Oct 2024

Extended reach

343,308
potential audience

Total likes

3,111

Video views

66,392

Mentions per month

Oct 2024 – Oct 2025

Where it's discussed

  • X / Twitter26 posts
  • YouTube3 videos
  • News2 articles

AI synopsis

What people are saying

Participants show moderate interest and engagement, referencing the study’s design, funding, and protocol publication through phrases like 'fascinated to know your thoughts' and 'the full trial protocol published,' indicating curiosity and support for transparency without deeply critiquing or analyzing the findings. The tone is mostly neutral and supportive, emphasizing community involvement and current research activity, but lacking strong opinions or calls to action.

AgreementNeither agree nor disagree

The discussions generally acknowledge the study but do not show strong consensus for or against its conclusions.

InterestModerate interest

Participants express some curiosity about the trial, funding, and design, but overall interest remains moderate.

EngagementModerate engagement

Comments include basic acknowledgments and questions, indicating some engagement but limited in-depth analysis.

ImpactNeutral impact

The discussions highlight awareness and support for the trial but do not indicate a perceived high impact on the field or practice.

Abstract in brief

  • This study investigates whether weekly doses of sirolimus rapamycin, combined with a 13-week exercise program, can safely improve muscle strength and endurance in older adults aged 65-85, using various tests and blood analyses to measure outcomes.
  • Participants are randomly assigned to receive either rapamycin or a placebo, and their progress is assessed at multiple points, including muscle performance tests, blood tests, and biological age markers like DNA methylation.
  • The goal is to explore a new strategy of alternating mTOR inhibition and activation to potentially enhance muscle health and combat age-related decline, contributing to better quality of life and reduced frailty in the elderly.

Top posts

Most liked on X and Bluesky
Dr Brad Stanfield
@BradStanfieldMD · X

The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particular @mkaeberlein (co-author) for assistance with the overall trial design (exciting update about study recruitment coming soon) https://t.co/fNaQmhFgSb

Oct 1, 2024 · 109 likes · 10 shares · 29,542 followers View post →
VitaDAO
@vitadao · X

The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 46 likes · 6 shares · 45,326 followers View post →
Agingdoc
@agingdoc1 · X

A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program @BradStanfieldMD @mkaeberlein @BruceArroll https://t.co/0fZxbtucQR

Oct 3, 2024 · 23 likes · 2 shares · 42,376 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

Here's the full trial protocol, published in a peer-reviewed journal: https://t.co/fNaQmhFgSb

Oct 20, 2024 · 9 likes · 1 share · 29,542 followers View post →
BZ2719
@BZ2719 · X

@OraBiomedical @KristerKauppi A very recent study on exercise and rapamycin. https://t.co/S10O7dshQy https://t.co/U8z8rUnH5a

Oct 22, 2024 · 4 likes · 20 followers View post →
Zanthous
@Zanthous · X

@precuneanplexus @nearcyan Well, studies are being done on older people to see if rapamycin helps improve muscle strength. In old age there is thought to be overactivation of mtor, and not enough proper rest. See this planned one: https://t.co/IQeReT2Z5V

Oct 27, 2024 · 1 like · 46 followers View post →

All mentions

ME/CFS Research
@cfs_research · X

@spirit_raccoon @annesmithmcc @ZacharyGrinDPT @bmj_latest Trial underway here: https://t.co/mZuYtZ6SXv

May 16, 2025 · 1,190 followers View post →
Jack Gibb
@JackGibb480867 · X

@PeterAttiaMD, would be fascinated to know your thoughts on this rapamycin RCT - thoughts on the design and outcome selection? https://t.co/Hskbnp6oy3

Dec 15, 2024 · 2 followers View post →
VitaDAO
@vitadao · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Nov 16, 2024 · 6 shares · 45,326 followers View post →
Zanthous
@Zanthous · X

@precuneanplexus @nearcyan Well, studies are being done on older people to see if rapamycin helps improve muscle strength. In old age there is thought to be overactivation of mtor, and not enough proper rest. See this planned one: https://t.co/IQeReT2Z5V

Oct 27, 2024 · 1 like · 46 followers View post →
BZ2719
@BZ2719 · X

@OraBiomedical @KristerKauppi A very recent study on exercise and rapamycin. https://t.co/S10O7dshQy https://t.co/U8z8rUnH5a

Oct 22, 2024 · 4 likes · 20 followers View post →
Jason Brock
@jason_brock · X

RT @BradStanfieldMD: Here's the full trial protocol, published in a peer-reviewed journal: https://t.co/fNaQmhFgSb

Oct 20, 2024 · 1 share · 95 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

Here's the full trial protocol, published in a peer-reviewed journal: https://t.co/fNaQmhFgSb

Oct 20, 2024 · 9 likes · 1 share · 29,542 followers View post →
Cancel-Aging
@Cancel_Aging · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 16, 2024 · 6 shares · 1,010 followers View post →
Laurence Ion
@longevion · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 6 shares · 3,929 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 6 shares · 29,542 followers View post →
Alex Dobrin
@alxdobrin · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 6 shares · 2,179 followers View post →
DeSci Alliance
@DeSciAlliance · X

RT @vita_dao: The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 6 shares · 3,880 followers View post →
VitaDAO
@vitadao · X

The VitaDAO community helped fund the Rapamycin & Exercise clinical trial.

Oct 14, 2024 · 46 likes · 6 shares · 45,326 followers View post →
Assoc. Prof. Tim Sargeant
@TimSargeant1 · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 10, 2024 · 10 shares · 1,115 followers View post →
死胖子
@waylliam · X

RT @agingdoc1: A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-wee…

Oct 5, 2024 · 2 shares · 2 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-wee…

Oct 3, 2024 · 2 shares · 132 followers View post →
Agingdoc
@agingdoc1 · X

A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program @BradStanfieldMD @mkaeberlein @BruceArroll https://t.co/0fZxbtucQR

Oct 3, 2024 · 23 likes · 2 shares · 42,376 followers View post →
Mind Your Science!
@MindYourSci · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 2, 2024 · 10 shares · 132 followers View post →
Tetrahedral
@Tetrahedral2 · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 2, 2024 · 10 shares · 92 followers View post →
Ljubomir Josifovski
@ljupc0 · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 2, 2024 · 10 shares · 5,719 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 2, 2024 · 10 shares · 641 followers View post →
Autoimmune CAR-T
@Car_T_cells · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 1, 2024 · 10 shares · 569 followers View post →
Matt Kaeberlein
@mkaeberlein · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 1, 2024 · 10 shares · 30,055 followers View post →
Max Unfried
@MaxUnfried · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 1, 2024 · 10 shares · 4,045 followers View post →
Revel Peters
@urbanlamb · X

RT @BradStanfieldMD: The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particul…

Oct 1, 2024 · 10 shares · 111 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

The Rapamycin & Exercise clinical trial protocol is now published! Thank you to all for your support, and in particular @mkaeberlein (co-author) for assistance with the overall trial design (exciting update about study recruitment coming soon) https://t.co/fNaQmhFgSb

Oct 1, 2024 · 109 likes · 10 shares · 29,542 followers View post →